Tissue Architecture and Regeneration Research Group

Group leaderProf Sigrun Lange
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A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release

Journal article

Jorfi, S., Ansa-Addo, E.A., Mariniello, K., Warde, P., Bin Senian, A.A., Stratton, D., Bax, B.E., Levene, M., Lange, S. and Inal, J.M. 2023. A Coxsackievirus B1-mediated nonlytic Extracellular Vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release. Journal of General Virology. 104 (9) 001884. https://doi.org/10.1099/jgv.0.001884

A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo

Article

Surendranath, K. and Karande A.A. 2008. A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo. Clinical and Vaccine Immunology. 15 (5), pp. 737-743. https://doi.org/10.1128/CVI.00254-07

A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.)

Journal article

Magnadóttir, B., Gudmundsdottir, S. and Lange, S. 2019. A novel ladder-like lectin relates to sites of mucosal immunity in Atlantic Halibut (Hippoglossus hippoglossus L.) . Fish & Shellfish Immunology. 87, pp. 9-12. https://doi.org/10.1016/j.fsi.2018.12.034

Abrus Toxins: Study on a dangerous lectin duo present in the seeds of Indian licorice

Book

Surendranath, K. 2009. Abrus Toxins: Study on a dangerous lectin duo present in the seeds of Indian licorice. Germany Lambert Academic Publishing GmbH & Company KG.

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy

Journal article

Rossi, S., Maisto, R., Gesualdo, C., Trotta, M.C., Ferraraccio, F., Kaneva, M.K., Getting, S.J., Surace, E., Testa, F., Simonelli, F., Grieco, P., Merlino, F., Perretti, M., D'Amico, M. and Di Filippo, C. 2016. Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy. Mediators of inflammation. 2016 7368389. https://doi.org/10.1155/2016/7368389

Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation

Conference poster

Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation. BNA Festival of Neuroscience. Birmingham 10 - 13 Apr 2017 Sage. https://doi.org/10.1177/2398212817705279

Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber)

Journal article

D'alessio, S., Cheng, H., Eaton, L., Kraev, I., Pamenter, M.E. and Lange, S. 2022. Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (Heterocephalus glaber). International Journal of Molecular Sciences. 23 (9) 4683. https://doi.org/10.3390/ijms23094683

Alcohol metabolism: implications for nutrution and health

Book chapter

Patel, V.B. and Preedy, V.R. 2017. Alcohol metabolism: implications for nutrution and health. in: Geissler, C. and Powers, H. (ed.) Human Nutrition, 13th Edition Oxford Oxford University Press. pp. 216-235

An investigation into the impact of peer- and self-marking in a first year biochemistry module

Conference paper

Smith, C.L. 2016. An investigation into the impact of peer- and self-marking in a first year biochemistry module. Inspire to succeed: Transforming teaching and learning in STEM. East Midlands Conference Centre, Nottingham on 28 and 29 January 2016 28 Jan 2016

Anatomy, embryology, and cell families

Book chapter

Locke, I.C. and Murray, J.F. 2014. Anatomy, embryology, and cell families. in: Orchard, G. and Nation, B. (ed.) Cell Structure & Function Oxford, UK Oxford University Press. pp. 82-110

Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins

Article

Basak, I., Pal, R., Patil, K.S., Dunne, A., Ho, H.P., Lee, S., Peiris, D., Maple-Grødem, J., Odell, M., Chang, E.J., Larsen, J.P. and Møller, S. 2014. Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins. Journal of Biological Chemistry. 289 (21), pp. 14458-69.

Biomarkers in Bone Disease (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Patel, V. and Preedy, V.R. (ed.) 2017. Biomarkers in Bone Disease (Biomarkers in Disease: Methods, Discoveries and Applications) . Springer.

Biomarkers in Cancer

Book

Preedy, V.R. and Patel, V. (ed.) 2015. Biomarkers in Cancer. Springer.

Biomarkers in Cardiovascular Disease (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Patel, V.B and Preedy, V.R. (ed.) 2016. Biomarkers in Cardiovascular Disease (Biomarkers in Disease: Methods, Discoveries and Applications). Springer.

Biomarkers in Health and Disease: Further Knowledge

Book chapter

Rajendram, R., Rajendram, R., Patel, V.B. and Preedy, V.R. 2015. Biomarkers in Health and Disease: Further Knowledge. in: Preedy, V.R. and Patel, V.B. (ed.) General Methods in Biomarker Research and their Applications Netherlands Springer. pp. 1311-1316

Biomarkers in Kidney Disease (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Patel, V.B. and Preedy, V.R. (ed.) 2016. Biomarkers in Kidney Disease (Biomarkers in Disease: Methods, Discoveries and Applications) . Springer.

Biomarkers in Liver Disease (Biomarkers in Disease: Methods, Discoveries and Applications)

Book

Patel, V.B and Preedy, V.R. (ed.) 2017. Biomarkers in Liver Disease (Biomarkers in Disease: Methods, Discoveries and Applications). Springer.

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.

Journal article

Holloway, P.M., Durrenberger, P.F., Trutschl, M., Cvek, U., Cooper, D., Orr, A.W., Perretti, M., Getting, S.J. and Gavins, F.N. 2015. Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. Arteriosclerosis, Thrombosis and Vascular biology . 35 (9), pp. 1936-44. https://doi.org/10.1161/ATVBAHA.115.305348

Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer

Journal article

Kosgodage, U., Mould, R., Henley, A., Nunn, A.V.W., Guy, G.W., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology. 9 889. https://doi.org/10.3389/fphar.2018.00889

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells

Journal article

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2019. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. https://doi.org/10.1016/j.tranon.2018.12.004

Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles

Journal article

Kosgodage, U., Matewele, P., Awamaria, B., Kraev, I., Warde, P., Mastroianni, G., Nunn, A., Guy, G.W., Bell, J.D., Inal, J.M. and Lange, S. 2019. Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles. Frontiers in Cellular and Infection Microbiology. 9 324. https://doi.org/10.3389/fcimb.2019.00324

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells

Article

Mehta, K., Greenwell, P., Renshaw, D., Busbridge, Mark, Garcia, M, Farnaud, S. and Patel, V. B. 2015. Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells, Molecules, and Diseases. 55 (2), pp. 110-118. https://doi.org/10.1016/j.bcmd.2015.05.002

Characterisation of Phage Susceptibility Variation in Salmonellaenterica Serovar Typhimurium DT104 and DT104b

Journal article

Mohammed, M. and Orzechowska, B. 2021. Characterisation of Phage Susceptibility Variation in Salmonellaenterica Serovar Typhimurium DT104 and DT104b. MDPI Microorganisms. 9 (4) 865. https://doi.org/10.3390/microorganisms9040865

Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells

Journal article

Mehta, K., Busbridge, Mark, Renshaw, D., Evans, R.W., Farnaud, S. and Patel, V. 2016. Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells. Blood Cells, Molecules, and Diseases. 61, pp. 37-45. https://doi.org/10.1016/j.bcmd.2016.06.008

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy

Journal article

Kosgodage, U., Trindade R.P., Thompson, P.R., Inal, J.M. and Lange, S. 2017. Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy. International Journal of Molecular Sciences. 18 (5) 1007. https://doi.org/10.3390/ijms18051007

Chondroprotection by urocortin involves blockade of a mechanosensitive piezo1 ion channel: novel, exploitable pathways for the treatment and prevention of osteoarthritis?

Conference paper

Lawrence, K.M., Jones, R.C., Jackson, T.R., Baylie, R.L., Abbot, B., Bruhn-Olszewska, B, Board, T.N., Locke, I.C., Richardson, S.M and Townsend, P.A. 2017. Chondroprotection by urocortin involves blockade of a mechanosensitive piezo1 ion channel: novel, exploitable pathways for the treatment and prevention of osteoarthritis? OARSI 2017 World Congress on Osteoarthritis. Las Vegas, USA. 17 - 20 Apr 2017 Elsevier. https://doi.org/10.1016/j.joca.2017.02.124

Clinical potential of oligonucleotide-based therapeutics in the respiratory system

Article

Moschos, S.A., Usher, L. and Lindsay, M.A. 2017. Clinical potential of oligonucleotide-based therapeutics in the respiratory system. Pharmacology and Therapeutics. 169, pp. 83-103. https://doi.org/10.1016/j.pharmthera.2016.10.009

CNN Health: How frequently should you wash your bed sheets? More often than you think

Other

Mohammed, M. 2021. CNN Health: How frequently should you wash your bed sheets? More often than you think. CNN.

Comparison of virulence genes found in draft genomes of F. necrophorum

Conference poster

Wright Katie Greenwell Pamela, Kimmitt, P.T. and Greenwell, P. 2015. Comparison of virulence genes found in draft genomes of F. necrophorum. Society for General Microbiology. Birmingham, UK 30 Mar 2015

Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles

Journal article

Lange, S., Kraev, I., Magnadottir, B. and Dodds, A.W. 2019. Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles. Developmental and Comparative Immunology. 101 103437. https://doi.org/10.1016/j.dci.2019.103437

Comprehensive Guide to Post-Traumatic Stress Disorders

Book

Martin, C.R., Preedy, V.R. and Patel, V.B. (ed.) 2016. Comprehensive Guide to Post-Traumatic Stress Disorders. Springer.

Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice

Journal article

Hofmann, I., Geer, M.J., Vögtle, T., Crispin, A., Campagna, D.R., Barr, A.J., Calicchio, M.L., Heising, S., van Geffen, J.P., Kuijpers, M.J.E., Heemskerk, J.W.M., Eble, J.A., Schmitz-Abe, K., Obeng, E.A., Douglas, M., Freson, K., Pondarré, C., Favier, R., Jarvis, G.E., Markianos, K., Turro, E., Ouwehand, W.H., Mazharian, A., Fleming, M.D. and Senis, Y. 2018. Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. Blood. 132, pp. 1399-1412. https://doi.org/10.1182/blood-2017-08-802769

Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres.

Journal article

Ahmed, D., Puthussery, Hima, Basnett, Pooja, Knowles, J., Lange, S. and Roy, I. 2021. Controlled Delivery of Pan-PAD-Inhibitor Cl-Amidine Using Poly(3-Hydroxybutyrate) Microspheres. International Journal of Molecular Sciences. 22 (23) 12852. https://doi.org/10.3390/ijms222312852

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory

Article

Virdee, K., Kentrop, J., Jupp, B., Venus, B., Hensman, D., McArthur, S., Wilkinson, J., Robbins, T.W., Gillies, G.E. and Dalley, J.W. 2016. Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. Psychopharmacology. 233 (21), pp. 3751-3761. https://doi.org/10.1007/s00213-016-4405-8

Curcumin: novel treatment in neonatal hypoxic-ischaemic brain injury

Journal article

Rocha-Ferreira, E., Sisa, C., Bright, S., Fautz, T., Harris, M., Contreras Riquelme, I., Agwu, C., Kurulday, T., Mistry, B., Hill, D., Lange, S. and Hristova, M. 2019. Curcumin: novel treatment in neonatal hypoxic-ischaemic brain injury. Frontiers in Physiology. 10 1351. https://doi.org/10.3389/fphys.2019.01351

Data‐driven integration of hippocampal CA1 synaptic physiology in silico

Journal article

Ecker, A., Romani, A., Sáray, S., Káli,S., Migliore, M., Falck, J., Lange, S., Mercer, A., Thomson, A.M., Muller, M., Reimann, M.W. and Ramaswamy, S. 2020. Data‐driven integration of hippocampal CA1 synaptic physiology in silico. Hippocampus. 30 (11), pp. 1129-1145. https://doi.org/10.1002/hipo.23220

Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin

Journal article

Dorofejeva, O. and Barr, A.J. 2017. Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin. PLoS ONE. 12 (9) e0184574. https://doi.org/10.1371/journal.pone.0184574

Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation.

Journal article

McArthur, S., Gobbetti, T., Kusters, D.H.M., Reutelingsperger, C.P.M., Flower, R.J. and Perretti, M. 2015. Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. Journal of Immunology. 195 (3), pp. 1139-1151. https://doi.org/10.4049/jimmunol.1500733

Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca

Journal article

Magnadóttir, B., Uysal-Onganer, P., Kraev, I., Svansson, V., Hayes, P.M. and Lange, S. 2020. Deiminated proteins and extracellular vesicles - Novel serum biomarkers in whales and orca. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 34, p. 100676 100676. https://doi.org/10.1016/j.cbd.2020.100676

Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina)

Journal article

Magnadóttir, B., Uysal Onganer, P., Kraev, I., Svansson, V., Skírnisson, K. and Lange, S. 2020. Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina). Biochimie . 171-172, pp. 79-90. https://doi.org/10.1016/j.biochi.2020.02.017


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Biggs, Christopher

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Curley, Paul

Senior Lecturer


Porakishvili, Nina

Principal Lecturer