Research Centre for Optimal Health

Osimo, E., Brugger, S., Thomas, E.L. and Howes, O. 2022. A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia. Schizophrenia. 8 24. https://doi.org/10.1038/s41537-022-00233-z

Basty, N., Sorokin, E., Thanaj, M., Srinivasan, R., Whitcher, B., Bell, J.D., Cule, M. and Thomas, E.L. 2023. Abdominal imaging associates body composition with COVID-19 severity. PLoS ONE. 18 (4) e0283506. https://doi.org/10.1371/journal.pone.0283506

Sahuri Arisoylu, M., Mould, R., Shinjyo, N., Bligh, S.W.A., Nunn, A., Guy, G., Thomas, E.L. and Bell, J.D. 2021. Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function. Frontiers in Nutrition: Nutrition and Metabolism. 8 588466. https://doi.org/10.3389/fnut.2021.588466

Osimo, E.F., Sweeney, M., de Marvao, A., Berry, A., Statton, B., Perry, B.I., Pillinger, T., Whitehurst, T., Cook, S.A., O’Regan, D.P., Thomas, E.L. and Howes, O.D. 2021. Adipose tissue dysfunction, inflammation, and insulin resistance alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study. Translational Psychiatry. 11 614. https://doi.org/10.1038/s41398-021-01741-9

Borga, M., West, J., Bell, J.D., Harvey, N.C., Romu, T., Heymsfield, S.B. and Leinhard, O.D. 2018. Advanced body composition assessment: from body mass index to body composition profiling. Journal of Investigative Medicine. 66 (5), pp. 887-895. https://doi.org/10.1136/jim-2018-000722

Sorokin, E., Basty, N., Whitcher, B., Liu, Y., Bell, J.D., Cohen, R.L., Cule, M. and Thomas, E.L. 2022. Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis. American Journal of Human Genetics. 109 (6), pp. P1092-1104. https://doi.org/10.1016/j.ajhg.2022.04.013

Basty, N., Thanaj, M., Cule, M., Sorokin, E., Liu, Y., Thomas, E.L., Bell, J.D. and Whitcher, B. 2023. Artifact-Free Fat-Water Separation in Dixon MRI using Deep Learning. Journal of Big Data. 10 4. https://doi.org/10.1186/s40537-022-00677-1

Basty, N., Liu, Y., Cule, M., Thomas, E.L., Bell, J.D. and Whitcher, B. 2020. Automated Measurement of Pancreatic Fat and Iron Concentration Using Multi-Echo and T1-Weghted MRI Data. International Symposium on Biomedical Imaging 2020. Iowa City, USA 03 - 07 Apr 2020 IEEE . https://doi.org/10.1109/ISBI45749.2020.9098650

Nunn, A.V.W., Guy, G.W. and Bell, J.D. 2022. Bioelectric Fields at the Beginnings of Life. Bioelectriciy. 4 (4), pp. 237-247. https://doi.org/10.1089/bioe.2022.0012

Linge, J., Borger Magnus, West, J., Tuthill, T., Miller, M.R., Dumitriu, A., Thomas, E.L., Romu, T., Tunón, P., Bell, J.D. and Leinhard, O.D. 2018. Body Composition Profiling in the UK Biobank Imaging Study. Obesity. 26 (11), pp. 1785-1795. https://doi.org/10.1002/oby.22210

Kosgodage, U., Mould, R., Henley, A., Nunn, A.V.W., Guy, G.W., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2018. Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer. Frontiers in Pharmacology. 9 889. https://doi.org/10.3389/fphar.2018.00889

Kosgodage, U., Uysal Onganer, P., Maclatchy, A., Mould, R., Nunn, A.V.W., Guy, G.W., Kraev, I., Chatterton, N.P., Thomas, E.L., Inal, J.M., Bell, J.D. and Lange, S. 2019. Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells. Translational Oncology. 12 (3), pp. 513-522. https://doi.org/10.1016/j.tranon.2018.12.004

Kosgodage, U., Matewele, P., Awamaria, B., Kraev, I., Warde, P., Mastroianni, G., Nunn, A., Guy, G.W., Bell, J.D., Inal, J.M. and Lange, S. 2019. Cannabidiol is a Novel Modulator of Bacterial Membrane Vesicles. Frontiers in Cellular and Infection Microbiology. 9 324. https://doi.org/10.3389/fcimb.2019.00324

Mould, R., Botchway, S, Parkinson, J., Thomas, E.L., Guy, G., Bell, J.D. and Nunn, A. 2021. Cannabidiol modulates mitochondrial redox and dynamics in MCF7 cancer cells: a study using fluorescence lifetime imaging microscopy of NAD(P)H. Frontiers in Molecular Biosciences. 8 630107. https://doi.org/10.3389/fmolb.2021.630107

Brody, L.P., Sahuri Arisoylu, M., Parkinson, J.R., Parkes, H.G., So, P-W, Hajji, N, Thomas, E.L., Frost, G.S., Miller, A.D. and Bell, J.D. 2017. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine. 12, pp. 6677-6685. https://doi.org/10.2147/IJN.S135968

Mould, R., Thomas, E.L., Guy, G., Nunn, A. and Bell, J.D. 2022. Cell-Cell Death Communication by Signals Passing Through Non-Aqueous Environments: A Reply . Results in Chemistry. 4 100538. https://doi.org/10.1016/j.rechem.2022.100538

Heymsfield, S., Bell, J.D. and Heber, D. 2023. Chapter 7: Phenotyping, Body Composition, and Precision Nutrition. in: Heber, D., Li, Z. and Ordovas, J. (ed.) Precision Nutrition: The Science and Promise of Personalized Nutrition and Health Academic Press. pp. 143-151

Wilman, H., Kelly, M., Garratt, S., Matthews, P., Milanesi, M., Herlihy, A.H., Gyngell, M, Neubauer, S, Bell, J.D., Banerjee, R and Thomas, E.L. 2017. Characterisation of liver fat in the UK Biobank cohort. PLoS ONE. 12 (2) e0172921. https://doi.org/10.1371/journal.pone.0172921

Ichim, M.C. and Booker, A. 2021. Chemical Authentication of Botanical Ingredients: A Review of Commercial Herbal Products. Frontiers in Pharmacology. 12 666850. https://doi.org/10.3389/fphar.2021.666850

Booker, A., Heinrich, P.M. and Tsou, W.H. 2022. Chinese and Western Herbal Medicines for the Topical Treatment of Psoriasis - a critical review of Efficacy and Safety. Journal of Herbal Medicine. 34. https://doi.org/10.1016/j.hermed.2022.100579

Gu, J., Scotti, F., Reich, E., Kirchhoff, R., Booker, A. and Heinrich, P.M. 2022. Chrysanthemum species used as food and medicine: Understanding quality differences on the global market. South African Journal of Botany. 148, pp. 123-134. https://doi.org/10.1016/j.sajb.2022.04.009

Frommenwiler, D., Booker, A., Vila, R., Heinrich, M., Reich, E. and Cañiguerala, S. 2019. Comprehensive HPTLC fingerprinting as a tool for a simplified analysis of purity of ginkgo products. Journal of Ethnopharmacology. 243, p. 112084 112084. https://doi.org/10.1016/j.jep.2019.112084

Rundle, M., Fiamoncini, J., Thomas, E.L., Wopereis, S., Afman, L.A., Brennan, L., Drevon, C.A., Gundersen, T.E., Daniel, H,, Garcia Perez, I., Posma, J.M., Ivanova, D.G., Bell, J.D., van Ommen, B. and Frost, G. 2023. Diet-induced weight loss and phenotypic flexibility among healthy overweight adults: a randomized trial . American Journal of Clinical Nutrition. 118 (3), pp. 591-604. https://doi.org/10.1016/j.ajcnut.2023.07.002

Eriksen, R., Perez, I.G., Posma, J.M., Haid, M., Sharma, S., Thomas, E.L., Koivula, R.W., Bizzotto, R., Mari, A., Giordano, G.N., Pavo, I., Schwenk, J., De Masi, F., Tsirigos, K., Brunak, S., Vinuela, A., Mahajan, A., McDonald, T.J., Kokkola, T., Teare, H.J.A., Hansen, T.H., Fernandez, J., Jones, A., Jennison, C., Walker, M., McCarthy, M., Pedersen, O., Reutten, H., Forgie, I., Bell, J.D., Pearson, E., Franks, P.W., Adamski, J., Holmes, E. and Frost, G.S. 2020. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI Direct study. EBioMedicine. 58 102932. https://doi.org/10.1016/j.ebiom.2020.102932

Arora, T., Loo, R.L., Anastasovska, J., Gibson, G.R., Tuohy, K., Kumar Sharma, R., Swann Jonathan, Deaville, E.R., Sleeth Michelle, L., Thomas, E.L., Holmes, E., Bell, J.D. and Frost, G.S. 2012. Differential effects of two fermentable carbohydrates on central appetite regulation and body composition. PLoS ONE. 7 (8) e43263. https://doi.org/10.1371/journal.pone.0043263

Koivula, R.W., Forgie, I.M., Kurbasic, A., Viñuela, A., Heggie, A., Giordano, G.N., Hansen, T.H., Hudson, M., Koopman, A.D., Rutters, F., Siloaho, M., Allin, K.H., Brage, S., Brorsson, C.A., Dawed, A.Y., De Masi, F., Groves, C.J., Kokkola, T., Mahajan, A., Perry, M.H., Rauh, S.P., Ridderstråle, M., Teare, H.J.A., Thomas, E.L., Tura, A., Vestergaard, H., White, T., Adamski, J., Bell, J.D., Beulens, J., Brunak, S., Dermitzakis, E.T., Froguel, P., Frost, G., Gupta, R., Hansen, T., Hattersley, A., Jablonka, B., Kaye, J., Laakso, M., McDonald, T.J., Pedersen, O., Schwenk, J.M., Pavo, I., Mari, A., McCarthy, M.I., Ruetten, H., Walker, M., Pearson, E. and Franks, P.W. 2019. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. 62 (9), pp. 1601-1615. https://doi.org/10.1007/s00125-019-4906-1

Allesøe, Rosa Lundbye, Lundgaard, A., Hernández Medina, R., Aguayo-Orozco, Alejandro, Johansen, J., Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, L., Biel, J., Brasas, Valentas, Webel, Henry, Benros, M., Pedersen, A., Chmura, Piotr Jaroslaw, Jacobsen, U., Mari, Andrea, Koivula, R., Mahajan, Anubha, Vinuela, A., Tajes, Juan Fernandez, Sharma, Sapna, Haid, M., Hong, M., Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, G., Bell, Jimmy, Thomas, E.L., Frost, G., Thomsen, Henrik, Hansen, Elizaveta, Hansen, T., Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, J., Hattersley, A., McDonald, Timothy, Ridderstråle, M., Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, O., Hansen, T., Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, J., Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, S., Brunak, S. and IMI DIRECT Consortium 2023. Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. 41, pp. 399-408. https://doi.org/10.1038/s41587-022-01520-x

Martin, S., Tyrrell, J., Thomas, E.L., Bown, M.J., Wood, A.R., Beaumont, R.N., Tsoi, L.C., Stuart, P.E., Elder, J.T., Law, P., Houlston, R., Kabrhel, C., Papadimitriou, N., Gunter, M.J., Bull, C.J., Bell, J.A., Vincent, E.E., Sattar, N., Dunlop, M.G., Tomlinson, I.P.M., Bell, J.D., Frayling, T. and Yaghootkar, H. 2022. Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife. 11 e72452. https://doi.org/10.7554/elife.72452

Jagoda, E., Lawson, D.J., Wall, J.D., Lambert, D., Muller, C., Westaway, M., Leavesley, M., Capellini, T.D., Lahr, M.M., Gerbault, P., Thomas, M.G., Migliano, A.B., Willerslev, E., Metspalu , M. and Pagani, L. 2018. Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans. Molecular Biology and Evolution. 35 (3), pp. 623-630. https://doi.org/10.1093/molbev/msx314

Gancitano, G., Mucci, N., Stange, R., Ogal, M., Vimalanathan, S., Sreya, M., Booker, A., Hadj-Cherif, B., Albrich, W., Woelkart-Ardjomand, K., Kreft, S., Vanden Berghe, W., Hoexter, G., Schapowal, A. and Johnston, S.L. 2024. Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA). Antibiotics. 13 (4) 364. https://doi.org/10.3390/antibiotics13040364

Dar, N.J., Bhat, S.A., Rehman, M.U. and Booker, A. 2023. Editorial: Investigating the molecular targets and therapeutic potential of Withania somnifera (Ashwagandha) in various pathophysiological conditions. Frontiers in Pharmacology. 14 1187334. https://doi.org/10.3389/fphar.2023.1187334

Jadoon, K.A., Ratcliffe, S.H., Barrett, D.A., Thomas, E.L., Stott, C., Bell, J.D., O’Sullivan S.E. and Tan, G.D. 2016. Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Diabetes Care. 39 (10), pp. 1777-1786. https://doi.org/10.2337/dc16-0650

Martin, Susan, Sorokin, Elena P, Thomas, E Louise, Sattar, Naveed, Cule, Madeleine, Bell, Jimmy D and Yaghootkar, H. 2022. Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study. Diabetes Care. 45 (2), pp. 460-468. https://doi.org/10.2337/dc21-1262

Yaghootkar, H., Bell, J.D., Whitcher, B. and Thomas, E.L. 2020. Ethnic differences in adiposity and diabetes risk – insights from genetic studies. Journal of Internal Medicine. 288 (3), pp. 271-283. https://doi.org/10.1111/joim.13082

Alenaini, Wareed, Parkinson, J., McCarthy, John P., Goldstone, Anthony P., Wilman, Henry R., Banerjee, Rajarshi, Yaghootkar, Hanieh, Bell, Jimmy D. and Thomas, E.L. 2020. Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts. Obesity (Silver Spring, Md.). 28 (11), pp. 2142-2152. https://doi.org/10.1002/oby.22948

Hakim, O., Bello, O., Bonadonna, O.C., Mohandas, C., Shojaee-Moradie, F., Jackson, N., Boselli, L., Whitcher, B., Shuaib, H., Alberti, K.G.M.M., Peacock, J.L., Umpleby, A.M., Charles-Edwards, E., Amiel, S.A. and Goff, L.M. 2019. Ethnic differences in intrahepatic lipid and its association with hepatic insulin sensitivity and insulin clearance between men of Black and White ethnicity with early type 2 diabetes. Diabetes, Obesity and Metabolism. 21 (9), pp. 2163-2168. https://doi.org/10.1111/dom.13771

Shojaee-Moradie, F., Cuthbertson, D.J., Barrett, M., Jackson, N.C., Herring, R, Thomas, E.L., Bell, J.D., Kemp, G.J., Wright, J. and Umpleby, A.M. 2016. Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance, but not VLDL Production in NAFLD. Journal of Clinical Endocrinology and Metabolism. 101 (11), pp. 4219-4228. https://doi.org/10.1210/jc.2016-2353

West, J., Leinhard, O.D., Romu, T., Collins, R., Garratt, S., Bell, J.D., Borga, M. and Thomas, E.L. 2016. Feasibility of MR-Based Body Composition Analysis in Large Scale Population Studies. PLoS ONE. 11 (9) e0163332. https://doi.org/10.1371/journal.pone.0163332

Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J., Cani, P., Everard, A., Sleeth, M., Psichas, A., Anastasovskaj, J., Bell, J.D., Bell-Anderson, K., Mackay, C., Ghatei, M., Bloom, S., Frost, G. and Bewick, G. 2017. Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety. Molecular Metabolism. 6 (1), pp. 48-60. https://doi.org/10.1016/J.MOLMET.2016.10.011

Wesolowska-Andersen, A., Brorsson, C.A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Viñuela, A., Fernandez Tajes, J, Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G, Musholt, P.B, Kurbasic, A., Masi, F., Tsirigos, K, Pedersen, H., Gudmundsdottir, V., Thomas, C., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J.D., Thomas, E.L., Frost, G., Thomsen, H., Allin, K., Hansen, T.H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G.N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E., Franks, P.W., Schwenk, J.M., Adamski, J., Pearson, E., McCarthy, M.I., Brunak, S. and IMI DIRECT Consortium 2022. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports Medicine. 3 (1) 100477. https://doi.org/10.1016/j.xcrm.2021.100477