Differential suppression of tumor-specific CD8+ T cells by regulatory T cells

James, E., Yeh, A., King, C., Korangy, F., Bailey, I., Boulanger, D.S., Van den Eynde, B.J., Murray, N. and Elliott, T.J. 2010. Differential suppression of tumor-specific CD8+ T cells by regulatory T cells. Journal of Immunology. 185 (9), pp. 5048-5055.

TitleDifferential suppression of tumor-specific CD8+ T cells by regulatory T cells
AuthorsJames, E., Yeh, A., King, C., Korangy, F., Bailey, I., Boulanger, D.S., Van den Eynde, B.J., Murray, N. and Elliott, T.J.
Abstract

In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8+ CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.

JournalJournal of Immunology
Journal citation185 (9), pp. 5048-5055
ISSN0022-1767
YearNov 2010
PublisherAmerican Association of Immunologists
Digital Object Identifier (DOI)doi:10.4049/jimmunol.1000134
Publication dates
PublishedNov 2010

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