A study of activation antigens involved in the pathological mechanisms and pathways of cutaneous malignant disease with particular emphasis on cutaneous T cell lymphoma and malignant melanoma

Orchard, G.R. 2010. A study of activation antigens involved in the pathological mechanisms and pathways of cutaneous malignant disease with particular emphasis on cutaneous T cell lymphoma and malignant melanoma. PhD thesis University of Westminster School of Life Sciences

TitleA study of activation antigens involved in the pathological mechanisms and pathways of cutaneous malignant disease with particular emphasis on cutaneous T cell lymphoma and malignant melanoma
TypePhD thesis
AuthorsOrchard, G.R.
Abstract

The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and

malignant melanoma (MM), presented here involved predominantly

immunocytochemical procedures and relate to the investigations into AP-1

protein expression in CTCL and melanocyte activation antigens in MM.

Results: Findings indicate that expression of AP-1 proteins differs not only

according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis.

Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression.

KeywordsCutaneous T cell lymphoma (CTCL), malignant melanoma (MM), immunocytochemistry (IMC)
Year2010
FileOrchard.pdf
Publication dates
Completed2010

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