AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene.

Haworth, Oliver and Korbonits, M. 2022. AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene. British Journal of Cancer. 127, pp. 1175-1176. https://doi.org/10.1038/s41416-022-01964-7

TitleAIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene.
TypeEdited issue
AuthorsHaworth, Oliver and Korbonits, M.
AbstractAryl hydrocarbon receptor-interacting protein (AIP) is a co-chaperone to heat shock proteins and nuclear receptors. Loss-of-function heterozygote germline mutations lead to predisposition to growth hormone- or prolactin-secreting pituitary typically presenting in childhood. Based on these data AIP behaves as a tumour suppressor. However, previously in diffuse large B cell lymphoma and now in this new manuscript in the British Journal of Cancer on colorectal cancer, it seems that high expression of AIP is associated with tumour development and more aggressive disease. AIP, therefore, joins a distinguished group of proteins that can behave both as a tumour suppressor and as an oncogene. [Abstract copyright: © 2022. The Author(s), under exclusive licence to Springer Nature Limited.]
JournalBritish Journal of Cancer
Journal citation127, pp. 1175-1176
ISSN1532-1827
0007-0920
Year2022
PublisherNature Publishing Group
Digital Object Identifier (DOI)https://doi.org/10.1038/s41416-022-01964-7
PubMed ID36064587
Publication dates
Published online05 Sep 2022
Page range10.1038/s41416-022-01964-7

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