AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene. : WestminsterResearch

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Title	AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene.
Type	Edited issue
Authors	Haworth, Oliver and Korbonits, M.
Abstract	Aryl hydrocarbon receptor-interacting protein (AIP) is a co-chaperone to heat shock proteins and nuclear receptors. Loss-of-function heterozygote germline mutations lead to predisposition to growth hormone- or prolactin-secreting pituitary typically presenting in childhood. Based on these data AIP behaves as a tumour suppressor. However, previously in diffuse large B cell lymphoma and now in this new manuscript in the British Journal of Cancer on colorectal cancer, it seems that high expression of AIP is associated with tumour development and more aggressive disease. AIP, therefore, joins a distinguished group of proteins that can behave both as a tumour suppressor and as an oncogene. [Abstract copyright: © 2022. The Author(s), under exclusive licence to Springer Nature Limited.]
Journal	British Journal of Cancer
Journal citation	127, pp. 1175-1176
ISSN	1532-1827
	0007-0920
Year	2022
Publisher	Nature Publishing Group
Digital Object Identifier (DOI)	https://doi.org/10.1038/s41416-022-01964-7
PubMed ID	36064587
Published online	05 Sep 2022
Page range	10.1038/s41416-022-01964-7

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AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene.

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