• Journal article

The evolutionary landscape of colorectal tumorigenesis

William Cross, Michal Kovac, Ville Mustonen, Daniel Temko, Hayley Davis, Ann-Marie Baker, Sujata Biswas, Roland Arnold, Laura Chegwidden, Chandler Gatenbee, Alexander R.A. Anderson, Viktor Koelzer, Pierre Martinez, Xiaowei Jiang, Enric Domingo, Dan J. Woodcock, Yun Feng, Monika Kovacova, Tim Maughan, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean-Baptiste Cazier, Enric Domingo, Andrew Blake, Che-Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Tim Maughan, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Phil Quirke, Manuel Salto-Tellez, Les Samuel, Anna Schuh and David Sebag-Montefiore 2018. The evolutionary landscape of colorectal tumorigenesis. Nature Ecology & Evolution. 2, pp. 1661-1672. https://doi.org/10.1038/s41559-018-0642-z

TitleThe evolutionary landscape of colorectal tumorigenesis
TypeJournal article
AuthorsWilliam Cross, Michal Kovac, Ville Mustonen, Daniel Temko, Hayley Davis, Ann-Marie Baker, Sujata Biswas, Roland Arnold, Laura Chegwidden, Chandler Gatenbee, Alexander R.A. Anderson, Viktor Koelzer, Pierre Martinez, Xiaowei Jiang, Enric Domingo, Dan J. Woodcock, Yun Feng, Monika Kovacova, Tim Maughan, Richard Adams, Simon Bach, Andrew Beggs, Louise Brown, Francesca Buffa, Jean-Baptiste Cazier, Enric Domingo, Andrew Blake, Che-Hsi Wu, Ekaterina Chatzpili, Susan Richman, Philip Dunne, Paul Harkin, Geoff Higgins, Jim Hill, Chris Holmes, Denis Horgan, Rick Kaplan, Richard Kennedy, Mark Lawler, Simon Leedham, Tim Maughan, Ultan McDermott, Gillies McKenna, Gary Middleton, Dion Morton, Graeme Murray, Phil Quirke, Manuel Salto-Tellez, Les Samuel, Anna Schuh and David Sebag-Montefiore
Abstract

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we investigate the evolutionary fitness landscape occupied by these neoplasms. Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations—considered to be functionally important in the carcinogenic process—that have not swept to fixation, and have relatively high genetic heterogeneity. Carcinomas are distinguished from adenomas by widespread aneusomies that are usually clonal and often accrue in a ‘punctuated’ fashion. We conclude that adenomas evolve across an undulating fitness landscape, whereas carcinomas occupy a sharper fitness peak, probably owing to stabilizing selection.

JournalNature Ecology & Evolution
Journal citation2, pp. 1661-1672
ISSN2397-334X
Year2018
PublisherNature Publishing Group
Digital Object Identifier (DOI)https://doi.org/10.1038/s41559-018-0642-z
Web address (URL)http://dx.doi.org/10.1038/s41559-018-0642-z
Publication dates
Published31 Aug 2018

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