A Point‐of‐Care Sensing Platform for Multiplexed Detection of Chronic Kidney Disease Biomarkers Using Molecularly Imprinted Polymers

Li, Y., Luo, Liuxiong, Kong, Yingqi, George, Sophiamma, Li, Yujia, Guo, Xiaotong, Li, Xin, Yeatman, Eric, Davenport, Andrew, Li, Ying and Li, B. 2024. A Point‐of‐Care Sensing Platform for Multiplexed Detection of Chronic Kidney Disease Biomarkers Using Molecularly Imprinted Polymers. Advanced Functional Materials. 34 (28) 2316865. https://doi.org/10.1002/adfm.202316865

TitleA Point‐of‐Care Sensing Platform for Multiplexed Detection of Chronic Kidney Disease Biomarkers Using Molecularly Imprinted Polymers
TypeJournal article
AuthorsLi, Y., Luo, Liuxiong, Kong, Yingqi, George, Sophiamma, Li, Yujia, Guo, Xiaotong, Li, Xin, Yeatman, Eric, Davenport, Andrew, Li, Ying and Li, B.
AbstractChronic kidney disease (CKD) is one of the most serious non‐communicable diseases affecting the population. In the early‐stages patients have no obvious symptoms, until it becomes life‐threatening leading end‐stage kidney failure. Therefore, it is important to early diagnose CKD to allow therapeutic interventions and progression monitoring. Here, a point‐of‐care (POC) sensing platform is reported for the simultaneous detection of three CKD biomarkers, namely creatinine, urea, and human serum albumin (HSA), using reduced graphene oxide/polydopamine‐molecularly imprinted polymer (rGO/PDA‐MIP) fabricated with novel surface‐molecularly imprinting technology. A multi‐channel electrochemical POC readout system with differential pulse voltammetry (DPV) function is developed, allowing the simultaneous detection of the three biomarkers, in combination with the surface‐MIP electrodes. This sensing platform achieves the record low limit‐of‐detection (LoD) at a femtomolar level for all three analytes, with wide detection ranges covering their physiological concentrations. Clinical validation is performed by measuring these analytes in serum and urine from healthy controls and patients with CKD. The average recovery rate is 81.8–119.1% compared to the results obtained from the hospital, while this platform is more cost‐effective, user‐friendly, and requires less sample‐to‐result time, showing the potential to be deployed in resource‐limited settings for the early diagnosis and tracking progression of CKD.
KeywordsElectrochemistry
Condensed Matter Physics
Biomaterials
Electronic, Optical and Magnetic Materials
Article number2316865
JournalAdvanced Functional Materials
Journal citation34 (28)
ISSN1616-301X
1616-3028
Year2024
PublisherWiley
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1002/adfm.202316865
Publication dates
Published online12 Feb 2024
Published in print10 Jul 2024
ProjectIEC∖NSFC∖223128
MR/X502984/1
EP/X525649/1
ARUK‐PPG2021B‐001
51808392
FunderRoyal Society
Medical Research Council
EPSRC
Alzheimer’s Research UK
China Scholarship Council
Licensehttp://creativecommons.org/licenses/by/4.0/

Related outputs

A Comparison of Chitosan Adhesion to KOH and H2O2 Pre-Treated Electrospun Poly(3-Hydroxybutyrate) Nanofibers
Zhou, Yansheng, Li, Daqing, Li, Xin, Li, Ying, Li, Bing and Zhou, Fenglei 2023. A Comparison of Chitosan Adhesion to KOH and H2O2 Pre-Treated Electrospun Poly(3-Hydroxybutyrate) Nanofibers. Fibers. 11 (11) 91. https://doi.org/10.3390/fib11110091

The role of hormones in financial markets
Bose, S., Ladley, D. and Li, X. 2020. The role of hormones in financial markets. International Review of Financial Analysis. 67 101434. https://doi.org/10.1016/j.irfa.2019.101434

Central counterparty auction design
Ferrara, G., Li, X. and Marszalec, D. 2019. Central counterparty auction design. Journal of Financial Market Infrastructures. 8 (2), pp. 47-58 2019.119. https://doi.org/10.21314/JFMI.2019.119

Permalink - https://westminsterresearch.westminster.ac.uk/item/w8446/a-point-of-care-sensing-platform-for-multiplexed-detection-of-chronic-kidney-disease-biomarkers-using-molecularly-imprinted-polymers


Share this

Usage statistics

41 total views
22 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.