Stromal Cells and Extracellular Vesicles : WestminsterResearch

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Chapter title	Stromal Cells and Extracellular Vesicles
Authors	Arinzechukwu Ude, Emmanuel Ogbodo and Kelechi Okeke
Editors	Yusuf Tutar and Lütfi Tutar
Abstract	Stromal cells are stem cells in the bone marrow microenvironment that can ‘talk’ with neighbouring and distant cells within the bone marrow microenvironment. Stromal cells propagate this intercellular communication via cytokines, growth factors as well as small extracellular vesicles. The interaction between stromal cells and the haematopoietic stem cells, is crucial in the regulation of haematopoiesis. Aberration in this regulatory process will lead to the development of various diseases, including cancer. These stromal cells also play important role in the patient’s response to cancer therapy. As a result, these stromal cells may be crucial in the development and metastasis of cancer within the bone marrow microenvironment. In this chapter, we will explore the role of these stromal cells in carcinogenesis and cancer metastasis.
Book title	Cancer Metastasis: Molecular Mechanism and Clinical Therapy
Year	2022
Publisher	IntechOpen
Published	08 Mar 2023
ISBN	9781803561615
	9781803561622
Digital Object Identifier (DOI)	https://doi.org/10.5772/intechopen.106721
Web address (URL)	http://dx.doi.org/10.5772/intechopen.106721

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