microRNA expression in the aging mouse lung : WestminsterResearch

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Title	microRNA expression in the aging mouse lung
Type	Journal article
Authors	Williams, A.E., Perry, M., Moschos, S.A. and Lindsay, M.A.
Abstract	Background MicroRNAs (miRNAs) are a novel class of short double stranded RNA that mediate the post-transcriptional regulation of gene expression. Previous studies have implicated changes in miRNA expression in the regulation of development and the induction of diseases such as cancer. However, although miRNAs have been implicated in the process of aging in C. elegans, nothing is known of their role in mammalian tissues. Results To address this question, we have used a highly-sensitive, semi-quantitative RT-PCR based approach to measure the expression profile of 256 of the 493 currently identified miRNAs in the lungs from 6 month (adult) and 18 month (aged) old female BALB/c mice. We show that, despite the characteristic changes in anatomy and gene expression associated with lung aging, there were no significant changes in the expression of 256 miRNAs. Conclusion Overall, these results show that miRNA transcription is unchanged during lung aging and suggests that stable expression of miRNAs might instead buffer age related changes in the expression of protein-encoding genes.
Article number	172
Journal	BMC Genomics
Journal citation	8
ISSN	1471-2164
Year	2007
Publisher	BMC
Publisher's version	1471-2164-8-172.pdf License CC BY 2.0 File Access Level Open (open metadata and files)
Digital Object Identifier (DOI)	https://doi.org/10.1186/1471-2164-8-172
Published	15 Jun 2007

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microRNA expression in the aging mouse lung

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