Dr Christopher Biggs

Senior Lecturer

DepartmentLife Sciences
Research groupTissue Architecture and Regeneration Research Group

Research outputs

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease
Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S. and Whitton, P.S. 2008. Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease. Journal of Neuroinflammation. 5 (1), p. 19. doi:10.1186/1742-2094-5-19

Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S. and Whitton, P.S. 1996. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Research. 717 (1-2), pp. 196-199. doi:10.1016/0006-8993(96)00127-8

Reversal of β-amyloid induced microglial activation by an agonist of Fpr2
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Reversal of β-amyloid induced microglial activation by an agonist of Fpr2. British Pharmacological Society: Pharmacology 2017. London 11 - 13 Dec 2017

Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2018. Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure. Alzheimer's Research UK Conference. London 20 - 21 Mar 2018

Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation. BNA Festival of Neuroscience. Birmingham 10 - 13 Apr 2017 Sage. doi:10.1177/2398212817705279

Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects. World Congress on Inflammation. London 08 - 12 Jul 2017

Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats
Segieth, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats. Neuroscience Letters. 200 (2), pp. 101-104. doi:10.1016/0304-3940(95)12088-L

Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat
Biggs, C.S., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat. 18th National Meeting of the British Neuroscience Association. Brighton, UK 03-06 Apr 2005

Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model
Biggs, C.S., Abuirmeileh, A., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model. Proceedings of the British Pharmacological Society. 3 (4).

The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease
Abuirmeileh, A., Lever, R., Kingsbury, A.E., Lees, A.J., Locke, I.C., Knight, R.A., Chowdrey, H.S., Biggs, C.S. and Whitton, P.S. 2007. The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease. European Journal of Neuroscience. 26 (2), pp. 417-423. doi:10.1111/j.1460-9568.2007.05653.x

Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
Abuirmeileh, A., Harkavyi, A., Lever, R., Biggs, C.S. and Whitton, P.S. 2007. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. Journal of Neuroinflammation. 4, p. 19. doi:10.1186/1742-2094-4-19