Dr Hershna Patel

Dr Hershna Patel


I am a Fellow of the Higher Education Academy, a Member of the Institute of Biomedical Science and the Biochemical Society.


Research expertise and interests: Application of Computational biochemistry, molecular modelling and bioinformatics methods to investigate viral proteins and proteins of biomedical importance.

Awards:

2021 High Performance Computing time granted via the UK High-End Computing Consortium for Biomolecular Simulation, supported by EPSRC (grant no. EP/R029407/1).

Publications:

Laich, A., Patel, H., Zarantonello, A., Sim, R.B. & Inal, J. (2022). C2 by-pass: Cross-talk between the complement classical and alternative pathways. Immunobiology, 227(3).

Rivera, J.F.,Baral, A.J., Nadat, F., Boyd,G., Smyth, R., Patel, H., Burman, E.L., Alameer, G., Boxall, S.A., Jackson, B.R., Baxter, E. J.,Laslo,P., Green,A.R., Kent, D.G.,Mullally, A.,& Chen, E. (2021). Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis. Blood Advances, 5(7): 1922–1932. doi: https://doi.org/10.1182/bloodadvances.2020002402

Patel, H., & Kukol, A. (2020). Integrating molecular modelling methods to advance influenza A virus drug discovery. Drug Discovery Today, 26(2), 503-510. https://doi.org/10.1016/j.drudis.2020.11.014.

Patel, H.,& Kukol, A. (2019).Prediction of ligands to universally conserved binding sites of the influenza A virus nuclear export protein. Virology, 537, 97-103.

Patel, H., & Kukol, A. (2017). Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors. Virology, 509, 112-120.

Patel, H., & Kukol, A. (2016). Recent discoveries of influenza A drug target sites to combat virus replication. Biochemical Society Transactions, 44(3), 932–936.

Patel, H., & Kukol, A. (2016). Evaluation of a novel virtual screening strategy using receptor decoy binding sites. Journal of Negative Results in BioMedicine, 15(15). 

Kukol, A., & Patel, H. (2014). Influenza A nucleoprotein binding sites for antivirals: current research and future potential. Future Virology, 9(7), 625-627.

Book Chapters:

Patel, H., & Whitehouse, D.(2021). Proteins and Proteomics. Molecular Biology and Biotechnology (Ed Rapley, R.), 7th Edition, Royal Society of Chemistry Publishing. Pg 123-152.

Patel, H., & Kukol, A. (2021). Modelling and Simulation of Proteins.Molecular Biology and Biotechnology (Ed Rapley, R.), 7th Edition, Royal Society of Chemistry Publishing. Pg 394-409.

Patel, H., & Whitehouse, D. (2019) Microbial Proteomics. Genomics and Clinical Diagnostics (Eds Rapley, R., & Whitehouse, D.). Royal Society of Chemistry. Pg 103-139.