|Title||Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of Tanzania|
|Authors||Guyatt, H.L., Brooker, S., Kihamia, C.M., Hall, A. and Bundy, D.A.P.|
Objective: To determine the impact of deworming on anaemia as part of a large-scale school-based anthelmintic treatment programme in the Tanga Region of the United Republic of Tanzania.
Methods: Both the reduction in the prevalence of anaemia and the cost per case prevented were taken into
consideration. Cross-sectional studies involved parasitological examination and anaemia evaluation before and at 10 months and 15 months after schoolchildren were dewormed.
Findings: Baseline studies indicated that the prevalence of anaemia (haemoglobin < 110 g/l) was high (54%)
among schoolchildren, particularly those with high intensities of hookworm and schistosomiasis. Attributable
fraction analysis suggested that hookworm and schistosomiasis were responsible for 6% and 15% of anaemia
cases, respectively. Fifteen months after deworming with albendazole and praziquantel the prevalence of anaemia
was reduced by a quarter and that of moderate-to-severe anaemia (haemoglobin <90 g/l) was reduced by nearly a
half. The delivery of these anthelmintics through the school system was achieved at the relatively low cost of US$ 1 per treated child. The cost per anaemia case prevented by deworming schoolchildren was in the range US$ 6 - 8, depending on the haemoglobin threshold used.
Conclusions: The results suggested that deworming programmes should be included in public health strategies for the control of anaemia in schoolchildren where there are high prevalences of hookworm and schistosomiasis.
|Keywords||Anthelmintics/therapeutic use, Albendazole/therapeutic use/administration and dosage, Praziquantel/ therapeutic use/administration and dosage, Anemia/parasitology, Hookworm infections/drug therapy/ complications, Schistosomiasis/drug therapy/complications, Child, School health services, Cross-sectional studies, Logistic models, Regression analysis, United Republic of Tanzania|
|Journal||Bulletin of the World Health Organization|
|Journal citation||79 (8), pp. 695-703|
|Web address (URL)||http://www.who.int/entity/bulletin/archives/79(8)695.pdf|