Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers

Macdonald, B., Murray, L., Moutsiana, C., Fearon, P., Cooper, P.J., Halligan, S.L. and Johnstone, T. 2016. Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers. Biological Psychology. 118, pp. 147-153. doi:10.1016/j.biopsycho.2016.05.006

TitleAltered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers
AuthorsMacdonald, B., Murray, L., Moutsiana, C., Fearon, P., Cooper, P.J., Halligan, S.L. and Johnstone, T.
Abstract

Maternal depression is associated with increased risk for offspring mood and anxiety disorders. One possible impact of maternal depression during offspring development is on the emotional autobiographical memory system.

We investigated the neural mechanisms of emotional autobiographical memory in adult offspring of mothers with postnatal depression (N = 16) compared to controls (N = 21). During fMRI, recordings of participants describing one pleasant and one unpleasant situation with their mother and with a companion, were used as prompts to re-live the situations. Compared to controls we predicted the PND offspring would show: greater activation in medial and posterior brain regions implicated in autobiographical memory and rumination; and decreased activation in lateral prefrontal cortex and decreased connectivity between lateral prefrontal and posterior regions, reflecting reduced control of autobiographical recall.

For negative situations, we found no group differences. For positive situations with their mothers, PND offspring showed higher activation than controls in left lateral prefrontal cortex, right frontal pole, cingulate cortex and precuneus, and lower connectivity of right middle frontal gyrus, left middle temporal gyrus, thalamus and lingual gyrus with the posterior cingulate.

Our results are consistent with adult offspring of PND mothers having less efficient prefrontal regulation of personally relevant pleasant autobiographical memories.

JournalBiological Psychology
Journal citation118, pp. 147-153
ISSN0301-0511
Year2016
PublisherElsevier
Publisher's version
Digital Object Identifier (DOI)doi:10.1016/j.biopsycho.2016.05.006
Publication dates
Published online18 May 2016
Published in printJun 2016
Published18 May 2016
LicenseCC BY 4.0

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