Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver

Bachtiar, V., Kelly, M.D., Wilman, H.R., Jacob, J., Newbould, R., Kelly, C.J., Gyngell, M.L., Groves, K.E., McKay, A., Herlihy, A.H., Fernandes, C.C., Halberstadt, M., Maguire, M., Jayaratne, N., Linden, S., Neubauer, S. and Banerjee, R. 2019. Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver. PLoS ONE. 14 (4), p. e0214921. doi:10.1371/journal.pone.0214921

TitleRepeatability and reproducibility of multiparametric magnetic resonance imaging of the liver
TypeJournal article
AuthorsBachtiar, V., Kelly, M.D., Wilman, H.R., Jacob, J., Newbould, R., Kelly, C.J., Gyngell, M.L., Groves, K.E., McKay, A., Herlihy, A.H., Fernandes, C.C., Halberstadt, M., Maguire, M., Jayaratne, N., Linden, S., Neubauer, S. and Banerjee, R.
Abstract

As the burden of liver disease reaches epidemic levels, there is a high unmet medical need to develop robust, accurate and reproducible non-invasive methods to quantify liver tissue characteristics for use in clinical development and ultimately in clinical practice. This prospective cross-sectional study systematically examines the repeatability and reproducibility of iron-corrected T1 (cT1), T2*, and hepatic proton density fat fraction (PDFF) quantification with multiparametric MRI across different field strengths, scanner manufacturers and models. 61 adult participants with mixed liver disease aetiology and those without any history of liver disease underwent multiparametric MRI on combinations of 5 scanner models from two manufacturers (Siemens and Philips) at different field strengths (1.5T and 3T). We report high repeatability and reproducibility across different field strengths, manufacturers, and scanner models in standardized cT1 (repeatability CoV: 1.7%, bias -7.5ms, 95% LoA of -53.6 ms to 38.5 ms; reproducibility CoV 3.3%, bias 6.5 ms, 95% LoA of -76.3 to 89.2 ms) and T2* (repeatability CoV: 5.5%, bias -0.18 ms, 95% LoA -5.41 to 5.05 ms; reproducibility CoV 6.6%, bias -1.7 ms, 95% LoA -6.61 to 3.15 ms) in human measurements. PDFF repeatability (0.8%) and reproducibility (0.75%) coefficients showed high precision of this metric. Similar precision was observed in phantom measurements. Inspection of the ICC model indicated that most of the variance in cT1 could be accounted for by study participants (ICC = 0.91), with minimal contribution from technical differences. We demonstrate that multiparametric MRI is a non-invasive, repeatable and reproducible method for quantifying liver tissue characteristics across manufacturers (Philips and Siemens) and field strengths (1.5T and 3T).

Article numbere0214921
JournalPLoS ONE
Journal citation14 (4), p. e0214921
ISSN1932-6203
Year2019
PublisherPublic Library of Science
Publisher's versionjournal.pone.0214921.pdf
Digital Object Identifier (DOI)doi:10.1371/journal.pone.0214921
PubMed ID30970039
Web address (URL)https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214921
Publication dates
Published10 Apr 2019
LicenseCC BY 4.0

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