Antibiotic-free antibacterial hydrogels for wound healing applications
Orlando, I. 2019. Antibiotic-free antibacterial hydrogels for wound healing applications. PhD thesis University of Westminster Life Sciences https://doi.org/10.34737/qz084
Orlando, I. 2019. Antibiotic-free antibacterial hydrogels for wound healing applications. PhD thesis University of Westminster Life Sciences https://doi.org/10.34737/qz084
Title | Antibiotic-free antibacterial hydrogels for wound healing applications |
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Type | PhD thesis |
Authors | Orlando, I. |
Abstract | Over the past decades, bacterial cellulose (BC) has attracted great interest as a wound dressing thanks to its innate hydrogel-like structure and high biocompatibility. However, the lack of antibacterial features of cellulose poses some limitations to its use, especially in the context of increasing antimicrobial resistance. In this work, various strategies were explored for the development of novel BC-based wound healing devices that can efficiently inhibit bacterial proliferation. First, the production of BC by fermentation of Gluconacetobacter xylinus and its purification from the biomass were optimised. The material was characterised with respect to its morphological, chemical and mechanical properties. The introduction of antibacterial functional groups was then investigated by ring-opening reaction of two epoxides with the hydroxyl groups of glucose in wet basic conditions. Biological tests evidenced that the |
Year | 2019 |
File | File Access Level Open (open metadata and files) |
Publisher | University of Westminster |
Publication dates | |
Published | Jul 2019 |
Digital Object Identifier (DOI) | https://doi.org/10.34737/qz084 |