Title | Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy |
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Type | Journal article |
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Authors | Mortoglou, M., Tabin, Zoey Kathleen, Arisan, E., Kocher, Hemant M and Uysal-Onganer, P. |
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Abstract | Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over the last 50 years. Early detection is particularly difficult due to the lack of disease-specific symptoms and a reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19-9 (CA 19-9) is the most common diagnostic biomarker; however, it is not specific enough especially for asymptomatic patients. Non-coding RNAs are often deregulated in human malignancies and shown to be involved in cancer-related mechanisms such as cell growth, differentiation, and cell death. Several micro, long non-coding and circular RNAs have been reported to date which are involved in PDAC. Aim of this review is to discuss the roles and functions of non-coding RNAs in diagnosis and treatments of PDAC. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.] |
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Keywords | Circular RNA |
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| Long non-coding RNA |
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| MicroRNA |
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| Non-coding RNAs |
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| Pancreatic ductal adenocarcinoma |
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Article number | 101090 |
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Journal | Translational Oncology |
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Journal citation | 14 (7) |
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ISSN | 1936-5233 |
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Year | 2021 |
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Publisher | Elsevier |
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Publisher's version | License CC BY-NC-ND 4.0 File Access Level Open (open metadata and files) |
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Digital Object Identifier (DOI) | https://doi.org/10.1016/j.tranon.2021.101090 |
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PubMed ID | 33831655 |
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Publication dates |
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Published online | 05 Apr 2021 |
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