Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy

Mortoglou, M., Tabin, Zoey Kathleen, Arisan, E., Kocher, Hemant M and Uysal-Onganer, P. 2021. Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy. Translational Oncology. 14 (7) 101090. https://doi.org/10.1016/j.tranon.2021.101090

TitleNon-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy
TypeJournal article
AuthorsMortoglou, M., Tabin, Zoey Kathleen, Arisan, E., Kocher, Hemant M and Uysal-Onganer, P.
AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over the last 50 years. Early detection is particularly difficult due to the lack of disease-specific symptoms and a reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19-9 (CA 19-9) is the most common diagnostic biomarker; however, it is not specific enough especially for asymptomatic patients. Non-coding RNAs are often deregulated in human malignancies and shown to be involved in cancer-related mechanisms such as cell growth, differentiation, and cell death. Several micro, long non-coding and circular RNAs have been reported to date which are involved in PDAC. Aim of this review is to discuss the roles and functions of non-coding RNAs in diagnosis and treatments of PDAC. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]
KeywordsCircular RNA
Long non-coding RNA
MicroRNA
Non-coding RNAs
Pancreatic ductal adenocarcinoma
Article number101090
JournalTranslational Oncology
Journal citation14 (7)
ISSN1936-5233
Year2021
PublisherElsevier
Publisher's version
License
CC BY-NC-ND 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1016/j.tranon.2021.101090
PubMed ID33831655
Publication dates
Published online05 Apr 2021

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