Aspects of cell growth control illustrated by the Schwann cell

Sinead A. Roberts and Alison C. Lloyd 2012. Aspects of cell growth control illustrated by the Schwann cell. Current Opinion in Cell Biology. 24 (6), pp. 852-857. https://doi.org/10.1016/j.ceb.2012.10.003

TitleAspects of cell growth control illustrated by the Schwann cell
TypeJournal article
AuthorsSinead A. Roberts and Alison C. Lloyd
Abstract

The control of cell biogenesis remains poorly understood, despite being critical for the development and maintenance of all organisms. Studies in vitro and in vivo using the Schwann cell, the glial cell of the peripheral nervous system, have provided important insights into cell growth control. These studies have demonstrated how instructive growth factor signals can control cell growth rates, cell size and organelle biogenesis and how deregulated cell growth can contribute to diseases, such as cancer. Additional studies on Schwann cells highlight the importance of cell size control within a tissue – the size of myelinating Schwann cells is coupled to the size of the axon they ensheath, which is necessary for efficient nerve conduction.

JournalCurrent Opinion in Cell Biology
Journal citation24 (6), pp. 852-857
ISSN0955-0674
Year2012
PublisherElsevier
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ceb.2012.10.003
Web address (URL)http://dx.doi.org/10.1016/j.ceb.2012.10.003
Publication dates
PublishedDec 2012

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