Course of vitamin D levels before and after liver transplantation in pediatric patients

Yuksel, Muhammed, Demir, Baris, Mizikoglu, Ozlem, Akyildiz, Murat, Baygul, Arzu and Arikan, Cigdem 2021. Course of vitamin D levels before and after liver transplantation in pediatric patients. Pediatric Transplantation. 25 (7) e14049. https://doi.org/10.1111/petr.14049

TitleCourse of vitamin D levels before and after liver transplantation in pediatric patients
TypeJournal article
AuthorsYuksel, Muhammed, Demir, Baris, Mizikoglu, Ozlem, Akyildiz, Murat, Baygul, Arzu and Arikan, Cigdem
Abstract

Background
25-hydroxy VD insufficiency is known in children undergoing LT but the serial post-transplant VD course and supplementation modalities in the peri-transplant period are lacking. We aimed to determine the pre-VD status and the post-transplant VD status course following VD supplementation and to elucidate its relationship with post-transplant outcome parameters such as infection and survival.

Methods
Pre- and post-VD levels were monitored in parallel with interventions to adjust VD levels in LT patients. VD status was categorized as circulating levels <30–21 ng/ml (insufficiency), 20–10 ng/ml (deficiency), and <10 ng/ml (severe deficiency). Patients received stoss (300000IU) VD3 within the pretransplant period if serum levels were <20 ng/ml.

Results
135 transplanted children were included. The age at LT was 22 months (IQR: 8–60). The pretransplant median VD level was 14 ng/ml. Despite stoss dose, post-transplant median VD level was 1.8 ng/ml (day one), 4 ng/ml (week one), 19 ng/ml (month one), 33 ng/ml (month three), 38 ng/ml (months 6–12), and 40 ng/ml (month 24). After 6 months, VD status reached >30 ng/ml in 98% of patients. Only at pre-LT, higher infection rate (18.7%) in the severe VD deficiency group was observed compared to the VD deficiency group (2.9%, p = .04). Survival was not affected by serum VD levels.

Conclusion
VD levels fell substantially after LT but are rectifiable by stoss dose, which was well tolerated. Only the infection rate was associated with the VD status.

Article numbere14049
JournalPediatric Transplantation
Journal citation25 (7)
ISSN1399-3046
Year2021
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1111/petr.14049
Web address (URL)https://publons.com/wos-op/publon/47274866/
Publication dates
PublishedNov 2021

Related outputs

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
Bonaccorsi-Riani, Eliano, Ghinolfi, Davide, Czigany, Zoltan, Dondossola, Daniele, Emamaullee, Juliet, Yuksel, Muhammed, Boteon, Yuri L., Al-Adra, David, Ho, Cheng-Maw, Abdelrahim, Maen, Pang, Li, Barbas, Andrew, Meier, Raphael, MacParland, Sonya, Sayed, Blayne Amir, Pavan-Guimaraes, Juliana, Brüggenwirth, Isabel M.A., Zarrinpar, Ali, Mas, Valeria R., Selzner, Markus, Martins, Paulo N. and Bhat, Mamatha 2024. What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society. Transplantation. https://doi.org/10.1097/tp.0000000000004980

Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease
Yuksel, Muhammed, Nazmi, Farinaz, Wardat, Dima, Akgul, Sebahat, Polat, Esra, Akyildiz, Murat and Arikan, Cigdem 2023. Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease. Frontiers in Immunology. 13. https://doi.org/10.3389/fimmu.2022.1053216

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020-2021?-Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
Czigany, Zoltan, Bruggenwirth, Isabel M. A., Ekser, Burcin, Abdelrahim, Maen, Bhat, Mamatha, Bonaccorsi-Riani, Eliano, Chen, Angela, Emamaullee, Juliet, Eymard, Corey, Ho, Cheng-Maw, Mas, Valeria R., Zarrinpar, Ali, Yuksel, Muhammed, Martins, Paulo N. and Selzner, Markus 2022. What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020-2021?-Report of the Basic and Translational Research Committee of the International Liver Transplantation Society. Transplantation. 106 (2), pp. 227-233. https://doi.org/10.1097/tp.0000000000004003

Telemedicine in monitoring pediatric LT patients before and during COVID-19 pandemic
Musaoglu, Mirac, Yuksel, Muhammed, Mizikoglu, Ozlem and Arikan, Cigdem 2022. Telemedicine in monitoring pediatric LT patients before and during COVID-19 pandemic. Pediatric Transplantation. 26 (1) e14138. https://doi.org/10.1111/petr.14138

Examining the Hepatic Immune System in Children With Liver Disease With Fine Needle Aspiration
Yuksel, Muhammed, Demirbas, Burak, Mizikoglu, Ozlem, Tutuncu, Yildiz, Kanmaz, Turan, Oguzkurt, Levent and Arikan, Cigdem 2022. Examining the Hepatic Immune System in Children With Liver Disease With Fine Needle Aspiration. Journal of Pediatric Gastroenterology and Nutrition. 74 (2), pp. 200-207. https://doi.org/10.1097/mpg.0000000000003353

Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis
Graham, Jonathon J., Mukherjee, Sujit, Yuksel, Muhammad, Mateos, Rebeca Sanabria, Si, Tengfei, Huang, Zhenlin, Huang, Xiahong, Abu Arqoub, Hadil, Patel, Vishal, McPhail, Mark, Zen, Yoh, Heaton, Nigel, Longhi, Maria Serena, Heneghan, Michael A., Liberal, Rodrigo, Vergani, Diego, Mieli-Vergani, Giorgina, Ma, Yun and Hayee, Bu'Hussain 2022. Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis. Hepatology. 75 (3), pp. 518-530. https://doi.org/10.1002/hep.32193

A single-center report of COVID-19 disease course and management in liver transplanted pediatric patients
Yuksel, Muhammed, Akturk, Hacer, Mizikoglu, Ozlem, Toroslu, Ertug and Arikan, Cigdem 2021. A single-center report of COVID-19 disease course and management in liver transplanted pediatric patients. Pediatric Transplantation. 25 (7) e14061. https://doi.org/10.1111/petr.14061

A novel insight into the pathophysiology of autoimmune hepatitis: An immune activator mutation in the FLT3 receptor
Yuksel, Muhammed, Armutlu, Ayse, Nazmi, Farinaz, Ceylaner, Serdar and Arikan, Cigdem 2021. A novel insight into the pathophysiology of autoimmune hepatitis: An immune activator mutation in the FLT3 receptor. Hepatology Forum. 2 (3), pp. 112-116. https://doi.org/10.14744/hf.2021.2021.0010

Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry
Ma, Yun, Su, Haibin, Yuksel, Muhammed, Longhi, Maria Serena, McPhail, Mark J., Wang, Pengyun, Bansal, Sanjay, Wong, Guan-Wee, Graham, Jonathon, Yang, Li, Thompson, Richard J., Doherty, Derek G., Hadzic, Nedim, Zen, Yoh, Quaglia, Alberto, Heneghan, Michael A., Samyn, Marianne, Vergani, Diego and Mieli-Vergani, Giorgina 2021. Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry. Hepatology. 74 (4), pp. 2032-2046. https://doi.org/10.1002/hep.31893

Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection
Yuksel, M., Akturk, H. and Arikan, C. 2020. Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection. European Journal of Gastroenterology and Hepatology. 32 (9), pp. 1251-1255. https://doi.org/10.1097/meg.0000000000001804

Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration
Jassem, W., Xystrakis, E., Ghnewa, Y.G., Yuksel, M., Pop, O., Martinez-Llordella, M., Jabri, Y., Huang, X., Lozano, J.J., Quaglia, A., Sanchez-Fueyo, A., Coussios, C.C., Rela, M., Friend, P., Heaton, N. and Ma, Y. 2019. Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration. Hepatology. 70 (2), pp. 682-695. https://doi.org/10.1002/hep.30475

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
Triantafyllou, E., Pop, O.T., Possamai, L.A., Wilhelm, A., Liaskou, E., Singanayagam, A., Bernsmeier, C., Khamri, W., Petts, G., Dargue, R., Davies, S.P., Tickle, J., Yuksel, M., Patel, V.C., Abeles, R.D., Stamataki, Z., Curbishley, S.M., Ma, Y., Wilson, I.D., Coen, M., Woollard, K.J., Quaglia, A., Wendon, J., Thursz, M.R., Adams, D.H., Weston, C.J. and Antoniades, C.G. 2018. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut. 67, pp. 333-347. https://doi.org/10.1136/gutjnl-2016-313615

The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model
Yuksel, M., Xiao, X., Tai, N., Vijay, G.M., Gülden, E., Beland, K., Lapierre, P., Alvarez, F., Hu, Z., Colle, I., Ma, Y. and Wen, L. 2018. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clinical and Experimental Immunology. 192 (1), pp. 164-176. https://doi.org/10.1111/cei.12843

Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis
Liberal, R., Grant, C.R., Yuksel, M., Graham, J., Kalbasi, A., Ma, Y., Heneghan, M.A., Mieli-Vergani, G., Vergani, D. and Longhi, M.S. 2017. Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis. Hepatology. 66 (5), pp. 1570-1584. https://doi.org/10.1002/hep.29307

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment
Halim, L., Romano, M., McGregor, R., Correa, I., Pavlidis, P., Grageda, N., Hoong, S.-J., Yuksel, M., Jassem, W., Hannen, R.F., Ong, M., Mckinney, O., Hayee, B.H., Karagiannis, S.N., Powell, N., Lechler, R.I., Nova-Lamperti, E. and Lombardi, G. 2017. An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment. Cell Reports. 20 (3), pp. P757-770. https://doi.org/10.1016/j.celrep.2017.06.079

A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation
Yuksel, M., Wang, Y., Tai, N., Peng, J., Guo, J., Beland, K., Lapierre, P., David, C., Alvarez, F., Colle, I., Yan, H., Mieli-Vergani, G., Vergani, D., Ma, Y. and Wen, L. 2015. A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology. 62 (5), pp. 1536-1550. https://doi.org/10.1002/hep.27998

Impact of donation mode on the proportion and function of T lymphocytes in the liver
Xystrakis, E., Yuksel, M., Lin, F., Huang, X., Pop, O.T., Quaglia, A., Heaton, N., Prachalias, A., Rela, M., Fuggle, S., Ma, Y. and Jassem, W. 2015. Impact of donation mode on the proportion and function of T lymphocytes in the liver. PLoS ONE. 10 (10) e0139791. https://doi.org/10.1371/journal.pone.0139791

Hepatitis mouse models: From acute-to-chronic autoimmune hepatitis
Yuksel, M., Laukens, D., Heindryckx, F., Van Vlierberghe, H., Geerts, A., Wong, F.S., Wen, L. and Colle, I. 2014. Hepatitis mouse models: From acute-to-chronic autoimmune hepatitis. International Journal of Experimental Pathology. 95 (5), pp. 309-320. https://doi.org/10.1111/iep.12090

Role of IRAK-M in Alcohol Induced Liver Injury
Wang, Y., Hu, Y., Chao, C., Yuksel, M., Colle, I., Flavell, R.A., Ma, Y., Yan, H. and Wen, L. 2013. Role of IRAK-M in Alcohol Induced Liver Injury. PLoS ONE. 9 (1) e57085. https://doi.org/10.1371/journal.pone.0057085

Permalink - https://westminsterresearch.westminster.ac.uk/item/w3zz6/course-of-vitamin-d-levels-before-and-after-liver-transplantation-in-pediatric-patients


Share this

Usage statistics

29 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.