Course of vitamin D levels before and after liver transplantation in pediatric patients : WestminsterResearch

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Title	Course of vitamin D levels before and after liver transplantation in pediatric patients
Type	Journal article
Authors	Yuksel, Muhammed, Demir, Baris, Mizikoglu, Ozlem, Akyildiz, Murat, Baygul, Arzu and Arikan, Cigdem
Abstract	Background 25-hydroxy VD insufficiency is known in children undergoing LT but the serial post-transplant VD course and supplementation modalities in the peri-transplant period are lacking. We aimed to determine the pre-VD status and the post-transplant VD status course following VD supplementation and to elucidate its relationship with post-transplant outcome parameters such as infection and survival. Methods Pre- and post-VD levels were monitored in parallel with interventions to adjust VD levels in LT patients. VD status was categorized as circulating levels <30–21 ng/ml (insufficiency), 20–10 ng/ml (deficiency), and <10 ng/ml (severe deficiency). Patients received stoss (300000IU) VD3 within the pretransplant period if serum levels were <20 ng/ml. Results 135 transplanted children were included. The age at LT was 22 months (IQR: 8–60). The pretransplant median VD level was 14 ng/ml. Despite stoss dose, post-transplant median VD level was 1.8 ng/ml (day one), 4 ng/ml (week one), 19 ng/ml (month one), 33 ng/ml (month three), 38 ng/ml (months 6–12), and 40 ng/ml (month 24). After 6 months, VD status reached >30 ng/ml in 98% of patients. Only at pre-LT, higher infection rate (18.7%) in the severe VD deficiency group was observed compared to the VD deficiency group (2.9%, p = .04). Survival was not affected by serum VD levels. Conclusion VD levels fell substantially after LT but are rectifiable by stoss dose, which was well tolerated. Only the infection rate was associated with the VD status.
Article number	e14049
Journal	Pediatric Transplantation
Journal citation	25 (7)
ISSN	1399-3046
Year	2021
Publisher	Wiley
Digital Object Identifier (DOI)	https://doi.org/10.1111/petr.14049
Web address (URL)	https://publons.com/wos-op/publon/47274866/
Published	Nov 2021

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Course of vitamin D levels before and after liver transplantation in pediatric patients

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