Wang, Y., Hu, Y., Chao, C., Yuksel, M., Colle, I., Flavell, R.A., Ma, Y., Yan, H. and Wen, L. 2013. Role of IRAK-M in Alcohol Induced Liver Injury. PLoS ONE. 9 (1) e57085. https://doi.org/10.1371/journal.pone.0057085
| Title | Role of IRAK-M in Alcohol Induced Liver Injury |
|---|---|
| Type | Journal article |
| Authors | Wang, Y., Hu, Y., Chao, C., Yuksel, M., Colle, I., Flavell, R.A., Ma, Y., Yan, H. and Wen, L. |
| Abstract | Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity. The main objective of this study was to investigate the negative regulator of innate immunity, IL-1/Toll-like receptor (TLR) signaling pathways and interleukin receptor-associated kinase-M (IRAK-M) in alcoholic liver injury. We established an alcohol-induced liver injury model using wild type and IRAK-M deficient B6 mice and investigated the possible mechanisms. We found that in the absence of IRAK-M, liver damage by alcohol was worse with higher alanine transaminase (ALT), more immune cell infiltration and increased numbers of IFNγ producing cells. We also found enhanced phagocytic activity in CD68+ cells. Moreover, our results revealed altered gut bacteria after alcohol consumption and this was more striking in the absence of IRAK-M. Our study provides evidence that IRAK-M plays an important role in alcohol-induced liver injury and IRAK-M negatively regulates the innate and possibly the adaptive immune response in the liver reacting to acute insult by alcohol. In the absence of IRAK-M, the hosts developed worse liver injury, enhanced gut permeability and altered gut microbiota. |
| Article number | e57085 |
| Journal | PLoS ONE |
| Journal citation | 9 (1) |
| ISSN | 1932-6203 |
| Year | 2013 |
| Publisher | Public Library of Science |
| Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
| Digital Object Identifier (DOI) | https://doi.org/10.1371/journal.pone.0057085 |
| Publication dates | |
| Published | 21 Feb 2013 |