Role of IRAK-M in Alcohol Induced Liver Injury

Wang, Y., Hu, Y., Chao, C., Yuksel, M., Colle, I., Flavell, R.A., Ma, Y., Yan, H. and Wen, L. 2013. Role of IRAK-M in Alcohol Induced Liver Injury. PLoS ONE. 9 (1) e57085. https://doi.org/10.1371/journal.pone.0057085

TitleRole of IRAK-M in Alcohol Induced Liver Injury
TypeJournal article
AuthorsWang, Y., Hu, Y., Chao, C., Yuksel, M., Colle, I., Flavell, R.A., Ma, Y., Yan, H. and Wen, L.
Abstract

Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity. The main objective of this study was to investigate the negative regulator of innate immunity, IL-1/Toll-like receptor (TLR) signaling pathways and interleukin receptor-associated kinase-M (IRAK-M) in alcoholic liver injury. We established an alcohol-induced liver injury model using wild type and IRAK-M deficient B6 mice and investigated the possible mechanisms. We found that in the absence of IRAK-M, liver damage by alcohol was worse with higher alanine transaminase (ALT), more immune cell infiltration and increased numbers of IFNγ producing cells. We also found enhanced phagocytic activity in CD68+ cells. Moreover, our results revealed altered gut bacteria after alcohol consumption and this was more striking in the absence of IRAK-M. Our study provides evidence that IRAK-M plays an important role in alcohol-induced liver injury and IRAK-M negatively regulates the innate and possibly the adaptive immune response in the liver reacting to acute insult by alcohol. In the absence of IRAK-M, the hosts developed worse liver injury, enhanced gut permeability and altered gut microbiota.

Article numbere57085
JournalPLoS ONE
Journal citation9 (1)
ISSN1932-6203
Year2013
PublisherPublic Library of Science
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0057085
Publication dates
Published21 Feb 2013

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