Role of IRAK-M in Alcohol Induced Liver Injury

HLA alleles predisposing to autoimmunity are linked to impaired immunoregulation in patients with juvenile autoimmune liver disease and in their first-degree relatives
Wang, P., Yuksel, M., Gabeta, S., Graham, J., Hussain, M., Blackmore, L.J., Huang, X., Hadzic, D., Samyn, M., Grammatikopoulos, T., Heneghan, M., Liberal, R., Longhi, M.S., Mieli-Vergani, G., Vergani, D. and Ma, Y. 2025. HLA alleles predisposing to autoimmunity are linked to impaired immunoregulation in patients with juvenile autoimmune liver disease and in their first-degree relatives. Journal of Autoimmunity. 154 103436. https://doi.org/10.1016/j.jaut.2025.103436

Detection of polyreactive immunoglobulin G facilitates diagnosis in children with autoimmune hepatitis.
Engel, Bastian, Diestelhorst, Jana, Hupa-Breier, Katharina Luise, Kirchner, Theresa, Henjes, Nicole, Loges, Stephanie, Yuksel, Muhammed, Janczyk, Wojciech, Lalanne, Claudine, Zachou, Kalliopi, Oo, Ye H, Gournay, Jérôme, Pape, Simon, Drenth, Joost P H, Renand, Amédée, Dalekos, George N, Muratori, Luigi, Socha, Piotr, Ma, Yun, Arikan, Cigdem, Baumann, Ulrich, Manns, Michael P, Wedemeyer, Heiner, Junge, Norman, Jaeckel, Elmar and Taubert, Richard 2024. Detection of polyreactive immunoglobulin G facilitates diagnosis in children with autoimmune hepatitis. Hepatology international. 18, pp. 1214-1226. https://doi.org/10.1007/s12072-024-10695-1

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
Bonaccorsi-Riani, Eliano, Ghinolfi, Davide, Czigany, Zoltan, Dondossola, Daniele, Emamaullee, Juliet, Yuksel, Muhammed, Boteon, Yuri L., Al-Adra, David, Ho, Cheng-Maw, Abdelrahim, Maen, Pang, Li, Barbas, Andrew, Meier, Raphael, MacParland, Sonya, Sayed, Blayne Amir, Pavan-Guimaraes, Juliana, Brüggenwirth, Isabel M.A., Zarrinpar, Ali, Mas, Valeria R., Selzner, Markus, Martins, Paulo N. and Bhat, Mamatha 2024. What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2023? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society. Transplantation. 108 (5), pp. 1043-1052. https://doi.org/10.1097/tp.0000000000004980

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2022? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
Bhat, Mamatha, Dondossola, Daniele, Varghese, Rhea, Czigany, Zoltan, Emamaullee, Juliet, Ghinolfi, Davide, Al-Adra, David, Bonaccorsi-Riani, Eliano, Pang, Li, Boteon, Yuri L., Brueggenwirth, Isabel, Pavan-Guimaraes, Juliana, Ho, Cheng-Maw, Yuksel, Muhammed, Zarrinpar, Ali, Abdelrahim, Maen, Barbas, Andrew S., Mas, Valeria, Selzner, Markus and Martins, Paulo N. 2023. What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2022? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society. Transplantation. 107 (4), pp. 808-814. https://doi.org/10.1097/tp.0000000000004476

Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease
Yuksel, Muhammed, Nazmi, Farinaz, Wardat, Dima, Akgul, Sebahat, Polat, Esra, Akyildiz, Murat and Arikan, Cigdem 2023. Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease. Frontiers in Immunology. 13. https://doi.org/10.3389/fimmu.2022.1053216

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020-2021?-Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
Czigany, Zoltan, Bruggenwirth, Isabel M. A., Ekser, Burcin, Abdelrahim, Maen, Bhat, Mamatha, Bonaccorsi-Riani, Eliano, Chen, Angela, Emamaullee, Juliet, Eymard, Corey, Ho, Cheng-Maw, Mas, Valeria R., Zarrinpar, Ali, Yuksel, Muhammed, Martins, Paulo N. and Selzner, Markus 2022. What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020-2021?-Report of the Basic and Translational Research Committee of the International Liver Transplantation Society. Transplantation. 106 (2), pp. 227-233. https://doi.org/10.1097/tp.0000000000004003

Telemedicine in monitoring pediatric LT patients before and during COVID-19 pandemic
Musaoglu, Mirac, Yuksel, Muhammed, Mizikoglu, Ozlem and Arikan, Cigdem 2022. Telemedicine in monitoring pediatric LT patients before and during COVID-19 pandemic. Pediatric Transplantation. 26 (1) e14138. https://doi.org/10.1111/petr.14138

Examining the Hepatic Immune System in Children With Liver Disease With Fine Needle Aspiration
Yuksel, Muhammed, Demirbas, Burak, Mizikoglu, Ozlem, Tutuncu, Yildiz, Kanmaz, Turan, Oguzkurt, Levent and Arikan, Cigdem 2022. Examining the Hepatic Immune System in Children With Liver Disease With Fine Needle Aspiration. Journal of Pediatric Gastroenterology and Nutrition. 74 (2), pp. 200-207. https://doi.org/10.1097/mpg.0000000000003353

Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis
Graham, Jonathon J., Mukherjee, Sujit, Yuksel, Muhammad, Mateos, Rebeca Sanabria, Si, Tengfei, Huang, Zhenlin, Huang, Xiahong, Abu Arqoub, Hadil, Patel, Vishal, McPhail, Mark, Zen, Yoh, Heaton, Nigel, Longhi, Maria Serena, Heneghan, Michael A., Liberal, Rodrigo, Vergani, Diego, Mieli-Vergani, Giorgina, Ma, Yun and Hayee, Bu'Hussain 2022. Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis. Hepatology. 75 (3), pp. 518-530. https://doi.org/10.1002/hep.32193

A single-center report of COVID-19 disease course and management in liver transplanted pediatric patients
Yuksel, Muhammed, Akturk, Hacer, Mizikoglu, Ozlem, Toroslu, Ertug and Arikan, Cigdem 2021. A single-center report of COVID-19 disease course and management in liver transplanted pediatric patients. Pediatric Transplantation. 25 (7) e14061. https://doi.org/10.1111/petr.14061

A novel insight into the pathophysiology of autoimmune hepatitis: An immune activator mutation in the FLT3 receptor
Yuksel, Muhammed, Armutlu, Ayse, Nazmi, Farinaz, Ceylaner, Serdar and Arikan, Cigdem 2021. A novel insight into the pathophysiology of autoimmune hepatitis: An immune activator mutation in the FLT3 receptor. Hepatology Forum. 2 (3), pp. 112-116. https://doi.org/10.14744/hf.2021.2021.0010

Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry
Ma, Yun, Su, Haibin, Yuksel, Muhammed, Longhi, Maria Serena, McPhail, Mark J., Wang, Pengyun, Bansal, Sanjay, Wong, Guan-Wee, Graham, Jonathon, Yang, Li, Thompson, Richard J., Doherty, Derek G., Hadzic, Nedim, Zen, Yoh, Quaglia, Alberto, Heneghan, Michael A., Samyn, Marianne, Vergani, Diego and Mieli-Vergani, Giorgina 2021. Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry. Hepatology. 74 (4), pp. 2032-2046. https://doi.org/10.1002/hep.31893

Course of vitamin D levels before and after liver transplantation in pediatric patients
Yuksel, Muhammed, Demir, Baris, Mizikoglu, Ozlem, Akyildiz, Murat, Baygul, Arzu and Arikan, Cigdem 2021. Course of vitamin D levels before and after liver transplantation in pediatric patients. Pediatric Transplantation. 25 (7) e14049. https://doi.org/10.1111/petr.14049

Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection
Yuksel, M., Akturk, H. and Arikan, C. 2020. Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection. European Journal of Gastroenterology and Hepatology. 32 (9), pp. 1251-1255. https://doi.org/10.1097/meg.0000000000001804

Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration
Jassem, W., Xystrakis, E., Ghnewa, Y.G., Yuksel, M., Pop, O., Martinez-Llordella, M., Jabri, Y., Huang, X., Lozano, J.J., Quaglia, A., Sanchez-Fueyo, A., Coussios, C.C., Rela, M., Friend, P., Heaton, N. and Ma, Y. 2019. Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration. Hepatology. 70 (2), pp. 682-695. https://doi.org/10.1002/hep.30475

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
Triantafyllou, E., Pop, O.T., Possamai, L.A., Wilhelm, A., Liaskou, E., Singanayagam, A., Bernsmeier, C., Khamri, W., Petts, G., Dargue, R., Davies, S.P., Tickle, J., Yuksel, M., Patel, V.C., Abeles, R.D., Stamataki, Z., Curbishley, S.M., Ma, Y., Wilson, I.D., Coen, M., Woollard, K.J., Quaglia, A., Wendon, J., Thursz, M.R., Adams, D.H., Weston, C.J. and Antoniades, C.G. 2018. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut. 67, pp. 333-347. https://doi.org/10.1136/gutjnl-2016-313615

The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model
Yuksel, M., Xiao, X., Tai, N., Vijay, G.M., Gülden, E., Beland, K., Lapierre, P., Alvarez, F., Hu, Z., Colle, I., Ma, Y. and Wen, L. 2018. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clinical and Experimental Immunology. 192 (1), pp. 164-176. https://doi.org/10.1111/cei.12843

Treg conditioning endows activated Teff with suppressor function in juvenile autoimmune liver disease
Liberal, R., Grant, C.R., Yuksel, M., Ma, Y., Heneghan, M.A., Mieli-Vergani, G., Vergani, D. and Longhi, M.S. 2017. Treg conditioning endows activated Teff with suppressor function in juvenile autoimmune liver disease. Journal of Hepatology. 66 (Issue 1, Supplement), p. S554. https://doi.org/10.1016/s0168-8278(17)31520-9

SAT-414 - Donation mode impacts on invariant natural killer T cell population leading to scarce iNKT cells in donation after cardiac death liver grafts despite a significant increase in B cells and CD1d expression
Ghnewa, Y. G., Yuksel, M., Khorsandi, S., Huang, X., Graham, J., Ramsay, L., Fiorou, L., Milan, Z., Ma, Y., Jassem, W. and Heaton, N. 2017. SAT-414 - Donation mode impacts on invariant natural killer T cell population leading to scarce iNKT cells in donation after cardiac death liver grafts despite a significant increase in B cells and CD1d expression. Journal of Hepatology. 66 (Issue 1, Supplement), pp. S615-S616. https://doi.org/10.1016/s0168-8278(17)31673-2

Association between disease-predisposing HLA DR3/DR7/DR13 genes with numeric impairment of immunoregulatory T-cells in patients with autoimmune hepatitis/sclerosing cholangitis
Wang, Pengyun, Yuksel, Muhammed, Gabeta, Stella, Graham, Jonathon, Hussain, Munther J., Blackmore, Laura J., Huang, Xiaohong, Hadzic, Nedim, Samyn, Marianne, Bansal, Sanjay, Grammatikopoulos, Tassos, Jassem, Wayel, Heneghan, Michael A., Liberal, Rodrigo, Longhi, Maria Serena, Vergani, Diego, Mieli-Vergani, Giorgina and Ma, Yun 2017. Association between disease-predisposing HLA DR3/DR7/DR13 genes with numeric impairment of immunoregulatory T-cells in patients with autoimmune hepatitis/sclerosing cholangitis. Hepatology. 66 (S1), p. Meeting Abstract 112. https://doi.org/10.1002/hep.29500

Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis
Liberal, R., Grant, C.R., Yuksel, M., Graham, J., Kalbasi, A., Ma, Y., Heneghan, M.A., Mieli-Vergani, G., Vergani, D. and Longhi, M.S. 2017. Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis. Hepatology. 66 (5), pp. 1570-1584. https://doi.org/10.1002/hep.29307

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment
Halim, L., Romano, M., McGregor, R., Correa, I., Pavlidis, P., Grageda, N., Hoong, S.-J., Yuksel, M., Jassem, W., Hannen, R.F., Ong, M., Mckinney, O., Hayee, B.H., Karagiannis, S.N., Powell, N., Lechler, R.I., Nova-Lamperti, E. and Lombardi, G. 2017. An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment. Cell Reports. 20 (3), pp. P757-770. https://doi.org/10.1016/j.celrep.2017.06.079

A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation
Yuksel, M., Wang, Y., Tai, N., Peng, J., Guo, J., Beland, K., Lapierre, P., David, C., Alvarez, F., Colle, I., Yan, H., Mieli-Vergani, G., Vergani, D., Ma, Y. and Wen, L. 2015. A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. Hepatology. 62 (5), pp. 1536-1550. https://doi.org/10.1002/hep.27998

Impact of donation mode on the proportion and function of T lymphocytes in the liver
Xystrakis, E., Yuksel, M., Lin, F., Huang, X., Pop, O.T., Quaglia, A., Heaton, N., Prachalias, A., Rela, M., Fuggle, S., Ma, Y. and Jassem, W. 2015. Impact of donation mode on the proportion and function of T lymphocytes in the liver. PLoS ONE. 10 (10) e0139791. https://doi.org/10.1371/journal.pone.0139791

Hepatitis mouse models: From acute-to-chronic autoimmune hepatitis
Yuksel, M., Laukens, D., Heindryckx, F., Van Vlierberghe, H., Geerts, A., Wong, F.S., Wen, L. and Colle, I. 2014. Hepatitis mouse models: From acute-to-chronic autoimmune hepatitis. International Journal of Experimental Pathology. 95 (5), pp. 309-320. https://doi.org/10.1111/iep.12090