Predictors of in-hospital mortality in HIV-infected patients with COVID-19

Moreno-Torres, Victor, de Mendoza, Carmen, Martinez-Urbistondo, Maria, Mills, Patricia, Trevino, Ana, de la Fuente, Sara, de Santiago, Alberto Diaz, Calderon-Parra, Jorge, Pintos-Pascual, Ilduara, Corpas, Manuel, Soriano, Vicente and Corpas, M. 2023. Predictors of in-hospital mortality in HIV-infected patients with COVID-19. QJM: An International Journal of Medicine. 116 (1), pp. 57-62. https://doi.org/10.1093/qjmed/hcac215

TitlePredictors of in-hospital mortality in HIV-infected patients with COVID-19
TypeJournal article
AuthorsMoreno-Torres, Victor, de Mendoza, Carmen, Martinez-Urbistondo, Maria, Mills, Patricia, Trevino, Ana, de la Fuente, Sara, de Santiago, Alberto Diaz, Calderon-Parra, Jorge, Pintos-Pascual, Ilduara, Corpas, Manuel, Soriano, Vicente and Corpas, M.
Abstract

Background
Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate.

Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain before vaccine availability.

Design: Retrospective nationwide public database analysis.

Methods
Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.

Results
A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P<0.001) and more frequently male (74.8% vs. 56.6%; P<0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia and cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs. 4.4%; P<0.001). In-hospital mortality was lower in PWH (9.4% vs. 16%; P=0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (relative risk (RR): 7.6) were the major determinants of death in PWH hospitalized with COVID-19.

Conclusion
HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19.

A correction has been published: QJM: An International Journal of Medicine, hcad121, https://doi.org/10.1093/qjmed/hcad121

JournalQJM: An International Journal of Medicine
Journal citation116 (1), pp. 57-62
ISSN1460-2393
1460-2725
Year2023
PublisherOxford University Press
Digital Object Identifier (DOI)https://doi.org/10.1093/qjmed/hcac215
Web address (URL)https://publons.com/wos-op/publon/53925569/
Publication dates
Published online01 Sep 2022
Published in printJan 2023

Related outputs

Preprint: Low-coverage whole genome sequencing for a highly selective cohort of severe COVID-19 patients
Renato Santos, Víctor Moreno-Torres, Ilduara Pintos, Octavio Corral, Carmen de Mendoza, Vicente Soriano and Manuel Corpas 2024. Preprint: Low-coverage whole genome sequencing for a highly selective cohort of severe COVID-19 patients. biorxiv.org. https://doi.org/10.1101/2024.01.28.577610

Addressing Ancestry and Sex Bias in Pharmacogenomics
Corpas, Manuel, Siddiqui, Moneeza K., Soremekun, Opeyemi, Mathur, Rohini, Gill, Dipender and Fatumo, Segun 2024. Addressing Ancestry and Sex Bias in Pharmacogenomics. Annual Review of Pharmacology and Toxicology. 64, pp. 53-64. https://doi.org/10.1146/annurev-pharmtox-030823-111731

Equity, diversity, and inclusion at the Global Alliance for Genomics and Health
Skantharajah, Neerjah, Baichoo, Shakuntala, Boughtwood, Tiffany F., Casas-Silva, Esmeralda, Chandrasekharan, Subhashini, Dave, Sanjay M., Fakhro, Khalid A., Falcon de Vargas, Aida B, Gayle, Sylvia S., Gupta, Vivek K., Hendricks-Sturrup, Rachele, Hobb, Ashley E., Li, Stephanie, Llamas, Bastien, Lopez-Correa, Catalina, Machirori, Mavis, Melendez-Zajgla, Jorge, Millner, Mareike A., Page, Angela J.H., Paglione, Laura D., Raven-Adams, Maili C., Smith, Lindsay, Thomas, Ericka M., Kumuthini, Judit and Corpas, Manuel 2023. Equity, diversity, and inclusion at the Global Alliance for Genomics and Health. Cell genomics. 3 (10) 100386. https://doi.org/10.1016/j.xgen.2023.100386

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry
Abram Bunya Kamiza, Sounkou M. Touré, Feng Zhou, Opeyemi Soremekun, Cheickna Cissé, Mamadou Wélé, Aboubacrine M. Touré, Oyekanmi Nashiru, Manuel Corpas, Moffat Nyirenda, Amelia Crampin, Jeffrey Shaffer, Seydou Doumbia, Eleftheria Zeggini, Andrew P. Morris, Jennifer L. Asimit, Tinashe Chikowore and Segun Fatumo 2023. Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry. Nature Communications . 14 5403. https://doi.org/10.1038/s41467-023-41271-0

Generalisation of genomic findings and applications of polygenic risk scores
Corpas, Manuel and Fatumo, Segun 2023. Generalisation of genomic findings and applications of polygenic risk scores. BMC Medical Genomics. 16 175. https://doi.org/10.1186/s12920-023-01615-7

Genetic signature detected in T cell receptors from patients with severe COVID-19
Manuel Corpas, Carmen de Mendoza, Víctor Moreno-Torres, Ilduara Pintos, Pedro Seoane, James R. Perkins, Juan A.G. Ranea, Segun Fatumo, Tamas Korcsmaros, José Manuel Martín-Villa, Pablo Barreiro, Octavio Corral and Vicente Soriano 2023. Genetic signature detected in T cell receptors from patients with severe COVID-19. iScience. 26 (10) 107735. https://doi.org/10.1016/j.isci.2023.107735

Is SARS- CoV-2 the only cause of long-COVID?
Pintos-Pascual, Ilduara, Moreno-Torres, Victor, Ibanez-Estellez, Fatima, Corrales-Rodriguez, Pilar, Trevino, Ana, Corpas, Manuel, Corral, Octavio, Soriano, Vicente and de Mendoza, Carmen 2022. Is SARS- CoV-2 the only cause of long-COVID? AIDS Reviews. 24 (4), pp. 183-196. https://doi.org/10.24875/aidsrev.22000025

Implementation of individualised polygenic risk score analysis: a test case of a family of four
Manuel Corpas, Karyn Megy, Antonio Metastasio and Edmund Lehmann 2022. Implementation of individualised polygenic risk score analysis: a test case of a family of four. BMC Medical Genomics. 15 (Supplement 3) 207. https://doi.org/10.1186/s12920-022-01331-8

Transferability of genetic risk scores in African populations
Abram B. Kamiza, Sounkou M. Toure, Marijana Vujkovic, Tafadzwa Machipisa, Opeyemi S. Soremekun, Christopher Kintu, Manuel Corpas, Fraser Pirie, Elizabeth Young, Dipender Gill, Manjinder S. Sandhu, Pontiano Kaleebu, Moffat Nyirenda, Ayesha A. Motala, Tinashe Chikowore and Segun Fatumo 2022. Transferability of genetic risk scores in African populations. Nature Medicine. https://doi.org/10.1038/s41591-022-01835-x

Editorial: Personal Genomes: Accessing, Sharing, and Interpretation
Corpas, Manuel, Beck, Stephan, Glusman, Gustavo and Shabani, Mahsa 2021. Editorial: Personal Genomes: Accessing, Sharing, and Interpretation. Frontiers in Genetics. 12 687584. https://doi.org/10.3389/fgene.2021.687584

A Key Action Plan for Education in a Global Crisis
Soriano, V., Cordona, P. and Corpas, M. 2021. A Key Action Plan for Education in a Global Crisis. in: Burgos, D., Tlili, A. and Tabacco, A. (ed.) Radical Solutions for Education in a Crisis Context Springer. pp. 263-272

Whole Genome Interpretation for a Family of Five
Corpas, M., Megy, K., Mistry, V., Metastasio, A. and Lehmann, E. 2021. Whole Genome Interpretation for a Family of Five. Frontiers in Genetics. 12 535123. https://doi.org/10.3389/fgene.2021.535123

Simplifying access to human genomic data: community platform Repositive.io
Kovalevskaya, N. V., Whicher, C., Corpas, M., Shaw, R. and Nielsen, F. 2019. Simplifying access to human genomic data: community platform Repositive.io. European Journal of Human Genetics. 26 (S), p. 714. https://doi.org/10.1038/s41431-018-0247-7

Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases
Bueno, A., Rodríguez-López, R., Reyes-Palomares, A., Rojano, E., Corpas, M., Nevado, J., Lapunzina, P., Sánchez-Jiménez, F. and Ranea, J.A.G. 2018. Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases. European Journal of Human Genetics. 26, pp. 1451-1461. https://doi.org/10.1038/s41431-018-0139-x

A FAIR guide for data providers to maximise sharing of human genomic data
Corpas, M., Kovalevskaya, N.V., McMurray, A. and Nielsen, F.G.G. 2018. A FAIR guide for data providers to maximise sharing of human genomic data. PLOS Computational Biology. 14 (3) e1005873. https://doi.org/10.1371/journal.pcbi.1005873

Personal Genome Project UK (PGP-UK): A research and citizen science hybrid project in support of personalized medicine
Beck, S., Berner, A.M., Bignell, G., Bond, M., Callanan, M.J., Chervova, O., Conde, L., Corpas, M., Ecker, S., Elliott, H.R., Fioramonti, S.A., Flanagan, A.M., Gaentzsch, R., Graham, D., Gribbin, D., Guerra-Assunção, J.A., Hamoudi, R., Harding, V., Harrison, P.L., Herrero, J., Hofmann, J., Jones, E., Khan, S., Kaye, J., Kerr, P., Libertini, E., Marks, L., McCormack, L., Moghul, I., Pontikos, N., Rajanayagam, S., Rana, K., Semega-Janneh, M., Smith, C.P., Strom, L., Umur, S., Webster, A.P., Williams, E.H., Wint, K. and Wood, J.N. 2018. Personal Genome Project UK (PGP-UK): A research and citizen science hybrid project in support of personalized medicine. BMC Medical Genomics. 11 108. https://doi.org/10.1186/s12920-018-0423-1

APPLaUD: Access for patients and participants to individual level uninterpreted genomic data
Thorogood, A., Bobe, J., Prainsack, B., Middleton, A., Scott, E., Nelson, S., Corpas, M., Bonhomme, N., Rodriguez, L.L., Murtagh, M. and Kleiderman, E. 2018. APPLaUD: Access for patients and participants to individual level uninterpreted genomic data. Human Genomics. 12 7. https://doi.org/10.1186/s40246-018-0139-5

Four simple recommendations to encourage best practices in research software [version 1; referees: awaiting peer review]
Jiménez, R.C., Kuzak, M., Alhamdoosh, M., Barker, M., Batut, B., Borg, M., Capella-Gutierrez, S., Hong, N.C., Cook, M., Corpas, M., Flannery, M., Leyla Garcia, L., Josep Ll. Gelpí, J.L., Simon Gladman, S., Carole Goble, C., González Ferreiro, M., Gonzalez-Beltran, A., Griffin, P.C., Grüning, B., Hagberg, J., Holub, P., Hooft, R., Ison, J., Katz, D.S., Leskošek, B., López Gómez, F., Luis J. Oliveira, L.J., David Mellor, D., Mosbergen, R., Mulder, N., Perez-Riverol, Y., Pergl, R., Pichler, H., Pope, B., Sanz, F., Schneider, M.V., Stodden, V., Suchecki, R., Vařeková, R.S., Talvik, H.-A., Todorov, I., Treloar, A., Tyagi, S., van Gompel, M., Vaughan, D., Via, A., Wang, X., Watson-Haigh, N.S. and Crouch, S. 2017. Four simple recommendations to encourage best practices in research software [version 1; referees: awaiting peer review]. F1000Research. 6 876. https://doi.org/10.12688/f1000research.11407.1

Genome sequencing of the staple food crop white Guinea yam enables the development of a molecular marker for sex determination.
Corpas, M. 2017. Genome sequencing of the staple food crop white Guinea yam enables the development of a molecular marker for sex determination. BMC Biology. 15 86. https://doi.org/10.1186/s12915-017-0419-x

BioCIDER: a Contextualisation InDEx for biological Resources discovery
Horro, C., Cook, M., Attwood, T.K., Brazas, M.D., Hancock, J.M., Palagi, P., Corpas, M. and Jimenez, R. 2017. BioCIDER: a Contextualisation InDEx for biological Resources discovery. Bioinformatics. 33 (16), pp. 2607-2608. https://doi.org/10.1093/bioinformatics/btx213

Systematic identification of phenotypically enriched loci using a patient network of genomic disorders
Reyes-Palomares, A., Bueno, A., Rodríguez-López, R., Medina, M., Sánchez-Jiménez, F., Corpas, M. and Ranea, J.A.G. 2016. Systematic identification of phenotypically enriched loci using a patient network of genomic disorders. BMC Genomics. 17 232. https://doi.org/10.1186/s12864-016-2569-6

Progress on the genome characterisation of D. alata
Corpas, M. 2016. Progress on the genome characterisation of D. alata. Plant and Animal Genome XXIV Conference. Town & Country Resort & Convention Center 09 - 13 Jan 2016

Cutting Edge: Lessons from fraxinus, a crowd-sourced citizen science game in genomics
Rallapalli, G., Players, F., Saunders, D.G., Yoshida, K., Edwards, A., Lugo, C.A., Collin, S., Clavijo, B., Corpas, M., Swarbreck, D., Clark, M., Downie, J.A., Kamoun, S., Cooper, T. and Maclean, D. 2015. Cutting Edge: Lessons from fraxinus, a crowd-sourced citizen science game in genomics. eLife. 4 e07460. https://doi.org/10.7554/elife.07460

GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training
Atwood, T.K., Bongcam-Rudloff, E., Brazas, M.E., Corpas, M., Gaudet, P., Lewitter, F., Mulder, N., Palagi, P.M., Schneider, M.V., van Gelder, C.W.G., Attwood, T.K., Banag, C., Blackford, S., Blatter, M.C., Bongcam-Rudloff, E., Brazas, M.D., Brooksbank, C., Budd, A., Charleston, M., Christoffels, A., Conesa, A., Crowe, M., Davies, A., de Crecy-Lagard, V., De Las Rivas, J., Doyle, M., Edwards, R., Facchiano, A., Fernandes, P., Gaeta, B., Gaudet, P., Heger, A., Herringa, J., Hughes, D., Jimenez, R.C., Kille, P., Korpelainen, E., Kumuthini, J., Lewitter, F., MacLean, D., Martinez, S.A.R., McGrath, A., Michalopoulos, I., Mulder, N., Ouellette, B.F., Palagi, P.M., Pearson, W.R., Qi, W., Romano, P., Rother, K., Sansone, S-A., Schneider, M.V., Schönbach, C., Tastan-Bishop, O., Trelles, O., Twells, R., van Gelder, C.W.G., Via, A., Vriend, G., Warnow, T., Watson, M., Westervelt, N. and Zanzoni, A. 2015. GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training. PLOS Computational Biology. 11 (5) e1004281. https://doi.org/10.1371/journal.pcbi.1004143

Crowdsourced direct-to-consumer genomic analysis of a family quartet
Corpas, M., Valdivia-Granda, W., Torres, N., Greshake, B., Coletta, A., Knaus, A., Harrison, A.P., Cariaso, M., Moran, F., Nielsen, F., Swan, D., Weiss Solís, D.Y., Krawitz, P., Schacherer, F., Schols, P., Yang, H., Borry, P., Glusman, G. and Robinson, P.N. 2015. Crowdsourced direct-to-consumer genomic analysis of a family quartet. BMC Genomics. 16 910. https://doi.org/10.1186/s12864-015-1973-7

A Quick Guide for Building a Successful Bioinformatics Community
Budd, A., Corpas, M., Brazas, M.D., Fuller, J.C., Goecks, J., Mulder, N.J., Michaut, M., Ouellette, B.F.F., Pawlik, A. and Blomberg, N. 2015. A Quick Guide for Building a Successful Bioinformatics Community. PLOS Computational Biology. 11 (2) e1003972. https://doi.org/10.1371/journal.pcbi.1003972

The GOBLET training portal: A global repository of bioinformatics training materials, courses and trainers
Corpas, M., Jimenez, R.C., Bongcam-Rudloff, E., Budd, A., Brazas, M.D., Fernandes, P.L., Gaeta, B., Van Gelder, C., Korpelainen, E., Lewitter, F., McGrath, A., MacLean, D., Palagi, P.M., Rother, K., Taylor, J., Via, A., Watson, M., Schneider, M.V. and Attwood, T.K. 2015. The GOBLET training portal: A global repository of bioinformatics training materials, courses and trainers. Bioinformatics. 31 (1), pp. 140-142. https://doi.org/10.1093/bioinformatics/btu601

Ten Simple Rules for Organizing an Unconference
Budd, A., Dinkel, H., Corpas, M., Fuller, J.C., Rubinat, L., Devos, D.P., Khoueiry, P.H., Förstner, K.U., Georgatos, F., Rowland, F., Sharan, M., Binder, J.X., Grace, T., Traphagen, K., Gristwood, A. and Wood, N.T. 2015. Ten Simple Rules for Organizing an Unconference. PLOS Computational Biology. 11 (1) e1003905. https://doi.org/10.1371/journal.pcbi.1003905

Future opportunities and trends for e-infrastructures and life sciences: Going beyond the grid to enable life science data analysis
Duarte, A.M.S., Psomopoulos, F.E., Blanchet, C., Bonvin, A.M.J.J., Corpas, M., Franc, A., Jimenez, R.C., de Lucas, J.M., Nyrönen, T., Sipos, G. and Suhr, S.B. 2015. Future opportunities and trends for e-infrastructures and life sciences: Going beyond the grid to enable life science data analysis. Frontiers in Genetics. 6 197. https://doi.org/10.3389/fgene.2015.00197

Anatomy of BioJS, an open source community for the life sciences
Yachdav, G., Goldberg, T., Wilzbach, S., Dao, D., Shih, I., Choudhary, S., Crouch, S., Franz, M., García, A., García, L.J., Grüning, B.A., Inupakutika, D., Sillitoe, I., Thanki, A.S., Vieira, B., Villaveces, J.M., Schneider, M.V., Lewis, S., Pettifer, S., Rost, B. and Corpas, M. 2015. Anatomy of BioJS, an open source community for the life sciences. eLife. 2015;4 e07009. https://doi.org/10.7554/elife.07009.001

A quick guide for building a successful bioinformatics community
Budd, A., Corpas, M., Brazas, M.D., Fuller, J.C., Goecks, J., Mulder, N.J., Michaut, M., Ouellette, B.F.F., Pawlik, A. and Blomberg, N. 2015. A quick guide for building a successful bioinformatics community. PLOS Computational Biology. 11 (2) e1003972. https://doi.org/10.1371/journal.pcbi.1003972

DNAContentViewer a BioJS component to visualise GC/AT Content
Thanki, A.S., Caim, S., Corpas, M. and Davey, R.P. 2014. DNAContentViewer a BioJS component to visualise GC/AT Content. F1000Research. 3 54. https://doi.org/10.12688/f1000research.3-54.v1

wigExplorer, a BioJS component to visualise wig data
Thanki, A.S., Jimenez, R.C., Kaithakottil, G.G., Corpas, M. and Davey, R.P. 2014. wigExplorer, a BioJS component to visualise wig data. F1000Research. 3 53. https://doi.org/10.12688/f1000research.3-53.v1

BioJS: An open source standard for biological visualisation - its status in 2014
Corpas, M., Jimenez, R., Carbon, S.J., GarcÍa, A., Garcia, L., Goldberg, T., Gomez, J., Kalderimis, A., Lewis, S.E., Mulvany, I., Pawlik, A., Rowland, F., Salazar, G., Schreiber, F., Sillitoe, I., Spooner, W.H., Thanki, A.S., Villaveces, J.M., Yachdav, G. and Hermjakob, H. 2014. BioJS: An open source standard for biological visualisation - its status in 2014. F1000Research. 3 55. https://doi.org/10.12688/f1000research.3-55.v1

The BioJS article collection of open source components for biological data visualisation.
Corpas, M. 2014. The BioJS article collection of open source components for biological data visualisation. F1000Research. 3 56. https://doi.org/10.12688/f1000research.3-56.v1

The Young PI Buzz: Learning from the Organizers of the Junior Principal Investigator Meeting at ISMB-ECCB 2013
de Ridder, J., Bromberg, Y., Michaut, M., Satagopam, V.P., Corpas, M., Macintyre, G. and Alexandrov, T. 2013. The Young PI Buzz: Learning from the Organizers of the Junior Principal Investigator Meeting at ISMB-ECCB 2013. PLOS Computational Biology. https://doi.org/10.1371/journal.pcbi.1003350

Bioinformatics workflows and web services in systems biology made easy for experimentalists
Jimenez, R.C. and Corpas, M. 2013. Bioinformatics workflows and web services in systems biology made easy for experimentalists. in: Schneider, M.V. (ed.) In Silico Systems Biology Humana Press. pp. 299-310

BioJS: an open source JavaScript framework for biological data visualization
Gómez, J., García, L.J., Salazar, G.A., Villaveces, J., Gore, S., García, A., Martín, M.J., Launay, G., Alcántara, R., Del-Toro, N., Dumousseau, M., Orchard, S., Velankar, S., Hermjakob, H., Zong, C., Ping, P., Corpas, M. and Jiménez, R.C. 2013. BioJS: an open source JavaScript framework for biological data visualization. Bioinformatics. 29 (8), pp. 1103-1104. https://doi.org/10.1093/bioinformatics/btt100

iAnn: an event sharing platform for the life sciences
Jimenez, R.C., Albar, J.P., Bhak, J., Blatter, M.C., Blicher, T., Brazas, M.D., Brooksbank, C., Budd, A., De Las Rivas, J., Dreyer, J., van Driel, M.A., Dunn, M.J., Fernandes, P.L., van Gelder, C.W., Hermjakob, H., Ioannidis, V., Judge, D.P., Kahlem, P., Korpelainen, E., Kraus, H.J., Loveland, J., Mayer, C., McDowall, J., Moran, F., Mulder, N., Nyronen, T., Rother, K., Salazar, G.A., Schneider, R., Via, A., Villaveces, J.M., Yu, P., Schneider, M.V., Attwood, T.K. and Corpas, M. 2013. iAnn: an event sharing platform for the life sciences. Bioinformatics. 29 (15), pp. 1919-1921. https://doi.org/10.1093/bioinformatics/btt306

Crowdsourcing the corpasome
Corpas M 2013. Crowdsourcing the corpasome. Source Code for Biology and Medicine. 8 13. https://doi.org/10.1186/1751-0473-8-13

A genome blogger manifesto
Corpas, M. 2012. A genome blogger manifesto. GigaScience. 1 (1) 15. https://doi.org/10.1186/2047-217x-1-15

A family experience of personal genomics
Corpas, M. 2012. A family experience of personal genomics. Journal of Genetic Counseling. 21 (3), pp. 386-391. https://doi.org/10.1007/s10897-011-9473-7

How not to be a bioinformatician
Corpas, M., Fatumo, S. and Schneider, R. 2012. How not to be a bioinformatician. Source Code for Biology and Medicine. 7 3. https://doi.org/10.1186/1751-0473-7-3

DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders.
Swaminathan, G.J., Bragin, E., Chatzimichali, E.A., Corpas, M., Bevan, A.P., Wright, C.F., Carter, N.P., Hurles, M.E. and Firth, H.V. 2012. DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders. Human Molecular Genetics. 21 (R1), pp. R37-R44. https://doi.org/10.1093/hmg/dds362

Interpretation of genomic copy number variants using DECIPHER
Corpas, M., Bragin, E., Clayton, S., Bevan, P. and Firth, H.V. 2012. Interpretation of genomic copy number variants using DECIPHER. Current Protocols in Human Genetics. Chapter 8:Unit 8.14. https://doi.org/10.1002/0471142905.hg0814s72

Spanish cuts: more economic damage.
Corpas, M. 2012. Spanish cuts: more economic damage. Nature. 487 38. https://doi.org/10.1038/487038d

Bamako 2009 Conference on the Bioinformatics of Infectious Diseases
Corpas, M., Doumbia, S., Gascuel, O. and Mulder, N. 2011. Bamako 2009 Conference on the Bioinformatics of Infectious Diseases. Infection, Genetics and Evolution. 11 (4), pp. 695-697. https://doi.org/10.1016/j.meegid.2011.02.012

myKaryoView: a light-weight client for visualization of genomic data
Jimenez, R.C., Salazar, G.A., Gel, B., Dopazo, J., Mulder, N. and Corpas, M. 2011. myKaryoView: a light-weight client for visualization of genomic data. PLoS ONE. 6 (10) e26345. https://doi.org/10.1371/journal.pone.0026345

DECIPHER: Shedding Light on Chromosomal Imbalance and Phenotype Interpretation
Corpas, M., Richards, S., Bevan, P., van Vooren, S., Pettett, R., Firth, H. and Carter, N. 2009. DECIPHER: Shedding Light on Chromosomal Imbalance and Phenotype Interpretation. 7th European Cytogenetics Conference. Stockholm, Sweden 04 - 07 Jul 2009

DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources.
Firth, H.V., Richards, S.M., Bevan, A.P., Clayton, S., Corpas, M., Rajan, D., Van Vooren, S., Moreau, Y., Pettett, R.M. and Carter, N.P. 2009. DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources. The American Journal of Human Genetics. 84 (4), pp. P524-533. https://doi.org/10.1016/j.ajhg.2009.03.010

ENFIN - An integrative structure for systems biology
Reisinger, F., Corpas, M., Hancock, J., Hermjakob, H., Birney, E. and Kahlem, P. 2008. ENFIN - An integrative structure for systems biology. in: International Workshop on Data Integration in the Life Sciences Springer. pp. 132-143

Ten simple rules for organizing a scientific meeting.
Corpas, M., Gehlenborg, N., Janga, S.C. and Bourne, P.E. 2008. Ten simple rules for organizing a scientific meeting. PLOS Computational Biology. 4 (6) e1000080. https://doi.org/10.1371/journal.pcbi.1000080

Highlights from the Third International Society for Computational Biology Student Council Symposium at the Fifteenth Annual International Conference on Intelligent Systems for Molecular Biology
Gehlenborg, N., Corpas, M. and Janga, S.C. 2007. Highlights from the Third International Society for Computational Biology Student Council Symposium at the Fifteenth Annual International Conference on Intelligent Systems for Molecular Biology. BMC Bioinformatics. 8 (Supplement 8) I1. https://doi.org/10.1186/1471-2105-8-s8-i1

Folding patterns in protein sequences
Corpas, M. 2007. Folding patterns in protein sequences. PhD thesis University of Manchester https://doi.org/10.6084/m9.figshare.964811.v1

PFF--an integrated database of residues and fragments critical for protein folding
Corpas, M., Sinnott, J., Thorne, D., Pettifer, S., Attwood , T. and the PFF consortium 2007. PFF--an integrated database of residues and fragments critical for protein folding. BMC Systems Biology. 1 P48. https://doi.org/10.1186/1752-0509-1-S1-P48

Scientists & societies: Community outreach
Corpas, M. 2005. Scientists & societies: Community outreach. Nature. 436, p. 1204. https://doi.org/10.1038/nj7054-1204b

Integrating simulation packages via systems biology mark-up language
Corpas, M. 2003. Integrating simulation packages via systems biology mark-up language. in: International Conference on Computational Methods in Systems Biology Springer.

Permalink - https://westminsterresearch.westminster.ac.uk/item/w52vy/predictors-of-in-hospital-mortality-in-hiv-infected-patients-with-covid-19


Share this

Usage statistics

31 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.