Predictors of in-hospital mortality in HIV-infected patients with COVID-19

Moreno-Torres, Victor, de Mendoza, Carmen, Martinez-Urbistondo, Maria, Mills, Patricia, Trevino, Ana, de la Fuente, Sara, de Santiago, Alberto Diaz, Calderon-Parra, Jorge, Pintos-Pascual, Ilduara, Corpas, Manuel, Soriano, Vicente and Corpas, M. 2023. Predictors of in-hospital mortality in HIV-infected patients with COVID-19. QJM: An International Journal of Medicine. 116 (1), pp. 57-62. https://doi.org/10.1093/qjmed/hcac215

TitlePredictors of in-hospital mortality in HIV-infected patients with COVID-19
TypeJournal article
AuthorsMoreno-Torres, Victor, de Mendoza, Carmen, Martinez-Urbistondo, Maria, Mills, Patricia, Trevino, Ana, de la Fuente, Sara, de Santiago, Alberto Diaz, Calderon-Parra, Jorge, Pintos-Pascual, Ilduara, Corpas, Manuel, Soriano, Vicente and Corpas, M.
Abstract

Background
Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate.

Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain before vaccine availability.

Design: Retrospective nationwide public database analysis.

Methods
Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.

Results
A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P<0.001) and more frequently male (74.8% vs. 56.6%; P<0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia and cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs. 4.4%; P<0.001). In-hospital mortality was lower in PWH (9.4% vs. 16%; P=0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (relative risk (RR): 7.6) were the major determinants of death in PWH hospitalized with COVID-19.

Conclusion
HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19.

A correction has been published: QJM: An International Journal of Medicine, hcad121, https://doi.org/10.1093/qjmed/hcad121

JournalQJM: An International Journal of Medicine
Journal citation116 (1), pp. 57-62
ISSN1460-2393
1460-2725
Year2023
PublisherOxford University Press
Digital Object Identifier (DOI)https://doi.org/10.1093/qjmed/hcac215
Web address (URL)https://publons.com/wos-op/publon/53925569/
Publication dates
Published online01 Sep 2022
Published in printJan 2023

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Reisinger, F., Corpas, M., Hancock, J., Hermjakob, H., Birney, E. and Kahlem, P. 2008. ENFIN - An integrative structure for systems biology. in: International Workshop on Data Integration in the Life Sciences Springer. pp. 132-143

Ten simple rules for organizing a scientific meeting.
Corpas, M., Gehlenborg, N., Janga, S.C. and Bourne, P.E. 2008. Ten simple rules for organizing a scientific meeting. PLOS Computational Biology. 4 (6) e1000080. https://doi.org/10.1371/journal.pcbi.1000080

Highlights from the Third International Society for Computational Biology Student Council Symposium at the Fifteenth Annual International Conference on Intelligent Systems for Molecular Biology
Gehlenborg, N., Corpas, M. and Janga, S.C. 2007. Highlights from the Third International Society for Computational Biology Student Council Symposium at the Fifteenth Annual International Conference on Intelligent Systems for Molecular Biology. BMC Bioinformatics. 8 (Supplement 8) I1. https://doi.org/10.1186/1471-2105-8-s8-i1

Folding patterns in protein sequences
Corpas, M. 2007. Folding patterns in protein sequences. PhD thesis University of Manchester https://doi.org/10.6084/m9.figshare.964811.v1

PFF--an integrated database of residues and fragments critical for protein folding
Corpas, M., Sinnott, J., Thorne, D., Pettifer, S., Attwood , T. and the PFF consortium 2007. PFF--an integrated database of residues and fragments critical for protein folding. BMC Systems Biology. 1 P48. https://doi.org/10.1186/1752-0509-1-S1-P48

Scientists & societies: Community outreach
Corpas, M. 2005. Scientists & societies: Community outreach. Nature. 436, p. 1204. https://doi.org/10.1038/nj7054-1204b

Integrating simulation packages via systems biology mark-up language
Corpas, M. 2003. Integrating simulation packages via systems biology mark-up language. in: International Conference on Computational Methods in Systems Biology Springer.

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