Title | Genetic signature detected in T cell receptors from patients with severe COVID-19 |
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Type | Journal article |
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Authors | Manuel Corpas, Carmen de Mendoza, Víctor Moreno-Torres, Ilduara Pintos, Pedro Seoane, James R. Perkins, Juan A.G. Ranea, Segun Fatumo, Tamas Korcsmaros, José Manuel Martín-Villa, Pablo Barreiro, Octavio Corral and Vicente Soriano |
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Abstract | Characterization of host genetic factors contributing to COVID-19 severity promises advances on drug discovery to fight the disease. Most genetic analyses to date have identified genome-wide significant associations involving loss-of-function variants for immune response pathways. Despite accumulating evidence supporting a role for T cells in COVID-19 severity, no definitive genetic markers have been found to support an involvement of T cell responses. We analyzed 205 whole exomes from both a well-characterized cohort of hospitalized severe COVID-19 patients and controls. Significantly enriched high impact alleles were found for 25 variants within the T-cell receptor beta (TRB) locus on chromosome 7. Although most of these alleles were found in heterozygosis, at least three or more in TRBV6-5, TRBV7-3, TRBV7-6, TRBV7-7 and TRBV10-1 suggested a possible TRB loss of function via compound heterozygosis. This loss-of-function in TRB genes supports suboptimal or dysfunctional T cell responses as a major contributor to severe COVID-19 pathogenesis. |
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Article number | 107735 |
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Journal | iScience |
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Journal citation | 26 (10) |
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ISSN | 2589-0042 |
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Year | 2023 |
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Publisher | Elsevier |
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Publisher's version | License CC BY 4.0 File Access Level Open (open metadata and files) |
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Digital Object Identifier (DOI) | https://doi.org/10.1016/j.isci.2023.107735 |
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Web address (URL) | https://doi.org/10.1016/j.isci.2023.107735 |
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Publication dates |
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Published | 25 Aug 2023 |
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Published in print | Oct 2023 |
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