Human Intestinal Epithelial Response(s) to Clostridium difficile

Jafari, N., Allan, E. and Bajaj-Elliott, M. 2010. Human Intestinal Epithelial Response(s) to Clostridium difficile. in: Mullany, P. and Roberts, A.P. (ed.) Clostridium difficile Methods and Protocols Humana Totowa. pp. 135-146

Chapter titleHuman Intestinal Epithelial Response(s) to Clostridium difficile
AuthorsJafari, N., Allan, E. and Bajaj-Elliott, M.
EditorsMullany, P. and Roberts, A.P.
Abstract

Clostridium difficile is a gram-positive, spore-forming, toxin-producing anaerobic bacillus that is being increasingly implicated as the leading cause of diarrhea and colitis, particularly in hospitalized, elderly patients. Studies to date suggest that C. difficile toxins A and B play a major role in the observed colonic inflammation and associated disease pathogenesis; however, the role of other potential bacterial factors at present remains unknown. Early effects of C. difficile on host intestinal epithelia include modest induction of innate immune responses with progressive loss of intestinal epithelial cell barrier function and cell death.

Book titleClostridium difficile Methods and Protocols
Page range135-146
Year2010
PublisherHumana Totowa
Publication dates
Published2010
ISBN9781603273640
9781603273657
ISSN1064-3745
1940-6029
Digital Object Identifier (DOI)https://doi.org/10.1007/978-1-60327-365-7_9
Web address (URL)http://dx.doi.org/10.1007/978-1-60327-365-7_9
JournalMethods in Molecular Biology

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