Introduction to Cancer Stem Cells : WestminsterResearch

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Chapter title	Introduction to Cancer Stem Cells
Authors	Saha, S., Khuda-Bukhsh, A.R., Samadder, A. and Saha, S.K.
Editors	Pathak, S. and Banerjee, A.
Abstract	Cancer is a persistent public health-care issue of modern life that poses a global challenge. It comprises several diseases that basically involve abnormal cell growth and have a potential to invade or metastasize to other distant organ systems, spreading the disease to other part(s) of the body. Development of resistance to conventional therapies and disease recurrence are some common phenomena encountered in almost all types of cancer. Understanding “hallmarks of cancer” and “tumor microenvironment” is therefore important for development of successful therapy for cancer. Numerous drugs have been designed and tested for their anticancer efficacy over decades to find out a complete cure for this lethal disease, but without desirable success so far. The concept and role of “stem cell” therapy in oncology research have drawn considerable interest in recent years. Thus, emphasis has been given on proper identification and characterization of the “cancer stem cells” and “other stem cells” for elucidation of the signaling cascades involved in the process of cancer limitation and progression (and resurgence). In the introductory part of this book, an attempt has been made to provide an overall idea on different aspects of cancer stem cells, optimization of rate and type of cell growth, and their associative cure strategy by adopting a well-defined scientific perspective.
Book title	Cancer Stem Cells: New Horizons in Cancer Therapies
Year	2020
Publisher	Springer
Published	18 Oct 2020
ISBN	9789811551192
	9789811551208
Digital Object Identifier (DOI)	https://doi.org/10.1007/978-981-15-5120-8_1
Web address (URL)	http://dx.doi.org/10.1007/978-981-15-5120-8_1

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Bioengineering of a tumour-stroma 3D-tumouroid co-culture model of hypopharyngeal cancer.
Saha, S., Howarth, R., Sharma-Saha, S. and Kelly, C. 2023. Bioengineering of a tumour-stroma 3D-tumouroid co-culture model of hypopharyngeal cancer. Biology Open. 12 (5) bio059949. https://doi.org/10.1242/bio.059949

Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy.
Saha, S., Rundle S, Kotsopoulos IC, Begbie J, Howarth R, Pappworth IY, Mukhopadhyay A, Kucukmetin A, Marchbank KJ and Curtin N 2022. Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer Therapy. Cancers. 14 (17) 4288. https://doi.org/10.3390/cancers14174288

Survival outcomes of parotid carcinoma treated with surgery and radiotherapy or radiotherapy alone.
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Molecular approaches toward targeted cancer therapy with some food plant products: On the role of antioxidants and immune microenvironment
Khuda-Bukhsh, A.R., Saha, S., Das, S. and Saha. S.S. 2021. Molecular approaches toward targeted cancer therapy with some food plant products: On the role of antioxidants and immune microenvironment. in: Preedy, V.R. and Patel, V.B. (ed.) Cancer (2nd edition) Academic Press. pp. 191-202

HCV Activates Somatic L1 Retrotransposition-A Potential Hepatocarcinogenesis Pathway.
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PARP inhibitors: A new frontier in the battle against cervical cancer
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Potential use of the PARP inhibitor rucaparib to enhance cervical cancer treatment
Saha, S., Howarth, R., Pappworth, I., Marchbank, K. and Curtin, N. 2020. Potential use of the PARP inhibitor rucaparib to enhance cervical cancer treatment. European Journal of Cancer. 138 (Supp 2), p. S37. https://doi.org/10.1016/s0959-8049(20)31169-2

SP-0517: Exploring rucaparib as chemo-radiosensitiser to increase therapeutic ratio in cervical cancer
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Association of Hyaluronan and CD44 during development of Head and Neck Squamous Cell Carcinoma in Indian patients
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Molecular progression of Head and Neck Squamous Cell Carcinoma
Saha, S., Maiti, G.P., Roychoudhury, S. and Panda, C.K. 2017. Molecular progression of Head and Neck Squamous Cell Carcinoma. The Nucleus. 60, pp. 111-119. https://doi.org/10.1007/s13237-017-0212-9

Molecular Approaches Toward Targeted Cancer Therapy with Some Food Plant Products
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Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways
Khuda-Bukhsh, A.R., Das, S. and Saha, S. 2014. Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways. Nutrition and Cancer. 66 (2), pp. 194-205. https://doi.org/10.1080/01635581.2014.864420

Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6--E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: A mechanistic study including molecular docking
Saha, S. and Khuda-Bukhsh, A.R. 2014. Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6--E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: A mechanistic study including molecular docking. European Journal of Pharmacology. 744, pp. 132-146. https://doi.org/10.1016/j.ejphar.2014.09.048

Water-Soluble Heteronuclear [NaCuII6] Metallomacrocyclic Sandwich Complexes: Synthesis, Structure, Properties and In Vitro Biological Studies
Patra, A., Saha, S., Sen, T.K., Carrella, L., Musie, G.T., Khuda-Bukhsh, A.R. and Bera, M. 2014. Water-Soluble Heteronuclear [NaCuII6] Metallomacrocyclic Sandwich Complexes: Synthesis, Structure, Properties and In Vitro Biological Studies. European Journal of Inorganic Chemistry. Volume 2014 (30), pp. 5217-5232. https://doi.org/10.1002/ejic.201402582

Poly (lactic-co-glycolic) acid loaded nano-insulin has greater potentials of combating arsenic induced hyperglycemia in mice: some novel findings
Asmita Samadder, A., Das, J., Das, S., De, A., Saha, S., Bhattacharyya, S.S. and Khuda-Bukhsh, A.R. 2013. Poly (lactic-co-glycolic) acid loaded nano-insulin has greater potentials of combating arsenic induced hyperglycemia in mice: some novel findings. Toxicology and Applied Pharmacology. 267 (1), pp. 57-73. https://doi.org/10.1016/j.taap.2012.12.018

Ethanolic extract of the Goldenseal, Hydrastis canadensis, has demonstrable chemopreventive effects on HeLa cells in vitro: Drug--DNA interaction with calf thymus DNA as target
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Molecular approaches towards development of purified natural products and their structurally known derivatives as efficient anti-cancer drugs: current trends
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Introduction to Cancer Stem Cells

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