Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes

Mackenzie, R.W.A., Maxwell, N.S., Castle, P.C., Elliott, B.T., Brickley, G. and Watt, P.W. 2012. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (4), pp. E546-E555. https://doi.org/10.1210/jc.2011-2829

TitleIntermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes
AuthorsMackenzie, R.W.A., Maxwell, N.S., Castle, P.C., Elliott, B.T., Brickley, G. and Watt, P.W.
Abstract

Context: Hypoxia and muscle contraction stimulate glucose transport activity in vitro. Exercise and hypoxia have additive effects on insulin sensitivity in type 2 diabetics (T2D).

Objective: The objective of the study was to examine the effectiveness of intermittent exercise with and without hypoxia on acute- and moderate-term glucose kinetics and insulin sensitivity in T2D.

Setting: The study was conducted at a university research center.

Design, Participants, and Interventions: Eight male T2D patients completed the following: 1) 60 min of continuous exercise at 90% lactate threshold in hypoxia (HyEx60); 2) intermittent exercise at 120% lactate threshold, separated by periods of passive recovery (5:5 min) in hypoxia [Hy5:5; O2 ∼ 14.7 (0.2)%]; and 3) intermittent exercise (5:5 min) at 120% lactate threshold in normoxia (O2 ∼ 20.93%).

Main Outcome Measures: Glucose appearance and glucose disappearance, using an adapted non-steady-state one-compartment model were measured. Homeostasis models of insulin resistance (HOMAIR), fasting insulin resistance index (FIRI), and β-cell function were calculated 24 and 48 h after exercise conditions.

Results: Glucose disappearance increased from baseline (1.85 mg/kg · min−1) compared with 24 h (2.01 min/kg · min−1) after HyEx60 (P = 0.031). No difference was noted for both Hy5:5 (P = 0.064) and normoxia (P = 0.385). Hy5:5 demonstrated improvements in HOMAIR from baseline [d 1, 6.20 (0.40)] when comparisons were made with d 2 [4.83 (0.41)] (P = 0.0013). HOMAIR and FIRI improved in the 24 h (HOMAIR, P = 0.002; FIRI, P = 0.003), remaining reduced 48 h after HyEx60 (HOMAIR, P = 0.028; and FIRI, P = 0.034).

Conclusion: HyEx60 offered the greatest improvements in acute and moderate-term glucose control in T2D. Intermittent exercise stimulated glucose disposal and improved after exercise insulin resistance, which was enhanced when exercise was combined with hypoxia (Hy5:5). The data suggest a use of hypoxic exercise in treatment of T2D.

JournalJournal of Clinical Endocrinology and Metabolism
Journal citation97 (4), pp. E546-E555
ISSN0021-972X
Year2012
PublisherEndocrine Society
Digital Object Identifier (DOI)https://doi.org/10.1210/jc.2011-2829
Publication dates
Published2012

Related outputs

High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals
Naufahu, J., Elliott, B., Markiv, A., Dunning-Foreman, P., McGrady, M., Howard, D., Watt, P.W. and Mackenzie, R.W.A. 2018. High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals. Journal of Clinical Endocrinology and Metabolism. 103 (4), pp. 1479-1490. https://doi.org/10.1210/jc.2017-02019

Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo
Elliott, B., Renshaw, D., Getting, S.J., Watt, P.W. and MacKenzie, R. 2014. Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo. FASEB. San Diego Jul 2015 Federation of American Societies for Experimental Biology.

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
Mackenzie, R.W.A. and Elliott, B.T. 2014. Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 7, pp. 55-64. https://doi.org/10.2147/DMSO.S48260

Attenuation of plasma annexin A1 in human obesity
Kosicka, A., Cunliffe, A., Mackenzie, R.W.A., Gulrez Zariwala, M., Perretti, M., Flower, R.J. and Renshaw, D. 2013. Attenuation of plasma annexin A1 in human obesity. FASEB Journal. 27 (1), pp. 368-378. https://doi.org/10.1096/fj.12-213728

Partial heat acclimation of athletes with spinal cord lesion
Castle, P.C., Pasan Kularatne, B., Brewer, J., Mauger, A.R., Austen, R.A., Tuttle, J.A., Sculthorpe, N., Mackenzie, R.W.A., Maxwell, N.S. and Webborn, A.D.J. 2013. Partial heat acclimation of athletes with spinal cord lesion. European Journal of Applied Physiology. 113 (1), pp. 109-115. https://doi.org/10.1007/s00421-012-2417-6

Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men
Donges, C.E., Burd, N.A., Duffield, R., Smith, G.C., West, D.D.W., Short, M.J., Mackenzie, R.W.A., Plank, L.D., Shepherd, P.R., Phillips, S.M. and Edge, J.A. 2012. Concurrent resistance and aerobic exercise stimulates both myofibrillar and mitochondrial protein synthesis in sedentary middle-aged men. Journal of Applied Physiology. 112 (12), pp. 1992-2001. https://doi.org/10.​1152/​japplphysiol.​00166.​2012

The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes
MacKenzie, R., Elliott, B., Maxwell, N.S., Brickley, G. and Watt, P.W. 2012. The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (1), pp. 155-62. https://doi.org/10.1210/jc.2011-1843

Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes
MacKenzie, R., Maxwell, N.S., Castle, P.C., Elliott, B., Brickley, G. and Watt, P.W. 2012. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (4), pp. 46-55. https://doi.org/10.1210/jc.2011-2829

The central role of myostatin in skeletal muscle and whole body homeostasis
Elliott, B.T., Renshaw, D., Getting, S.J. and Mackenzie, R.W.A. 2012. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica. 205 (3), pp. 324-340. https://doi.org/10.1111/j.1748-1716.2012.02423.x

The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes
Mackenzie, R.W.A., Elliott, B.T., Maxwell, N.S., Brickley, G. and Watt, P.W. 2012. The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (1), pp. 155-162. https://doi.org/10.1210/jc.2011-1843

Heat acclimation improves intermittent sprinting in the heat but additional pre-cooling offers no further ergogenic effect
Castle, P.C., Mackenzie, R.W.A., Maxwell, N.S., Webborn, A.D.J. and Watt, P.W. 2011. Heat acclimation improves intermittent sprinting in the heat but additional pre-cooling offers no further ergogenic effect. Journal of Sports Sciences. 29 (11), pp. 1125-1134. https://doi.org/10.1080/02640414.2011.583673

Acute hypoxia and exercise improve insulin sensitivity (S(I) (2) *) in individuals with type 2 diabetes
Mackenzie, R.W.A., Maxwell, N.S., Castle, P.C., Brickley, G. and Watt, P.W. 2011. Acute hypoxia and exercise improve insulin sensitivity (S(I) (2) *) in individuals with type 2 diabetes. Diabetes - Metabolism: Research and Reviews. 27 (1), pp. 94-101. https://doi.org/10.1002/dmrr.1156

Acute hypoxia improves insulin sensitivity (SI2*) and β cell function in individuals with Type 2 Diabetes
Mackenzie, R.W.A., Elliott, B.T., Brickley, G. and Watt, P.W. 2010. Acute hypoxia improves insulin sensitivity (SI2*) and β cell function in individuals with Type 2 Diabetes. The Physiological Society. University of Manchester

Influence of hypohydration on intermittent sprint performance in the heat
Maxwell, N.S., Mackenzie, R.W.A. and Bishop, D. 2009. Influence of hypohydration on intermittent sprint performance in the heat. International Journal of Sports Physiology and Performance. 4 (1), pp. 54-67.

"I felt really inspired by it, it was really interesting to interact with the pupils": Active citizenship in the British undergraduate social science curriculum
Watt, P.W., Gifford, C., Koster, S. and Clark, W. 2009. "I felt really inspired by it, it was really interesting to interact with the pupils": Active citizenship in the British undergraduate social science curriculum. Greek Social Science Tribune - Special English Edition: From a National Identity to a European One. 14 (55), pp. 153-174.

Intermittent exercise decreases insulin resistance in the 48 hrs following exercise in individuals with type 2 diabetes
Mackenzie, R.W.A. and Watt, P.W. 2009. Intermittent exercise decreases insulin resistance in the 48 hrs following exercise in individuals with type 2 diabetes. Endocrine Society 91st Annual Meeting. Washington, DC 10 - 13 Jun 2009

Exercise and acute hypoxia improve insulin sensitivity (SI2*) in individuals with type 2 diabetes
Mackenzie, R.W.A. and Watt, P.W. 2009. Exercise and acute hypoxia improve insulin sensitivity (SI2*) in individuals with type 2 diabetes. Society for Endocrinology BES 2009. Harrogate 16 - 19 Mar 2009

Importance of lifelong activity levels to longevity. Commentary in response to ‘Does occupational success influence longevity among England test cricketers?’ P J Boyle, British Journal of Sports Medicine 2009;43:851-855
Elliott, B.T. 2009. Importance of lifelong activity levels to longevity. Commentary in response to ‘Does occupational success influence longevity among England test cricketers?’ P J Boyle, British Journal of Sports Medicine 2009;43:851-855. BJSM Blog.

Heat acclimation improves intermittent sprint performance in the heat, but additional pre-cooling is not further ergogenic
Castle, P.C., Mackenzie, R.W.A., Maxwell, N.S., Webborn, A.D.J. and Watt, P.W. 2009. Heat acclimation improves intermittent sprint performance in the heat, but additional pre-cooling is not further ergogenic. BASES Annual Conference. Leeds Metropolitan University 01 - 03 Sep 2009

Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats
Legerlotz, K., Elliott, B.T., Guillemin, B. and Smith, H.K. 2008. Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats. Experimental Physiology. 93 (6), pp. 754-762. https://doi.org/10.1113/expphysiol.2007.041244

Acute normobaric hypoxia stimulates erythropoietin release
Mackenzie, R.W.A., Watt, P.W. and Maxwell, N.S. 2008. Acute normobaric hypoxia stimulates erythropoietin release. High Altitude Medicine and Biology. 9 (1), pp. 28-37. https://doi.org/10.1089/ham.2007.1043

Acute hypoxia alters glucose tolerance in type 2 diabetes
Mackenzie, R.W.A., Hammond, E. and Watt, P.W. 2007. Acute hypoxia alters glucose tolerance in type 2 diabetes. The Endocrine Society 89th Annual Meeting. Toronto, Canada 02 - 05 Jun 2007

Increased carbon dioxide expiration in recovery from maximal exercise in children with cystic fibrosis
Brickley, G., Adams, A., Mackenzie, R.W.A., Lenton, J. and Seddon, P. 2006. Increased carbon dioxide expiration in recovery from maximal exercise in children with cystic fibrosis. American Thoracic Society International Conference. San Diego 19 - 24 May 2006

Physical activity and fitness in children with Cystic Fibrosis
Adams, A., Mackenzie, R.W.A., Lenton, J., Brickley, G. and Seddon, P. 2006. Physical activity and fitness in children with Cystic Fibrosis. Journal of Cystic Fibrosis. 5 (sup. 1), p. S80.

Physical activity and fitness in children with cystic fibrosis
Adams, A., Lenton, J., Brickley, G., Mackenzie, R.W.A. and Seddon, P. 2006. Physical activity and fitness in children with cystic fibrosis. 29th European Cystic Fibrosis Conference. Copenhagen, Denmark 15 - 18 Jun 2006

Invited Response – Levine, B D & Stray-Gundersen, J (2005). Comments on Point: Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume"
Mackenzie, R.W.A. 2005. Invited Response – Levine, B D & Stray-Gundersen, J (2005). Comments on Point: Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume". Journal of Applied Physiology. 99 (6), pp. 2453-2462. https://doi.org/10.1152/japplphysiol.01157.2005

Permalink - https://westminsterresearch.westminster.ac.uk/item/8z838/intermittent-exercise-with-and-without-hypoxia-improves-insulin-sensitivity-in-individuals-with-type-2-diabetes


Share this

Usage statistics

124 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.