Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis

Barry, J.A., Kuczmierczyk, A.R. and Hardiman, P.J. 2011. Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction. 26 (9), pp. 2442-2451.

TitleAnxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis
AuthorsBarry, J.A., Kuczmierczyk, A.R. and Hardiman, P.J.
Abstract

BACKGROUND - Our aim was to assess differences in anxiety and depression between women with and without (controls) polycystic ovary syndrome (PCOS).

METHODS - We conducted a systematic review and meta-analysis of published literature comparing women with PCOS to control groups on anxiety and depression. Electronic databases were searched up to 17 December 2010. The inverse variance method based, as appropriate, on a random- or fixed-effects model in Review Manager, Version 5 was used to analyse the data.

RESULTS - Twelve comparative studies were included; all studies assessed depression (910 women with PCOS and 1347 controls) and six also assessed anxiety (208 women with PCOS and 169 controls). Analysis revealed higher depression (Z = 17.92, P < 0.00001; Hedges’ g = 0.82; 95% CI 0.73–0.92) and anxiety (Z = 5.03, P < 0.00001; Hedges’ g = 0.54; 95% CI 0.33–0.75) scores in the participants with, than without, PCOS. Studies controlling for BMI showed a smaller difference between women with PCOS and controls on anxiety and depression scores than studies not controlling for BMI.

CONCLUSIONS - Women with PCOS on average tend to experience mildly elevated anxiety and depression, significantly more than women without PCOS. Women with PCOS with lower BMI tended to have slightly lower anxiety and depression scores, suggesting that having a lower BMI reduces anxiety and depression. Future studies might consider (i) controlling for BMI, (ii) stratifying by medication use in order to control for any anti-androgenic effects of medication and (iii) excluding women with polycystic ovaries from control groups.

JournalHuman Reproduction
Journal citation26 (9), pp. 2442-2451
ISSN0268-1161
YearSep 2011
PublisherOxford University Press
Digital Object Identifier (DOI)doi:10.1093/humrep/der197
Publication dates
PublishedSep 2011

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