Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels

Barry, J.A., Kay, A.R., Navaratnarajah, R., Iqbal, S., Bamfo, J.E.A.K. and David, A.L. 2010. Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels. Journal of Obstetrics and Gynaecology. 30 (5), pp. 444-446.

TitleUmbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels
AuthorsBarry, J.A., Kay, A.R., Navaratnarajah, R., Iqbal, S., Bamfo, J.E.A.K. and David, A.L.
Abstract

The aetiology of polycystic ovary syndrome (PCOS) is poorly understood, but an intrauterine hyperandrogenic environment has been implicated. This study was designed to assess whether the female offspring of mothers with PCOS are exposed to raised levels of testosterone (T) in utero. In this case–control study, three groups of pregnant women were recruited from the labour ward: PCOS women with a female baby (n = 10, PCOS girls); control women with a female baby (n = 20, control girls) and control women with a male baby (n = 10, control boys). Maternal and umbilical vein (UV) blood was assayed for T levels. UV T in PCOS girls was significantly raised, compared with control girls (p < 0.012). The difference in UV T between PCOS girls and control boys was not significant (p < 0.254). This is the first demonstration of a hyperandrogenic in utero environment in PCOS pregnancies; UV T in female infants is raised to male levels.

JournalJournal of Obstetrics and Gynaecology
Journal citation30 (5), pp. 444-446
ISSN0144-3615
YearJul 2010
PublisherInforma Healthcare
Digital Object Identifier (DOI)doi:10.3109/01443615.2010.485254
Publication dates
PublishedJul 2010

Related outputs

Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis
Barry, J.A., Kuczmierczyk, A.R. and Hardiman, P.J. 2011. Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction. 26 (9), pp. 2442-2451.

Age and sex differences in complications and convalescence after laparoscopic cholecystectomy
Siddiqui, M.R., Barry, J.A., Lodha, K., Parker, M. and Hasan, F.A. 2011. Age and sex differences in complications and convalescence after laparoscopic cholecystectomy. Magyar Sebészet (Hungarian Journal of Surgery). 64 (4), pp. 193-201.

The impact of eating behavior on psychological symptoms typical of reactive hypoglycemia. A pilot study comparing women with polycystic ovary syndrome to controls
Barry, J.A., Bouloux, P. and Hardiman, P.J. 2011. The impact of eating behavior on psychological symptoms typical of reactive hypoglycemia. A pilot study comparing women with polycystic ovary syndrome to controls. Appetite. 57 (1), pp. 73-76.

Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: a pilot study
Lakhani, K., Kay, A.R., Leiper, J., Barry, J.A. and Hardiman, P.J. 2011. Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: a pilot study. Journal of Obstetrics and Gynaecology. 31 (5), pp. 417-419.

Testosterone and mood dysfunction in women with polycystic ovarian syndrome compared to subfertile controls
Barry, J.A., Hardiman, P.J., Saxby, B.K. and Kuczmierczyk, A.R. 2011. Testosterone and mood dysfunction in women with polycystic ovarian syndrome compared to subfertile controls. Journal of Psychosomatic Obstetrics and Gynecology. 32 (2), pp. 104-111.

Measurement issues when assessing quality of life outcomes for different types of hernia mesh repair
Zaborszky, A., Gyanti, R., Barry, J.A., Saxby, B.K., Bhattacharya, P. and Hasan, F.A. 2011. Measurement issues when assessing quality of life outcomes for different types of hernia mesh repair. Annals of the Royal College of Surgeons of England. 93 (4), pp. 281-285.

Meta-analysis of sex difference in testosterone levels in umbilical cord blood
Barry, J.A., Hardiman, P.J., Siddiqui, M.R. and Thomas, M. 2011. Meta-analysis of sex difference in testosterone levels in umbilical cord blood. Journal of Obstetrics and Gynaecology. 31 (8), pp. 697-702.

Permalink - https://westminsterresearch.westminster.ac.uk/item/9023q/umbilical-vein-testosterone-in-female-infants-born-to-mothers-with-polycystic-ovary-syndrome-is-elevated-to-male-levels


Share this
Tweet
Email