Bhogal, S. and Revett, K. 2005. Animal toxins: what features differentiate pore blockers from gate modifiers. in: 2005 ICSC Congress on Computational Intelligence Methods and Applications USA IEEE .
| Chapter title | Animal toxins: what features differentiate pore blockers from gate modifiers |
|---|---|
| Authors | Bhogal, S. and Revett, K. |
| Abstract | A surprisingly large number of animal toxins target voltage sensitive ion channels. Even though there exists toxins for all four major voltage sensitive ion channels, a majority act either on sodium or potassium channels. Given a specific primary sequence, the challenge is to determine in an automated fashion whether a given substance is toxic, and what its site of action might be. Currently, there are signals such as functional dyads that are indicative of a toxin, but are not yet specific enough to allow accurate prediction of the site of action. In this paper, an automated approach for detecting whether a toxin acts on voltage-sensitive sodium versus potassium channels is presented. In addition, our consensus sequence is also able to reliably determine whether the toxin acts as a gate modifier or pore blocker (> 93% accuracy). |
| Keywords | Gate blocker, multiple sequence alignment, pore blocker, venom, voltage-sensitive ion channels |
| Book title | 2005 ICSC Congress on Computational Intelligence Methods and Applications |
| Year | 2005 |
| Publisher | IEEE |
| Publication dates | |
| Published | 2005 |
| Place of publication | USA |
| ISBN | 1424400201 |
| Digital Object Identifier (DOI) | https://doi.org/10.1109/CIMA.2005.1662329 |
| File | |
| Event | CIMA 2005: ICSC Congress on Computational Intelligence Methods and Applications |
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