“Nanostandardization” in action: implementing standardization processes in a multidisciplinary nanoparticle-based research and development project

Roubert, F., Beuzelin-Ollivier, Marie-G., Hofmann-Amtenbrink, M., Hofmann, H. and Hool, A. 2016. “Nanostandardization” in action: implementing standardization processes in a multidisciplinary nanoparticle-based research and development project. NanoEthics. 10 (1), pp. 41-62. doi:10.1007/s11569-015-0248-8

Title“Nanostandardization” in action: implementing standardization processes in a multidisciplinary nanoparticle-based research and development project
AuthorsRoubert, F., Beuzelin-Ollivier, Marie-G., Hofmann-Amtenbrink, M., Hofmann, H. and Hool, A.
Abstract

Nanomaterials have attracted much interest in the medical field and related applications as their distinct properties in the nano-range enable new and improved diagnosis and therapies. Owing to these properties and their potential interactions with the human body and the environment, the impact of nanomaterials on humans and their potential toxicity have been regarded a very significant issue. Consequently, nanomaterials are the subject of a wide range of cutting-edge research efforts in the medical and related fields to thoroughly probe their potential beneficial utilizations and their more negative effects. We posit that the lack of standardization in the field is a serious shortcoming as it has led to the establishment of methods and results that do not ensure sufficient consistency and thus in our view can possibly result in research outputs that are not as robust as they should be. The main aim of this article is to present how NanoDiaRA, a large FP7 European multidisciplinary project that seeks to investigate and develop nanotechnology-based diagnostic systems, has developed and implemented robust, standardized methods to support research practices involving the engineering and manipulation of nanomaterials. First, to contextualize this research, an overview of the measures defined by different regulatory bodies concerning nano-safety is presented. Although these authorities have been very active in the past several years, many questions remain unanswered in our view. Second, a number of national and international projects that attempted to ensure more reliable exchanges of methods and results are discussed. However, the frequent lack of publication of procedures and protocols in research can often be a hindrance for sharing those good practices. Subsequently, the efforts made through NanoDiaRA to introduce standardized methods and techniques to support the development and utilization of nanomaterials are discussed in depth. A series of semi-structured interviews were conducted with the partners of this project, and the interviews were analyzed thematically to highlight the determined efforts of the researchers to standardize their methods. Finally, some recommendations are made towards the setting up of well-defined methods to support the high-quality work of collaborative nanoparticle-based research and development projects and to enhance standardization processes.

KeywordsNanoparticle-based research and development, Collaboration, Standardization methods, Standard operating procedures, Regulation, SPIONs
JournalNanoEthics
Journal citation10 (1), pp. 41-62
ISSN1871-4757
1871-4765
Year2016
PublisherSpringer
Accepted author manuscript
Digital Object Identifier (DOI)doi:10.1007/s11569-015-0248-8
Web address (URL)http://link.springer.com/article/10.1007/s11569-015-0248-8
Publication dates
Published29 Feb 2016
PublishedApr 2016

Related outputs

Nanotechnology in medicine: European research and its implications
Hofmann-Amtenbrink, M, Hofmann, H., Hool, A. and Roubert, F. 2014. Nanotechnology in medicine: European research and its implications. Swiss Medical Weekly. 144 (w14044). doi:10.4414/smw.2014.14044

Managing Operating Procedures in Distributed Collaborative Projects
Hool, A., Ollivier, M-G. B. and Roubert, F. 2013. Managing Operating Procedures in Distributed Collaborative Projects. Journal of Physics: Conference Series. 429 (1). doi:10.1088/1742-6596/429/1/01207

Putting the Lab in the Lab Book: Supporting Coordination in Large, Multi-site Research
Roubert, F. and Perry, M. 2013. Putting the Lab in the Lab Book: Supporting Coordination in Large, Multi-site Research. The 27th International British Computer Society Human Computer Interaction Conference: The Internet of things. Brunel University London, UK 09 - 13 Sep 2013 BCS Learning and Development Ltd.

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