Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa : WestminsterResearch

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Title	Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa
Authors	Fonville, L., Giampietro, V., Surguladze, S., Williams, S.C.R. and Tchanturia, K.
Abstract	Background The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions. Methods Functional magnetic resonance imaging (fMRI) was used alongside a FEPT, depicting neutral, mildly happy and happy faces, to examine the neural correlates of implicit emotion processing in AN. Participants were instructed to specify the gender of the faces. Levels of depression, anxiety, obsessive–compulsive symptoms and eating disorder behaviour were obtained and principal component analysis (PCA) was performed to acquire uncorrelated variables. Results fMRI analysis revealed a greater blood-oxygenation level dependent (BOLD) response in AN in the right fusiform gyrus to all facial expressions. This response showed a linear increase with the happiness of the facial expression and was found to be stronger in those not taking medication. PCA analysis revealed a single component indicating a greater level of general clinical symptoms. Conclusion Neuroimaging findings would suggest that alterations in implicit emotion processing in AN occur during early perceptual processing of social signals and illustrate greater engagement on the FEPT. The lack of separate components using PCA suggests that the questionnaires used might not be suited as predictive measures.
Keywords	Anorexia nervosa
	fMRI
	Emotion processing
Journal	Neuroimage: Clinical
Journal citation	4, pp. 266-273
ISSN	2213-1582
Year	2014
Publisher	Elsevier
Publisher's version	1-s2.0-S2213158213001617-main.pdf
Digital Object Identifier (DOI)	https://doi.org/10.1016/j.nicl.2013.12.002
Published online	07 Dec 2013
Published in print	2014
Published	07 Dec 2013
Funder	NIHR (National Institute for Health Research)
License	CC BY-NC-ND 3.0

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Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa

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