Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa

Fonville, L., Giampietro, V., Surguladze, S., Williams, S.C.R. and Tchanturia, K. 2014. Increased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa. Neuroimage: Clinical. 4, pp. 266-273. doi:10.1016/j.nicl.2013.12.002

TitleIncreased BOLD signal in the fusiform gyrus during implicit emotion processing in anorexia nervosa
AuthorsFonville, L., Giampietro, V., Surguladze, S., Williams, S.C.R. and Tchanturia, K.
Abstract

Background
The behavioural literature in anorexia nervosa (AN) has suggested impairments in psychosocial functioning and studies using facial expression processing tasks (FEPT) have reported poorer recognition and slower identification of emotions.

Methods
Functional magnetic resonance imaging (fMRI) was used alongside a FEPT, depicting neutral, mildly happy and happy faces, to examine the neural correlates of implicit emotion processing in AN. Participants were instructed to specify the gender of the faces. Levels of depression, anxiety, obsessive–compulsive symptoms and eating disorder behaviour were obtained and principal component analysis (PCA) was performed to acquire uncorrelated variables.

Results
fMRI analysis revealed a greater blood-oxygenation level dependent (BOLD) response in AN in the right fusiform gyrus to all facial expressions. This response showed a linear increase with the happiness of the facial expression and was found to be stronger in those not taking medication. PCA analysis revealed a single component indicating a greater level of general clinical symptoms.

Conclusion
Neuroimaging findings would suggest that alterations in implicit emotion processing in AN occur during early perceptual processing of social signals and illustrate greater engagement on the FEPT. The lack of separate components using PCA suggests that the questionnaires used might not be suited as predictive measures.

KeywordsAnorexia nervosa
fMRI
Emotion processing
JournalNeuroimage: Clinical
Journal citation4, pp. 266-273
ISSN2213-1582
Year2014
PublisherElsevier
Publisher's version
Digital Object Identifier (DOI)doi:10.1016/j.nicl.2013.12.002
Publication dates
Published online07 Dec 2013
Published in print2014
Published07 Dec 2013
LicenseCC BY-NC-ND 3.0

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