Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease : WestminsterResearch

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Title	Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
Type	PhD thesis
Authors	Mursaleen, L.
Abstract	In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in sustained oxidative stress and cellular damage. The blood‐brain barrier (BBB) prevents most pharmaceuticals from entering the brain, therefore, to enable the advancement of potential antioxidant and iron chelator therapies for PD, limiting factors such as brain penetrance and bioavailability need to be overcome. This study aimed to develop novel nanocarrier delivery systems of the antioxidants curcumin, n‐acetylcysteine (NAC) and hydroxytyrosol (HT), alone or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s disease (PD), excess free iron drives the accumulation of toxic hydroxyl radicals within mitochondria of dopaminergic neurons, resulting in sustained oxidative stress and cellular damage. The blood‐brain barrier (BBB) prevents most pharmaceuticals from entering the brain, therefore, to enable the advancement of potential antioxidant and iron chelator therapies for PD, limiting factors such as brain penetrance and bioavailability need to be overcome. This study aimed to develop novel nanocarrier delivery systems of the antioxidants curcumin, n‐acetylcysteine (NAC) and hydroxytyrosol (HT), alone or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model.
Year	2021
File	20211111_ Leah Mursaleen_Final thesis_Awarded.pdf File Access Level Open (open metadata and files)
Publisher	University of Westminster
Published	Jul 2021
Digital Object Identifier (DOI)	https://doi.org/10.34737/v9v45

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Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease
Mursaleen, L., Chan, S., Noble, B., Somavarapu, S. and Zariwala, M. 2023. Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease. Antioxidants. 12 (1) 130. https://doi.org/10.3390/antiox12010130

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity
Mursaleen, L., Somavarapu, S. and Zariwala, M. 2020. Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity. Journal of Parkinson's Disease. 10 (1), pp. 99-111. https://doi.org/10.3233/JPD-191754

N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease
Mursaleen, Leah, Noble, Brendon, Chan, S., Somavarapu, Satyanarayana and Zariwala, M. 2020. N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease. Antioxidants. 9 (7), p. 600. https://doi.org/10.3390/antiox9070600

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults
Lorinczova, H., Fitzsimons, O., Mursaleen, L., Renshaw, D., Begum, G. and Zariwala, M. 2020. Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants. 9 (8) 645. https://doi.org/10.3390/antiox9080645

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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease

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