N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease

Mursaleen, Leah, Noble, Brendon, Chan, S., Somavarapu, Satyanarayana and Zariwala, M. 2020. N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease. Antioxidants. 9 (7), p. 600. https://doi.org/10.3390/antiox9070600

TitleN-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease
TypeJournal article
AuthorsMursaleen, Leah, Noble, Brendon, Chan, S., Somavarapu, Satyanarayana and Zariwala, M.
AbstractOxidative stress is a key mediator in the development and progression of Parkinson's disease (PD). The antioxidant n-acetylcysteine (NAC) has generated interest as a disease-modifying therapy for PD but is limited due to poor bioavailability, a short half-life, and limited access to the brain. The aim of this study was to formulate and utilise mitochondria-targeted nanocarriers for delivery of NAC alone and in combination with the iron chelator deferoxamine (DFO), and assess their ability to protect against oxidative stress in a cellular rotenone PD model. Pluronic F68 (P68) and dequalinium (DQA) nanocarriers were prepared by a modified thin-film hydration method. An MTT assay assessed cell viability and iron status was measured using a ferrozine assay and ferritin immunoassay. For oxidative stress, a modified cellular antioxidant activity assay and the thiobarbituric acid-reactive substances assay and mitochondrial hydroxyl assay were utilised. Overall, this study demonstrates, for the first time, successful formulation of NAC and NAC + DFO into P68 + DQA nanocarriers for neuronal delivery. The results indicate that NAC and NAC + DFO nanocarriers have the potential characteristics to access the brain and that 1000 μM P68 + DQA NAC exhibited the strongest ability to protect against reduced cell viability ( = 0.0001), increased iron ( = 0.0033) and oxidative stress ( ≤ 0.0003). These NAC nanocarriers therefore demonstrate significant potential to be transitioned for further preclinical testing for PD.
KeywordsParkinson’s disease
antioxidant capacity
deferoxamine
iron
n-acetylcysteine
neurodegeneration
oxidative stress
JournalAntioxidants
Journal citation9 (7), p. 600
ISSN2076-3921
Year2020
PublisherMDPI
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.3390/antiox9070600
PubMed ID32660079
Publication dates
Published online09 Jul 2020
ProjectFST Studentship
FunderUniversity of Westminster

Related outputs

Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial
Kim, N., Parolin, B., Renshaw, D., Deb, S. and Zariwala, Mohammed Gulrez 2024. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. Nutrients. 16 (4), p. 489. https://doi.org/10.3390/nu16040489

Incentivized physical activity intervention promoting daily steps amongst university employees in the workplace through a team-based competition
Safi, A., Deb, D.S., Kelly, A., Cole, M., Walker, N. and Zariwala, M. 2023. Incentivized physical activity intervention promoting daily steps amongst university employees in the workplace through a team-based competition. Frontiers in Public Health. 11 1121936. https://doi.org/10.3389/fpubh.2023.1121936

Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line
Elisabetta Schiano, Ettore Novellino, Marta María Gámez Fernández, Helena Tiekou Lorinczova, Gian Carlo Tenore, Fortuna Iannuzzo, Vinood B. Patel, Satyanarayana Somavarapu and Mohammed Gulrez Zariwala 2023. Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line. Antioxidants. 13 (1) 63. https://doi.org/10.3390/antiox13010063

Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments.
Petagine, Lucy, Zariwala, Mohammed Gulrez and Patel, Vinood B 2023. Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments. World Journal of Gastroenterology. 29 (32), pp. 4831-4850. https://doi.org/10.3748/wjg.v29.i32.4831

Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles
McCormick, A.L., Basnett, P., Vecchiato, V., Wright, E., Noble, B., Marcello, E. and Paxinou, A. 2023. Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles. Frontiers in Nanotechnology. 5 1243056. https://doi.org/10.3389/fnano.2023.1243056

Dry Powder Formulation of Azithromycin for COVID-19 Therapeutics
Chan, Stefanie Ho Yi, Sheikh, Khalid, Zariwala, Mohammed Gulrez and Somavarapu, Satyanarayana 2023. Dry Powder Formulation of Azithromycin for COVID-19 Therapeutics. Journal of Microencapsulation. 40 (4), pp. 217-232. https://doi.org/10.1080/02652048.2023.2175924

Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease
Mursaleen, L., Chan, S., Noble, B., Somavarapu, S. and Zariwala, M. 2023. Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease. Antioxidants. 12 (1) 130. https://doi.org/10.3390/antiox12010130

Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment.
Esposito, Fortunato Palma, Vecchiato, Vittoria, Buonocore, Carmine, Tedesco, Pietro, Noble, Brendon, Basnett, Pooja and de Pascale, Donatella 2023. Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment. Bioresource Technology. 368, p. 128287. https://doi.org/10.1016/j.biortech.2022.128287

Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis.
Al-Obaidi, Hisham, Petraityte, Ieva, Hibbard, Thomas, Majumder, Mridul, Kalgudi, Rachith and Zariwala, Mohammed Gulrez 2022. Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 179, pp. 194-205. https://doi.org/10.1016/j.ejpb.2022.09.004

Workplace Physical Activity Barriers and Facilitators: A Qualitative Study Based on Employees Physical Activity Levels
Safi, A., Cole, M., Kelly, A., Zariwala, M. and Walker, N.C. 2022. Workplace Physical Activity Barriers and Facilitators: A Qualitative Study Based on Employees Physical Activity Levels. International Journal of Environmental Research and Public Health. 19 (15) e9442. https://doi.org/10.3390/ijerph19159442

Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study
Tiekou Lorinczova, H., Begum, G., Temouri, L., Renshaw, D. and Zariwala, M. 2022. Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study. Nutrients. 14 (3) 712. https://doi.org/10.3390/nu14030712

Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells.
Blesia, V., Patel, V.B., Al-Obaidi, H., Renshaw, D. and Zariwala, M. 2021. Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells. Cells. 10 (5) 1141. https://doi.org/10.3390/cells10051141

Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
Mursaleen, L. 2021. Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease. PhD thesis University of Westminster School of Life Sciences https://doi.org/10.34737/v9v45

Alcoholic liver disease: Current insights into cellular mechanisms
Petagine, Lucy, Zariwala, Mohammed Gulrez and Patel, V. 2021. Alcoholic liver disease: Current insights into cellular mechanisms. World Journal of Biological Chemistry. 12 (5), pp. 87-103. https://doi.org/10.4331/wjbc.v12.i5.87

Comparative Assessment of the Acute Effects of Whey, Rice and Potato Protein Isolate Intake on Markers of Glycaemic Regulation and Appetite in Healthy Males Using a Randomised Study Design
Tiekou Lorinczova, Helena, Deb, Sanjoy, Begum, G., Renshaw, Derek and Zariwala, Mohammed Gulrez 2021. Comparative Assessment of the Acute Effects of Whey, Rice and Potato Protein Isolate Intake on Markers of Glycaemic Regulation and Appetite in Healthy Males Using a Randomised Study Design. Nutrients. 13 (7). https://doi.org/nu13072157

Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial.
Tiekou Lorinczova, H., Begum, G., Renshaw, D. and Zariwala, M. 2021. Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial. Nutrients. 13 (7) 2300. https://doi.org/10.3390/nu13072300

The Assessment of Daily Energy Expenditure of Commercial Saturation Divers Using Doubly Labelled Water
Deb, S., Dolan, Eimear, Hambly, Catherine, Speakman, John R., Eftedal, Olav, Zariwala, Mohammed Gulrez and Eftedal, Ingrid 2021. The Assessment of Daily Energy Expenditure of Commercial Saturation Divers Using Doubly Labelled Water. Frontiers in Physiology. 12 687605. https://doi.org/10.3389/fphys.2021.687605

Micellar Nanocarriers of Hydroxytyrosol Are Protective against Parkinson’s Related Oxidative Stress in an In Vitro hCMEC/D3-SH-SY5Y Co-Culture System
Mursaleen, L., Noble, B., Somavarapu, Satyanarayana and Zariwala, M. 2021. Micellar Nanocarriers of Hydroxytyrosol Are Protective against Parkinson’s Related Oxidative Stress in an In Vitro hCMEC/D3-SH-SY5Y Co-Culture System. Antioxidants. 10 (6) e887. https://doi.org/10.3390/antiox10060887

Mouth Rinsing With a Pink Non-caloric, Artificially-Sweetened Solution Improves Self-Paced Running Performance and Feelings of Pleasure in Habitually Active Individuals
Brown, Daniel R., Cappozzo, Francesca, De Roeck, Dakota, Zariwala, Mohammed Gulrez and Deb, S. 2021. Mouth Rinsing With a Pink Non-caloric, Artificially-Sweetened Solution Improves Self-Paced Running Performance and Feelings of Pleasure in Habitually Active Individuals. Frontiers in Nutrition. 8, p. 678105. https://doi.org/10.3389/fnut.2021.678105

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity
Mursaleen, L., Somavarapu, S. and Zariwala, M. 2020. Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity. Journal of Parkinson's Disease. 10 (1), pp. 99-111. https://doi.org/10.3233/JPD-191754

Fabrication of Biopolymer Based Nanoparticles for the Entrapment of Chromium and Iron Supplements
Patel, N., Zariwala, M. and Al-Obaidi, H. 2020. Fabrication of Biopolymer Based Nanoparticles for the Entrapment of Chromium and Iron Supplements. Processes. 8, p. 707. https://doi.org/10.3390/pr8060707

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults
Lorinczova, H., Fitzsimons, O., Mursaleen, L., Renshaw, D., Begum, G. and Zariwala, M. 2020. Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants. 9 (8) 645. https://doi.org/10.3390/antiox9080645

Generation of High Dose Inhalable Effervescent Dispersions against Pseudomonas aeruginosa Biofilms
Mohammed, Aram, Zurek, Jakub, Madueke, Somto, Al-Kassimy, Hareir, Yaqoob, Muhammad, Houacine, Chahinez, Ferraz, Amina, Kalgudi, Rachith, Zariwala, Mohammed Gulrez, Hawkins, Nicholas and Al-Obaidi, H. 2020. Generation of High Dose Inhalable Effervescent Dispersions against Pseudomonas aeruginosa Biofilms. Pharmaceutical Research. 37 (8), p. 150. https://doi.org/10.1007/s11095-020-02878-w

Non-formal physical education influence on health related physical fitness of children
Sarkauskiene, Asta, Noble, Brendon, Kardeliene, Laimute and Noble, Brendon 2019. Non-formal physical education influence on health related physical fitness of children. SOCIETY. INTEGRATION. EDUCATION. Proceedings of the International Scientific Conference. 4, pp. 252-267. https://doi.org/10.17770/sie2019vol4.3865

Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms
Al-Obaidi, H., Kowalczyk, R.M., Kalgudi, R. and Zariwala, M. 2019. Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms. Colloids and Surfaces B: Biointerfaces. 184 110540. https://doi.org/10.1016/j.colsurfb.2019.110540

Techniques for the study of apoptosis in bone
Mann, V. and Noble, B. 2019. Techniques for the study of apoptosis in bone. in: Idris, A.I. (ed.) Bone research protocols Springer. pp. 451-465

Excessive iron accumulation induces beta cell cellular oxidative stress and insulin secretory dysfunction in MIN6 cells
Blesia, V., Patel, V., Al‐Obaidi, H. and Zariwala, M. 2019. Excessive iron accumulation induces beta cell cellular oxidative stress and insulin secretory dysfunction in MIN6 cells. Diabetes UK Professional Conference 2019. Liverpool 06 - 08 Mar 2019 Wiley. https://doi.org/10.1111/dme.2_13883

Fabrication of inhaled hybrid silver/ciprofloxacin nanoparticles with synergetic effect against Pseudomonas aeruginosa
Al-Obaidi, H., Kalgudi, R. and Zariwala, M. 2018. Fabrication of inhaled hybrid silver/ciprofloxacin nanoparticles with synergetic effect against Pseudomonas aeruginosa. European Journal of Pharmaceutics and Biopharmaceutics. 127 (27), pp. 27-35. https://doi.org/10.1016/j.ejpb.2018.04.006

Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery
Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K.M.G. and Somavarapu, S. 2018. Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery. International Journal of Nanomedicine. 13, pp. 5837-5848. https://doi.org/10.2147/IJN.S166901

Fabrication of inhaled hybrid silver/ciprofloxacin nanoparticles with synergetic effect against Pseudomonas aeruginosa
Al-Obaidi, H., Kalgudi, R. and Zariwala, M. 2018. Fabrication of inhaled hybrid silver/ciprofloxacin nanoparticles with synergetic effect against Pseudomonas aeruginosa. European Journal of Pharmaceutics and Biopharmaceutics. 128, pp. 27-35. https://doi.org/10.1016/j.ejpb.2018.04.006

The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis in vivo by promoting insulin secretion and maintaining functional β-cell mass
Liu, B., Moulton, C.D., Ruz‐Maldonaldo, I., Zariwala, M., Ismail, K., Jones, P.M. and Persaud, S.J. 2018. The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis in vivo by promoting insulin secretion and maintaining functional β-cell mass. Diabetes UK Professional Conference 2018. ExCeL, London 14 - 16 Mar 2018 Wiley. https://doi.org/10.1111/dme.9_13570

Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery
Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K.M.G. and Somavarapu, S. 2018. Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery. International Journal of Nanomedicine. 2018:13, pp. 5837-5848. https://doi.org/10.2147/IJN.S166901

A novel in vitro model of simulated twice a day iron supplementation for assessment of iron uptake and cellular damage
Apostolova, P., Blesia, C., Tossou, C., Renshaw, D., Farnaud, S., Evans, R. and Zariwala, M. 2017. A novel in vitro model of simulated twice a day iron supplementation for assessment of iron uptake and cellular damage. 7th Meeting of the International Bioiron Society. Los Angeles 07 - 11 May 2017 https://doi.org/10.1002/ajh.24812

Natural vegetarian origin protein polysaccharide nano sized carriers for food and nutrition applications
Zariwala, M. 2017. Natural vegetarian origin protein polysaccharide nano sized carriers for food and nutrition applications. Vitafoods 2017. Palexpo, Geneva, Switzerland 09 - 11 May 2017

Novel nanotechnology approaches to improve human nutrition and health
Zariwala, M. 2017. Novel nanotechnology approaches to improve human nutrition and health. STEM for Britain. London, UK Feb - Mar 2017

A novel natural origin biopolymer based iron nano-delivery system resistant to nutritional inhibitors
Zariwala, M. 2017. A novel natural origin biopolymer based iron nano-delivery system resistant to nutritional inhibitors. European Iron Club Annual Meeting 2017. Muenster, Germany 25 - 26 Jun 2017

Assessment of iron absorption and cellular oxidative damage utilising a novel in vitro model of twice a day iron supplementation
Zariwala, M. 2017. Assessment of iron absorption and cellular oxidative damage utilising a novel in vitro model of twice a day iron supplementation. European Iron Club Annual Meeting 2017. Muenster, Germany 25 - 26 Jun 2017

Novel nano-encapsulated antioxidant botanicals to counteract ferrous iron supplement mediated intestinal oxidative damage
Zariwala, M. 2017. Novel nano-encapsulated antioxidant botanicals to counteract ferrous iron supplement mediated intestinal oxidative damage. European Iron Club Annual Meeting 2017. Muenster, Germany 25 - 26 Jun 2017

Fair assessment to enhance students’ learning: a beginner’s guide
Zariwala, M. 2017. Fair assessment to enhance students’ learning: a beginner’s guide. HEA Annual Conference 2017: Generation TEF: Teaching in the spotlight. Manchester, UK 04 - 06 Jul 2017

The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis by promoting insulin secretion and maintaining functional β-cell mass
Liu, B., Ruz-Maldonado, I., Zariwala, M., Huang, G.C., Zhao, M., Jones, P.M. and Persaud, S.J. 2017. The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis by promoting insulin secretion and maintaining functional β-cell mass. European Association for the Study of Diabetes. Lisbon, Portugal Sep - Oct 2017 Springer. https://doi.org/10.1007/s00125-017-4350-z

Study on the pulmonary delivery system of apigenin loaded albumin nanocarriers with antioxidant activity
Papay, Z.E., Kosa, A., Boddi, B., Merchant, Z., Saleem, I.Y., Zariwala, M., Klebovich, I., Somavarapu, S. and Antal, I. 2017. Study on the pulmonary delivery system of apigenin loaded albumin nanocarriers with antioxidant activity. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 30 (4), pp. 274-288. https://doi.org/10.1089/jamp.2016.1316

Is elite sport a driver for medical advance? ; Ar didelio meistriškumo sportas skatina medicinos pažangą?
Noble, Brendon 2016. Is elite sport a driver for medical advance? ; Ar didelio meistriškumo sportas skatina medicinos pažangą? Sport Science. 1 (86), pp. 2-7. https://doi.org/10.15823/sm.2016.1

The selective serotonin reuptake inhibitor fluoxetine promotes insulin secretion and maintains functional β-cell mass
Liu, B., O'Donnell, C., Wong, C., Zariwala, M., Huang, G.C., Jones, P.M. and Persaud, S.J. 2016. The selective serotonin reuptake inhibitor fluoxetine promotes insulin secretion and maintains functional β-cell mass. Diabetes UK Professional Conference . SECC, Glasgow, United Kingdom 02 - 04 Mar 2016 Wiley. https://doi.org/10.1111/dme.8_13047

Comparative study of the bioavailability of different iron supplements to bacteria
Renshaw, D., Zariwala, M. and Farnaud, S. 2016. Comparative study of the bioavailability of different iron supplements to bacteria. European Iron Club. Innsbruck, Austria 07 - 10 Apr 2016

Fabrication and characterisation of novel protein-polysaccharide biopolymer based nanoparticles for iron delivery
Al-Obaidi, H., Patel, N., Ghafarzada, R., Malik, R., Musa, S., Chandramohan, S., Apostolova, P., Farnaud, S., Renshaw, D. and Zariwala, M. 2016. Fabrication and characterisation of novel protein-polysaccharide biopolymer based nanoparticles for iron delivery. European Iron Club. Innsbruck, Austria 07 - 10 Apr 2016

Beef protein isolate: a novel bio-matrix for formulating ferrous iron for nutritional applications
Zariwala, M., Farnaud, S., Renshaw, D. and Somavarapu, S. 2016. Beef protein isolate: a novel bio-matrix for formulating ferrous iron for nutritional applications. European Iron Club Meeting. Innsbruck, Austria 07 - 10 Apr 2016

Novel potato protein-polysaccharide nano-formulations for oral nutrient delivery
Zariwala, M., Somavarapu, S., Evans, R.W., Farnaud, S. and Renshaw, D. 2016. Novel potato protein-polysaccharide nano-formulations for oral nutrient delivery. Vitafoods. Geneva, Switzerland 30 - 30 May 2016

A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections
Merchant, Z., Buckton, G., Taylor, K.M.G., Stapleton, P., Saleem, I.Y., Zariwala, M. and Somavarapu, S. 2016. A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections. Current Pharmaceutical Design. 22 (17), pp. 2577-2598. https://doi.org/10.2174/1381612822666160317142139

Comparative study of bioavailability of different iron supplements to bacteria
Dagos, D., Selvam, P., Kelly, P., Evans, R., Zariwala, M., Renshaw, D. and Farnaud, S. 2015. Comparative study of bioavailability of different iron supplements to bacteria. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

A preliminary study of the link between iron increase in dopaminergic cells and Parkinson's disease
Mehta, K., Ahmed, B., Zariwala, M., Evans, R. and Farnaud, S. 2015. A preliminary study of the link between iron increase in dopaminergic cells and Parkinson's disease. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

What could insulin teach us about hepcidin? A comparative study between the iron hormone hepcidin and insulin
Mehta, K., Zariwala, M., Renshaw, D. and Farnaud, S. 2015. What could insulin teach us about hepcidin? A comparative study between the iron hormone hepcidin and insulin. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

Novel beta-casein nanocarriers for oral iron delivery
Zariwala, M., Somavarapu, S., Evans, R., Farnaud, S. and Renshaw, D. 2015. Novel beta-casein nanocarriers for oral iron delivery. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

Platform delivery technologies for nutraceutical applications
Zariwala, M., Somavarapu, S., Evans, R.W., Farnaud, S. and Renshaw, D. 2015. Platform delivery technologies for nutraceutical applications. Vitafoods . Geneva, Switzerland 05 - 07 May 2015

Novel whey protein isolate nanocarriers for oral micronutrient delivery
Farnaud, S., Renshaw, D., Somavarapu, S. and Zariwala, M. 2015. Novel whey protein isolate nanocarriers for oral micronutrient delivery. 9th NIZO Dairy Conference Milk Protein Functionality . Papendal, Netherlands 30 Sep - 02 Oct 2015

Drug Delivery Approaches for Apigenin: A Review
Papay, Z.E., Balogh, E., Zariwala, M., Somavarapu, S. and Antal, I. 2015. Drug Delivery Approaches for Apigenin: A Review. in: Stacks, N.M. (ed.) Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention New York, USA Nova Science Publishers. pp. 1-20

Formulation and characterization of curcumin loaded DQAsomes for pulmonary delivery
Zupancic, S., Kocbek, P., Kristl, J., Zariwala, M., Renshaw, D., Gul, M.O., Elsaid, Z., Taylor, K.M.G. and Somavarapu, S. 2014. Formulation and characterization of curcumin loaded DQAsomes for pulmonary delivery. 10th International Conference and Workshop on Biological Barriers. Saarbrücken 16 - 21 Feb 2014

Serum ferritin levels are correlated with total adiposity, but not BMI in obese males
Zariwala, M., Kosicka, A., MacKenzie, R. and Renshaw, D. 2014. Serum ferritin levels are correlated with total adiposity, but not BMI in obese males. Society for Endocrinology BES 2014. Liverpool, UK 24 - 27 Mar 2014 BioScientifica Ltd.. https://doi.org/10.1530/endoabs.34.P255

A human cell model of Parkinson’s disease confirms iron accumulation in dopaminergic neurons following 6-OHDOPA treatment
Zariwala, M. and Farnaud, S. 2014. A human cell model of Parkinson’s disease confirms iron accumulation in dopaminergic neurons following 6-OHDOPA treatment. European Iron Club Annual Meeting 2014. Verona, Italy 11 - 14 Sep 2014

Fabrication and characterization of novel hydrophobically modified chitosan nanoliposomes for oral iron delivery
Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Somavarapu, S. and Renshaw, D. 2014. Fabrication and characterization of novel hydrophobically modified chitosan nanoliposomes for oral iron delivery. European Iron Club Annual Meeting 2014. Verona, Italy 11 - 14 Sep 2014

Design and Development of Novel Mitochondrial Targeted Nanocarriers, DQAsomes for Curcumin Inhalation
Zupančič, Š., Kocbek, P., Zariwala, M., Renshaw, D., Gul, M.O., Elsaid, Z., Taylor, K.M.G. and Somavarapu, S. 2014. Design and Development of Novel Mitochondrial Targeted Nanocarriers, DQAsomes for Curcumin Inhalation. Molecular Pharmaceutics. 11 (7), pp. 2334-2345. https://doi.org/10.1021/mp500003q

Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery:Preparation, characterisation and in vitro evaluation
Zariwala, M., Farnaud, S., Merchant, Z., Somavarapu, S. and Renshaw, D. 2014. Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery:Preparation, characterisation and in vitro evaluation. Colloids and Surfaces B: Biointerfaces. 115 (1), p. 86– 92. https://doi.org/10.1016/j.colsurfb.2013.11.028

Design and Development of Novel Mitochondrial Targeted
Zupančič, Š., Kocbek, P., Zariwala, M., Renshaw, D., Gul, M.O., Elsaid, Z., Taylor, K.M.G. and Somavarapu, S. 2014. Design and Development of Novel Mitochondrial Targeted. Molecular Pharmaceutics. 11 (7), pp. 2334-2345. https://doi.org/10.1021/mp500003q

3-D printouts of the tracheobronchial tree generated from CT images as an aid to management in a case of tracheobronchial chondromalacia caused by relapsing polychondritis
Tam, Matthew D.B.S., Laycock, Stephen, Jayne, David, Babar, Judith and Noble, Brendon 2013. 3-D printouts of the tracheobronchial tree generated from CT images as an aid to management in a case of tracheobronchial chondromalacia caused by relapsing polychondritis. Journal of Radiology Case Reports. 7 (8), pp. 34-43. https://doi.org/10.3941/jrcr.v7i8.1390

Osteocyte apoptosis
Jilka, Robert L., Noble, Brendon and Weinstein, Robert S. 2013. Osteocyte apoptosis. Bone. 54 (2), pp. 264-271. https://doi.org/10.1016/j.bone.2012.11.038

Directed osteogenic differentiation of human mesenchymal stem/precursor cells on silicate substituted calcium phosphate
Cameron, Kate, Travers, Paul, Chander, Chaman, Buckland, Tom, Campion, Charlie and Noble, Brendon 2013. Directed osteogenic differentiation of human mesenchymal stem/precursor cells on silicate substituted calcium phosphate. Journal of Biomedical Materials Research Part A. 101A (1), pp. 13-22. https://doi.org/10.1002/jbm.a.34261

Macronutrient regulation of PYY and DPPIV in human intestinal epithelial cells
Zariwala, M., Kosicka, A. and Renshaw, D. 2013. Macronutrient regulation of PYY and DPPIV in human intestinal epithelial cells. ENDO 2013: The Endocrine Society’s 95th Annual Meeting. San Francisco, USA 15 - 18 Jun 2013

Preparation and Characterisation of Solid Lipid Particles for Oral Iron Delivery
Zariwala, M., Farnaud, S., Somavarapu, S. and Renshaw, D. 2013. Preparation and Characterisation of Solid Lipid Particles for Oral Iron Delivery. Fifth Congress of the International BioIron Society (IBIS), Biennial World Meeting. University College London 14 - 18 Apr 2013 Wiley. https://doi.org/10.1002/ajh.23453

Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms
Mehta, K., Patel, V., Busbridge, M., Renshaw, D., Zariwala, M., Evans, R. and Farnaud, S. 2013. Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms. Fifth Congress of the International BioIron Society (IBIS), Biennial World Meeting. University College London 14 - 18 Apr 2013 Wiley. https://doi.org/10.1002/ajh.23453

Comparison Study of Oral Iron Preparations Using a Human Intestinal Model
Zariwala, M., Somavarapu, S., Farnaud, S. and Renshaw, D. 2013. Comparison Study of Oral Iron Preparations Using a Human Intestinal Model. Scientia Pharmaceutica. 81 (4), pp. 1123-1139. https://doi.org/10.3797/scipharm.1304-03

A novel approach to oral iron delivery using ferrous sulphate loadedsolid lipid nanoparticles
Zariwala, M., Elsaid, N., Jackson, T.L., Corral López, F., Farnaud, S., Somavarapu, S. and Renshaw, D. 2013. A novel approach to oral iron delivery using ferrous sulphate loadedsolid lipid nanoparticles. International Journal of Pharmaceutics. 456 (2), pp. 400-407. https://doi.org/10.1016/j.ijpharm.2013.08.070

Annexin-A1 protein and its relationship to cortisol
Fowkes, R.C., Moradi-Bidhendi, N., Branceleone, V., Zariwala, M., Brady, D., Jessop, D.S., Perretti, M. and Renshaw, D. 2013. Annexin-A1 protein and its relationship to cortisol. Psychoneuroendocrinology. 38 (5), pp. 722-727. https://doi.org/10.1016/j.psyneuen.2012.08.003

Attenuation of plasma annexin A1 in human obesity
Kosicka, A., Cunliffe, AD., MacKenzie, R., Zariwala, M., Perretti, M., Flower, R.J. and Renshaw, D. 2013. Attenuation of plasma annexin A1 in human obesity. FASEB Journal. 27 (1), pp. 1-11. https://doi.org/10.1096/fj.12-213728

Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation
Tremoleda, J.L., Khan, N.S., Mann, V., Racey, S.N., Martin, A.J., Simpson, A.H.W.R. and Noble, B. 2012. Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation. Journal of Musculoskeletal Neuronal Interactions. 12 (4), pp. 241-253.

Increased transferrin-bound iron uptake in HepG2 cells is followed by an increase in expression of the iron hormone hepcidin pre-and post-translationally
Mehta, K., Patel, V., Busbridge Mark, Renshaw, D., Zariwala, M., Evans, R. and Farnaud, S. 2012. Increased transferrin-bound iron uptake in HepG2 cells is followed by an increase in expression of the iron hormone hepcidin pre-and post-translationally. European Iron Club Annual Meeting 2012. Rennes, France 29 - 31 Aug 2012

Comparison of iron absorption from iron supplement preparations using an in vitro Caco-2 model
Zariwala, M., Farnaud, S. and Renshaw, D. 2012. Comparison of iron absorption from iron supplement preparations using an in vitro Caco-2 model. European Iron Club Annual Meeting 2012. Rennes, France 29 - 31 Aug 2012

DPPIV and macronutrients regulate the expression of PYY3–36 in human gut epithelial cells
Kosicka, A., Renshaw, D. and Zariwala, M. 2012. DPPIV and macronutrients regulate the expression of PYY3–36 in human gut epithelial cells. Society for Endocrinology BES 2012. Harrogate, UK Mar - Apr 2012 BioScientifica Ltd.. https://doi.org/10.1530/endoabs.31.P197

Ac 2-26, an annexin A1-derived peptide, reduces inflammation in human SGBS adipocytes after hypoxia treatment
Kosicka-Knox, A., Cunliffe, A., Mackenzie, R., Zariwala, M. and Renshaw, D. 2012. Ac 2-26, an annexin A1-derived peptide, reduces inflammation in human SGBS adipocytes after hypoxia treatment. 15th International & 14th European Congress of Endocrinology. Florence, Italy 05 - 09 May 2012 BioScientifica Ltd..

Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes
Kosicka-Knox, A., Cunliffe, A., Mackenzie, R., Zariwala, M. and Renshaw, D. 2012. Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes. Society for Endocrinology BES 2012. Harrogate, UK Mar - Apr 2012

Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity
Holness, M.J., Zariwala, M., Walker, C.G. and Sugden, M.C. 2012. Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity. FEBS Open Bio. 2, pp. 32-36. https://doi.org/10.1016/j.fob.2012.02.003

Techniques for the Study of Apoptosis in Bone
Riahi, Sudeh, Noble, Brendon and Noble, B. 2011. Techniques for the Study of Apoptosis in Bone. in: Miep H. Helfrich and Stuart H. Ralston (ed.) Bone Research Protocols. 2nd edition Springer Nature. pp. 335-349

Collaborative project to co-ordinate care for patients with dementia.
Kennerley, D., Bolas, R., Bourne, J., Branson, K., Cavenagh, P., Collins, G., Coveney, N., Day, N., Hardman, M., Hayter, S., Fenner, P., Jones, J., Jordan, S., Noble, B., Osbourne, S., Smith, C. and Wigens, L. 2011. Collaborative project to co-ordinate care for patients with dementia. Nursing Management. 18 (2), pp. 27-31. https://doi.org/10.7748/nm2011.05.18.2.27.c8484

Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis
Sun, H., Raja, A., O’Connell, M.A., Mann, V., Noble, B. and Keegan, L.P. 2011. Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis. in: RNA and DNA Editing: Methods and Protocols Humana Press. pp. 75–87

Blunting of adaptive responses to resistance exercise training in women over 75y
Greig, C.A., Gray, C., Rankin, D., Young, A., Mann, V., Noble, B. and Atherton, P.J. 2011. Blunting of adaptive responses to resistance exercise training in women over 75y. Experimental Gerontology. 46 (11), pp. 884-890. https://doi.org/10.1016/j.exger.2011.07.010

A novel method for the directed osteogenic differentiation of human mesenchymal stem/precursor cells
B. Noble, C. Chander, T. Buckland and K.R. Cameron 2010. A novel method for the directed osteogenic differentiation of human mesenchymal stem/precursor cells. Bone. 47 (Supp.1), p. S128. https://doi.org/10.1016/j.bone.2010.04.283

Changes in adipocyte circadian clock function via SRT1 and AMPK in programmed obesity
Caton, P.W., Zariwala, M., Holness, M.J. and Sugden, M.C. 2010. Changes in adipocyte circadian clock function via SRT1 and AMPK in programmed obesity. Diabetic Medicine. 27 (S1), pp. 1-36. https://doi.org/10.1111/j.1464-5491.2009.02935.x

Development of stem cell carriers for bone regeneration
Hou, Q.P., Spadaccino, A., Hughes, O., Dauphin, D.S. and Noble, B.S. 2009. Development of stem cell carriers for bone regeneration. European Cells and Materials. 18 (Supp. 1), p. 41.

The role of estrogen in the repair of osteocytes following physical injury in vitro
V. Mann, L. Kitto and B. Noble 2009. The role of estrogen in the repair of osteocytes following physical injury in vitro. Bone. 44 (Supp.1), p. S62. https://doi.org/10.1016/j.bone.2009.01.028

TGF β 3 and loading increases osteocyte survival in human cancellous bone cultured ex vivo
Simpson, Angharad E., Stoddart, Martin J., Davies, Catrin M., Jähn, Katharina, Furlong, Pamela I., Gasser, Jürg A., Jones, David B., Noble, Brendon S. and Richards, Robert G. 2009. TGF β 3 and loading increases osteocyte survival in human cancellous bone cultured ex vivo. Cell Biochemistry & Function. 27 (1), pp. 23-29. https://doi.org/10.1002/cbf.1529

The biology of osteocytes
Kogianni, Giolanta and Noble, Brendon S. 2009. The biology of osteocytes. Current Osteoporosis Reports. 5, pp. 81-86. https://doi.org/10.1007/s11914-007-0007-z

PPARalpha deficiency impacts the regulation ofadipocyte leptin synthesis and secretion
Holness, M.J., Zariwala, M., Walker, C.G. and Sugden, M.C. 2009. PPARalpha deficiency impacts the regulation ofadipocyte leptin synthesis and secretion. Diabetic Medicine. 26 (S1), pp. 37-38. https://doi.org/10.1111/j.1464-5491.2009.02662.x

The molecular regulation of adipose-tissue gene expression by an early life intervention
Sugden, M.C., Zariwala, M., Nooristani, S. and Holness, M.J. 2009. The molecular regulation of adipose-tissue gene expression by an early life intervention. Diabetic Medicine. 26 (S1), pp. 37-38. https://doi.org/10.1111/j.1464-5491.2009.02662.x

PPARs and the orchestration of metabolic fuel selection
Sugden, M.C., Zariwala, M.G. and Holness, M.J. 2009. PPARs and the orchestration of metabolic fuel selection. Pharmacological Research. 60 (3), p. 141–150. https://doi.org/10.1016/j.phrs.2009.03.014

The role of the osteocyte in bone turnover
Brendon Noble 2008. The role of the osteocyte in bone turnover. Bone. 43 (Supp. 1), p. S22. https://doi.org/10.1016/j.bone.2008.07.258

The osteocyte lineage
Noble, Brendon S. 2008. The osteocyte lineage. Archives of Biochemistry and Biophysics. 473 (2), pp. 106-111. https://doi.org/10.1016/j.abb.2008.04.009

Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction
Kogianni, Giolanta, Mann, Val and Noble, Brendon S. 2008. Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction. Journal of Bone and Mineral Research. 23 (6), pp. 915-927. https://doi.org/10.1359/jbmr.080207

Bone tissue formation from human embryonic stem cells in vivo
Tremoleda, Jordi, Forsyth, Nicholas, Khan, Nusrat, Wojtacha, Davina, Christodoulou, Ioannis, Tye, B.J., Racey, Seth, Collinshaw, S., Sottile, Virginie, Thomson, Alison, Simpson, Hamish, Noble, Brendon and McWhir, Jim 2008. Bone tissue formation from human embryonic stem cells in vivo. Cloning and Stem Cells. 10 (1), pp. 119-132. https://doi.org/10.1089/clo.2007.0r36

Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain
David, Valentin, Guignandon, Alain, Martin, Aline, Malaval, Luc, Lafage-Proust, Marie-Hélène, Rattner, Aline, Mann, Val, Noble, Brendon, Jones, David, B. and Vico, Laurence 2008. Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Engineering Part A. 14 (1), pp. 117-126. https://doi.org/10.1089/ten.a.2007.0051

The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitro
Mann, Val, Huber, Christene, Kogianni, Giolanta, Collins, Frances and Noble, Brendon 2007. The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitro. Bone. 40 (3), pp. 674-684. https://doi.org/10.1016/j.bone.2006.10.014

Selective estrogen receptor modulator inhibits osteocyte apoptosis during abrupt estrogen withdrawal: Implications for bone quality maintenance
Huber, C., Collishaw, S., Mosley, J.R., Reeve, J. and Noble, B.S. 2007. Selective estrogen receptor modulator inhibits osteocyte apoptosis during abrupt estrogen withdrawal: Implications for bone quality maintenance. Calcified Tissue International. 81, pp. 139-144. https://doi.org/10.1007/s00223-007-9049-6

Prolactin in culture leads to a shift in stimulatory threshold but does not augment the K-ATP channel independent pathway for glucose-stimulated insulin secretion
Zariwala, M., Holness, M.J., Turner, M.D. and Sugden, M.C. 2007. Prolactin in culture leads to a shift in stimulatory threshold but does not augment the K-ATP channel independent pathway for glucose-stimulated insulin secretion. Diabetic Medicine. 24 (S1), p. 33. https://doi.org/10.1111/j.1464-5491.2007.02126.x

Enhancement of immune response of HBsAg loaded poly(L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan
Pandit, S., Cevher, E, Zariwala, M., Somavarapu, S. and Alpar, H.O. 2007. Enhancement of immune response of HBsAg loaded poly(L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan. Journal of Microencapsulation. 24 (6), p. 539–552. https://doi.org/10.1080/02652040701443700

Diet, obesity and diabetes: a current update
Walker, C.G., Zariwala, M.G., Holness, M.J. and Sugden, M.C. 2007. Diet, obesity and diabetes: a current update. Clinical Science. 112 (2), pp. 93-111. https://doi.org/10.1042/CS20060150

Skeletal muscle IGF-I isoform expression in healthy women after isometric exercise
Greig, Carolyn A., Hameed, Mahjabeen, Young, Archie, Goldspink, Geoffrey and Noble, Brendon 2006. Skeletal muscle IGF-I isoform expression in healthy women after isometric exercise. Growth Hormone & IGF Research. 16 (5-6), pp. 373-376. https://doi.org/10.1016/j.ghir.2006.09.005

Physiologic Oxygen Enhances Human Embryonic Stem Cell Clonal Recovery and Reduces Chromosomal Abnormalities
Forsyth, Nicholas R., Musio, Antonio, Vezzoni, Paolo, Simpson, A. Hamish R.W., Noble, Brendon S. and McWhir, Jim 2006. Physiologic Oxygen Enhances Human Embryonic Stem Cell Clonal Recovery and Reduces Chromosomal Abnormalities. Cloning and Stem Cells. 8 (1), pp. 16-23. https://doi.org/10.1089/clo.2006.8.16

The role of growth factors and related agents in accelerating fracture healing
A. H. R. W. Simpson, L. Mills and Noble, B. 2006. The role of growth factors and related agents in accelerating fracture healing. The Journal of Bone and Joint Surgery. British volume. 88-B (6), pp. 701 - 705. https://doi.org/10.1302/0301-620x.88b6.17524

The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone
Mann, V., Huber, C., Kogianni, G., Jones, D. and Noble, B. 2006. The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone. Journal of Musculoskeletal Neuronal Interactions. 6 (4), pp. 408-417.

Early protein restriction attenuates effects of increased age to suppress the response of adipose-tissue LPL activity to feeding
Zariwala, M., Holness, M.J. and Sugden, M.C. 2006. Early protein restriction attenuates effects of increased age to suppress the response of adipose-tissue LPL activity to feeding. Diabetic Medicine. 23 (S2), pp. 31-138. https://doi.org/10.1111/j.1466-5468.2006.01875.x

Stem cells and orthopaedic disease
McWhir, J. and Noble, B. 2005. Stem cells and orthopaedic disease. European Cells and Materials. 10 (SUPPL.2), p. 8.

Microdamage and apoptosis
Noble, B. 2005. Microdamage and apoptosis. European Journal of Morphology. 42 (1-2), pp. 91-98. https://doi.org/10.1080/09243860500096248

Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis
Kogianni, G., Mann, V., Ebetino, F., Nuttall, M., Nijweide, P., Simpson, H. and Noble, B. 2004. Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis. Life Sciences. 75 (24), pp. 2879-2895. https://doi.org/10.1016/j.lfs.2004.04.048

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
Clarke, Murray C.H., Savill, John, Jones, David B., Noble, Brendon S. and Brown, Simon B. 2003. Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. in: Bone Research Protocols Springer. pp. 225-236

Mechanical stimulation & cell death-shaping our bones
Noble, B. 2003. Mechanical stimulation & cell death-shaping our bones. European Cells and Materials. 5 (Suppl.2), p. 25.

Bone microdamage and cell apoptosis
Noble, B., Alini, M. and Richards, R.G. 2003. Bone microdamage and cell apoptosis. European Cells and Materials. 6, pp. 46-55.

A bone fluid flow hypothesis for muscle pump-driven capillary filtration: II Proposed role for exercise in erodible scaffold implant incorporation
Winet, H., Noble, B. and Jones, D. 2003. A bone fluid flow hypothesis for muscle pump-driven capillary filtration: II Proposed role for exercise in erodible scaffold implant incorporation. European Cells and Materials. 6. https://doi.org/10.22203/ecm.v006a01

Mechanical loading: Biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone
Noble, B.S., Peet, N., Stevens, H.Y., Brabbs, A., Mosley, J.R., Reilly, G.C., Reeve, J., Skerry, T.M. and Lanyon, L.E. 2003. Mechanical loading: Biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. American Journal of Physiology: Cell Physiology. 284 (4), pp. C934-C943. https://doi.org/10.1152/ajpcell.00234.2002

The effect of in vivo mechanical loading on estrogen receptor α expression in rat ulnar osteocytes
Ehrlich, P.J., Noble, B.S., Jessop, H.L., Stevens, H.Y., Mosley, J.R. and Lanyon, L.E. 2002. The effect of in vivo mechanical loading on estrogen receptor α expression in rat ulnar osteocytes. Journal of Bone and Mineral Research. 17 (9), pp. 1646-1655. https://doi.org/10.1359/jbmr.2002.17.9.1646

Osteocyte lacunar occupancy in the femoral neck cortex: An association with cortical remodeling in hip fracture cases and controls
Power, J., Noble, B.S., Loveridge, N., Bell, K.L., Rushton, N. and Reeve, J. 2001. Osteocyte lacunar occupancy in the femoral neck cortex: An association with cortical remodeling in hip fracture cases and controls. Calcified Tissue International. 69 (1), pp. 13-19. https://doi.org/10.1007/s00223-001-0013-6

Osteocyte function, osteocyte death and bone fracture resistance
Noble, Brendon S. and Reeve, Jonathan 2000. Osteocyte function, osteocyte death and bone fracture resistance. Molecular and Cellular Endocrinology. 159 (1-2), pp. 7-13. https://doi.org/10.1016/s0303-7207(99)00174-4

Bcl-2, tissue transglutaminase and p53 protein expression in the apoptotic cascade in ribs of premature infants
Stevens, H.Y., Reeve, J. and Noble, B.S. 2000. Bcl-2, tissue transglutaminase and p53 protein expression in the apoptotic cascade in ribs of premature infants. Journal of Anatomy. 196 (2). https://doi.org/10.1017/s0021878299005889

Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells
H. MacPherson, B.S. Noble and S.H. Ralston 1999. Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells. Bone. 24 (3), pp. 179-185. https://doi.org/10.1016/s8756-3282(98)00173-2

Characterization of 11β-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines
Bland, R., Worker, C.A., Noble, B.S., Eyre, L.J., Bujalska, J.I., Sheppard, M.C., Stewart, P.M. and Hewison, M. 1999. Characterization of 11β-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines. Journal of Endocrinology. 161 (3), pp. 455-464. https://doi.org/10.1677/joe.0.1610455

Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging
A. Boyde, J.E. Compston, J. Reeve, K.L. Bell, B.S. Noble, S.J. Jones and N. Loveridge 1998. Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging. Bone. 22 (3), pp. 241-250. https://doi.org/10.1016/s8756-3282(97)00275-5

The role of estrogen in the control of rat osteocyte apoptosis
Tomkinson, A., Gevers, E.F., Wit, J.M., Reeve, J. and Noble, B.S. 1998. The role of estrogen in the control of rat osteocyte apoptosis. Journal of Bone and Mineral Research. 13 (8), pp. 1243-1250. https://doi.org/10.1359/jbmr.1998.13.8.1243

Identification of apoptotic changes in osteocytes in normal and pathological human bone
B.S. Noble, H. Stevens, N. Loveridge and J. Reeve 1997. Identification of apoptotic changes in osteocytes in normal and pathological human bone. Bone. 20 (3), pp. 273-282. https://doi.org/10.1016/s8756-3282(96)00365-1

The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone
Tomkinson, A., Reeve, J., Shaw, R.W. and Noble, B.S. 1997. The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. Journal of Clinical Endocrinology and Metabolism. 82 (9), pp. 3128-3135. https://doi.org/10.1210/jc.82.9.3128

O7. Does apoptosis play a role in osteocyte function?
B.S. Noble, H. Stevens, J. Reeve and N. Loveridge 1996. O7. Does apoptosis play a role in osteocyte function? Bone. 19 (6), p. 686. https://doi.org/10.1016/s8756-3282(97)84303-7

Dextran sulfate promotes the rapid aggregation of porcine bone-marrow stromal cells
B.S. Noble, V. Dean, N. Loveridge and B.M. Thomson 1995. Dextran sulfate promotes the rapid aggregation of porcine bone-marrow stromal cells. Bone. 17 (4), pp. 375-382. https://doi.org/10.1016/s8756-3282(95)00247-2

Apoptosis in growing rat bone: preliminary studies
B.S. Noble, J. Milne and N. Loveridge 1995. Apoptosis in growing rat bone: preliminary studies. Bone. 16 (6), p. 689. https://doi.org/10.1016/8756-3282(95)91680-6

Differential responses of human tumour cells to polyunsaturated fatty acids: Stimulation of proliferation of a colon tumour cell line by docosahexaenoic acid
McMillan, D.N., Heys, S.D., Murray, A.W., Noble, B.S., Purasiri, P., Deehan, D.J., Eremin, O. and Noble, B. 1995. Differential responses of human tumour cells to polyunsaturated fatty acids: Stimulation of proliferation of a colon tumour cell line by docosahexaenoic acid. International Journal of Oncology. 7 (4), pp. 927-933.

The differentiation of a potential mesenchymal stem cell population within ovine bone marrow
Jessop, H.L., Noble, B.S. and Cryer, A. 1994. The differentiation of a potential mesenchymal stem cell population within ovine bone marrow. Biochemical Society Transactions. 22 (3), p. 248S. https://doi.org/10.1042/bst022248s

P8. Bone marrow stromal cells separated by buoyant density: an initial characterisation
Noble, B.S., Rucklidge, G.J. and Thomson, B.M. 1994. P8. Bone marrow stromal cells separated by buoyant density: an initial characterisation. Bone. 15 (2), p. 232. https://doi.org/10.1016/8756-3282(94)90742-0

P12. Dextran sulphate promotes stromal cell aggregation and initiates type II collagen production
B.M. Thomson, V. Dean, B. Noble and N. Loveridge 1994. P12. Dextran sulphate promotes stromal cell aggregation and initiates type II collagen production. Bone. 15 (1), p. 120. https://doi.org/10.1016/8756-3282(94)90935-0

Control of longitudinal growth: The role of nutrition
Loveridge, N. and Noble, B.S. 1994. Control of longitudinal growth: The role of nutrition. European Journal of Clinical Nutrition. 48 (2), pp. 75-84.

Calcitonin gene related peptide stimulates differentiation of neonatal rat myogenic cultures
Noble, B.S., McMillan, D.N. and Maltin, C.A. 1993. Calcitonin gene related peptide stimulates differentiation of neonatal rat myogenic cultures. Growth Regulation. 3 (4), pp. 245-248.

Visualisation and selective elimination of a subpopulation of mitogen-responsive bone marrow stromal cells using bromodeoxyuridine and photo-induced cell killing
B.M. Thomson, V. Dean, C. Farquharson and B.S. Noble 1993. Visualisation and selective elimination of a subpopulation of mitogen-responsive bone marrow stromal cells using bromodeoxyuridine and photo-induced cell killing. Bone. 14 (5), pp. 779-786. https://doi.org/10.1016/8756-3282(93)90210-2

The effect of the beta-adrenergic agonist clenbuterol on growth and protein metabolism in rat muscle cell cultures
McMillan, D.N., Noble, B.S. and Maltin, C.A. 1992. The effect of the beta-adrenergic agonist clenbuterol on growth and protein metabolism in rat muscle cell cultures. Journal of Animal Science. 70 (10), p. 3014–3023. https://doi.org/10.2527/1992.70103014x

Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats
Palmer, R.M., Delday, M.I., McMillan, D.N., Noble, B.S., Bain, P. and Maltin, C.A. 1990. Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats. British Journal of Pharmacology. 101 (4), pp. 835-838. https://doi.org/10.1111/j.1476-5381.1990.tb14166.x

Permalink - https://westminsterresearch.westminster.ac.uk/item/v030v/n-acetylcysteine-nanocarriers-protect-against-oxidative-stress-in-a-cellular-model-of-parkinson-s-disease


Share this

Usage statistics

189 total views
71 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.