Novel beta-casein nanocarriers for oral iron delivery

Innovative Microencapsulation of Polymyxin B for Enhanced Antimicrobial Efficacy via Coated Spray Drying
Yousfan, Amal, Al Khatib, Arwa Omar, Salman, Afrah M. H., Abu Elella, Mahmoud H., Barrett, Glyn, Michael, Nicholas, Zariwala, M. and Al-Obaidi, H. 2024. Innovative Microencapsulation of Polymyxin B for Enhanced Antimicrobial Efficacy via Coated Spray Drying. Molecular Pharmaceutics. Advanced online publication. https://doi.org/10.1021/acs.molpharmaceut.4c00594

Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial
Kim, N., Parolin, B., Renshaw, D., Deb, S. and Zariwala, Mohammed Gulrez 2024. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. Nutrients. 16 (4), p. 489. https://doi.org/10.3390/nu16040489

Incentivized physical activity intervention promoting daily steps amongst university employees in the workplace through a team-based competition
Safi, A., Deb, D.S., Kelly, A., Cole, M., Walker, N. and Zariwala, M. 2023. Incentivized physical activity intervention promoting daily steps amongst university employees in the workplace through a team-based competition. Frontiers in Public Health. 11 1121936. https://doi.org/10.3389/fpubh.2023.1121936

Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line
Elisabetta Schiano, Ettore Novellino, Marta María Gámez Fernández, Helena Tiekou Lorinczova, Gian Carlo Tenore, Fortuna Iannuzzo, Vinood B. Patel, Satyanarayana Somavarapu and Mohammed Gulrez Zariwala 2023. Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line. Antioxidants. 13 (1) 63. https://doi.org/10.3390/antiox13010063

Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments.
Petagine, Lucy, Zariwala, Mohammed Gulrez and Patel, Vinood B 2023. Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments. World Journal of Gastroenterology. 29 (32), pp. 4831-4850. https://doi.org/10.3748/wjg.v29.i32.4831

Dry Powder Formulation of Azithromycin for COVID-19 Therapeutics
Chan, Stefanie Ho Yi, Sheikh, Khalid, Zariwala, Mohammed Gulrez and Somavarapu, Satyanarayana 2023. Dry Powder Formulation of Azithromycin for COVID-19 Therapeutics. Journal of Microencapsulation. 40 (4), pp. 217-232. https://doi.org/10.1080/02652048.2023.2175924

Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease
Mursaleen, L., Chan, S., Noble, B., Somavarapu, S. and Zariwala, M. 2023. Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease. Antioxidants. 12 (1) 130. https://doi.org/10.3390/antiox12010130

Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis.
Al-Obaidi, Hisham, Petraityte, Ieva, Hibbard, Thomas, Majumder, Mridul, Kalgudi, Rachith and Zariwala, Mohammed Gulrez 2022. Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 179, pp. 194-205. https://doi.org/10.1016/j.ejpb.2022.09.004

Workplace Physical Activity Barriers and Facilitators: A Qualitative Study Based on Employees Physical Activity Levels
Safi, A., Cole, M., Kelly, A., Zariwala, M. and Walker, N.C. 2022. Workplace Physical Activity Barriers and Facilitators: A Qualitative Study Based on Employees Physical Activity Levels. International Journal of Environmental Research and Public Health. 19 (15) e9442. https://doi.org/10.3390/ijerph19159442

Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study
Tiekou Lorinczova, H., Begum, G., Temouri, L., Renshaw, D. and Zariwala, M. 2022. Co-Administration of Iron and Bioavailable Curcumin Reduces Levels of Systemic Markers of Inflammation and Oxidative Stress in a Placebo-Controlled Randomised Study. Nutrients. 14 (3) 712. https://doi.org/10.3390/nu14030712

Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells.
Blesia, V., Patel, V.B., Al-Obaidi, H., Renshaw, D. and Zariwala, M. 2021. Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells. Cells. 10 (5) 1141. https://doi.org/10.3390/cells10051141

Alcoholic liver disease: Current insights into cellular mechanisms
Petagine, Lucy, Zariwala, Mohammed Gulrez and Patel, V. 2021. Alcoholic liver disease: Current insights into cellular mechanisms. World Journal of Biological Chemistry. 12 (5), pp. 87-103. https://doi.org/10.4331/wjbc.v12.i5.87

Comparative Assessment of the Acute Effects of Whey, Rice and Potato Protein Isolate Intake on Markers of Glycaemic Regulation and Appetite in Healthy Males Using a Randomised Study Design
Tiekou Lorinczova, Helena, Deb, Sanjoy, Begum, G., Renshaw, Derek and Zariwala, Mohammed Gulrez 2021. Comparative Assessment of the Acute Effects of Whey, Rice and Potato Protein Isolate Intake on Markers of Glycaemic Regulation and Appetite in Healthy Males Using a Randomised Study Design. Nutrients. 13 (7). https://doi.org/nu13072157

Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial.
Tiekou Lorinczova, H., Begum, G., Renshaw, D. and Zariwala, M. 2021. Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial. Nutrients. 13 (7) 2300. https://doi.org/10.3390/nu13072300

The Assessment of Daily Energy Expenditure of Commercial Saturation Divers Using Doubly Labelled Water
Deb, S., Dolan, Eimear, Hambly, Catherine, Speakman, John R., Eftedal, Olav, Zariwala, Mohammed Gulrez and Eftedal, Ingrid 2021. The Assessment of Daily Energy Expenditure of Commercial Saturation Divers Using Doubly Labelled Water. Frontiers in Physiology. 12 687605. https://doi.org/10.3389/fphys.2021.687605

Micellar Nanocarriers of Hydroxytyrosol Are Protective against Parkinson’s Related Oxidative Stress in an In Vitro hCMEC/D3-SH-SY5Y Co-Culture System
Mursaleen, L., Noble, B., Somavarapu, Satyanarayana and Zariwala, M. 2021. Micellar Nanocarriers of Hydroxytyrosol Are Protective against Parkinson’s Related Oxidative Stress in an In Vitro hCMEC/D3-SH-SY5Y Co-Culture System. Antioxidants. 10 (6) e887. https://doi.org/10.3390/antiox10060887

Mouth Rinsing With a Pink Non-caloric, Artificially-Sweetened Solution Improves Self-Paced Running Performance and Feelings of Pleasure in Habitually Active Individuals
Brown, Daniel R., Cappozzo, Francesca, De Roeck, Dakota, Zariwala, Mohammed Gulrez and Deb, S. 2021. Mouth Rinsing With a Pink Non-caloric, Artificially-Sweetened Solution Improves Self-Paced Running Performance and Feelings of Pleasure in Habitually Active Individuals. Frontiers in Nutrition. 8, p. 678105. https://doi.org/10.3389/fnut.2021.678105

Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity
Mursaleen, L., Somavarapu, S. and Zariwala, M. 2020. Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity. Journal of Parkinson's Disease. 10 (1), pp. 99-111. https://doi.org/10.3233/JPD-191754

Fabrication of Biopolymer Based Nanoparticles for the Entrapment of Chromium and Iron Supplements
Patel, N., Zariwala, M. and Al-Obaidi, H. 2020. Fabrication of Biopolymer Based Nanoparticles for the Entrapment of Chromium and Iron Supplements. Processes. 8, p. 707. https://doi.org/10.3390/pr8060707

N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease
Mursaleen, Leah, Noble, Brendon, Chan, S., Somavarapu, Satyanarayana and Zariwala, M. 2020. N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson's Disease. Antioxidants. 9 (7), p. 600. https://doi.org/10.3390/antiox9070600

Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults
Lorinczova, H., Fitzsimons, O., Mursaleen, L., Renshaw, D., Begum, G. and Zariwala, M. 2020. Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults. Antioxidants. 9 (8) 645. https://doi.org/10.3390/antiox9080645

Generation of High Dose Inhalable Effervescent Dispersions against Pseudomonas aeruginosa Biofilms
Mohammed, Aram, Zurek, Jakub, Madueke, Somto, Al-Kassimy, Hareir, Yaqoob, Muhammad, Houacine, Chahinez, Ferraz, Amina, Kalgudi, Rachith, Zariwala, Mohammed Gulrez, Hawkins, Nicholas and Al-Obaidi, H. 2020. Generation of High Dose Inhalable Effervescent Dispersions against Pseudomonas aeruginosa Biofilms. Pharmaceutical Research. 37 (8), p. 150. https://doi.org/10.1007/s11095-020-02878-w

Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms
Al-Obaidi, H., Kowalczyk, R.M., Kalgudi, R. and Zariwala, M. 2019. Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms. Colloids and Surfaces B: Biointerfaces. 184 110540. https://doi.org/10.1016/j.colsurfb.2019.110540

Excessive iron accumulation induces beta cell cellular oxidative stress and insulin secretory dysfunction in MIN6 cells
Blesia, V., Patel, V., Al‐Obaidi, H. and Zariwala, M. 2019. Excessive iron accumulation induces beta cell cellular oxidative stress and insulin secretory dysfunction in MIN6 cells. Diabetes UK Professional Conference 2019. Liverpool 06 - 08 Mar 2019 Wiley. https://doi.org/10.1111/dme.2_13883

Fabrication of inhaled hybrid silver/ciprofloxacin nanoparticles with synergetic effect against Pseudomonas aeruginosa
Al-Obaidi, H., Kalgudi, R. and Zariwala, M. 2018. Fabrication of inhaled hybrid silver/ciprofloxacin nanoparticles with synergetic effect against Pseudomonas aeruginosa. European Journal of Pharmaceutics and Biopharmaceutics. 127 (27), pp. 27-35. https://doi.org/10.1016/j.ejpb.2018.04.006

Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery
Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K.M.G. and Somavarapu, S. 2018. Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery. International Journal of Nanomedicine. 13, pp. 5837-5848. https://doi.org/10.2147/IJN.S166901

The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis in vivo by promoting insulin secretion and maintaining functional β-cell mass
Liu, B., Moulton, C.D., Ruz‐Maldonaldo, I., Zariwala, M., Ismail, K., Jones, P.M. and Persaud, S.J. 2018. The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis in vivo by promoting insulin secretion and maintaining functional β-cell mass. Diabetes UK Professional Conference 2018. ExCeL, London 14 - 16 Mar 2018 Wiley. https://doi.org/10.1111/dme.9_13570

A novel in vitro model of simulated twice a day iron supplementation for assessment of iron uptake and cellular damage
Apostolova, P., Blesia, C., Tossou, C., Renshaw, D., Farnaud, S., Evans, R. and Zariwala, M. 2017. A novel in vitro model of simulated twice a day iron supplementation for assessment of iron uptake and cellular damage. 7th Meeting of the International Bioiron Society. Los Angeles 07 - 11 May 2017 https://doi.org/10.1002/ajh.24812

Natural vegetarian origin protein polysaccharide nano sized carriers for food and nutrition applications
Zariwala, M. 2017. Natural vegetarian origin protein polysaccharide nano sized carriers for food and nutrition applications. Vitafoods 2017. Palexpo, Geneva, Switzerland 09 - 11 May 2017

Novel nanotechnology approaches to improve human nutrition and health
Zariwala, M. 2017. Novel nanotechnology approaches to improve human nutrition and health. STEM for Britain. London, UK Feb - Mar 2017

A novel natural origin biopolymer based iron nano-delivery system resistant to nutritional inhibitors
Zariwala, M. 2017. A novel natural origin biopolymer based iron nano-delivery system resistant to nutritional inhibitors. European Iron Club Annual Meeting 2017. Muenster, Germany 25 - 26 Jun 2017

Assessment of iron absorption and cellular oxidative damage utilising a novel in vitro model of twice a day iron supplementation
Zariwala, M. 2017. Assessment of iron absorption and cellular oxidative damage utilising a novel in vitro model of twice a day iron supplementation. European Iron Club Annual Meeting 2017. Muenster, Germany 25 - 26 Jun 2017

Novel nano-encapsulated antioxidant botanicals to counteract ferrous iron supplement mediated intestinal oxidative damage
Zariwala, M. 2017. Novel nano-encapsulated antioxidant botanicals to counteract ferrous iron supplement mediated intestinal oxidative damage. European Iron Club Annual Meeting 2017. Muenster, Germany 25 - 26 Jun 2017

Fair assessment to enhance students’ learning: a beginner’s guide
Zariwala, M. 2017. Fair assessment to enhance students’ learning: a beginner’s guide. HEA Annual Conference 2017: Generation TEF: Teaching in the spotlight. Manchester, UK 04 - 06 Jul 2017

The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis by promoting insulin secretion and maintaining functional β-cell mass
Liu, B., Ruz-Maldonado, I., Zariwala, M., Huang, G.C., Zhao, M., Jones, P.M. and Persaud, S.J. 2017. The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis by promoting insulin secretion and maintaining functional β-cell mass. European Association for the Study of Diabetes. Lisbon, Portugal Sep - Oct 2017 Springer. https://doi.org/10.1007/s00125-017-4350-z

HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication
Mehta, K., Farnaud, S. and Patel, V.B. 2017. HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication. Molecular Biology Reports. 44 (5), pp. 399-403. https://doi.org/10.1007/s11033-017-4123-2

Study on the pulmonary delivery system of apigenin loaded albumin nanocarriers with antioxidant activity
Papay, Z.E., Kosa, A., Boddi, B., Merchant, Z., Saleem, I.Y., Zariwala, M., Klebovich, I., Somavarapu, S. and Antal, I. 2017. Study on the pulmonary delivery system of apigenin loaded albumin nanocarriers with antioxidant activity. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 30 (4), pp. 274-288. https://doi.org/10.1089/jamp.2016.1316

The selective serotonin reuptake inhibitor fluoxetine promotes insulin secretion and maintains functional β-cell mass
Liu, B., O'Donnell, C., Wong, C., Zariwala, M., Huang, G.C., Jones, P.M. and Persaud, S.J. 2016. The selective serotonin reuptake inhibitor fluoxetine promotes insulin secretion and maintains functional β-cell mass. Diabetes UK Professional Conference . SECC, Glasgow, United Kingdom 02 - 04 Mar 2016 Wiley. https://doi.org/10.1111/dme.8_13047

Comparative study of the bioavailability of different iron supplements to bacteria
Renshaw, D., Zariwala, M. and Farnaud, S. 2016. Comparative study of the bioavailability of different iron supplements to bacteria. European Iron Club. Innsbruck, Austria 07 - 10 Apr 2016

Fabrication and characterisation of novel protein-polysaccharide biopolymer based nanoparticles for iron delivery
Al-Obaidi, H., Patel, N., Ghafarzada, R., Malik, R., Musa, S., Chandramohan, S., Apostolova, P., Farnaud, S., Renshaw, D. and Zariwala, M. 2016. Fabrication and characterisation of novel protein-polysaccharide biopolymer based nanoparticles for iron delivery. European Iron Club. Innsbruck, Austria 07 - 10 Apr 2016

Beef protein isolate: a novel bio-matrix for formulating ferrous iron for nutritional applications
Zariwala, M., Farnaud, S., Renshaw, D. and Somavarapu, S. 2016. Beef protein isolate: a novel bio-matrix for formulating ferrous iron for nutritional applications. European Iron Club Meeting. Innsbruck, Austria 07 - 10 Apr 2016

Novel potato protein-polysaccharide nano-formulations for oral nutrient delivery
Zariwala, M., Somavarapu, S., Evans, R.W., Farnaud, S. and Renshaw, D. 2016. Novel potato protein-polysaccharide nano-formulations for oral nutrient delivery. Vitafoods. Geneva, Switzerland 30 - 30 May 2016

A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections
Merchant, Z., Buckton, G., Taylor, K.M.G., Stapleton, P., Saleem, I.Y., Zariwala, M. and Somavarapu, S. 2016. A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections. Current Pharmaceutical Design. 22 (17), pp. 2577-2598. https://doi.org/10.2174/1381612822666160317142139

Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells
Mehta, K., Busbridge, Mark, Renshaw, D., Evans, R.W., Farnaud, S. and Patel, V. 2016. Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells. Blood Cells, Molecules, and Diseases. 61, pp. 37-45. https://doi.org/10.1016/j.bcmd.2016.06.008

Comparative study of bioavailability of different iron supplements to bacteria
Dagos, D., Selvam, P., Kelly, P., Evans, R., Zariwala, M., Renshaw, D. and Farnaud, S. 2015. Comparative study of bioavailability of different iron supplements to bacteria. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

A preliminary study of the link between iron increase in dopaminergic cells and Parkinson's disease
Mehta, K., Ahmed, B., Zariwala, M., Evans, R. and Farnaud, S. 2015. A preliminary study of the link between iron increase in dopaminergic cells and Parkinson's disease. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

What could insulin teach us about hepcidin? A comparative study between the iron hormone hepcidin and insulin
Mehta, K., Zariwala, M., Renshaw, D. and Farnaud, S. 2015. What could insulin teach us about hepcidin? A comparative study between the iron hormone hepcidin and insulin. 6th Meeting of the International Bioiron Society. Hangzhou, China 06 - 10 Sep 2015 Wiley. https://doi.org/10.1002/ajh.24277

Platform delivery technologies for nutraceutical applications
Zariwala, M., Somavarapu, S., Evans, R.W., Farnaud, S. and Renshaw, D. 2015. Platform delivery technologies for nutraceutical applications. Vitafoods . Geneva, Switzerland 05 - 07 May 2015

Novel whey protein isolate nanocarriers for oral micronutrient delivery
Farnaud, S., Renshaw, D., Somavarapu, S. and Zariwala, M. 2015. Novel whey protein isolate nanocarriers for oral micronutrient delivery. 9th NIZO Dairy Conference Milk Protein Functionality . Papendal, Netherlands 30 Sep - 02 Oct 2015

Drug Delivery Approaches for Apigenin: A Review
Papay, Z.E., Balogh, E., Zariwala, M., Somavarapu, S. and Antal, I. 2015. Drug Delivery Approaches for Apigenin: A Review. in: Stacks, N.M. (ed.) Apigenin and Naringenin: Natural Sources, Pharmacology and Role in Cancer Prevention New York, USA Nova Science Publishers. pp. 1-20

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells
Mehta, K., Greenwell, P., Renshaw, D., Busbridge, Mark, Garcia, M, Farnaud, S. and Patel, V. B. 2015. Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells, Molecules, and Diseases. 55 (2), pp. 110-118. https://doi.org/10.1016/j.bcmd.2015.05.002

Acute hypoxia reduces plasma myostatin independent of hypoxic dose
Elliott, B., Simonson, T.S., Getting, S.J., Renshaw, D., Wagner Peter, D. and MacKenzie, R. 2015. Acute hypoxia reduces plasma myostatin independent of hypoxic dose. 8th International Conference on Cachexia, Sarcopenia and Muscle Wasting. Paris 04 - 06 Dec 2015 The Society on Sarcopenia, Cachexia and Wasting Disorders.

Formulation and characterization of curcumin loaded DQAsomes for pulmonary delivery
Zupancic, S., Kocbek, P., Kristl, J., Zariwala, M., Renshaw, D., Gul, M.O., Elsaid, Z., Taylor, K.M.G. and Somavarapu, S. 2014. Formulation and characterization of curcumin loaded DQAsomes for pulmonary delivery. 10th International Conference and Workshop on Biological Barriers. Saarbrücken 16 - 21 Feb 2014

Serum ferritin levels are correlated with total adiposity, but not BMI in obese males
Zariwala, M., Kosicka, A., MacKenzie, R. and Renshaw, D. 2014. Serum ferritin levels are correlated with total adiposity, but not BMI in obese males. Society for Endocrinology BES 2014. Liverpool, UK 24 - 27 Mar 2014 BioScientifica Ltd.. https://doi.org/10.1530/endoabs.34.P255

A human cell model of Parkinson’s disease confirms iron accumulation in dopaminergic neurons following 6-OHDOPA treatment
Zariwala, M. and Farnaud, S. 2014. A human cell model of Parkinson’s disease confirms iron accumulation in dopaminergic neurons following 6-OHDOPA treatment. European Iron Club Annual Meeting 2014. Verona, Italy 11 - 14 Sep 2014

Fabrication and characterization of novel hydrophobically modified chitosan nanoliposomes for oral iron delivery
Zariwala, M., Bendre, H., Markiv, A., Farnaud, S., Somavarapu, S. and Renshaw, D. 2014. Fabrication and characterization of novel hydrophobically modified chitosan nanoliposomes for oral iron delivery. European Iron Club Annual Meeting 2014. Verona, Italy 11 - 14 Sep 2014

Design and Development of Novel Mitochondrial Targeted
Zupančič, Š., Kocbek, P., Zariwala, M., Renshaw, D., Gul, M.O., Elsaid, Z., Taylor, K.M.G. and Somavarapu, S. 2014. Design and Development of Novel Mitochondrial Targeted. Molecular Pharmaceutics. 11 (7), pp. 2334-2345. https://doi.org/10.1021/mp500003q

Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo
Elliott, B., Renshaw, D., Getting, S.J., Watt, P.W. and MacKenzie, R. 2014. Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo. FASEB. San Diego Jul 2015 Federation of American Societies for Experimental Biology.

The role of acute hypoxia in skeletal muscle atrophy
Elliott, B., Renshaw, D., Getting, S.J., Watt, P., Howard, D. and MacKenzie, R. 2014. The role of acute hypoxia in skeletal muscle atrophy. Physiology. London 30 Jun 2014 The Physiological Society.

Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation
Zariwala, M.G., Farnaud, S., Merchant, Z., Somavarapu, S. and Renshaw, D. 2014. Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation. Colloids and Surfaces B: Biointerfaces. 115 (3), pp. 86-92. https://doi.org/10.1016/j.colsurfb.2013.11.028

A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles
Gulrez Zariwala, M., Elsaid, N., Jackson, T.L., Corral López, F., Farnaud, S., Somavarapu, S. and Renshaw, D. 2013. A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles. International Journal of Pharmaceutics. 456 (2), pp. 400-407. https://doi.org/10.1016/j.ijpharm.2013.08.070

Macronutrient regulation of PYY and DPPIV in human intestinal epithelial cells
Zariwala, M., Kosicka, A. and Renshaw, D. 2013. Macronutrient regulation of PYY and DPPIV in human intestinal epithelial cells. ENDO 2013: The Endocrine Society’s 95th Annual Meeting. San Francisco, USA 15 - 18 Jun 2013

Preparation and Characterisation of Solid Lipid Particles for Oral Iron Delivery
Zariwala, M., Farnaud, S., Somavarapu, S. and Renshaw, D. 2013. Preparation and Characterisation of Solid Lipid Particles for Oral Iron Delivery. Fifth Congress of the International BioIron Society (IBIS), Biennial World Meeting. University College London 14 - 18 Apr 2013 Wiley. https://doi.org/10.1002/ajh.23453

Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms
Mehta, K., Patel, V., Busbridge, M., Renshaw, D., Zariwala, M., Evans, R. and Farnaud, S. 2013. Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms. Fifth Congress of the International BioIron Society (IBIS), Biennial World Meeting. University College London 14 - 18 Apr 2013 Wiley. https://doi.org/10.1002/ajh.23453

Comparison Study of Oral Iron Preparations Using a Human Intestinal Model
Zariwala, M., Somavarapu, S., Farnaud, S. and Renshaw, D. 2013. Comparison Study of Oral Iron Preparations Using a Human Intestinal Model. Scientia Pharmaceutica. 81 (4), pp. 1123-1139. https://doi.org/10.3797/scipharm.1304-03

Attenuation of plasma annexin A1 in human obesity
Kosicka, A., Cunliffe, AD., MacKenzie, R., Zariwala, M., Perretti, M., Flower, R.J. and Renshaw, D. 2013. Attenuation of plasma annexin A1 in human obesity. FASEB Journal. 27 (1), pp. 1-11. https://doi.org/10.1096/fj.12-213728

Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms
Mehta, K., Patel, V., Busbridge Mark, Renshaw, D., Zariwala, M.G., Evans, R. and Farnaud, S. 2013. Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms. American Journal of Hematology. 88, p. E55.

Annexin-A1 protein and its relationship to cortisol in human saliva
Fowkes, R.C., Moradi-Bidhendi, N., Branceleone, V., Gulrez Zariwala, M., Brady, D., Jessop, D.S., Perretti, M., Renshaw, D. and Brancaleone, V. 2013. Annexin-A1 protein and its relationship to cortisol in human saliva. Psychoneuroendocrinology. 38 (5), pp. 722-727. https://doi.org/10.1016/j.psyneuen.2012.08.003

The transfer of iron between ceruloplasmin and transferrins
White, K.N., Conesa, C., Sánchez, L., Amini, M., Farnaud, S., Lorvoralaka, C. and Evans, R.W. 2012. The transfer of iron between ceruloplasmin and transferrins. Biochimica et Biophysica Acta: general subjects. 1820 (3), pp. 411-416. https://doi.org/10.1016/j.bbagen.2011.10.006

Increased transferrin-bound iron uptake in HepG2 cells is followed by an increase in expression of the iron hormone hepcidin pre-and post-translationally
Mehta, K., Patel, V., Busbridge Mark, Renshaw, D., Zariwala, M., Evans, R. and Farnaud, S. 2012. Increased transferrin-bound iron uptake in HepG2 cells is followed by an increase in expression of the iron hormone hepcidin pre-and post-translationally. European Iron Club Annual Meeting 2012. Rennes, France 29 - 31 Aug 2012

Comparison of iron absorption from iron supplement preparations using an in vitro Caco-2 model
Zariwala, M., Farnaud, S. and Renshaw, D. 2012. Comparison of iron absorption from iron supplement preparations using an in vitro Caco-2 model. European Iron Club Annual Meeting 2012. Rennes, France 29 - 31 Aug 2012

DPPIV and macronutrients regulate the expression of PYY3–36 in human gut epithelial cells
Kosicka, A., Renshaw, D. and Zariwala, M. 2012. DPPIV and macronutrients regulate the expression of PYY3–36 in human gut epithelial cells. Society for Endocrinology BES 2012. Harrogate, UK Mar - Apr 2012 BioScientifica Ltd.. https://doi.org/10.1530/endoabs.31.P197

Ac 2-26, an annexin A1-derived peptide, reduces inflammation in human SGBS adipocytes after hypoxia treatment
Kosicka-Knox, A., Cunliffe, A., Mackenzie, R., Zariwala, M. and Renshaw, D. 2012. Ac 2-26, an annexin A1-derived peptide, reduces inflammation in human SGBS adipocytes after hypoxia treatment. 15th International & 14th European Congress of Endocrinology. Florence, Italy 05 - 09 May 2012 BioScientifica Ltd..

Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes
Kosicka-Knox, A., Cunliffe, A., Mackenzie, R., Zariwala, M. and Renshaw, D. 2012. Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes. Society for Endocrinology BES 2012. Harrogate, UK Mar - Apr 2012

Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity
Holness, M.J., Zariwala, M., Walker, C.G. and Sugden, M.C. 2012. Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity. FEBS Open Bio. 2, pp. 32-36. https://doi.org/10.1016/j.fob.2012.02.003

The central role of myostatin in skeletal muscle and whole body homeostasis
Elliott, B., Renshaw, D., Getting, S.J. and MacKenzie, R. 2012. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica. 205 (3), pp. 324-40. https://doi.org/10.1111/j.1748-1716.2012.02423.x

Targeting the melanocortin receptor system for anti-stroke therapy
Holloway, P.M., Smith, H.K., Renshaw, D., Flower, R.J., Getting, S.J. and Gavins, F.N.E. 2011. Targeting the melanocortin receptor system for anti-stroke therapy. Trends in Pharmacological Sciences. 32 (2), pp. 90-98. https://doi.org/10.1016/j.tips.2010.11.010

Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
Rapisarda, C., Puppi, J., Hughes, R.D., Dhawan, A., Farnaud, S., Evans, R.W. and Sharp, P.A. 2010. Transferrin receptor 2 is crucial for iron sensing in human hepatocytes. American Journal of Physiology: Gastrointestinal and liver physiology. 299 (3), pp. G778-G783. https://doi.org/10.​1152/​ajpgi.​00157.​2010

Saliva: physiology and diagnostic potential in health and disease
Farnaud, S., Kosti, O., Getting, S.J. and Renshaw, D. 2010. Saliva: physiology and diagnostic potential in health and disease. ScientificWorldJournal. 10, pp. 434-456. https://doi.org/10.1100/tsw.2010.38

Changes in adipocyte circadian clock function via SRT1 and AMPK in programmed obesity
Caton, P.W., Zariwala, M., Holness, M.J. and Sugden, M.C. 2010. Changes in adipocyte circadian clock function via SRT1 and AMPK in programmed obesity. Diabetic Medicine. 27 (S1), pp. 1-36. https://doi.org/10.1111/j.1464-5491.2009.02935.x

Downstream gene activation of the receptor ALX by the agonist Annexin A1
Renshaw, D., Montero-Melendez, T., Dalli, J., Kamal, A., Brancaleone, V., D'Acquisto, F., Cirino, G. and Perretti, M. 2010. Downstream gene activation of the receptor ALX by the agonist Annexin A1. PLoS ONE. 5 (9) e12771. https://doi.org/10.1371/journal.pone.0012771

Opinion: Microdosing: safer clinical trials
Langley, G. and Farnaud, S. 2010. Opinion: Microdosing: safer clinical trials. Bioanalysis. 2 (3), pp. 393-395.

The Dr Hadwen Trust for humane research: 39 years of replacement science
Farnaud, S. 2009. The Dr Hadwen Trust for humane research: 39 years of replacement science. Alternatives to Laboratory Animals. 37 (S2), pp. 39-43.

The evolution of the three Rs
Farnaud, S. 2009. The evolution of the three Rs. Alternatives to Laboratory Animals. 37 (3), pp. 249-254.

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study
Tripatara, P., Patel, N.S.A., Brancaleone, V., Renshaw, D., Rocha, J., Sepodes, B., Mota-Filipe, H., Perretti, M. and Thiemermann, C. 2009. Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. European Journal of Pharmacology. 606 (1-3), pp. 205-209. https://doi.org/10.1016/j.ejphar.2009.01.041

PPARalpha deficiency impacts the regulation ofadipocyte leptin synthesis and secretion
Holness, M.J., Zariwala, M., Walker, C.G. and Sugden, M.C. 2009. PPARalpha deficiency impacts the regulation ofadipocyte leptin synthesis and secretion. Diabetic Medicine. 26 (S1), pp. 37-38. https://doi.org/10.1111/j.1464-5491.2009.02662.x

The molecular regulation of adipose-tissue gene expression by an early life intervention
Sugden, M.C., Zariwala, M., Nooristani, S. and Holness, M.J. 2009. The molecular regulation of adipose-tissue gene expression by an early life intervention. Diabetic Medicine. 26 (S1), pp. 37-38. https://doi.org/10.1111/j.1464-5491.2009.02662.x

PPARs and the orchestration of metabolic fuel selection
Sugden, M.C., Zariwala, M.G. and Holness, M.J. 2009. PPARs and the orchestration of metabolic fuel selection. Pharmacological Research. 60 (3), p. 141–150. https://doi.org/10.1016/j.phrs.2009.03.014

Melanocortin peptide therapy for the treatment of arthritic pathologies
Getting, S.J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, G., Patel, H.B., Kerrigan, M.J.P. and Locke, I.C. 2009. Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal. 9, pp. 1394-1414. https://doi.org/10.1100/tsw.2009.163

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles
Dalli, J., Norling, L.V., Renshaw, D., Cooper, D., Leung Kit-Y and Perretti, M. 2008. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood. 112 (6), pp. 2512-2519. https://doi.org/10.1182/blood-2008-02-140533

Identification of an iron-hepcidin complex
Farnaud, S., Rapisarda, C., Bui, T.T.T., Drake, A.F., Cammack, R. and Evans, R.W. 2008. Identification of an iron-hepcidin complex. Biochemical Journal. 413 (3), pp. 553-557. https://doi.org/10.1042/BJ20080406

Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies
Conesa, C., Sánchez, L., Rota, C., Pérez, M.D., Calvo, M., Farnaud, S. and Evans, R.W. 2008. Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies. Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology. 150 (1), pp. 131-139. https://doi.org/10.1016/j.cbpb.2008.02.005

The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes
Junkes, C., Wessolowski, A., Farnaud, S., Evans, R.W., Good, L., Bienert, M. and Dathe, M. 2008. The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes. Journal of Peptide Science. 14 (4), pp. 535-543. https://doi.org/10.1002/psc.940

Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins
Farnaud, S., Amini, M., Rapisarda, C., Cammack, R., Buic, T., Drake, A.F., Evans, R.W., Rahmanto, Y.S. and Richardson, D.R. 2008. Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins. International Journal of Biochemistry & Cell Biology. 40 (12), pp. 2739-2745. https://doi.org/10.1016/j.biocel.2008.07.003

Therapeutic exploitation of endogenous anti-inflammatory mechanisms: old and new leads
Renshaw, D., Urquhart, P. and Perretti, M. 2007. Therapeutic exploitation of endogenous anti-inflammatory mechanisms: old and new leads. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5 (4), pp. 289-305. https://doi.org/10.2174/187152306778772838

Prolactin in culture leads to a shift in stimulatory threshold but does not augment the K-ATP channel independent pathway for glucose-stimulated insulin secretion
Zariwala, M., Holness, M.J., Turner, M.D. and Sugden, M.C. 2007. Prolactin in culture leads to a shift in stimulatory threshold but does not augment the K-ATP channel independent pathway for glucose-stimulated insulin secretion. Diabetic Medicine. 24 (S1), p. 33. https://doi.org/10.1111/j.1464-5491.2007.02126.x

Enhancement of immune response of HBsAg loaded poly(L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan
Pandit, S., Cevher, E, Zariwala, M., Somavarapu, S. and Alpar, H.O. 2007. Enhancement of immune response of HBsAg loaded poly(L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan. Journal of Microencapsulation. 24 (6), p. 539–552. https://doi.org/10.1080/02652040701443700

Diet, obesity and diabetes: a current update
Walker, C.G., Zariwala, M.G., Holness, M.J. and Sugden, M.C. 2007. Diet, obesity and diabetes: a current update. Clinical Science. 112 (2), pp. 93-111. https://doi.org/10.1042/CS20060150

Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae
Sargent, P.J., Farnaud, S., Cammack, R., Zoller, H.M.P. and Evans, R.W. 2006. Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae. BioMetals. 19 (5), pp. 513-519. https://doi.org/10.1007/s10534-005-5532-6

Modelling of a metal-containing hepcidin
Farnaud, S., Patel, A. and Evans, R.W. 2006. Modelling of a metal-containing hepcidin. BioMetals. 19 (5), pp. 527-533. https://doi.org/10.1007/s10534-005-5883-z

Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells
Schwarz, N., Renshaw, D., Kapas, S. and Hinson, J.P. 2006. Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells. Journal of Endocrinology. 190 (2), pp. 505-514. https://doi.org/10.1677/joe.1.06806

Intra-adrenal mechanisms in the response to chronic stress: investigation in a rat model of emotionality
Kosti, O., Raven, P.W., Renshaw, D. and Hinson, J.P. 2006. Intra-adrenal mechanisms in the response to chronic stress: investigation in a rat model of emotionality. Journal of Endocrinology. 189 (2), pp. 211-218. https://doi.org/10.1677/joe.1.06638

Early protein restriction attenuates effects of increased age to suppress the response of adipose-tissue LPL activity to feeding
Zariwala, M., Holness, M.J. and Sugden, M.C. 2006. Early protein restriction attenuates effects of increased age to suppress the response of adipose-tissue LPL activity to feeding. Diabetic Medicine. 23 (S2), pp. 31-138. https://doi.org/10.1111/j.1466-5468.2006.01875.x

An overview of molecular aspects of iron metabolism
Syed, B.A., Sargent, P.J., Farnaud, S. and Evans, R.W. 2006. An overview of molecular aspects of iron metabolism. Hemoglobin. 30 (1), pp. 69-80. https://doi.org/10.1080/03630260500455318

Towards a tree-induction approach to antimicrobial activity analysis of cationic peptides
Farnaud, S., Wang, Z., Dybowski, R., Odell, E.W. and Evans, R.W. 2006. Towards a tree-induction approach to antimicrobial activity analysis of cationic peptides. Biochemistry and Cell Biology. 84 (3), p. 394. https://doi.org/10.1139/O06-900

Structure/function overview of proteins involved in iron storage and transport
Sargent, P.J., Farnaud, S. and Evans, R.W. 2005. Structure/function overview of proteins involved in iron storage and transport. Current Medicinal Chemistry. 12 (23), pp. 2683-2693. https://doi.org/10.2174/092986705774462969

Lactoferrin: the conductor of the immunological system?
Farnaud, S. and Evans, R.W. 2005. Lactoferrin: the conductor of the immunological system? in: Veskler, B.A. (ed.) New research on immunology New York Nova Science Publishers.

Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
Farnaud, S., Patel, A., Odell, E.W. and Evans, R.W. 2004. Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling. FEMS Microbiology Letters. 238 (1), pp. 221-226. https://doi.org/10.1111/j.1574-6968.2004.tb09759.x

The plug domain of a neisserial TonB-dependent transporter retains structural integrity in the absence of its transmembrane β-barrel
Oke, M., Sarra, R., Ghirlando, R., Farnaud, S., Gorringe, A.R., Evans, R.W. and Buchanan, S.K. 2004. The plug domain of a neisserial TonB-dependent transporter retains structural integrity in the absence of its transmembrane β-barrel. FEBS Letters. 564 (3), pp. 294-300. https://doi.org/10.1016/S0014-5793(04)00196-6

Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity
Farnaud, S., Spiller, C., Moriarty, L.C., Patel, A., Gant, V., Odell, E.W. and Evans, R.W. 2004. Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity. FEMS Microbiology Letters. 233 (2/29), pp. 193-199. https://doi.org/10.1111/j.1574-6968.2004.tb09482.x

Lactoferrin: a multifunctional protein with antimicrobial properties
Farnaud, S. and Evans, R.W. 2003. Lactoferrin: a multifunctional protein with antimicrobial properties. Molecular Immunology. 40 (7), pp. 395-405. https://doi.org/10.1016/S0161-5890(03)00152-4

Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity
Novo, C., Farnaud, S., Tata, R., Clemente, A. and Brown, P.R. 2002. Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity. Biochemical Journal. 365 (3), pp. 731-738. https://doi.org/10.1042/BJ20011714

Bacterial lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells
Vakharia, K., Renshaw, D. and Hinson, J.P. 2002. Bacterial lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells. Endocrine Research. 28 (4), pp. 357-361. https://doi.org/10.1081/ERC-120016809

Regulation of rat adrenal vasoactive intestinal peptide content: effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake
Hinson, J.P., Renshaw, D., Carroll, M. and Kapas, S. 2001. Regulation of rat adrenal vasoactive intestinal peptide content: effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake. Journal of Neuroendocrinology. 13 (9), pp. 769-773. https://doi.org/10.1046/j.1365-2826.2001.00692.x

Evidence that cysteine-166 is the active-site nucleophile of Pseudomonas aeruginosa amidase: crystallization and preliminary X-ray diffraction analysis of the enzyme
Farnaud, S., Tata, R., Sohi, M.K., Wan, T., Brown, P.R. and Sutton, B.J. 1999. Evidence that cysteine-166 is the active-site nucleophile of Pseudomonas aeruginosa amidase: crystallization and preliminary X-ray diffraction analysis of the enzyme. Biochemical Journal. 340 (3), pp. 711-714.