Diet, obesity and diabetes: a current update

Walker, C.G., Zariwala, M.G., Holness, M.J. and Sugden, M.C. 2007. Diet, obesity and diabetes: a current update. Clinical Science. 112 (2), pp. 93-111.

TitleDiet, obesity and diabetes: a current update
AuthorsWalker, C.G., Zariwala, M.G., Holness, M.J. and Sugden, M.C.
Abstract

The prevalence of obesity has been increasing at a rapid rate over the last few decades. Although the primary defect can be attributed to an imbalance of energy intake over energy expenditure, the regulation of energy balance is now recognized to be complex. Adipose-tissue factors play a central role in the control of energy balance and whole-body fuel homoeostasis. The regulation of adipose-tissue function, in particular its secretion of adipokines, is impaired by increases in adipose mass associated with obesity, and with the development of insulin resistance and Type 2 diabetes. This review analyses adipose-regulated energy input and expenditure, together with the impact of dietary macronutrient composition on energy balance in relation to susceptibility to the development of obesity and Type 2 diabetes, and how these metabolic conditions may be exacerbated by the consequences of abnormal adipose function. By gaining a greater understanding of how energy balance is controlled in normal, and in obese and diabetic states, a more practical approach can be employed to prevent and better treat obesity and metabolic disorders.

Keywordsadipokine
adipose-tissue nutrient transport
diabetes
dietary composition
insulin resistance
obesity
JournalClinical Science
Journal citation112 (2), pp. 93-111
ISSN0143-5221
Year2007
PublisherPortland Press
Digital Object Identifier (DOI)doi:10.1042/CS20060150
Publication dates
Published01 Jan 2007

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