PPARs and the orchestration of metabolic fuel selection

Sugden, M.C., Zariwala, M.G. and Holness, M.J. 2009. PPARs and the orchestration of metabolic fuel selection. Pharmacological Research. 60 (3), p. 141–150.

TitlePPARs and the orchestration of metabolic fuel selection
AuthorsSugden, M.C., Zariwala, M.G. and Holness, M.J.
Abstract

This contribution describes recent advances in our knowledge of the regulatory interactions between the two major oxidative fuels glucose and lipid. It also addresses how the metabolic abnormalities associated with insulin resistance and ischemic diseases impair the ability of skeletal muscle to switch between the use of alternative metabolic fuels and the ability of adipose tissue to function appropriately in relation to the body's requirements for triglyceride mobilisation or storage, as appropriate to nutritional status. We discuss how targeting PPARs might ameliorate metabolic inflexibility in muscle through altered expression of pyruvate dehydrogenase kinase (PDK) isoforms and impact the functions of the adipocyte in lipid buffering and energy homeostasis. Focus has been placed on the participation of the regulatory pyruvate dehydrogenase kinases, PPAR targets, both in the beneficial and the potentially adverse actions of the PPARs in metabolic control.

KeywordsPyruvate dehydrogenase kinase
Metabolic inflexibility
Lipid buffering
Skeletal muscle
Adipose tissue
JournalPharmacological Research
Journal citation60 (3), p. 141–150
ISSN1043-6618
Year2009
PublisherElsevier
Digital Object Identifier (DOI)doi:10.1016/j.phrs.2009.03.014
Publication dates
Published02 Apr 2009

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