Title | Alcoholic liver disease: Current insights into cellular mechanisms |
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Type | Journal article |
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Authors | Petagine, Lucy, Zariwala, Mohammed Gulrez and Patel, V. |
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Abstract | Alcoholic liver disease (ALD) due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality. Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of ALD is widely recognized, the precise triggers for disease progression are still to be fully elucidated. Oxidative stress, mitochondrial dysfunction, gut dysbiosis and altered immune system response plays an important role in disease pathogenesis, triggering the activation of inflammatory pathways and apoptosis. Despite many recent clinical studies treatment options for ALD are limited, especially at the alcoholic hepatitis stage. We have therefore reviewed some of the key pathways involved in the pathogenesis of ALD and highlighted current trials for treating patients. [Abstract copyright: ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.] |
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Keywords | Liver |
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| Alcohol |
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| Mitochondria |
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| Inflammation |
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| Oxidative stress |
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| Gut microbiome |
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Journal | World Journal of Biological Chemistry |
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Journal citation | 12 (5), pp. 87-103 |
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ISSN | 1949-8454 |
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Year | 2021 |
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Publisher | Baishideng Publishing Group |
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Publisher's version | License CC BY-NC 4.0 File Access Level Open (open metadata and files) |
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Digital Object Identifier (DOI) | https://doi.org/10.4331/wjbc.v12.i5.87 |
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PubMed ID | 34630912 |
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Publication dates |
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Published | 27 Sep 2021 |
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