Title | Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments. |
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Type | Journal article |
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Authors | Petagine, Lucy, Zariwala, Mohammed Gulrez and Patel, Vinood B |
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Abstract | Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility. We have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity, lipotoxicity and fibrogenesis, and highlighted current trials and treatment options for NAFLD patients. [Abstract copyright: ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.] |
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Keywords | Inflammation |
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| Liver |
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| Mitochondria |
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| Fat |
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| Non-alcoholic Fatty Liver Disease - therapy |
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| Hepatocytes |
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| Humans |
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| Immune system |
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| Adaptive Immunity |
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| Global Burden of Disease |
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| Disease Progression |
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Journal | World Journal of Gastroenterology |
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Journal citation | 29 (32), pp. 4831-4850 |
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ISSN | 2219-2840 |
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Year | 2023 |
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Publisher | Baishideng Publishing Group |
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Publisher's version | License CC BY-NC 4.0 File Access Level Open (open metadata and files) |
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Digital Object Identifier (DOI) | https://doi.org/10.3748/wjg.v29.i32.4831 |
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PubMed ID | 37701135 |
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Publication dates |
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Published in print | 28 Aug 2023 |
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