Alcohol Metabolism: General Aspects

Ghazali, R. and Patel, V.B. 2015. Alcohol Metabolism: General Aspects. in: Patel, V.B. (ed.) Molecular Aspects of Alcohol and Nutrition Academic Press.

Chapter titleAlcohol Metabolism: General Aspects
AuthorsGhazali, R. and Patel, V.B.
EditorsPatel, V.B.
Abstract

Alcoholism is a major health problem worldwide with potentially deleterious genetic consequences. Various genes influence the risk of alcoholism, some of which predispose the person to alcohol cravings and others that become altered after excessive alcohol consumption through up- or down-regulation of their expression. In this chapter, an overview of the role of a number of genes will be discussed, including neurotransmitter genes such as the brain serotonin genes, genes believed to be involved in foetal alcohol syndrome such as the Goosecoid (GSC) gene, and the dopamine receptor D2 gene (DRD2), which indicates a correlation between sweet preference and alcoholism. Cirrhosis of the liver is one of the main manifestations of alcoholism. However, bone marrow stem cell infusion is a potentially promising therapy due to the ability of bone marrow cells to proliferate into hepatocytes such as positive CD34 stem cells. In conclusion, more research and study are required to uncover novel genes that can either help in treating alcoholism or be used as analytical markers to predict the vulnerability of a person to alcoholism.

KeywordsAlcoholism
brain serotonin genes
foetal alcohol syndrome genes
sweet preference
stem cell therapy
genetic risks
Book titleMolecular Aspects of Alcohol and Nutrition
Year2015
PublisherAcademic Press
Publication dates
Published06 Nov 2015
ISBN9780128007730

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