High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells

Ghazali, R., Mehta, K., Bligh, S.W.A., Tewfik, I., Clemens, D.L. and Patel, V.B. 2020. High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. World Journal of Hepatology. 12 (3), pp. 84-98. https://doi.org/10.4254/wjh.v12.i3.84

TitleHigh omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells
TypeJournal article
AuthorsGhazali, R.
Mehta, K.
Bligh, S.W.A.
Tewfik, I.
Clemens, D.L.
Patel, V.B.
Abstract

Background
Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to ROS-mediated damage, perhaps leading to mitochondrial dysfunction. Therefore, these parameters were investigated to understand their contribution to NAFLD development.

Aim
To examine the effect of increasing ratios of omega-6:3 fatty acids on mitochondrial function and lipid metabolism mediators.

Methods
HepG2-derived VL-17A cells were treated with normal (1:1, 4:1) and high (15:1, 25:1) ratios of omega-6: omega-3 fatty acids (arachidonic (AA): docosahexaenoic (DHA)) at various time points. Mitochondrial activity and function was examined via MTT assay and Seahorse XF24 analyzer, respectively. Triglyceride accumulation was determined by using EnzyChrom™ and levels of ROS were measured by fluorescence intensity. Protein expression of the mediators of lipogenic, lipolytic and endocannabinoid pathways was assessed by Western blotting.

Results
High AA:DHA ratio decreased mitochondrial activity (p<0.01; upto 80%) and promoted intracellular triglyceride accumulation (p<0.05; 40-70%). Mechanistically, it altered the mediators of lipid metabolism; increased the expression of stearoyl-CoA desaturase (p<0.05; 22-35%), decreased the expression of peroxisome proliferator-activated receptor-alpha (p<0.05; 30-40%) and increased the expression of cannabinoid receptor 1 (p<0.05; 31%). Furthermore, the high ratio increased ROS production (p<0.01; 74-115%) and reduced mitochondrial respiratory functions such as basal and maximal respiration, ATP production, spare respiratory capacity and proton leak (p<0.01; 35-68%).

Conclusion
High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD development.

KeywordsNon alcoholic fatty liver disease; Lipogenesis, Omega fatty acids; Mitochondrial dysfunction; Reactive oxygen species, Oxidative stress
JournalWorld Journal of Hepatology
Journal citation12 (3), pp. 84-98
ISSN1948-5182
Year2020
PublisherBaishideng Publishing Group
Accepted author manuscript
File Access Level
Open (open metadata and files)
Publisher's version
License
CC BY-NC 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.4254/wjh.v12.i3.84
Web address (URL)https://www.f6publishing.com/ArticleInPressDetail?id=53546
Publication dates
Published27 Mar 2020
Supplemental file
File Access Level
Open (open metadata and files)

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Al-Joufi, F., El-Bana, M., Tewfik, I. and Anwar, M. 2018. Efficacy of co-supplementation therapy with vitamins B9, B12, and D on endothelial dysfunction in streptozotocin-induced diabetic rats. Asian Journal of Pharmaceutical and Clinical Research . 11 (9), pp. 407-410. https://doi.org/10.22159/ajpcr.2018.v11i9.25361

Appraising the Effects of Physical Activity Interventions on Risk Factors of Cardiovascular Diseases and Obesity: A Systematic Review
Sum, K. and Tewfik, I. 2018. Appraising the Effects of Physical Activity Interventions on Risk Factors of Cardiovascular Diseases and Obesity: A Systematic Review. International Journal of Food, Nutrition and Public Health. 10 (1), pp. 40-77. https://doi.org/10.47556/J.IJFNPH.10.1.2018.4

Evaluation of a photographic food atlas as a tool for quantifying food portion size in the United Arab Emirates
Ali, H., Platat, C., El Mesmoudi, N., El Sadig, M. and Tewfik, I. 2018. Evaluation of a photographic food atlas as a tool for quantifying food portion size in the United Arab Emirates. PLoS ONE. 13 (4) e0196389. https://doi.org/10.1371/journal.pone.0196389

Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease
Riva, A., Patel, V., Kurioka, A., Jeffery, H.C., Wright, G., Tarff, S., Shawcross, D., Ryan, J.M., Evans, A., Azarian, S., Bajaj, J.S., Fagan, A., Patel, V., Mehta, K., Lopez, C., Simonova, M., Katzarov, K., Hadzhiolova, T., Pavlova, S., Wendon, J.A., Oo, Y.T., Klenerman, P., Williams, R. and Chokshi, S. 2018. Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease. Gut. 67 (5), pp. 918-930. https://doi.org/10.1136/gutjnl-2017-314458

Evaluation of plasma neurotransmitters in children living with Attention-Deficit Hyperactivity Disorder (ADHD)
Meguid, N., Anwar, M., Hussein, J., Hasan, H., Hashish, A., Seleet, F., Foda, M. and Tewfik, I. 2018. Evaluation of plasma neurotransmitters in children living with Attention-Deficit Hyperactivity Disorder (ADHD). Bioscience Research. 15 (1), pp. 152-159.

Iron enhances hepatic fibrogenesis and activates TGF-β signaling in murine hepatic stellate cells
Mehta, K.J., Coombes, J.D., Briones-Orta, M., Manka, P.P., Williams, R., Patel, V.B. and Sin, W.-K. 2018. Iron enhances hepatic fibrogenesis and activates TGF-β signaling in murine hepatic stellate cells. American Journal of the Medical Sciences. 355 (2), pp. 183-190. https://doi.org/10.1016/j.amjms.2017.08.012

Dietary fibre regimen to modulate weight management: a pilot intervention based on fibre rich fruit-mix (FRFM)
Khawandanah, J. and Tewfik, I. 2017. Dietary fibre regimen to modulate weight management: a pilot intervention based on fibre rich fruit-mix (FRFM). International Journal of Food, Nutrition and Public Health. 9 (2), pp. 67-79.

The effect of silymarin on chondrocytes
Can, V.C., Abouelnour, A., Locke, I.C., Bligh, S.W.A. and Getting, S.J. 2017. The effect of silymarin on chondrocytes. ICMAN/ IUPHAR Natural Products. Aberdeen, Scotland 27 - 29 Sep 2017 Elsevier. https://doi.org/10.1016/j.bcp.2017.06.036

Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol
Ghazali, R. 2017. Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol. PhD thesis University of Westminster Biomedical Sciences https://doi.org/10.34737/q5vv0

Faecal Calprotectin and a Twenty-Four-Parameter Questionnaire in Autistic Children with Gastrointestinal Symptoms
Bramati-castellarin, I., Patel, V.B. and Drysdale, I.P. 2017. Faecal Calprotectin and a Twenty-Four-Parameter Questionnaire in Autistic Children with Gastrointestinal Symptoms. SM Journal of Psychiatry & Mental Health. 2 (1), p. 1009 1009.

HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication
Mehta, K., Farnaud, S. and Patel, V.B. 2017. HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication. Molecular Biology Reports. 44 (5), pp. 399-403. https://doi.org/10.1007/s11033-017-4123-2

Alcohol metabolism: implications for nutrution and health
Patel, V.B. and Preedy, V.R. 2017. Alcohol metabolism: implications for nutrution and health. in: Geissler, C. and Powers, H. (ed.) Human Nutrition, 13th Edition Oxford Oxford University Press. pp. 216-235

Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’
Henley, A., Yang L., Chuang K-L., Sahuri Arisoylu, M., Wu, L-H., Bligh, S.W.A. and Bell, J.D. 2017. Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’. PLoS ONE. 12 (1) e0170917. https://doi.org/10.1371/journal.pone.0170917

Core-sheath nanofibers as drug delivery system for thermoresponsive controlled release
Lv, Y., Pan, Q., Bligh, S.W.A., Li, H., Wu, H, Sang, Qingqing and Zhu, Li-Min 2017. Core-sheath nanofibers as drug delivery system for thermoresponsive controlled release. Journal of Pharmaceutical Sciences. 106 (5), pp. 1258-1265. https://doi.org/10.1016/j.xphs.2016.12.031

Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity
Usman, M., Tewfik, I. and Volpi, E. 2017. Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity. International Journal of Food, Nutrition and Public Health. 9 (1), pp. 1-12.

A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India
Kapoor, N., Naufahu, J., Tewfik, S., Bhatnagar, S., Garg, R. and Tewfik, I. 2017. A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India. Integrative Cancer Therapies. 6 (1), pp. 74-84. https://doi.org/10.1177/1534735416651968

Fad Diets: Lifestyle Promises and Health Challenges
Khawandanah, Jomana and Tewfik, Ihab 2016. Fad Diets: Lifestyle Promises and Health Challenges. Journal of Food Research. 5 (6), pp. 80-94. https://doi.org/10.5539/jfr.v5n6p80

Palliative Nutritional Care for Cancer Patients
Kapoor, Neha, Garg, Rakesh and Tewfik, Ihab 2016. Palliative Nutritional Care for Cancer Patients. Palliative Medicine and Hospice Care. 1 (3), pp. e1-e6. https://doi.org/10.17140/PMHCOJ1-e002

Iron enhances hepatic fibrogenesis through TGF-β activation
Mehta, K., Briones-Orta, M., Manka P., Coombes, J.D., Williams, R., Patel, V.B. and Syn, W-K. 2016. Iron enhances hepatic fibrogenesis through TGF-β activation. Hepatology. 64 (1 suppl), p. 360A. https://doi.org/10.1002/hep.28797

Risk Factors for Maternal Vitamin D Deficiency within the United Arab Emirates
Hussein, I., Taha, Z., Tewfik, I., Badawi, S., Siddieg, H., Adegboye, A.R. and McGrady, K. 2016. Risk Factors for Maternal Vitamin D Deficiency within the United Arab Emirates. Journal of Pregnancy and Child Health. 3 (5), p. 1000276 1000276. https://doi.org/10.4172/2376-127X.1000276

Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique
Wang, D., Qi, M., Yang, Q., Tong, R, Wang, R, Bligh, S.W.A., Yang, L. and Wang, Z. 2016. Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique. Journal of Separation Science. 39 (10), pp. 1842-1852. https://doi.org/10.1002/jssc.201501149

Theranostic Fibers for Simultaneous Imaging and Drug Delivery
Bligh, S.W.A., Williams, G.R., Yu, D.G., Jin, M. and Geraldes, C. 2016. Theranostic Fibers for Simultaneous Imaging and Drug Delivery. Molecular Pharmaceutics. 13 (7), pp. 2457-2465. https://doi.org/10.1021/acs.molpharmaceut.6b00197

Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells
Mehta, K., Busbridge, Mark, Renshaw, D., Evans, R.W., Farnaud, S. and Patel, V. 2016. Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells. Blood Cells, Molecules, and Diseases. 61, pp. 37-45. https://doi.org/10.1016/j.bcmd.2016.06.008

A comparative study: long and short term effect of a nutrition sensitive approach to delay the progression of HIV to AIDS among people living with HIV (PLWH) in Nigeria
Amlogu, A., Tewfik, S., Wambebe, C. and Tewfik, I. 2016. A comparative study: long and short term effect of a nutrition sensitive approach to delay the progression of HIV to AIDS among people living with HIV (PLWH) in Nigeria. Functional Foods in Health and Disease. 6 (2), pp. 79-90.

Repeat-measures longitudinal study evaluating behavioural and gastrointestinal symptoms in children with autism before, during and after visceral osteopathic technique (VOT)
Bramati-Castellarin, I., Patel, V. and Drysdale, I.P. 2016. Repeat-measures longitudinal study evaluating behavioural and gastrointestinal symptoms in children with autism before, during and after visceral osteopathic technique (VOT). Journal of Bodywork and Movement Therapies. 20 (3), pp. 461-470. https://doi.org/10.1016/j.jbmt.2016.01.001

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process
Bligh, S.W.A., Yang, C., Yu, D.G., Pan, D., Liu, X.-K., Wang, X. and Williams, G.R. 2016. Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process. Acta Biomaterialia. 35, pp. 77-86. https://doi.org/10.1016/j.actbio.2016.02.029

Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI
Bligh, S.W.A., Jin, M., Yu, D.G., Wang, X., Geraldes, C.F.G.C. and Williams, G.R. 2016. Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI. Advanced Healthcare Materials. 5 (8), pp. 977-985. https://doi.org/10.1002/adhm.201500872

Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret
Bligh, S.W.A., Yu, D.G., Shen, C.Y., Jin, M., Williams, G.R., Zou, H. and Wang, X. 2016. Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret. Colloids and Surfaces B: Biointerfaces. 138, p. 110–116. https://doi.org/doi:10.1016/j.colsurfb.2015.11.055

Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents
Bligh, S.W.A., Jin, M., Spillane, D.E.M., Geraldes, C.F.G.C. and Williams, G.R. 2016. Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents. Solid State Sciences. 53, p. 9–16. https://doi.org/10.1016/j.solidstatesciences.2015.12.024.

Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide
Bligh, S.W.A., Lv, Y., Tao, L., Yang, H., Pan, Q. and Zhua, L. 2016. Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide. Materials Science and Engineering: C. 59, p. 652–660. https://doi.org/10.1016/j.msec.2015.10.065

Dietary Patterns of Children with Autism Spectrum Disorder: A Study Based in Egypt
Meguid, N., Anwar, M., Zaki, S., Kandeel, W., Ahmed, N. and Tewfik, I. 2015. Dietary Patterns of Children with Autism Spectrum Disorder: A Study Based in Egypt. Open Access Macedonian Journal of Medical Sciences. 3 (2), pp. 262-267. https://doi.org/10.3889/oamjms.2015.051

Betaine: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus)
Patel, V.B and Preedy, V.R. Patel, V.B. and Preedy, V.R. (ed.) 2015. Betaine: Chemistry, Analysis, Function and Effects (Food and Nutritional Components in Focus). Royal Society of Chemistry.

Molecular effects of alcohol on iron metabolism
Mehta, K., Farnaud, S. and Patel, V.B. 2015. Molecular effects of alcohol on iron metabolism . in: Patel, V.B. (ed.) Molecular Aspects of Alcohol and Nutrition Academic Press.

Alcohol Metabolism: General Aspects
Ghazali, R. and Patel, V.B. 2015. Alcohol Metabolism: General Aspects. in: Patel, V.B. (ed.) Molecular Aspects of Alcohol and Nutrition Academic Press.

Biomarkers in Health and Disease: Further Knowledge
Rajendram, R., Rajendram, R., Patel, V.B. and Preedy, V.R. 2015. Biomarkers in Health and Disease: Further Knowledge. in: Preedy, V.R. and Patel, V.B. (ed.) General Methods in Biomarker Research and their Applications Netherlands Springer. pp. 1311-1316

Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity
Hull, J., Patel, V.B., El Hindy, M., Hezwani, M., Love, S., Kehoe, P.G., Chalmers, C. and Conway, M.E. 2015. Regional Increase in the Expression of the BCAT Proteins in Alzheimer's Disease Brain: Implications in Glutamate Toxicity. Journal of Alzheimer's Disease. 45 (3), pp. 891-905. https://doi.org/10.3233/JAD-142970

New insights into the role of the branched-chain aminotransferase proteins in the human brain
Hull, J., Patel, V.B., Hutson, S.M. and Conway, M.E. 2015. New insights into the role of the branched-chain aminotransferase proteins in the human brain. Journal of Neuroscience Research. 93, pp. 987-998. https://doi.org/10.1002/jnr.23558

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells
Mehta, K., Greenwell, P., Renshaw, D., Busbridge, Mark, Garcia, M, Farnaud, S. and Patel, V. B. 2015. Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells. Blood Cells, Molecules, and Diseases. 55 (2), pp. 110-118. https://doi.org/10.1016/j.bcmd.2015.05.002

Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents
Bligh, S.W.A., Jin, M., Spillane, D.E.M., Geraldes, C.F.G.C. and Williams, G.R. 2015. Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents. Dalton Transactions: The International Journal for Inorganic, Organometallic and Bioinorganic Chemistry. 44 (47), pp. 20728-20734. https://doi.org/10.1039/C5DT03433G

Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems
Yu, D.G., Wang, X., Li, X.-Y., Yang, J.-H., Bligh, S.W.A. and Williams, G.R. 2015. Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems. ACS Applied Materials & Interfaces. 7 (33), p. 18891–18897. https://doi.org/10.1021/acsami.5b06007

A thin-layer chromatography-bioautographic method for detecting dipeptidyl peptidase IV inhibitors in plants
Bligh, S.W.A., Gu, L.-H., Liao, L.P., Hu, H.J., Wang, C.-H., Chou, G.-X. and Wang, Z.T. 2015. A thin-layer chromatography-bioautographic method for detecting dipeptidyl peptidase IV inhibitors in plants. Journal of Chromatography A. 1411 (11), p. 116–122. https://doi.org/10.1016/j.chroma.2015.07.123

Structure-inhibition relationship of phenylethanoid glycosides on angiotensin-converting enzyme using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry
Bligh, S.W.A., Li, P., Qi, M., Hu, H., Liu, Q., Yang, Q., Wang, D., Guo, F., Wang, Z. and Yang, L. 2015. Structure-inhibition relationship of phenylethanoid glycosides on angiotensin-converting enzyme using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry. RSC Advances. 5 (64), pp. 51701-51707. https://doi.org/10.1039/C5RA05027H

Electrospun medicated shellac nanofibers for colon-targeted drug delivery
Wang, X., Yu, D.G., Li, X.-Y., Bligh, S.W.A. and Williams, G.R. 2015. Electrospun medicated shellac nanofibers for colon-targeted drug delivery. International Journal of Pharmaceutics. 490 (1-2), pp. 384-390. https://doi.org/doi:10.1016/j.ijpharm.2015.05.077

Molecularly imprinted polymer based on MWCNTs-QDs as fluorescent biomimetic sensor for specific recognition of target protein
Ding, X., Tao, L., Quan, J., Nie, H., Gong, X., Bligh, S.W.A. and Limin, Z. 2015. Molecularly imprinted polymer based on MWCNTs-QDs as fluorescent biomimetic sensor for specific recognition of target protein. Materials Science and Engineering C. 48, pp. 469-479. https://doi.org/10.1016/j.msec.2014.12.032

Betaine, in context
Mehta, K. and Patel, V. 2015. Betaine, in context. in: Preedy, V.R. (ed.) Betaine: chemistry, analysis, function and effects Royal Society of Chemistry.

A public health nutrition intervention to delay the progression of cachexia to refractory cachexia in Indian female cancer patients: A conceptual framework
Kapoor, N., Naufahu, J., Tewfik, S., Bhatnagar, S., Garg, R. and Tewfik, I. 2014. A public health nutrition intervention to delay the progression of cachexia to refractory cachexia in Indian female cancer patients: A conceptual framework. International Journal of Food, Nutrition and Public Health. 7 (1), pp. 1-11.

Therapeutic antioxidant activity of monascus-fermented durian seed: a potential functional food ingredient, Ignatius Srianta, Ira Nugerahani, Netty Kusumawati, Elisabet Suryatanijaya, Christine Subianto, Sundus Tewfik and Ihab Tewfik
Srianta I., Nugerahani, I., Kusumawati, N., Suryatanijaya, E., Subianto, C., Tewfik S. and Tewfik, I. 2014. Therapeutic antioxidant activity of monascus-fermented durian seed: a potential functional food ingredient, Ignatius Srianta, Ira Nugerahani, Netty Kusumawati, Elisabet Suryatanijaya, Christine Subianto, Sundus Tewfik and Ihab Tewfik. International Journal of Food, Nutrition and Public Health. 7 (1), pp. 53-59.

Physical activity delivered in workplace: A pilot study to assess the health outcomes among employees at work
Hammarberg, E., Papp, R., Gaywood, A., Ferraroli, J. and Tewfik, I. 2014. Physical activity delivered in workplace: A pilot study to assess the health outcomes among employees at work. International Journal of Food, Nutrition and Public Health. 7 (1), pp. 41-52.

Tailored Functional Recipe (TFR) Approach to Delay the Progression of HIV to AIDS among People Living with HIV (PLWH) in Abuja, Nigeria
Amlogu, A., Tewfik, S., Wambebe C., Godden, K. and Tewfik, I. 2014. Tailored Functional Recipe (TFR) Approach to Delay the Progression of HIV to AIDS among People Living with HIV (PLWH) in Abuja, Nigeria. Pharmacology & Pharmacy. 5 (10), pp. 926-936. https://doi.org/10.4236/pp.2014.510104

The impact of tailored nutrition intervention and dietary counseling on body weight in female cancer cachexia patients in India
Kapoor, N., Naufahu, J., Tewfik, S., Bhatnagar, S., Gargand, R. and Tewfik, I. 2014. The impact of tailored nutrition intervention and dietary counseling on body weight in female cancer cachexia patients in India. Journal of Clinical Oncology. 32 (31), p. 67. https://doi.org/10.1200/jco.2014.32.31_suppl.67

Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization
Sun, K., Bligh, S.W.A., Nie, H.L., Quan, J. and Zhu, L.M. 2014. Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization. RSC Advances. 4, pp. 34912-34921. https://doi.org/10.1039/C4RA04874A

A RG-II type polysaccharide purified from Aconitum coreanum and their anti-inflammatory activity
Li Xiaojun, Jiang Jiaye, Shi, S.S., Li Yuan, Jiang Yongbo, Huang Dan Ke Yan, Wang, S.C., Bligh, S.W.A. and Ke, Yan 2014. A RG-II type polysaccharide purified from Aconitum coreanum and their anti-inflammatory activity. PLoS ONE. 9 (6) e99697. https://doi.org/10.1371/journal.pone.0099697

Cardiovascular disease in aging and the role of oxidative stress
Alzaid, F., Patel, V. and Preedy, V.R. 2014. Cardiovascular disease in aging and the role of oxidative stress. in: Preedy, V.R. (ed.) Aging: oxidative stress and dietary antioxidants Academic Press. pp. 23-36

Quinolone alkaloids from fructus euodiae show activity against methicillin-resistant staphylococcus aureus
Pan, X., Bligh, S.W.A. and Smith, E. 2014. Quinolone alkaloids from fructus euodiae show activity against methicillin-resistant staphylococcus aureus. Phytotherapy Research. 28 (2), pp. 305-307. https://doi.org/10.1002/ptr.4987

Metabolic profiles of 20(S)-protopanaxadiol in rats after oral administration using ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry
He, C., Li, J., Wang, R., Li, Z., Bligh, S.W.A., Yang, L. and Wang, Z. 2014. Metabolic profiles of 20(S)-protopanaxadiol in rats after oral administration using ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 28 (6), pp. 595-604. https://doi.org/10.1002/rcm.6813

American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2014. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytotherapy Research. 28 (5), pp. 692-698. https://doi.org/10.1002/ptr.5044

Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives
Fan, H., Liu, F., Bligh, S.W.A., Shi, S.S. and Wang, S.C. 2014. Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives. Carbohydrate Polymers. 105, pp. 152-160. https://doi.org/10.1016/j.carbpol.2014.01.084

Characterization of two immunomodulating homogalacturonan pectins from green tea
Wang, H., Wei, G., Liu, F., Banerjee, G., Joshi, M., Bligh, S.W.A., Shi, S.S., Lian, H., Fan, H., Gu, X. and Wang, S.C. 2014. Characterization of two immunomodulating homogalacturonan pectins from green tea. International Journal of Molecular Sciences. 15 (6), pp. 9963-9978. https://doi.org/10.3390/ijms15069963

The branched-chain aminotransferase proteins: novel redox chaperones for protein disulfide isomerase: implications in Alzheimer’s disease
Conway, M.E., El Hindy, M., Hezwani, M., Hull, J., Corry, D., Mansbridge, A., Hassler, M., Patel, V., Kehoe, P.G., Love, S., Harris, M., Forshaw, T., Lee, C.S., El Amraoui, F. and Wilson, A. 2014. The branched-chain aminotransferase proteins: novel redox chaperones for protein disulfide isomerase: implications in Alzheimer’s disease. Antioxidants and Redox Signaling. 20 (16), pp. 2497-2513. https://doi.org/10.1089/ars.2012.4869

Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid
Cui, L., Liu, Z., Yu, D.G., Zhang, S.P., Bligh, S.W.A. and Zhao, N. 2014. Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid. Colloid and Polymer Science. 292 (9), pp. 2089-2096. https://doi.org/10.1007/s00396-014-3226-8

Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core
Machakanur, S.S., Patil, B.R., Naik, G.N., Bakale, R.P., Bligh, S.W.A. and Gudasi, K.B. 2014. Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core. Inorganica Chimica Acta. 421, pp. 459-464. https://doi.org/10.1016/j.ica.2014.06.040

Characterization of metabolites of sweroside in rat urine using ultra-high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and NMR spectroscopy
Han, H., Zeng, W., He, C., Bligh, S.W.A., Liu, Q., Yang, L. and Wang, Z. 2014. Characterization of metabolites of sweroside in rat urine using ultra-high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and NMR spectroscopy. Journal of Mass Spectrometry. 49 (11), pp. 1108-1116. https://doi.org/10.1002/jms.3429

Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2013. Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products. Journal of Herbal Medicine. 3 (2), pp. 57-64. https://doi.org/10.1016/j.hermed.2013.02.001

Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease
Wardle, N.J., Hudson, H.R., Matthews, R.W., Nunn, C., Vella, C. and Bligh, S.W.A. 2013. Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease. ChemMedChem. 8 (5), pp. 719-721. https://doi.org/10.1002/cmdc.201300051

Public Health Nutrition Intervention Programme to Attenuate the Progression of HIV to AIDS among People Living with HIV (PLWH) in Abuja, Nigeria: A Conceptual Framework
Amlogu, A., Godden, K., Tewfik, I., Tewfik, S. and Wambebe, C. 2013. Public Health Nutrition Intervention Programme to Attenuate the Progression of HIV to AIDS among People Living with HIV (PLWH) in Abuja, Nigeria: A Conceptual Framework. International Journal of Food, Nutrition and Public Health. 6 (1), pp. 83-98.

The impact of dietary and lifestyle factors on the risk of dental caries among young children in Qatar
Bener, A., Al Darwish, Mohammed S., Tewfik, I. and Hoffmann, Georg F. 2013. The impact of dietary and lifestyle factors on the risk of dental caries among young children in Qatar. Journal of the Egyptian Public Health Association. 88 (2), pp. 67-73. https://doi.org/10.1097/01.EPX.0000430962.70261.8e

Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms
Mehta, K., Patel, V., Busbridge, M., Renshaw, D., Zariwala, M., Evans, R. and Farnaud, S. 2013. Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms. Fifth Congress of the International BioIron Society (IBIS), Biennial World Meeting. University College London 14 - 18 Apr 2013 Wiley. https://doi.org/10.1002/ajh.23453

Dual drug release nanocomposites prepared using a combination of electrospraying and electrospinning
Yu, D.G., Williams, G.R., Wang, X., Liu, X.-K., Li, H.L. and Bligh, S.W.A. 2013. Dual drug release nanocomposites prepared using a combination of electrospraying and electrospinning. RSC Advances. 2013 (3), pp. 4652-4658. https://doi.org/10.1039/C3RA40334C

Coaxial electrospinning using a concentric Teflon spinneret to prepare biphasic-release nanofibers of helicid
Yu, D.G., Liu, F., Cui, L., Liu, Z., Wang, X. and Bligh, S.W.A. 2013. Coaxial electrospinning using a concentric Teflon spinneret to prepare biphasic-release nanofibers of helicid. RSC Advances. OnlineFirst. https://doi.org/10.1039/C3RA43222J

Interlinking diet, nutrition, menopause and recommended resources
Rajendram, R., Rajendram, R., Patel, V. and Preedy, V.R. 2013. Interlinking diet, nutrition, menopause and recommended resources. in: Hollins Martin, C.J., Watson, R.R. and Preedy, V.R. (ed.) Nutrition and diet in menopause Springer. pp. 451-456

Effect of Salvia miltiorrhiza on antioxidant enzymes in diabetic patients
Quan, Q., Quan, S. and Patel, V. 2013. Effect of Salvia miltiorrhiza on antioxidant enzymes in diabetic patients. in: Preedy, V.R. (ed.) Diabetes: oxidative stress and dietary antioxidants Academic Press. pp. 79-87

Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms
Mehta, K., Patel, V., Busbridge Mark, Renshaw, D., Zariwala, M.G., Evans, R. and Farnaud, S. 2013. Hepcidin transcription and peptide secretion are governed by different regulatory mechanisms. American Journal of Hematology. 88, p. E55.

The role of cancer stem cells in osteosarcoma
Jenks, A., Smith, C.L., Patel, V. and Clements, M.O. 2013. The role of cancer stem cells in osteosarcoma. International society for stem cell research conference. Boston (Massachusetts, USA) June 12 – 15 2013

Damaging effect of free fatty acids and alcohol on hepatic mitochondrial function
Gyamfi, D., Clemens, D.L. and Patel, V. 2013. Damaging effect of free fatty acids and alcohol on hepatic mitochondrial function. Alcohol & Alcoholism. 48, pp. i48-i50.

Sensitized terbium(III) macrocyclic-phthalimide complexes as luminescent pH switches
Chen, G., Wardle, N.J., Sarris, J.L., Chatterton, N.P. and Bligh, S.W.A. 2013. Sensitized terbium(III) macrocyclic-phthalimide complexes as luminescent pH switches. Dalton Transactions. OnlineFirst. https://doi.org/10.1039/C3DT51236C

Evaluation of behavioural and gastrointestinal symptoms in autistic children after visceral osteopathic treatment
Castellarin, I.B., Drysdale, I. and Patel, V. 2013. Evaluation of behavioural and gastrointestinal symptoms in autistic children after visceral osteopathic treatment. International Journal of Osteopathy. 16, pp. e13-e14.

Flavonoids by HPLC
Bligh, S.W.A., Ogegbo, O. and Wang, Z. 2013. Flavonoids by HPLC. in: Ramawat, K.G. and Merillon, J.M. (ed.) Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes Berlin Springer. pp. 2107-2144

Hepatic mitochondrial dysfunction induced by fatty acids and ethanol
Gyamfi, D., Everitt, H.E., Tewfik, I., Clemens, D.L. and Patel, V. 2012. Hepatic mitochondrial dysfunction induced by fatty acids and ethanol. Free Radical Biology & Medicine. 53 (11), pp. 2131-2145. https://doi.org/10.1016/j.freeradbiomed.2012.09.024

Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy
Zhao, T., Zheng, S.S., Zhang, B.F., Li, Y.Y., Bligh, S.W.A., Wang, C.-H. and Wang, Z. 2012. Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy. Food Chemistry. 134 (2), pp. 1096-1105. https://doi.org/10.1016/j.foodchem.2012.03.024

Chemotaxonomically significant roburic acid from section cruciata of gentiana
Wu, L.H., Bligh, S.W.A., Leon, C., Li, X.S., Wang, Z., Branford-White, C.J. and Simmonds, M.S.J. 2012. Chemotaxonomically significant roburic acid from section cruciata of gentiana. Biochemical Systematics and Ecology. 43, pp. 152-155. https://doi.org/10.1016/j.bse.2012.03.008

The use of Scutellaria lateriflora: a pilot survey amongst herbal medicine practitioners
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2012. The use of Scutellaria lateriflora: a pilot survey amongst herbal medicine practitioners. Journal of Herbal Medicine. 2 (2), pp. 34-41. https://doi.org/10.1016/j.hermed.2012.04.005,

Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles
Yeh, J.C., Garrard, I.J., Cho, C.W.C., Bligh, S.W.A., Lu, G.H., Fan, T.P. and Fisher, D. 2012. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. Journal of Chromatography A. 1236, pp. 132-138. https://doi.org/10.1016/j.chroma.2012.03.013

Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill
Yuan, J., Wang, Y., An, R., Wang, S., Li, S.J., Jia, J.Y., Bligh, S.W.A., Wang, X.H. and Ma, Y.M. 2012. Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill. Journal of Chromatography B: Biomedical Sciences and Applications. 895-896, pp. 154-161. https://doi.org/10.1016/j.jchromb.2012.03.036

Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells
Pan, X., Hartley, J.M., Hartley, J.A., White, K.N., Wang, Z. and Bligh, S.W.A. 2012. Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. Phytomedicine. 19 (7), pp. 618-624. https://doi.org/10.1016/j.phymed.2012.02.003

Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones
Machakanur, S.S., Patil, B.R., Badiger, D.S., Bakale, R.P., Gudasi, K.B. and Bligh, S.W.A. 2012. Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones. Journal of Molecular Structure. 1011, pp. 121-127. https://doi.org/10.1016/j.molstruc.2011.12.023

Coaxial electrospinning with sodium dodecylbenzene sulfonate solution for high quality polyacrylonitrile nanofibers
Yu, D.G., Williams, G.R., Gao, L.D., Bligh, S.W.A., Yang, J.-H. and Wang, X. 2012. Coaxial electrospinning with sodium dodecylbenzene sulfonate solution for high quality polyacrylonitrile nanofibers. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 396, pp. 161-168. https://doi.org/10.1016/j.colsurfa.2011.12.063

Tailored food recipes-TFR: employing the European perspective
Amlogu, A., Godden, K., Tewfik, S., Wambebe, C. and Tewfik, I. 2012. Tailored food recipes-TFR: employing the European perspective. International Journal of Food, Nutrition and Public Health. 5 (1/2/3), pp. 3-18.

Increased transferrin-bound iron uptake in HepG2 cells is followed by an increase in expression of the iron hormone hepcidin pre-and post-translationally
Mehta, K., Patel, V., Busbridge Mark, Renshaw, D., Zariwala, M., Evans, R. and Farnaud, S. 2012. Increased transferrin-bound iron uptake in HepG2 cells is followed by an increase in expression of the iron hormone hepcidin pre-and post-translationally. European Iron Club Annual Meeting 2012. Rennes, France 29 - 31 Aug 2012

Metabolomics of four TCM herbal products: application of HPTLC analysis
Ogegbo, O., Eyob, S., Parmar, S., Wang, Z. and Bligh, S.W.A. 2012. Metabolomics of four TCM herbal products: application of HPTLC analysis. Analytical Methods. 4, pp. 2522-2527. https://doi.org/10.1039/C2AY25373A

Synthesis of novel tri-arm star shaped 1,3,5-triazine hydrazones from 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine core
Machakanur, S.S., Patil, B.R., Badiger, D.S., Pathan, A.H., Gudasi, K.B. and Bligh, S.W.A. 2012. Synthesis of novel tri-arm star shaped 1,3,5-triazine hydrazones from 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine core. Letters in Organic Chemistry. 9 (1), pp. 29-34. https://doi.org/10.2174/157017812799304051

N-Heterocyclic dronic acids: applications and synthesis
Hudson, H.R., Wardle, N.J., Bligh, S.W.A., Greiner, I., Grun, A. and Keglevich, G. 2012. N-Heterocyclic dronic acids: applications and synthesis. Minireviews in Medicinal Chemistry. 12, pp. 313-325.

Chinese herbal products in the prevention and treatment of liver disease
Gyamfi, D., Everitt, H.E. and Patel, V. 2012. Chinese herbal products in the prevention and treatment of liver disease. in: Watson, R.R. and Preedy, V.R. (ed.) Bioactive food as dietary interventions for liver and gastrointestinal disease Academic Press. pp. 537-550

Quantification of norisoboldine in Linderae Radix by ultra-performance liquid chromatography and high performance liquid chromatography with UV detection
Chen, J.Z., Chou, G.-X., Yang, L., Bligh, S.W.A. and Wang, Z. 2012. Quantification of norisoboldine in Linderae Radix by ultra-performance liquid chromatography and high performance liquid chromatography with UV detection. Journal of Liquid Chromatography and Related Technologies. 35 (6), pp. 788-797. https://doi.org/10.1080/10826076.2011.608236

A chemically unlocked binary molecular switch
Chen, G., Sarris, J.L., Wardle, N.J., Bligh, S.W.A. and Chatterton, N.P. 2012. A chemically unlocked binary molecular switch. Chemical Communications. 48 (72), pp. 9026-9028. https://doi.org/10.1039/C2CC34425D

Dietary sugars: TLC screening of sugars in urine and blood samples
Alonso-Fernandez, J.R. and Patel, V. 2012. Dietary sugars: TLC screening of sugars in urine and blood samples. in: Preedy, V.R. (ed.) Dietary sugars: chemistry, analysis, function and effects Royal Society of Chemistry. pp. 186-205

Urinary 1H-NMR metabonomics study on intervention effects of soya milk in Africans
Ogegbo, O., Dissanyake, W., Crowder, J., Asekun, O., Familoni, O., Branford-White, C.J. and Bligh, S.W.A. 2012. Urinary 1H-NMR metabonomics study on intervention effects of soya milk in Africans. Phytotherapy Research. 26 (1), pp. 127-135. https://doi.org/10.1002/ptr.3547

Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes
Cooke, B.R., Bligh, S.W.A., Cybulski, Z.R., Ioannides, C. and Hall, M. 2012. Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes. Drug Metabolism and Disposition. 40 (1), pp. 70-75. https://doi.org/10.1124/dmd.111.041566

Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
Han, H., Yang, L., Xu, Y., Ding, Y., Bligh, S.W.A., Zhang, T. and Wang, Z. 2011. Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 25 (21), pp. 3339-3350. https://doi.org/10.1002/rcm.5216

1H NMR study of monocrotaline and its metabolites in human blood
Yang, Y.C., Crowder, J., Wardle, N.J., Yang, L., White, K.N., Wang, Z. and Bligh, S.W.A. 2011. 1H NMR study of monocrotaline and its metabolites in human blood. Food and Chemical Toxicology. 49 (11), pp. 2793-2799. https://doi.org/10.1016/j.fct.2011.07.063

Hexa-arm star shaped hydrazone derivatives from hexakis(4-formylphenoxy)-cyclotriphosphazene core
Patil, B.R., Machakanur, S.S., Badiger, D.S., Hunoor, R.S., Gudasi, K.B., Nethaji, M. and Bligh, S.W.A. 2011. Hexa-arm star shaped hydrazone derivatives from hexakis(4-formylphenoxy)-cyclotriphosphazene core. Journal of Molecular Structure. 1003 (1-3), pp. 52-61. https://doi.org/10.1016/j.molstruc.2011.07.020

Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features
Wardle, N.J., Kalber, T., Bell, J.D. and Bligh, S.W.A. 2011. Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features. Bioorganic and Medicinal Chemistry Letters. 21 (11), pp. 3346-3348. https://doi.org/10.1016/j.bmcl.2011.04.014

Improving polymer nanofiber quality using a modified co-axial electrospinning process
Yu, D.G., Branford-White, C.J., Bligh, S.W.A., White, K.N., Chatterton, N.P. and Zhu, L.M. 2011. Improving polymer nanofiber quality using a modified co-axial electrospinning process. Macromolecular Rapid Communications. 32 (9-10), pp. 744-750. https://doi.org/10.1002/marc.201100049

Obesity and low vision as a result of excessive internet use, and television viewing
Bener, A., Al-Mahdi, H.S., Ali, A.I., Al-Nufal, M., Vachhani, P.J. and Tewfik, I. 2011. Obesity and low vision as a result of excessive internet use, and television viewing. International Journal of Food Sciences and Nutrition. 62 (1), pp. 60-62. https://doi.org/10.3109/09637486.2010.495711

Artificial trans fatty acids in food supply: A global health threat
Salomaa V.K. and Tewfik, I. 2011. Artificial trans fatty acids in food supply: A global health threat. World Journal of Science, Technology and Sustainable Development. 8 (4), pp. 361-401. https://doi.org/10.1108/20425945201100017

Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticles
Yu, D.G., Zhu, L.M., Bligh, S.W.A., Branford-White, C.J. and White, K.N. 2011. Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticles. Chemical Communications. 47 (4), pp. 1216-1218. https://doi.org/10.1039/C0CC03521A

Self-assembled liposomes from amphiphilic electrospun nanofibers
Yu, D.G., Branford-White, C.J., Williams, G.R., Bligh, S.W.A., White, K.N., Zhu, L.M. and Chatterton, N.P. 2011. Self-assembled liposomes from amphiphilic electrospun nanofibers. Soft matter. 7, pp. 8239-8247. https://doi.org/10.1039/C1SM05961K

Globesity in action: systematic review and pilot intervention to assess the potential health benefit of moderate physical activity
Salah, M. and Tewfik, I. 2011. Globesity in action: systematic review and pilot intervention to assess the potential health benefit of moderate physical activity. in: Ahmed, A. and Busler, M. (ed.) World sustainable development outlook 2011. Sharing knowledge, making a difference: the role of international scientific cooperation World Association for Sustainable Development (WASD).

Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives
Patil, B.R., Machakanur, S.S., Hunoor, R.S., Badiger, D.S., Gudasi, K.B. and Bligh, S.W.A. 2011. Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives. Der Pharma Chemica. 3 (4), pp. 377-388.

Alterations to liver energy metabolism and cell death following alcohol exposure
Gyamfi, D., Clemens, D.L. and Patel, V. 2011. Alterations to liver energy metabolism and cell death following alcohol exposure. Alcohol & Alcoholism. 46, pp. p47-48.

Conceptual framework of public health-nutrition intervention programme to attenuate the progression of HIV to AIDS among people living with HIV (PLWH) in Abuja, Nigeria
Amlogu, M.A., Tewfik, S., Wambebe, C., Godden, K. and Tewfik, I. 2011. Conceptual framework of public health-nutrition intervention programme to attenuate the progression of HIV to AIDS among people living with HIV (PLWH) in Abuja, Nigeria. in: Ahmed, A. and Busler, M. (ed.) World sustainable development outlook 2011. Sharing knowledge, making a difference: the role of international scientific cooperation World Association for Sustainable Development (WASD). pp. 11-20

Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy
Chen, J.Z., Chou, G.-X., Wang, C.-H., Yang, L., Bligh, S.W.A. and Wang, Z. 2010. Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 52 (5), pp. 687-693. https://doi.org/10.1016/j.jpba.2010.02.008

Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography–circular dichroism analysis
Zhu, J.-J., Zhang, C.-F., Zhang, M., Bligh, S.W.A., Yang, L., Wang, Z.-M. and Wang, Z. 2010. Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography–circular dichroism analysis. Journal of Chromatography A. 1217 (33), pp. 5384-5388. https://doi.org/10.1016/j.chroma.2010.05.039

American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety?
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2010. American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety? British Journal of Wellbeing. 1 (4), pp. 25-30.

O-phosphotyrosine analogues: aynthesis and therapeutic role in modulation of signal transduction
Wardle, N.J., Hudson, H.R. and Bligh, S.W.A. 2010. O-phosphotyrosine analogues: aynthesis and therapeutic role in modulation of signal transduction. Current Organic Chemistry. 14 (5), pp. 426-446. https://doi.org/10.2174/138527210790601189

Is Africa facing a nutrition transition under the double burden of disease?
Tewfik, I., Bener, A. and Tewfik, S. 2010. Is Africa facing a nutrition transition under the double burden of disease? in: Ahmed, A. and Nwankwo, S. (ed.) Achieving sustainable development in Africa: science, technology & innovation trajectory London World Association for Sustainable Development (WASD).

Apoptosis in alcoholic liver disease
Gyamfi, D., Everitt, H.E. and Patel, V. 2010. Apoptosis in alcoholic liver disease. in: Preedy, V.R. (ed.) Apoptosis: modern insights into disease from molecules to man Science Publishers. pp. 211-233

The effect of alcohol exposure on liver energy metabolism and cell death
Gyamfi, D., Clemens, D.L. and Patel, V. 2010. The effect of alcohol exposure on liver energy metabolism and cell death. Hepatology. 52, p. 455A.

Treatment with qing'e, a kidney-invigorating chinese herbal formula, antagonizes the estrogen decline in ovariectomized mice
Xu, Y., Zhang, Z.J., Geng, F., Su, S.B., White, K.N., Bligh, S.W.A., Branford-White, C.J. and Wang, Z. 2010. Treatment with qing'e, a kidney-invigorating chinese herbal formula, antagonizes the estrogen decline in ovariectomized mice. Rejuvenation Research. 13 (4), pp. 479-488. https://doi.org/10.1089/rej.2009.1000

Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry
Xiong, A., Yang, L., He, Y.Q., Zhang, F., Wang, J., Han, H., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2009. Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry. 23 (24), pp. 3907-3916. https://doi.org/10.1002/rcm.4329

Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction
Wang, Y., Kong, L., Lei, X., Hu, L., Zou, H., Welbeck, E., Bligh, S.W.A. and Wang, Z. 2009. Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction. Journal of Chromatography A. 1216 (11), pp. 2185-2191. https://doi.org/10.1016/j.chroma.2008.05.074

S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-Nitrosation and S-Thiolation
Coles, S.J., Easton, P., Sharrod, H., Hutson, S.M., Hancock, J., Patel, V. and Conway, M.E. 2009. S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-Nitrosation and S-Thiolation. Biochemistry. 48 (3), pp. 645-656. https://doi.org/10.1021/bi801805h

Preparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles
Yu, D.G., Shen, X.X., Zhu, L.M., Branford-White, C.J., Bligh, S.W.A. and Yang, Y.C. 2009. Preparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles. in: ICBBE 2009: 3rd international conference on bioinformatics and biomedical engineering IEEE .

Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers
Yu, D.G., Shen, X.X., Branford-White, C.J., White, K.N., Zhu, L.M. and Bligh, S.W.A. 2009. Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers. Nanotechnology. 20 (5), p. 055104. https://doi.org/10.1088/0957-4484/20/5/055104

Presentation of the beta-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PR
Wardle, N.J., Hudson, H.R., Matthews, R.W., Nunn, C., Vella, C. and Bligh, S.W.A. 2009. Presentation of the beta-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PR. Letters in Drug Design and Discovery. 6, pp. 139-145.

Childhood obesity prevention in Emirates (COPE): a conceptual framework for pilot intervention
Tewfik, I., Mackenzie, J., Cunliffe, A., Al-Dhaheri, A., Ali, H., Washi, S. and Platat, C. 2009. Childhood obesity prevention in Emirates (COPE): a conceptual framework for pilot intervention. in: Ahmed, A. (ed.) World sustainable development outlook: the impact of the global financial crisis on the environment, energy and sustainable development 2009 London World Association for Sustainable Development (WASD).

Nutritional quality of deep fried street-vended foods: a public health concern
Tewfik, I., Ismail, H. and Tewfik, S. 2009. Nutritional quality of deep fried street-vended foods: a public health concern. in: Ahmed, A. (ed.) World sustainable development outlook: the impact of the global financial crisis on the environment, energy and sustainable development 2009 London World Association for Sustainable Development (WASD).

Liver metabolism: biochemical and molecular regulations
Gyamfi, D. and Patel, V. 2009. Liver metabolism: biochemical and molecular regulations. in: Preedy, V.R. (ed.) Nutrition, diet therapy, and the liver London CRC Press. pp. 3-15

Hepatic oxidative stress and apoptosis following acute alcohol
Everitt, H.E., Tewfik, I., Preedy, V.R. and Patel, V. 2009. Hepatic oxidative stress and apoptosis following acute alcohol. Alcohol & Alcoholism. 44, p. p85.

Assessment of shelf-life of irradiated frozen chicken
Alnasser, M.A., Park, S.F., Jenesson, P. and Tewfik, I. 2009. Assessment of shelf-life of irradiated frozen chicken. International Journal of Food Safety, Nutrition and Public Health. 2 (1), pp. 48-58. https://doi.org/10.1504/IJFSNPH.2009.026918

Would it still be possible to identify irradiated lipid-containing foods towards the end of their shelf-life?
Tewfik, I. and Tewfik, S. 2008. Would it still be possible to identify irradiated lipid-containing foods towards the end of their shelf-life? Food Science and Technology International. 14 (6), pp. 519-524. https://doi.org/10.1177/1082013208100465

Extraction and identification of cyclobutanones from irradiated cheese employing a rapid direct solvent extraction method
Tewfik, I. 2008. Extraction and identification of cyclobutanones from irradiated cheese employing a rapid direct solvent extraction method. International Journal of Food Sciences and Nutrition. 59 (7 & 8), pp. 590-598. https://doi.org/10.1080/09637480701515450

Cytotoxic sesquiterpenes from Ligularia platyglossa
Liu, J.Q., Zhang, M., Zhang, C.-F., Qi, H.Y., Bashall, A., Bligh, S.W.A. and Wang, Z. 2008. Cytotoxic sesquiterpenes from Ligularia platyglossa. Phytochemistry. 69 (11), pp. 2231-2236. https://doi.org/10.1016/j.phytochem.2008.05.018

Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection
Wang, Y., Yang, L., He, Y.Q., Wang, C.-H., Welbeck, E., Bligh, S.W.A. and Wang, Z. 2008. Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection. Rapid Communications in Mass Spectrometry. 22 (12), pp. 1767-1778. https://doi.org/10.1002/rcm.3536

Inter-laboratory trial to validate the direct solvent extraction method for the identification of 2-dodecylcyclobutanone in irradiated chicken and whole liquid egg
Tewfik, I. 2008. Inter-laboratory trial to validate the direct solvent extraction method for the identification of 2-dodecylcyclobutanone in irradiated chicken and whole liquid egg. Food Science and Technology International. 14 (3), pp. 277-283. https://doi.org/10.1177/1082013208095689

Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas?
Bener, A., Hoffmann, G.F., Afify, Z., Rasul, K., Mian, M., Guiter, G. and Tewfik, I. 2008. Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas? Minerva Pediatrica. 60 (2), pp. 155-161.

Research Student Supervision: Developing Reflective Practice in Higher Education
Tewfik, I. 2008. Research Student Supervision: Developing Reflective Practice in Higher Education. in: Ahmed, Allam (ed.) World Sustainable Development Outlook 2008: Managing Science and Technology for a Sustainable Future Routledge. pp. 85-92

Tomatoes: origin, cultivation techniques, and germplasm resources
da Silva, D.J.H., Abreu, F.B., Caliman, F.R.B., Antonio, A.C. and Patel, V. 2008. Tomatoes: origin, cultivation techniques, and germplasm resources. in: Preedy, V.R. and Watson, R.R. (ed.) Tomatoes and tomato products: nutritional, medicinal and therapeutic properties CRC Press. pp. 3-26

High performance liquid chromatography-ion trap mass spectrometric analysis for metabolites of isoline in rat urine and bile
Zhang, F., Zhong, D.F., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2008. High performance liquid chromatography-ion trap mass spectrometric analysis for metabolites of isoline in rat urine and bile. Drug Metabolism Reviews. 40, p. 216.

Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens
Zhang, F., Wang, C.-H., Wang, W., Chen, L.X., Ma, H.Y., Zhang, C.-F., Zhang, M., Bligh, S.W.A. and Wang, Z. 2008. Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens. Phytochemical Analysis. 19 (1), pp. 25-31. https://doi.org/10.1002/pca.1009

Organophosphorus compounds: intervention in mechanisms of signal transduction relevant to proliferative, immunological and circulatory disorders
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2008. Organophosphorus compounds: intervention in mechanisms of signal transduction relevant to proliferative, immunological and circulatory disorders. Current Medicinal Chemistry. 15, pp. 2230-2257.

Sulfated beta-glucan derived from oat bran with potent anti-HIV activity
Wang, S.C., Bligh, S.W.A., Zhu, C.L., Shi, S.S., Wang, Z., Hu, Z.B., Crowder, J., Branford-White, C.J. and Vella, C. 2008. Sulfated beta-glucan derived from oat bran with potent anti-HIV activity. Journal of Agricultural and Food Chemistry. 56 (8), pp. 2624-2629. https://doi.org/10.1021/jf072888h

Nutraceuticals, functional foods and botanical dietary supplements; promote wellbeing and underpin public health
Tewfik, S. and Tewfik, I. 2008. Nutraceuticals, functional foods and botanical dietary supplements; promote wellbeing and underpin public health. World Review of Science, Technology and Sustainable Development. 5 (2), pp. 104-123. https://doi.org/10.1504/WRSTSD.2008.018552

Childhood obesity prevention (CHOP) programme: a conceptual framework for nutrition intervention
Tewfik, I. 2008. Childhood obesity prevention (CHOP) programme: a conceptual framework for nutrition intervention. International Journal of Food Safety, Nutrition and Public Health. 1 (1), pp. 16-32. https://doi.org/10.1504/IJFSNPH.2008.018853

Metabolic Syndrome and its components among Qatari population
Musallam, M., Bener, A., Zirie, M., Al-Gaud, Y.K., Al-Hamaq, A.A., Othman, M.A. and Tewfik, I. 2008. Metabolic Syndrome and its components among Qatari population. International Journal of Food Safety, Nutrition and Public Health. 1 (1), pp. 88-102. https://doi.org/10.1504/IJFSNPH.2008.018858

Impact of lifestyle and dietary habits on hypovitaminosis D in type 1 diabetes mellitus and healthy children from Qatar, a sun-rich country
Bener, A., Alsaied, A., Al-Ali, M., Hassan, A.S., Basha, B., Al-Kubaisi, A., Abraham, A., Mian, M., Guiter, G., Tewfik, I. and Agha, M. 2008. Impact of lifestyle and dietary habits on hypovitaminosis D in type 1 diabetes mellitus and healthy children from Qatar, a sun-rich country. Annals of Nutrition and Metabolism. 53 (3-4), pp. 215-222. https://doi.org/10.1159/000184439

A rapid direct solvent extraction (DSE) method for the extraction of cyclobutanones from irradiated chicken and liquid whole egg
Tewfik, I. 2008. A rapid direct solvent extraction (DSE) method for the extraction of cyclobutanones from irradiated chicken and liquid whole egg. International Journal of Food Science and Technology. 43 (1), pp. 108-113. https://doi.org/10.1111/j.1365-2621.2006.01399.x

Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography
Zhang, F., Wang, C.-H., Xiong, A., Wang, W., Yang, L., Branford-White, C.J., Wang, Z. and Bligh, S.W.A. 2007. Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography. Analytica Chimica Acta. 605 (1), pp. 94-101. https://doi.org/10.1016/j.aca.2007.10.021

Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography
Wang, Y., Kong, L., Hu, L., Lei, X., Yang, L., Chou, G.-X., Zou, H., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2007. Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. Journal of Chromatography B: Biomedical Sciences and Applications. 860 (2), pp. 185-194. https://doi.org/10.1016/j.jchromb.2007.10.027

Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3methylglutaryl (HMG-CoA) synthase
Patel, V., Spencer, C.H., Young, T.A., Lively, M.O. and Cunningham, C.C. 2007. Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3methylglutaryl (HMG-CoA) synthase. Free Radical Biology and Medicine. 43 (11), pp. 1499-1507. https://doi.org/10.1016/j.freeradbiomed.2007.08.004

Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina
Wang, S.C., Bligh, S.W.A., Shi, S.S., Wang, Z., Hu, Z.B., Crowder, J., Branford-White, C.J. and Vella, C. 2007. Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina. International Journal of Biological Macromolecules. 41 (4), pp. 369-375. https://doi.org/10.1016/j.ijbiomac.2007.05.008

Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone
Wang, C.-H., Cheng, X.M., He, Y.Q., White, K.N., Bligh, S.W.A., Branford-White, C.J. and Wang, Z. 2007. Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone. Archives of pharmacal research. 30 (9), pp. 1149-1154. https://doi.org/10.1007/BF02980251

Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone
Wang, C.-H., Cheng, X.M., Bligh, S.W.A., White, K.N., Branford-White, C.J. and Wang, Z. 2007. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone. Journal of Pharmaceutical and Biomedical Analysis. 44 (5), pp. 1113-1117. https://doi.org/10.1016/j.jpba.2007.04.036

Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex
Wardle, N.J., Herlihy, A.H., So, P.W., Bell, J.D. and Bligh, S.W.A. 2007. Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex. Bioorganic & medicinal chemistry. 15 (14), pp. 4714-4721. https://doi.org/10.1016/j.bmc.2007.05.004

High-performance liquid chromatography-diode array detection/electrospray ionization mass spectrometry for the simultaneous analysis of cis-, trans- and dihydro-2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants
Yang, L., Nakamura, N., Hattori, M., Wang, Z., Bligh, S.W.A. and Xu, L. 2007. High-performance liquid chromatography-diode array detection/electrospray ionization mass spectrometry for the simultaneous analysis of cis-, trans- and dihydro-2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants. Rapid Communications in Mass Spectrometry. 21 (12), pp. 1833-1840. https://doi.org/10.1002/rcm.3025

Nutrition and alcoholic liver disease
Everitt, H.E., Patel, V. and Tewfik, I. 2007. Nutrition and alcoholic liver disease. Nutrition Bulletin. 32 (2), pp. 138-144. https://doi.org/10.1111/j.1467-3010.2007.00627.x

Nutrition and alcoholic liver disease
Everitt, H.E., Patel, V.B. and Tewfik, I. 2007. Nutrition and alcoholic liver disease. Nutrition Bulletin. 32 (2), pp. 138-144. https://doi.org/10.1111/j.1467-3010.2007.00627

Research Supervision: Training, process and experience
Tewfik, I. and Tewfik, S. 2007. Research Supervision: Training, process and experience. in: World Sustainable Development Outlook 2007: Knowledge Management and Sustainable Development in the 21st Century Routledge.

Plasma 5-HT And Fatigue During Endurance Cycle Exercise: Effects Of Exercise Intensity And Duration
Vleck, Veronica E., Asensio, Karine, Tewfik, Ihab, Webb, Heather, McNaughton, Lars, Lowry, Christopher and Bentley, David J. 2007. Plasma 5-HT And Fatigue During Endurance Cycle Exercise: Effects Of Exercise Intensity And Duration. Medicine & Science in Sports & Exercise. 39 (5), p. S273. https://doi.org/10.1249/01.mss.0000274050.00286.a9

ω-Phosphinyl-α-amino acids: synthesis, and development towards use as therapeutic agents
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2007. ω-Phosphinyl-α-amino acids: synthesis, and development towards use as therapeutic agents. Current Organic Chemistry. 11 (18), pp. 1635-1651. https://doi.org/10.2174/138527207783221200

The public health advocate: food irradiation's offer to food security
Tewfik, I. and Tewfik, S. 2007. The public health advocate: food irradiation's offer to food security. in: Ahmed, A. (ed.) Science, technology and sustainability in the Middle East and North Africa Genève InderScience. pp. 197-209

Competitive food safety program: the case of Qatar
Al-Hamaq, A.A., Zeyadah, S.S., Ahmed, A., Amuna, P. and Tewfik, I. 2007. Competitive food safety program: the case of Qatar. in: Ahmed, A. (ed.) Science, technology and sustainability in the Middle East and North Africa Genève InderScience. pp. 210-228

Book review: B. Freire Wilma (editor). Nutrition and an Active Life: From Knowledge to Action. Scientific and Technical Publication No. 612. Washington DC: Pan American Health Organization 2005. US$ 36·00 (paperback) pp. 260. ISBN: 92 75 11612 1
Tewfik, I. 2006. Book review: B. Freire Wilma (editor). Nutrition and an Active Life: From Knowledge to Action. Scientific and Technical Publication No. 612. Washington DC: Pan American Health Organization 2005. US$ 36·00 (paperback) pp. 260. ISBN: 92 75 11612 1. British Journal of Nutrition. 96 (4), p. 793. https://doi.org/10.1079/BJN20061844

Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes
Gudasi, K.B., Patil, S., Vadavi, R.S., Shenoy, R.V., Nethaji, M. and Bligh, S.W.A. 2006. Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes. Inorganica Chimica Acta. 359 (10), pp. 3229-3236. https://doi.org/10.1016/j.ica.2006.03.009

A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities
Yang, L., Qin, L.H., Bligh, S.W.A., Bashall, A., Zhang, C.-F., Zhang, M., Wang, Z. and Xu, L. 2006. A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities. Bioorganic & medicinal chemistry. 14 (10), pp. 3496-3501. https://doi.org/10.1016/j.bmc.2006.01.004

Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population
Bener, A. and Tewfik, I. 2006. Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population. Obesity Reviews. 7 (2), pp. 139-145. https://doi.org/10.1111/j.1467-789X.2006.00209.x

Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population
Bener, A. and Tewfik, I. 2006. Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population. Obesity Reviews. 7 (2), pp. 139-145. https://doi.org/10.1111/j.1467-789X.2006.00209.x

Industrial and dietetic applications of the food multimix (FMM) concept in meeting the nutritional needs of vulnerable groups in South Africa
Zotor, F., Amuna, P., Oldewage-Theron, W.H., Adewuya, T., Prinsloo, G., Chinyanga, Y., Tewfik, I. and Amuna, N. 2006. Industrial and dietetic applications of the food multimix (FMM) concept in meeting the nutritional needs of vulnerable groups in South Africa. Academic Journal of Vaal University of Technology. 3, pp. 54-67.

Phytoestrogen levels in selected Jamaican food
Simon, G., McFarlane-Anderson, N., Fletcher, H., Golden, K., Wharfe, G., Ogegbo, O., Bligh, S.W.A. and Branford-White, C.J. 2006. Phytoestrogen levels in selected Jamaican food. West Indian Medical Journal. 55, p. 24.

CO2 photoassimilation, chlorophyll fluorescence, lipid peroxidation and yield in cotton (Gossypium hirsutum L. cv Giza 65) in response to O3
Hassan, I.A. and Tewfik, I. 2006. CO2 photoassimilation, chlorophyll fluorescence, lipid peroxidation and yield in cotton (Gossypium hirsutum L. cv Giza 65) in response to O3. World Review of Science, Technology and Sustainable Development. 3 (1), pp. 70-79. https://doi.org/10.1504/WRSTSD.2006.008764

Prevalence of dieting, overweight, body image satisfaction and associated psychological problems in adolescent boys
Bener, A., Kamal, A., Tewfik, I. and Sabuncuoglu, O. 2006. Prevalence of dieting, overweight, body image satisfaction and associated psychological problems in adolescent boys. Nutrition & Food Science. 36 (5), pp. 295-304. https://doi.org/10.1108/00346650610703144

Organophosphorus chemistry: therapeutic intervention in mechanisms of viral and cellular replication
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2005. Organophosphorus chemistry: therapeutic intervention in mechanisms of viral and cellular replication. Current Organic Chemistry. 9 (18), pp. 1803-1828. https://doi.org/10.2174/138527205774913123

Protein adduct species in muscle and liver of rats following acute ethanol administration
Patel, V., Worrall, S., Emery, P.W. and Preedy, V.R. 2005. Protein adduct species in muscle and liver of rats following acute ethanol administration. Alcohol & Alcoholism. 40 (6), pp. 485-493. https://doi.org/10.1093/alcalc/agh196

Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii
Wu, T., Cheng, X.M., Bligh, S.W.A., Chou, G.-X., Wang, Z., Bashall, A. and Branford-White, C.J. 2005. Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii. Helvetica Chimica Acta. 88 (10), pp. 2617-2623. https://doi.org/10.1002/hlca.200590202

Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum
Zhang, G.N., Zhong, L.Y., Bligh, S.W.A., Guo, Y.L., Zhang, C.-F., Zhang, M., Wang, Z. and Xu, L. 2005. Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum. Phytochemistry. 66 (10), pp. 1113-1120. https://doi.org/10.1016/j.phytochem.2005.04.001

Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV
Wu, T., Bligh, S.W.A., Gu, L.-H., Wang, Z., Liu, H.P., Cheng, X.M., Branford-White, C.J. and Hu, Z.B. 2005. Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV. Fitoterapia. 76 (2), pp. 157-165. https://doi.org/10.1016/j.fitote.2004.11.006

Health habits and risk of obesity among 6–13 year old school children and adolescents
Al-Shammari, H., Bumejjdad, A., Amuna, P. and Tewfik, I. 2005. Health habits and risk of obesity among 6–13 year old school children and adolescents. in: Carr, T. and Descheemaeker, K. (ed.) Nutrition and health - Current Topics IV Garant. pp. 207–208

Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice
Wang, C.-H., Wang, Z., Bligh, S.W.A., White, K.N. and Branford-White, C.J. 2004. Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. European Journal of Drug Metabolism and Pharmacokinetics. 29 (3), pp. 199-203. https://doi.org/10.1007/BF03190598

Liver dysfunction induced by bile duct ligation and galactosamine injection alters cardiac protein synthesis
Hunter, R.V., Patel, V., Baker, A.J. and Preedy, V.R. 2004. Liver dysfunction induced by bile duct ligation and galactosamine injection alters cardiac protein synthesis. Metabolism: Clinical and Experimental. 53 (8), pp. 964-968. https://doi.org/10.1016/j.metabol.2003.11.015

Would food irradiation as a means of technology transfer assist food productivity and security in Africa and sustain its development?
Tewfik, I., Amuna, P. and Zotor, F. 2004. Would food irradiation as a means of technology transfer assist food productivity and security in Africa and sustain its development? International Journal of Technology Policy and Management. 4 (1), pp. 44-52.

Taraxer-14-en-3β-ol, an anti-inflammatory compound from Sterculia foetida L.
Naik, D.G., Mujumdar, A.M., Waghole, R.J., Misar, A.V., Bligh, S.W.A., Bashall, A. and Crowder, J. 2004. Taraxer-14-en-3β-ol, an anti-inflammatory compound from Sterculia foetida L. Planta Medica. 70 (1), pp. 68-69. https://doi.org/10.1055/s-2004-815459

cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus
Cheng, Z.H., Wu, T., Bligh, S.W.A., Bashall, A. and Yu, B.Y. 2004. cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus. Journal of Natural Products. 67 (10), pp. 1761-1763. https://doi.org/10.1021/np049864e

Human and economic development in developing countries: a public health dimension employing the food multimix concept
Amuna, P., Zotor, F. and Tewfik, I. 2004. Human and economic development in developing countries: a public health dimension employing the food multimix concept. World Review of Science, Technology and Sustainable Development. 1 (2), pp. 129-137.

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase
Collinson, A.D., Bligh, S.W.A., Graham, D.L., Mott, H.R., Chalk, P.A., Korniotis, N. and Lowe, P.N. 2004. Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase. Assay and Drug Development Technologies. 2 (6), pp. 659-673. https://doi.org/10.1089/adt.2004.2.659

Protein metabolism in alcohol misuse and toxicity
Preedy, V.R., Koll, M., Adachi, J., Mantle, D., Patel, V. and Peters, T. 2003. Protein metabolism in alcohol misuse and toxicity. in: Watson, R.R. and Preedy, V.R. (ed.) Nutrition and alcohol: linking nutrient interactions and dietary intake London CRC Press. pp. 261-300

Chronic ethanol consumption increases the concentration of a 4-hydroxynonenal adduct with the mitochondrial hydroxy methyl glutaryl CoA synthase in liver
Patel, V., Spencer, C. and Cunningham, C.C. 2003. Chronic ethanol consumption increases the concentration of a 4-hydroxynonenal adduct with the mitochondrial hydroxy methyl glutaryl CoA synthase in liver. Hepatology. 38, p. p393.

Emerging techniques in biomedical research and their application to alcohol toxicity
Patel, V., Chaurand, P., Caprioli, R., Austen, B., Frears, E., Manca, F., Davies, H., Vrana, K., Wheeler, M. and Preedy, V.R. 2003. Emerging techniques in biomedical research and their application to alcohol toxicity. Alcoholism: Clinical and Experimental Research. 27 (2), pp. 348-353.

Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry
Bligh, S.W.A., Haley, T. and Lowe, P.N. 2003. Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry. Journal of Molecular Recognition. 16 (3), pp. 139-148. https://doi.org/10.1002/jmr.622

Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(II) with nucleosides and its biological activity
Bligh, S.W.A., Bashall, A., Garrud, C., McPartlin, M., Wardle, N.J., White, K.N., Padhye, S., Barve, V. and Kundu, G. 2003. Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(II) with nucleosides and its biological activity. Dalton Transactions. 2003 (2), pp. 184-188. https://doi.org/10.1039/B208790A

How chemistry brought me to the life-sciences interface
Bligh, S.W.A. 2003. How chemistry brought me to the life-sciences interface. Science.

Altered hepatic mitochondrial ribosome structure following chronic ethanol consumption
Patel, V. and Cunningham, C.C. 2002. Altered hepatic mitochondrial ribosome structure following chronic ethanol consumption. Archives of Biochemistry and Biophysics. 398 (1), pp. 41-50. https://doi.org/10.1006/abbi.2001.2701

Chronic ethanol consumption increases the formation of an aldehyde-protein adduct in hepatic mitochondria
Patel, V., Young, T.A. and Cunningham, C.C. 2002. Chronic ethanol consumption increases the formation of an aldehyde-protein adduct in hepatic mitochondria. Alcoholism: Clinical and Experimental Research.

IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids
Fogg, P.G.T., Bligh, S.W.A., Derrick, M.E., Yampol’skii, Y.P., Clever, H.L., Skrzecz, A. and Young, C.L. 2001. IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids. Journal of Physical and Chemical Reference Data. 30 (6), pp. 1693-1875. https://doi.org/10.1063/1.1397768

Cardioprotective effect of propranolol from alcohol-induced heart muscle damage as assessed by plasma cardiac troponin-T.
Patel, V., Ajmal, R., Sherwood, R., Sullivan, A., Richardson, P. and Preedy, V.R. 2001. Cardioprotective effect of propranolol from alcohol-induced heart muscle damage as assessed by plasma cardiac troponin-T. Alcoholism: Clinical and Experimental Research. 25 (6), pp. 882-889. https://doi.org/10.1111/j.1530-0277.2001.tb02294.x

Diarrhea reduces the rates of cardiac protein synthesis in myofibrillar protein fractions in rats in vivo
Hunter, R.V., Patel, V., Miell, J., Wong, H.J., Marway, J., Richardson, P. and Preedy, V.R. 2001. Diarrhea reduces the rates of cardiac protein synthesis in myofibrillar protein fractions in rats in vivo. Journal of Nutrition. 131 (5), pp. 1513-1519.

Acute doxorubicin (adriamycin) dosage does not reduce cardiac protein synthesis in vivo, but decreases diaminopeptidase I and proline endopeptidase activities
Zima, T., Tesar, V., Mantle, D., Koll, M., Patel, V., Richardson, P. and Preedy, V.R. 2001. Acute doxorubicin (adriamycin) dosage does not reduce cardiac protein synthesis in vivo, but decreases diaminopeptidase I and proline endopeptidase activities. Experimental and Molecular Pathology. 70 (2), pp. 154-161. https://doi.org/10.1006/exmp.2000.2353

Physiochemical properties of rat liver mitochondrial ribosomes
Patel, V., Cunningham, C.C. and Hantgan, R. 2001. Physiochemical properties of rat liver mitochondrial ribosomes. Journal of Biological Chemistry. 276 (9), pp. 6739-6746. https://doi.org/10.1074/jbc.M005781200

In vivo protein synthetic rates of atrial, ventricular, and pulmonary tissue proteins in aortic constriction, goldblatt, and bromoethylamine models of hypertension
Siddiq, T., Patel, V., Sherwood, R., Richardson, P. and Preedy, V.R. 2001. In vivo protein synthetic rates of atrial, ventricular, and pulmonary tissue proteins in aortic constriction, goldblatt, and bromoethylamine models of hypertension. Experimental and Molecular Pathology. 70 (1), pp. 19-30. https://doi.org/10.1006/exmp.2000.2333

Ethanol and oxidative stress
Sun, A., Ingelman-Sundberg, M., Neve, E., Matsumoto, H., Nishitani, Y., Minowa, Y., Fukui, Y., Bailey, S., Patel, V., Cunningham, C.C., Zima, T., Fialova, L., Mikulikova, L., Popov, P., Malbohan, I., Janebova, M., Nespor, K. and Sun, G. 2001. Ethanol and oxidative stress. Alcoholism: Clinical and Experimental Research. 25 (5 Suppl.), pp. 237S-243S.

Alpha-Tocopherol supplementation does not prevent acute alcohol-induced heart muscle damage
Koll, M., Patel, V., Sherwood, R.A., Seitz, H.K., Simanowski, U.A., Richardson, P.J., Peters, T.J. and Preedy, V.R. 2001. Alpha-Tocopherol supplementation does not prevent acute alcohol-induced heart muscle damage. Proceedings of the Nutrition Society. 60, p. P125A.

Ethanol and protein metabolism
Cunningham, C.C., Preedy, V.R., Paice, A., Hesketh, J., Peters, T., Patel, V., Volpi, E., Mawatari, K., Masaki, H., Mori, H. and Torii, K. 2001. Ethanol and protein metabolism. Alcoholism: Clinical and Experimental Research. 25 (5 Suppl.), pp. 262S-268S.

Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA
Bligh, S.W.A., Choi, N., Evagorou, E.G., McPartlin, M. and White, K.N. 2001. Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA. Journal of the Chemical Society, Dalton Transactions. 2001 (21), pp. 3169-3172. https://doi.org/10.1039/B102533N

Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver
Bailey, S., Patel, V., Young, T.A., Asayama, K. and Cunningham, C.C. 2001. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcoholism: Clinical and Experimental Research. 25 (5), pp. 726-733.

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging
Prata, M.I.M., Santos, A.C., Bligh, S.W.A., Chowdhury, A.H.M.S., Geraldes, C.F.G.C. and de Lima, J.J.P. 2000. Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging. Nuclear Medicine and Biology. 27 (6), pp. 605-610. https://doi.org/10.1016/S0969-8051(00)00127-X

Synthesis and structural properties of metal complexes of dialkyl α-hydroxyiminophosphonates
Bligh, S.W.A., Choi, N., McGrath, C.M., McPartlin, M. and Woodroffe, T.M. 2000. Synthesis and structural properties of metal complexes of dialkyl α-hydroxyiminophosphonates. Journal of the Chemical Society, Dalton Transactions. 2000 (15), pp. 2587-2594. https://doi.org/10.1039/B003241G

Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging
Bligh, S.W.A., Chowdhury, A.H.M.S., Kennedy, D., Luchinat, C. and Parigi, G. 1999. Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging. Magnetic Resonance in Medicine. 41 (4), pp. 767-773. https://doi.org/10.1002/(SICI)1522-2594(199904)41:4<767::AID-MRM16>3.0.CO;2-G

The effect of intermittent heating on some chemical parameters of refined oils used in Egypt. A public health nutrition concern
Tewfik, I., Ismail, H. and Sumar, S. 1998. The effect of intermittent heating on some chemical parameters of refined oils used in Egypt. A public health nutrition concern. International Journal of Food Sciences and Nutrition. 49 (5), pp. 339-342. https://doi.org/10.3109/09637489809089408

A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken. Lebensmittel-Wissenschaft und-Technologie = Journal of Food Sciences and Technology. 31 (4), pp. 366-370. https://doi.org/10.1006/fstl.1998.0371

A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef. Bulletin of High Institute of Public Health. 28 (3), pp. 85-92.

A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish
Tewfik, I. 1998. A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish. International Journal of Food Sciences and Nutrition. 50 (1), pp. 51-56. https://doi.org/10.1080/096374899101418

Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate
Bligh, S.W.A., McPartlin, M., Sanganee, M.J., Woodroffe, T.M. and Geraldes, C.F.G.C. 1998. Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate. Chemical Communications. 1998 (19), pp. 2073-2074. https://doi.org/10.1039/A805189E

A gadolinium cryptate with two coordinated water molecules
Bligh, S.W.A., Drew, M.G.B., Martin, N., Maubert, B. and Nelson, J. 1998. A gadolinium cryptate with two coordinated water molecules. Journal of the Chemical Society, Dalton Transactions. 1998 (22), pp. 3711-3714. https://doi.org/10.1039/A805859H

A novel hexaaza macrocycle with methylenephosphonate pendant arms: a potential useful chelate for biomedical applications
Bligh, S.W.A., Choi, N., Geraldes, C.F.G.C., Knoke, S., McPartlin, M., Sanganee, M.J. and Woodroffe, T.M. 1997. A novel hexaaza macrocycle with methylenephosphonate pendant arms: a potential useful chelate for biomedical applications. Journal of the Chemical Society, Dalton Transactions. 1997 (21), pp. 4119-4126. https://doi.org/10.1039/A703678G

Hexaaza and octaaza macrocycles with 2-hydroxy 3,5-dimethylbenzyl pendant arms
Bligh, S.W.A., Choi, N., Evagorou, E.G. and McPartlin, M. 1997. Hexaaza and octaaza macrocycles with 2-hydroxy 3,5-dimethylbenzyl pendant arms. Journal of the Chemical Society, Perkin Transactions. 1997 (21), pp. 3151-3156. https://doi.org/10.1039/A704835A

A rapid method (SFE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H., Amine, E. and Rady, A. 1996. A rapid method (SFE-GC-MS) used to detect irradiated minced beef. Arab Journal of Nuclear Sciences and Applications. 29 (4), pp. 345-353.

α-aminophosphonate monoesters in one step
Bligh, S.W.A., McGrath, C.M., Failla, S. and Finocchiaro, P. 1996. α-aminophosphonate monoesters in one step. Phosphorus, Sulfur, and Silicon and the Related Elements. 118 (1), pp. 189-194. https://doi.org/10.1080/10426509608038811

Lanthanide and transition metal complexes of dialkyl alpha-hydroxyiminophosphonates
Bligh, S.W.A., Choi, N., Green, D.S.C., Hudson, H.R., McGrath, C.M., McPartlin, M. and Pianka, M. 1996. Lanthanide and transition metal complexes of dialkyl alpha-hydroxyiminophosphonates. Phosphorus, Sulfur, and Silicon and the Related Elements. 111 (1-4), p. 49. https://doi.org/10.1080/10426509608054678

Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging
Bligh, S.W.A., Chowdhury, A.H.M.S., McPartlin, M. and Scowen, I.J. 1995. Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging. Polyhedron. 14 (4), pp. 567-569. https://doi.org/10.1016/0277-5387(94)00318-9

Teaching techniques in inorganic chemistry
Bligh, S.W.A., Conole, G. and McPartlin, M. 1995. Teaching techniques in inorganic chemistry. in: Variety in Chemistry Proceedings UK Physical Sciences Centre.

Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents
Bligh, S.W.A., Harding, C.T., McEwen, A.B. and Sadler, P.J. 1994. Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents. Polyhedron. 13 (12), pp. 1937-1943. https://doi.org/10.1016/0277-5387(94)80018-9

Synthesis of the first lanthanide complexes of dialkyl α-hydroxyiminophosphonates; ambivalent ligand bonding in the PrIII and NdIII complexes of diisopropyl α-hydroxyiminopropylphosphonate (L1), [PrL13Cl3] and [NdL12(NO3)3(H2O)]
Bligh, S.W.A., Choi, N., Hudson, H.R., McGrath, C.M. and McPartlin, M. 1994. Synthesis of the first lanthanide complexes of dialkyl α-hydroxyiminophosphonates; ambivalent ligand bonding in the PrIII and NdIII complexes of diisopropyl α-hydroxyiminopropylphosphonate (L1), [PrL13Cl3] and [NdL12(NO3)3(H2O)]. Journal of the Chemical Society, Dalton Transactions. 1994 (15), pp. 2335-2337. https://doi.org/10.1039/DT9940002335

First structural characterisation of an amino phosphonate monoester metal complex
Bligh, S.W.A., Choi, N., Failla, S., Finocchiaro, P., Il'yasov, A., Libertini, M., McGrath, C.M., McPartlin, M. and Woodroffe, T.M. 1994. First structural characterisation of an amino phosphonate monoester metal complex. Journal of the Chemical Society, Dalton Transactions. 1994 (22), pp. 3333-3334. https://doi.org/10.1039/DT9940003333

Metal-ion controlled helicity of an 18-membered hexaaza tetraamine macrocycle
Bligh, S.W.A., Choi, N., Evagorou, E.G., Li, W.S. and McPartlin, M. 1994. Metal-ion controlled helicity of an 18-membered hexaaza tetraamine macrocycle. Journal of the Chemical Society, Chemical Communications. 1994 (20), pp. 2399-2400. https://doi.org/10.1039/C39940002399

Yttrium(III) and lanthanide(III) metal complexes of an 18-membered hexaaza tetraimine macrocycle. Crystal structure of the gadolinium(III) complex
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D. and McPartlin, M. 1994. Yttrium(III) and lanthanide(III) metal complexes of an 18-membered hexaaza tetraimine macrocycle. Crystal structure of the gadolinium(III) complex. Journal of the Chemical Society, Dalton Transactions. 1994 (23), pp. 3369-3376. https://doi.org/10.1039/DT9940003369

Transition metal complexes of dialkyl α-hydroxyiminophosphonates, a novel class of metal complexes
Bligh, S.W.A., Choi, N., Green, D.S.C., Hudson, H.R., McGrath, C.M., McPartlin, M. and Pianka, M. 1993. Transition metal complexes of dialkyl α-hydroxyiminophosphonates, a novel class of metal complexes. Polyhedron. 12 (23), pp. 2887-2890. https://doi.org/10.1016/S0277-5387(00)80073-X

Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D., McPartlin, M. and Parkes, H.G. 1993. Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging. Journal of Inorganic Biochemistry. 51 (1-2), p. 438. https://doi.org/10.1016/0162-0134(93)85467-M

Synthesis and crystal structure of a novel hexaaza macrocyclic ligand with 2-hydroxy-3,5-dimethylbenzyl pendant arms and its gadolinium(III) complex
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D. and McPartlin, M. 1993. Synthesis and crystal structure of a novel hexaaza macrocyclic ligand with 2-hydroxy-3,5-dimethylbenzyl pendant arms and its gadolinium(III) complex. Journal of the Chemical Society, Dalton Transactions. 1993 (24), pp. 3829-3831. https://doi.org/10.1039/DT9930003829

Distortional isomerism in oxomolybdenum systems: the evidence re-evaluated
Bashall, A., Bligh, S.W.A., Edwards, A.J., McPartlin, M., Gibson, V.C. and Robinson, O.B. 1992. Distortional isomerism in oxomolybdenum systems: the evidence re-evaluated. Angewandte Chemie: International Edition in English. 31 (12), pp. 1607-1609. https://doi.org/10.1002/anie.199216071

Synthesis and crystal structure of a gadolinium(III) complex of a tetraimine schiff-base macrocycle: a potential contrast agent for magnetic resonance imaging
Bligh, S.W.A., Choi, N., Evagorou, E.G., McPartlin, M., Cummins, W.J. and Kelly, J.D. 1992. Synthesis and crystal structure of a gadolinium(III) complex of a tetraimine schiff-base macrocycle: a potential contrast agent for magnetic resonance imaging. Polyhedron. 11 (19), pp. 2571-2573. https://doi.org/10.1016/S0277-5387(00)83580-9

H-1-Nmr studies of reactions of copper complexes with human blood plasma and urine
Bligh, S.W.A., Boyle, H.A., McEwen, A.B., Sadler, P.J. and Woodham, R.H. 1992. H-1-Nmr studies of reactions of copper complexes with human blood plasma and urine. Biochemical Pharmacology. 43 (2), pp. 137-145. https://doi.org/10.1016/0006-2952(92)90270-S

Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging
Bligh, S.W.A., Harding, C.T., Sadler, P.J., Bulman, R.A., Bydder, G.M., Pennock, J.M., Kelly, J.D., Clatham, I.A. and Marriott, J.A. 1991. Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging. Magnetic Resonance in Medicine. 17 (2), pp. 516-532. https://doi.org/10.1002/mrm.1910170222

Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma
Bligh, S.W.A., Drake, A.F. and Sadler, P.J. 1990. Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma. Biochemical Society Transactions. 18, pp. 999-1000. https://doi.org/10.1042/bst0180999

Ultraviolet and magnetic-circular-diochroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid
Bligh, S.W.A., Drake, A.F. and Sadler, P.J. 1989. Ultraviolet and magnetic-circular-diochroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid. European Journal of Biochemistry. 181 (1), pp. 223-224. https://doi.org/10.1111/j.1432-1033.1989.tb14714.x

Characterization and invivo distribution of Tc-99m-labeled and In-111-labelled magnetite
Bligh, S.W.A., Sadler, P.J., Marriott, J.A., Latham, I.A. and Kelly, J.D. 1989. Characterization and invivo distribution of Tc-99m-labeled and In-111-labelled magnetite. Applied Radiation and Isotopes. 40, pp. 751-757.

Labels and contrast agents in biomedical magnetic resonance spectroscopy and imaging
Bligh, S.W.A. and Sadler, P.J. 1989. Labels and contrast agents in biomedical magnetic resonance spectroscopy and imaging. in: Dykes, J. and Delpy, D.T. (ed.) Clinical NMR spectroscopy York, England The Institute of Physical Sciences in Medicine. pp. 77-81

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