Evaluation of plasma neurotransmitters in children living with Attention-Deficit Hyperactivity Disorder (ADHD)

Meguid, N., Anwar, M., Hussein, J., Hasan, H., Hashish, A., Seleet, F., Foda, M. and Tewfik, I. 2018. Evaluation of plasma neurotransmitters in children living with Attention-Deficit Hyperactivity Disorder (ADHD). Bioscience Research. 15 (1), pp. 152-159.

TitleEvaluation of plasma neurotransmitters in children living with Attention-Deficit Hyperactivity Disorder (ADHD)
AuthorsMeguid, N., Anwar, M., Hussein, J., Hasan, H., Hashish, A., Seleet, F., Foda, M. and Tewfik, I.
Abstract

This study aimed to ascertain the underlying neuro-biochemical imbalances that exist in children with ADHD by assessing the plasma levels of dopamine, serotonin, norepinephrine, γ aminobutyric acid (GABA) and glutamate. Moreover, it investigated the potential effects of PUFA and vitamins supplementation as an alternative therapy to modulate the levels of these neurotransmitters and the overall clinical status of ADHD patients. The study included 40 ADHD patients, aged 4-6 years. The diagnostic and statistical manual of mental disorders (DSM-5) test has been employed to diagnose patients with ADHD and the severity of symptoms was assessed using the Arabic version of Conners' Parent Rating Scale. Additionally, patients were assessed using the Arabic versions of Mini International Neuropsychiatric Interview for Children (M.I.N.I. Kid) and Stanford-Binet Intelligence Scale, 5th Edition (SB5). Recruited patient received nutritional supplement of semi-solid diet containing 1000 mg PUFA with selected vitamins once daily for six months. The evaluation of ADHD symptoms and levels of neurotransmitters has been carried out at pre-/post-intervention stage. Post-nutrition intervention assessment, there was a significant increase in dopamine, norepinephrine, GABA levels (p-value < 0.0001) with significant decrease in glutamate level (p-value < 0.0001) when compared to their correspondent pre-intervention levels. Symptoms of inattention and/or hyperactivity-impulsivity were significantly improved after 6 months nutrition intervention program (p-value<0.001). Therefore, supplementation with omega-3 fatty acids and vitamins could be considered more extensively in therapy of ADHD patients particularly those who are less than 6 years old.

KeywordsKeywords: ADHD; Neurotransmitters; Dopamine; PUFA; Omega-3; semi-solid diet
JournalBioscience Research
Journal citation15 (1), pp. 152-159
ISSN1811-9506
2218-3973
Year2018
PublisherInnovative Scientific Information & Services Network
Publisher's version152-159-15(1)2018BR-1630.pdf
Web address (URL)https://www.isisn.org/BR15(1)2018/152-159-15(1)2018BR-1630.pdf
Publication dates
Published04 Mar 2018
LicenseCC BY 4.0

Related outputs

Optimization of water extract of Cinnamomum burmannii bark to ascertain its in vitro antidiabetic and antioxidant activities
Ervina, M., Lie, H.S., Diva, J., Caroline, Tewfik, S. and Tewfik, I. 2019. Optimization of water extract of Cinnamomum burmannii bark to ascertain its in vitro antidiabetic and antioxidant activities. Biocatalysis and Agricultural Biotechnology. 19, p. 101152. doi:10.1016/j.bcab.2019.101152

Nutritional Management in Polycystic Ovary Syndrome: Challenges and opportunities
Hmedeh, C., Ghazeeri, G. and Tewfik, I. 2018. Nutritional Management in Polycystic Ovary Syndrome: Challenges and opportunities. International Journal of Food Safety, Nutrition and Public Health.

Evaluation of a photographic food atlas as a tool for quantifying food portion size in the United Arab Emirates
Ali, H., Platat, C., El Mesmoudi, N., El Sadig, M. and Tewfik, I. 2018. Evaluation of a photographic food atlas as a tool for quantifying food portion size in the United Arab Emirates. PLoS ONE. 13 (4), p. 0196389. doi:10.1371/journal.pone.0196389

Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity
Usman, M., Tewfik, I. and Volpi, E. 2017. Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity. International Journal of Food, Nutrition and Public Health. 9 (1), pp. 1-12.

A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India
Kapoor, N., Naufahu, J., Tewfik, S., Bhatnagar, S., Garg, R. and Tewfik, I. 2017. A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India. Integrative Cancer Therapies. 6 (1), pp. 74-84. doi:10.1177/1534735416651968

Risk Factors for Maternal Vitamin D Deficiency within the United Arab Emirates
Hussein, I., Taha, Z., Tewfik, I., Badawi, S., Siddieg, H., Adegboye, A.R. and McGrady, K. 2016. Risk Factors for Maternal Vitamin D Deficiency within the United Arab Emirates. Journal of Pregnancy and Child Health. 3 (5), p. 1000276. doi:10.4172/2376-127X.1000276

A comparative study: long and short term effect of a nutrition sensitive approach to delay the progression of HIV to AIDS among people living with HIV (PLWH) in Nigeria
Amlogu, A., Tewfik, S., Wambebe, C. and Tewfik, I. 2016. A comparative study: long and short term effect of a nutrition sensitive approach to delay the progression of HIV to AIDS among people living with HIV (PLWH) in Nigeria. Functional Foods in Health and Disease. 6 (2), pp. 79-90.

American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2014. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytotherapy Research. 28 (5), pp. 692-698. doi:10.1002/ptr.5044

Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2013. Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimised high performance liquid chromatography method to authenticate commercially available products. Journal of Herbal Medicine. 3 (2), pp. 57-64. doi:10.1016/j.hermed.2013.02.001

Hepatic mitochondrial dysfunction induced by fatty acids and ethanol
Gyamfi, D., Everitt, H.E., Tewfik, I., Clemens, D.L. and Patel, V. 2012. Hepatic mitochondrial dysfunction induced by fatty acids and ethanol. Free Radical Biology & Medicine. 53 (11), pp. 2131-2145. doi:10.1016/j.freeradbiomed.2012.09.024

The use of Scutellaria lateriflora: a pilot survey amongst herbal medicine practitioners
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2012. The use of Scutellaria lateriflora: a pilot survey amongst herbal medicine practitioners. Journal of Herbal Medicine. 2 (2), pp. 34-41. doi:10.1016/j.hermed.2012.04.005,

Obesity and low vision as a result of excessive internet use, and television viewing
Bener, A., Al-Mahdi, H.S., Ali, A.I., Al-Nufal, M., Vachhani, P.J. and Tewfik, I. 2011. Obesity and low vision as a result of excessive internet use, and television viewing. International Journal of Food Sciences and Nutrition. 62 (1), pp. 60-62. doi:10.3109/09637486.2010.495711

Globesity in action: systematic review and pilot intervention to assess the potential health benefit of moderate physical activity
Salah, M. and Tewfik, I. 2011. Globesity in action: systematic review and pilot intervention to assess the potential health benefit of moderate physical activity. in: Ahmed, A. and Busler, M. (ed.) World sustainable development outlook 2011. Sharing knowledge, making a difference: the role of international scientific cooperation World Association for Sustainable Development (WASD).

Conceptual framework of public health-nutrition intervention programme to attenuate the progression of HIV to AIDS among people living with HIV (PLWH) in Abuja, Nigeria
Amlogu, M.A., Tewfik, S., Wambebe, C., Godden, K. and Tewfik, I. 2011. Conceptual framework of public health-nutrition intervention programme to attenuate the progression of HIV to AIDS among people living with HIV (PLWH) in Abuja, Nigeria. in: Ahmed, A. and Busler, M. (ed.) World sustainable development outlook 2011. Sharing knowledge, making a difference: the role of international scientific cooperation World Association for Sustainable Development (WASD). pp. 11-20

American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety?
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2010. American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety? British Journal of Wellbeing. 1 (4), pp. 25-30.

Is Africa facing a nutrition transition under the double burden of disease?
Tewfik, I., Bener, A. and Tewfik, S. 2010. Is Africa facing a nutrition transition under the double burden of disease? in: Ahmed, A. and Nwankwo, S. (ed.) Achieving sustainable development in Africa: science, technology & innovation trajectory London World Association for Sustainable Development (WASD).

Childhood obesity prevention in Emirates (COPE): a conceptual framework for pilot intervention
Tewfik, I., Mackenzie, J., Cunliffe, A., Al-Dhaheri, A., Ali, H., Washi, S. and Platat, C. 2009. Childhood obesity prevention in Emirates (COPE): a conceptual framework for pilot intervention. in: Ahmed, A. (ed.) World sustainable development outlook: the impact of the global financial crisis on the environment, energy and sustainable development 2009 London World Association for Sustainable Development (WASD).

Nutritional quality of deep fried street-vended foods: a public health concern
Tewfik, I., Ismail, H. and Tewfik, S. 2009. Nutritional quality of deep fried street-vended foods: a public health concern. in: Ahmed, A. (ed.) World sustainable development outlook: the impact of the global financial crisis on the environment, energy and sustainable development 2009 London World Association for Sustainable Development (WASD).

Hepatic oxidative stress and apoptosis following acute alcohol
Everitt, H.E., Tewfik, I., Preedy, V.R. and Patel, V. 2009. Hepatic oxidative stress and apoptosis following acute alcohol. Alcohol & Alcoholism. 44, p. p85.

Assessment of shelf-life of irradiated frozen chicken
Alnasser, M.A., Park, S.F., Jenesson, P. and Tewfik, I. 2009. Assessment of shelf-life of irradiated frozen chicken. International Journal of Food Safety, Nutrition and Public Health. 2 (1), pp. 48-58. doi:10.1504/IJFSNPH.2009.026918

Would it still be possible to identify irradiated lipid-containing foods towards the end of their shelf-life?
Tewfik, I. and Tewfik, S. 2008. Would it still be possible to identify irradiated lipid-containing foods towards the end of their shelf-life? Food Science and Technology International. 14 (6), pp. 519-524. doi:10.1177/1082013208100465

Extraction and identification of cyclobutanones from irradiated cheese employing a rapid direct solvent extraction method
Tewfik, I. 2008. Extraction and identification of cyclobutanones from irradiated cheese employing a rapid direct solvent extraction method. International Journal of Food Sciences and Nutrition. 59 (7 & 8), pp. 590-598. doi:10.1080/09637480701515450

Inter-laboratory trial to validate the direct solvent extraction method for the identification of 2-dodecylcyclobutanone in irradiated chicken and whole liquid egg
Tewfik, I. 2008. Inter-laboratory trial to validate the direct solvent extraction method for the identification of 2-dodecylcyclobutanone in irradiated chicken and whole liquid egg. Food Science and Technology International. 14 (3), pp. 277-283. doi:10.1177/1082013208095689

Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas?
Bener, A., Hoffmann, G.F., Afify, Z., Rasul, K., Mian, M., Guiter, G. and Tewfik, I. 2008. Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas? Minerva Pediatrica. 60 (2), pp. 155-161.

Nutraceuticals, functional foods and botanical dietary supplements; promote wellbeing and underpin public health
Tewfik, S. and Tewfik, I. 2008. Nutraceuticals, functional foods and botanical dietary supplements; promote wellbeing and underpin public health. World Review of Science, Technology and Sustainable Development. 5 (2), pp. 104-123. doi:10.1504/WRSTSD.2008.018552

Childhood obesity prevention (CHOP) programme: a conceptual framework for nutrition intervention
Tewfik, I. 2008. Childhood obesity prevention (CHOP) programme: a conceptual framework for nutrition intervention. International Journal of Food Safety, Nutrition and Public Health. 1 (1), pp. 16-32. doi:10.1504/IJFSNPH.2008.018853

Metabolic Syndrome and its components among Qatari population
Musallam, M., Bener, A., Zirie, M., Al-Gaud, Y.K., Al-Hamaq, A.A., Othman, M.A. and Tewfik, I. 2008. Metabolic Syndrome and its components among Qatari population. International Journal of Food Safety, Nutrition and Public Health. 1 (1), pp. 88-102. doi:10.1504/IJFSNPH.2008.018858

Impact of lifestyle and dietary habits on hypovitaminosis D in type 1 diabetes mellitus and healthy children from Qatar, a sun-rich country
Bener, A., Alsaied, A., Al-Ali, M., Hassan, A.S., Basha, B., Al-Kubaisi, A., Abraham, A., Mian, M., Guiter, G., Tewfik, I. and Agha, M. 2008. Impact of lifestyle and dietary habits on hypovitaminosis D in type 1 diabetes mellitus and healthy children from Qatar, a sun-rich country. Annals of Nutrition and Metabolism. 53 (3-4), pp. 215-222. doi:10.1159/000184439

A rapid direct solvent extraction (DSE) method for the extraction of cyclobutanones from irradiated chicken and liquid whole egg
Tewfik, I. 2008. A rapid direct solvent extraction (DSE) method for the extraction of cyclobutanones from irradiated chicken and liquid whole egg. International Journal of Food Science and Technology. 43 (1), pp. 108-113. doi:10.1111/j.1365-2621.2006.01399.x

Nutrition and alcoholic liver disease
Everitt, H.E., Patel, V. and Tewfik, I. 2007. Nutrition and alcoholic liver disease. Nutrition Bulletin. 32 (2), pp. 138-144. doi:10.1111/j.1467-3010.2007.00627.x

The public health advocate: food irradiation's offer to food security
Tewfik, I. and Tewfik, S. 2007. The public health advocate: food irradiation's offer to food security. in: Ahmed, A. (ed.) Science, technology and sustainability in the Middle East and North Africa Genève InderScience. pp. 197-209

Competitive food safety program: the case of Qatar
Al-Hamaq, A.A., Zeyadah, S.S., Ahmed, A., Amuna, P. and Tewfik, I. 2007. Competitive food safety program: the case of Qatar. in: Ahmed, A. (ed.) Science, technology and sustainability in the Middle East and North Africa Genève InderScience. pp. 210-228

Book review: B. Freire Wilma (editor). Nutrition and an Active Life: From Knowledge to Action. Scientific and Technical Publication No. 612. Washington DC: Pan American Health Organization 2005. US$ 36·00 (paperback) pp. 260. ISBN: 92 75 11612 1
Tewfik, I. 2006. Book review: B. Freire Wilma (editor). Nutrition and an Active Life: From Knowledge to Action. Scientific and Technical Publication No. 612. Washington DC: Pan American Health Organization 2005. US$ 36·00 (paperback) pp. 260. ISBN: 92 75 11612 1. British Journal of Nutrition. 96 (4), p. 793. doi:10.1079/BJN20061844

Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population
Bener, A. and Tewfik, I. 2006. Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population. Obesity Reviews. 7 (2), pp. 139-145. doi:10.1111/j.1467-789X.2006.00209.x

Industrial and dietetic applications of the food multimix (FMM) concept in meeting the nutritional needs of vulnerable groups in South Africa
Zotor, F., Amuna, P., Oldewage-Theron, W.H., Adewuya, T., Prinsloo, G., Chinyanga, Y., Tewfik, I. and Amuna, N. 2006. Industrial and dietetic applications of the food multimix (FMM) concept in meeting the nutritional needs of vulnerable groups in South Africa. Academic Journal of Vaal University of Technology. 3, pp. 54-67.

CO2 photoassimilation, chlorophyll fluorescence, lipid peroxidation and yield in cotton (Gossypium hirsutum L. cv Giza 65) in response to O3
Hassan, I.A. and Tewfik, I. 2006. CO2 photoassimilation, chlorophyll fluorescence, lipid peroxidation and yield in cotton (Gossypium hirsutum L. cv Giza 65) in response to O3. World Review of Science, Technology and Sustainable Development. 3 (1), pp. 70-79. doi:10.1504/WRSTSD.2006.008764

Prevalence of dieting, overweight, body image satisfaction and associated psychological problems in adolescent boys
Bener, A., Kamal, A., Tewfik, I. and Sabuncuoglu, O. 2006. Prevalence of dieting, overweight, body image satisfaction and associated psychological problems in adolescent boys. Nutrition & Food Science. 36 (5), pp. 295-304. doi:10.1108/00346650610703144

Would food irradiation as a means of technology transfer assist food productivity and security in Africa and sustain its development?
Tewfik, I., Amuna, P. and Zotor, F. 2004. Would food irradiation as a means of technology transfer assist food productivity and security in Africa and sustain its development? International Journal of Technology Policy and Management. 4 (1), pp. 44-52.

Human and economic development in developing countries: a public health dimension employing the food multimix concept
Amuna, P., Zotor, F. and Tewfik, I. 2004. Human and economic development in developing countries: a public health dimension employing the food multimix concept. World Review of Science, Technology and Sustainable Development. 1 (2), pp. 129-137.

The effect of intermittent heating on some chemical parameters of refined oils used in Egypt. A public health nutrition concern
Tewfik, I., Ismail, H. and Sumar, S. 1998. The effect of intermittent heating on some chemical parameters of refined oils used in Egypt. A public health nutrition concern. International Journal of Food Sciences and Nutrition. 49 (5), pp. 339-342. doi:10.3109/09637489809089408

A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken. Lebensmittel-Wissenschaft und-Technologie = Journal of Food Sciences and Technology. 31 (4), pp. 366-370. doi:10.1006/fstl.1998.0371

A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef. Bulletin of High Institute of Public Health. 28 (3), pp. 85-92.

A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish
Tewfik, I. 1998. A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish. International Journal of Food Sciences and Nutrition. 50 (1), pp. 51-56. doi:10.1080/096374899101418

A rapid method (SFE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H., Amine, E. and Rady, A. 1996. A rapid method (SFE-GC-MS) used to detect irradiated minced beef. Arab Journal of Nuclear Sciences and Applications. 29 (4), pp. 345-353.

Permalink - https://westminsterresearch.westminster.ac.uk/item/q4058/evaluation-of-plasma-neurotransmitters-in-children-living-with-attention-deficit-hyperactivity-disorder-adhd


Share this
Tweet
Email