Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity

Usman, M., Tewfik, I. and Volpi, E. 2017. Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity. International Journal of Food, Nutrition and Public Health. 9 (1), pp. 1-12.

TitleGenome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity
AuthorsUsman, M., Tewfik, I. and Volpi, E.
Abstract

Purpose: Recent studies have raised concerns that obese children may present an increased pre-disposition towards age–related disorders such as cancer. Initial evidence would suggest that the increased risk of developing cancer later in life might be linked to the reported presence of chronic low–grade inflammation in childhood obesity and the sustained accumulation of Reactive Oxygen Species (ROS) capable of inflicting DNA damage, a well–known promoter and driver of carcinogenesis. This conceptual framework outlines the clinical and laboratory investigations required for the combined assessment and monitoring of systemic inflammation, micro–nutritional deficiencies and acquired genome damage in childhood obesity.
Approach: A case–control study is proposed in a cohort of obese and healthy weight 11–15 year olds.
This study combines assessments of blood, together with minimally invasive investigations of saliva and urine samples to obtain an overview of inflammation and DNA damage status in obesity. Furthermore, we present a nutrition sensitive intervention programme to investigate the reversibility of these pathological states.
Findings: It is hypothesised that chronic inflammation in childhood obesity can establish a harmful
microenvironment that inflicts damage to DNA. It is postulated that a nutrition sensitive intervention may reverse implications of inflammation and DNA damage in obese children.
Value: An evaluation of the role of genomic instability and cumulative DNA damage early in life as a possible causative link between childhood obesity and the ncreased risk of developing cancer in adulthood.
The conceptual framework proposes a personalised approach to disease diagnosis and monitoring of ‘genome health’ that can inform the prioritisation and severity of intervention measures in the clinical setting.

KeywordsGenome instability; Childhood Obesity; Nutrition sensitive intervention; DNA damage; Cancer;
JournalInternational Journal of Food, Nutrition and Public Health
Journal citation9 (1), pp. 1-12
ISSN2042-5988
Year2017
PublisherWorld Association for Sustainable Development (WASD)
Web address (URL)http://www.wasd.org.uk/download/01-12-usman-m-tewfik-i-and-volpi-e-2017-genome-instability-in-childhood-obesity-a-conceptual-framework-for-an-assessment-intervention-and-monitoring-programme-of-inflamm/
Publication dates
Published12 Jul 2017

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Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken. Lebensmittel-Wissenschaft und-Technologie = Journal of Food Sciences and Technology. 31 (4), pp. 366-370. doi:10.1006/fstl.1998.0371

A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef. Bulletin of High Institute of Public Health. 28 (3), pp. 85-92.

A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish
Tewfik, I. 1998. A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish. International Journal of Food Sciences and Nutrition. 50 (1), pp. 51-56. doi:10.1080/096374899101418

A rapid method (SFE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H., Amine, E. and Rady, A. 1996. A rapid method (SFE-GC-MS) used to detect irradiated minced beef. Arab Journal of Nuclear Sciences and Applications. 29 (4), pp. 345-353.

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