Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity

Usman, M., Tewfik, I. and Volpi, E. 2017. Genome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity. International Journal of Food, Nutrition and Public Health. 9 (1), pp. 1-12.

TitleGenome instability in childhood obesity: A conceptual framework for an assessment, intervention and monitoring programme of inflammation and DNA damage in paediatric obesity
TypeJournal article
AuthorsUsman, M., Tewfik, I. and Volpi, E.
Abstract

Purpose: Recent studies have raised concerns that obese children may present an increased pre-disposition towards age–related disorders such as cancer. Initial evidence would suggest that the increased risk of developing cancer later in life might be linked to the reported presence of chronic low–grade inflammation in childhood obesity and the sustained accumulation of Reactive Oxygen Species (ROS) capable of inflicting DNA damage, a well–known promoter and driver of carcinogenesis. This conceptual framework outlines the clinical and laboratory investigations required for the combined assessment and monitoring of systemic inflammation, micro–nutritional deficiencies and acquired genome damage in childhood obesity.
Approach: A case–control study is proposed in a cohort of obese and healthy weight 11–15 year olds.
This study combines assessments of blood, together with minimally invasive investigations of saliva and urine samples to obtain an overview of inflammation and DNA damage status in obesity. Furthermore, we present a nutrition sensitive intervention programme to investigate the reversibility of these pathological states.
Findings: It is hypothesised that chronic inflammation in childhood obesity can establish a harmful
microenvironment that inflicts damage to DNA. It is postulated that a nutrition sensitive intervention may reverse implications of inflammation and DNA damage in obese children.
Value: An evaluation of the role of genomic instability and cumulative DNA damage early in life as a possible causative link between childhood obesity and the ncreased risk of developing cancer in adulthood.
The conceptual framework proposes a personalised approach to disease diagnosis and monitoring of ‘genome health’ that can inform the prioritisation and severity of intervention measures in the clinical setting.

KeywordsGenome instability; Childhood Obesity; Nutrition sensitive intervention; DNA damage; Cancer;
JournalInternational Journal of Food, Nutrition and Public Health
Journal citation9 (1), pp. 1-12
ISSN2042-5988
Year2017
PublisherWorld Association for Sustainable Development (WASD)
Web address (URL)http://www.wasd.org.uk/download/01-12-usman-m-tewfik-i-and-volpi-e-2017-genome-instability-in-childhood-obesity-a-conceptual-framework-for-an-assessment-intervention-and-monitoring-programme-of-inflamm/
Publication dates
Published12 Jul 2017

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Pagnamenta, A.T., Holt, R., Yusuf, M., Pinto, D., Wing, K., Betancur, C., Scherer, S.W., Volpi, E.V. and Monaco, A.P. 2011. A family with autism and rare copy number variants disrupting the Duchenne/Becker muscular dystrophy gene DMD and TRPM3. Journal of Neurodevelopmental Disorders. 3, pp. 124-131. https://doi.org/10.1007/s11689-011-9076-5

Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of Loci associated with human dominant retinal dystrophy.
Lipinski, D.M., Yusuf, M., Barnard, A.R., Damant, C., Charbel Issa, P., Singh, M.S., Lee, E., Davies, W.L., Volpi, E.V. and MacLaren R.E. 2011. Characterization of a dominant cone degeneration in a green fluorescent protein-reporter mouse with disruption of Loci associated with human dominant retinal dystrophy. Investigative Ophthalmology & Visual Science. 52 (9), pp. 6617-6623. https://doi.org/10.1167/iovs.11-7932

Perforin activity at membranes leads to invaginations and vesicle formation
Praper, T., Sonnen, A.F., Kladnik, A., Andrighetti, A.O., Viero, G., Morris, K.J., Volpi, E.V., Lunelli, L., Dalla Serra, M., Froelich, C.J., Gilbert, R.J. and Anderluh, G. 2011. Perforin activity at membranes leads to invaginations and vesicle formation. Proceedings of the National Academy of Sciences of the United States of America. 108 (52). https://doi.org/10.1073/pnas.1107473108

Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions
Yusuf, M., Bauer, D.L.V., Lipinski, D.M., MacLaren, R.E., Wade-Martins, R., Mir, K.U. and Volpi, E. 2011. Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions. BMC Biotechnology. 11, pp. 121-131. https://doi.org/10.1186/1472-6750-11-121

Globesity in action: systematic review and pilot intervention to assess the potential health benefit of moderate physical activity
Salah, M. and Tewfik, I. 2011. Globesity in action: systematic review and pilot intervention to assess the potential health benefit of moderate physical activity. in: Ahmed, A. and Busler, M. (ed.) World sustainable development outlook 2011. Sharing knowledge, making a difference: the role of international scientific cooperation World Association for Sustainable Development (WASD).

Conceptual framework of public health-nutrition intervention programme to attenuate the progression of HIV to AIDS among people living with HIV (PLWH) in Abuja, Nigeria
Amlogu, M.A., Tewfik, S., Wambebe, C., Godden, K. and Tewfik, I. 2011. Conceptual framework of public health-nutrition intervention programme to attenuate the progression of HIV to AIDS among people living with HIV (PLWH) in Abuja, Nigeria. in: Ahmed, A. and Busler, M. (ed.) World sustainable development outlook 2011. Sharing knowledge, making a difference: the role of international scientific cooperation World Association for Sustainable Development (WASD). pp. 11-20

An improved technique for chromosomal analysis of human ES and iPS cells.
Moralli, D., Yusuf, M., Mandegar, M.A., Khoja, S., Monaco, Z.L. and Volpi, E.V. 2011. An improved technique for chromosomal analysis of human ES and iPS cells. Stem Cell Reviews. 7 (2), pp. 471-477. https://doi.org/10.1007/s12015-010-9224-4

Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells
Mandegar, M.A., Moralli, D., Khoja, S., Cowley, S., Chan, D.Y.L., Yusuf, M., Mukherjee, S., Blundell, M.P., Volpi, E., Thrasher, A.J., James, W. and Monaco, Z.L. 2011. Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells. Human Molecular Genetics. 20 (15), pp. 2905-2913. https://doi.org/10.1093/hmg/ddr144

American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety?
Brock, C., Whitehouse, J., Tewfik, I. and Towell, A. 2010. American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety? British Journal of Wellbeing. 1 (4), pp. 25-30.

Fluorescence in situ hybridization (FISH) for genomic investigations in rat
Jefferson, A. and Volpi, E.V. 2010. Fluorescence in situ hybridization (FISH) for genomic investigations in rat. in: Bridger, J. and Volpi, E. (ed.) Fluorescence in situ Hybridization (FISH). Methods in Molecular Biology (Methods and Protocols), vol 659 Humana Press. pp. 409-426

A novel three-dimensional culture system allows prolonged culture of functional human granulosa cells and mimics the ovarian environment.
Kossowska-Tomaszczuk, K., Pelczar, P., Güven, S., Kowalski, J., Volpi, E., De Geyter, C. and Scherberich, A. 2010. A novel three-dimensional culture system allows prolonged culture of functional human granulosa cells and mimics the ovarian environment. Tissue Engineering Part A. 16 (6), pp. 2063-73. https://doi.org/10.1089/ten.tea.2009.0684

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.
Ashrafian, H., O'Flaherty, L., Adam, J., Steeples, V., Chung, Y.L., East, P., Vanharanta, S., Lehtonen, H., Nye, E., Hatipoglu, E., Miranda, M., Howarth, K., Shukla, D., Pollard, P.J. and Volpi, E. 2010. Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis. Cancer Research. 70 (22), pp. 9153-9165. https://doi.org/10.1158/0008-5472.can-10-1949

Is Africa facing a nutrition transition under the double burden of disease?
Tewfik, I., Bener, A. and Tewfik, S. 2010. Is Africa facing a nutrition transition under the double burden of disease? in: Ahmed, A. and Nwankwo, S. (ed.) Achieving sustainable development in Africa: science, technology & innovation trajectory London World Association for Sustainable Development (WASD).

Altered intra-nuclear organisation of heterochromatin and genes in ICF syndrome.
Jefferson, A., Colella, S., Moralli, D., Wilson, N., Yusuf, M., Gimelli, G., Ragoussis, J. and Volpi, E.V. 2010. Altered intra-nuclear organisation of heterochromatin and genes in ICF syndrome. PLoS ONE. 5 (6) e11364. https://doi.org/10.1371/journal.pone.0011364

Mapping of partially overlapping de novo deletions across an autism susceptibility region (AUTS5) in two unrelated individuals affected by developmental delays with communication impairment.
Newbury, D.F., Warburton, P.C., Wilson, N., Bacchelli, E., Carone, S., International Molecular Genetic Study of Autism Consortium, Lamb, J.A., Maestrini, E., Monaco, A.P. and Volpi, E. 2009. Mapping of partially overlapping de novo deletions across an autism susceptibility region (AUTS5) in two unrelated individuals affected by developmental delays with communication impairment. American Journal of Medical Genetics Part A. 149A (4), pp. 588-597. https://doi.org/10.1002/ajmg.a.32704

HAC stability in murine cells is influenced by nuclear localization and chromatin organization.
Moralli, D., Chan, D.Y., Jefferson, A., Volpi, E.V. and Monaco, Z.L. 2009. HAC stability in murine cells is influenced by nuclear localization and chromatin organization. BMC Cell Biology. 10 18. https://doi.org/10.1186/1471-2121-10-18

Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection.
Sykes, N.H., Toma, C., Wilson, N., Volpi, E., Sousa, I., Pagnamenta, A.T., Tancredi, R., Battaglia, A., Maestrini, E., Bailey, A.J., Monaco, A.P. and International Molecular Genetic Study of Autism Consortium (IMGSAC) 2009. Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection. European Journal of Human Genetics. 17, pp. 1347-1353. https://doi.org/10.1038/ejhg.2009.47

Severe insulin resistance and intrauterine growth deficiency associated with haploin sufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism
Suliman, S.G., Stanik, J., McCulloch, L.J., Wilson, N., Edghill, E.L., Misovicova, N., Gasperikova, D., Sandrikova, V., Elliott, K.S., Barak, L., Ellard, S., Volpi, E.V., Klimes, I. and Gloyn, A.L. 2009. Severe insulin resistance and intrauterine growth deficiency associated with haploin sufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism. Diabetes. 58 (12), pp. 2954-2961. https://doi.org/10.2337/db09-0787

Childhood obesity prevention in Emirates (COPE): a conceptual framework for pilot intervention
Tewfik, I., Mackenzie, J., Cunliffe, A., Al-Dhaheri, A., Ali, H., Washi, S. and Platat, C. 2009. Childhood obesity prevention in Emirates (COPE): a conceptual framework for pilot intervention. in: Ahmed, A. (ed.) World sustainable development outlook: the impact of the global financial crisis on the environment, energy and sustainable development 2009 London World Association for Sustainable Development (WASD).

Nutritional quality of deep fried street-vended foods: a public health concern
Tewfik, I., Ismail, H. and Tewfik, S. 2009. Nutritional quality of deep fried street-vended foods: a public health concern. in: Ahmed, A. (ed.) World sustainable development outlook: the impact of the global financial crisis on the environment, energy and sustainable development 2009 London World Association for Sustainable Development (WASD).

Hepatic oxidative stress and apoptosis following acute alcohol
Everitt, H.E., Tewfik, I., Preedy, V.R. and Patel, V. 2009. Hepatic oxidative stress and apoptosis following acute alcohol. Alcohol & Alcoholism. 44, p. p85.

Assessment of shelf-life of irradiated frozen chicken
Alnasser, M.A., Park, S.F., Jenesson, P. and Tewfik, I. 2009. Assessment of shelf-life of irradiated frozen chicken. International Journal of Food Safety, Nutrition and Public Health. 2 (1), pp. 48-58. https://doi.org/10.1504/IJFSNPH.2009.026918

Would it still be possible to identify irradiated lipid-containing foods towards the end of their shelf-life?
Tewfik, I. and Tewfik, S. 2008. Would it still be possible to identify irradiated lipid-containing foods towards the end of their shelf-life? Food Science and Technology International. 14 (6), pp. 519-524. https://doi.org/10.1177/1082013208100465

Extraction and identification of cyclobutanones from irradiated cheese employing a rapid direct solvent extraction method
Tewfik, I. 2008. Extraction and identification of cyclobutanones from irradiated cheese employing a rapid direct solvent extraction method. International Journal of Food Sciences and Nutrition. 59 (7 & 8), pp. 590-598. https://doi.org/10.1080/09637480701515450

Inter-laboratory trial to validate the direct solvent extraction method for the identification of 2-dodecylcyclobutanone in irradiated chicken and whole liquid egg
Tewfik, I. 2008. Inter-laboratory trial to validate the direct solvent extraction method for the identification of 2-dodecylcyclobutanone in irradiated chicken and whole liquid egg. Food Science and Technology International. 14 (3), pp. 277-283. https://doi.org/10.1177/1082013208095689

Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas?
Bener, A., Hoffmann, G.F., Afify, Z., Rasul, K., Mian, M., Guiter, G. and Tewfik, I. 2008. Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas? Minerva Pediatrica. 60 (2), pp. 155-161.

FISH glossary: an overview of the fluorescence in situ hybridization technique.
Volpi, E.V. and Bridger, J.M. 2008. FISH glossary: an overview of the fluorescence in situ hybridization technique. BioTechniques. 45 (4), pp. 385-409. https://doi.org/10.2144/000112811

Nutraceuticals, functional foods and botanical dietary supplements; promote wellbeing and underpin public health
Tewfik, S. and Tewfik, I. 2008. Nutraceuticals, functional foods and botanical dietary supplements; promote wellbeing and underpin public health. World Review of Science, Technology and Sustainable Development. 5 (2), pp. 104-123. https://doi.org/10.1504/WRSTSD.2008.018552

Childhood obesity prevention (CHOP) programme: a conceptual framework for nutrition intervention
Tewfik, I. 2008. Childhood obesity prevention (CHOP) programme: a conceptual framework for nutrition intervention. International Journal of Food Safety, Nutrition and Public Health. 1 (1), pp. 16-32. https://doi.org/10.1504/IJFSNPH.2008.018853

Metabolic Syndrome and its components among Qatari population
Musallam, M., Bener, A., Zirie, M., Al-Gaud, Y.K., Al-Hamaq, A.A., Othman, M.A. and Tewfik, I. 2008. Metabolic Syndrome and its components among Qatari population. International Journal of Food Safety, Nutrition and Public Health. 1 (1), pp. 88-102. https://doi.org/10.1504/IJFSNPH.2008.018858

Impact of lifestyle and dietary habits on hypovitaminosis D in type 1 diabetes mellitus and healthy children from Qatar, a sun-rich country
Bener, A., Alsaied, A., Al-Ali, M., Hassan, A.S., Basha, B., Al-Kubaisi, A., Abraham, A., Mian, M., Guiter, G., Tewfik, I. and Agha, M. 2008. Impact of lifestyle and dietary habits on hypovitaminosis D in type 1 diabetes mellitus and healthy children from Qatar, a sun-rich country. Annals of Nutrition and Metabolism. 53 (3-4), pp. 215-222. https://doi.org/10.1159/000184439

A rapid direct solvent extraction (DSE) method for the extraction of cyclobutanones from irradiated chicken and liquid whole egg
Tewfik, I. 2008. A rapid direct solvent extraction (DSE) method for the extraction of cyclobutanones from irradiated chicken and liquid whole egg. International Journal of Food Science and Technology. 43 (1), pp. 108-113. https://doi.org/10.1111/j.1365-2621.2006.01399.x

Nutrition and alcoholic liver disease
Everitt, H.E., Patel, V. and Tewfik, I. 2007. Nutrition and alcoholic liver disease. Nutrition Bulletin. 32 (2), pp. 138-144. https://doi.org/10.1111/j.1467-3010.2007.00627.x

Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice.
Bendall, J.K., Rinze, R., Adlam, D., Tatham, A.L., de Bono, J., Wilson, N., Volpi, E. and Channon, K.M. 2007. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circulation Research. 100, pp. 1016-1025. https://doi.org/10.1161/01.res.0000263381.83835.7b

Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2.
Wilson, N.D., Ross, L.J., Close, J., Mott, R., Crow, T.J. and Volpi, E.V. 2007. Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2. Chromosome Research. 15, pp. 485-498. https://doi.org/10.1007/s10577-007-1153-y

Search for neuroblastoma loci: characterization of tumor cell lines that could facilitate their positional cloning.
Romani, M., Muresu, R., Volpi, E.V., Rozzo, C., Marchi, J.M. and Casciano, I. 2007. Search for neuroblastoma loci: characterization of tumor cell lines that could facilitate their positional cloning. Journal of Neuro-oncology . 31, pp. 41-47. https://doi.org/10.1023/a:1005725112688

The public health advocate: food irradiation's offer to food security
Tewfik, I. and Tewfik, S. 2007. The public health advocate: food irradiation's offer to food security. in: Ahmed, A. (ed.) Science, technology and sustainability in the Middle East and North Africa Genève InderScience. pp. 197-209

Competitive food safety program: the case of Qatar
Al-Hamaq, A.A., Zeyadah, S.S., Ahmed, A., Amuna, P. and Tewfik, I. 2007. Competitive food safety program: the case of Qatar. in: Ahmed, A. (ed.) Science, technology and sustainability in the Middle East and North Africa Genève InderScience. pp. 210-228

Book review: B. Freire Wilma (editor). Nutrition and an Active Life: From Knowledge to Action. Scientific and Technical Publication No. 612. Washington DC: Pan American Health Organization 2005. US$ 36·00 (paperback) pp. 260. ISBN: 92 75 11612 1
Tewfik, I. 2006. Book review: B. Freire Wilma (editor). Nutrition and an Active Life: From Knowledge to Action. Scientific and Technical Publication No. 612. Washington DC: Pan American Health Organization 2005. US$ 36·00 (paperback) pp. 260. ISBN: 92 75 11612 1. British Journal of Nutrition. 96 (4), p. 793. https://doi.org/10.1079/BJN20061844

Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population
Bener, A. and Tewfik, I. 2006. Prevalence of overweight, obesity, and associated psychological problems in Qatari's female population. Obesity Reviews. 7 (2), pp. 139-145. https://doi.org/10.1111/j.1467-789X.2006.00209.x

PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes.
Wilson, N.D., Ross, L.J., Crow, T.J. and Volpi, E.V. 2006. PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes. Cytogenetic and Genome Research. 114, pp. 137-139. https://doi.org/10.1159/000093329

The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci.
Laun, K., Coggill, P., Palmer, S., Sims, S., Ning, Z., Ragoussis, J., Volpi, E., Wilson, N., Beck, S., Ziegler, A. and Volz, A. 2006. The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci. PLoS Genetics. 2 (5) e73. https://doi.org/10.1371/journal.pgen.0020073

Industrial and dietetic applications of the food multimix (FMM) concept in meeting the nutritional needs of vulnerable groups in South Africa
Zotor, F., Amuna, P., Oldewage-Theron, W.H., Adewuya, T., Prinsloo, G., Chinyanga, Y., Tewfik, I. and Amuna, N. 2006. Industrial and dietetic applications of the food multimix (FMM) concept in meeting the nutritional needs of vulnerable groups in South Africa. Academic Journal of Vaal University of Technology. 3, pp. 54-67.

CO2 photoassimilation, chlorophyll fluorescence, lipid peroxidation and yield in cotton (Gossypium hirsutum L. cv Giza 65) in response to O3
Hassan, I.A. and Tewfik, I. 2006. CO2 photoassimilation, chlorophyll fluorescence, lipid peroxidation and yield in cotton (Gossypium hirsutum L. cv Giza 65) in response to O3. World Review of Science, Technology and Sustainable Development. 3 (1), pp. 70-79. https://doi.org/10.1504/WRSTSD.2006.008764

Prevalence of dieting, overweight, body image satisfaction and associated psychological problems in adolescent boys
Bener, A., Kamal, A., Tewfik, I. and Sabuncuoglu, O. 2006. Prevalence of dieting, overweight, body image satisfaction and associated psychological problems in adolescent boys. Nutrition & Food Science. 36 (5), pp. 295-304. https://doi.org/10.1108/00346650610703144

An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism.
Bowl, M.R., Nesbit, M.A., Harding, B., Levy, E., Jefferson, A., Volpi, E.V., Rizzoti, K., Lovell-Badge, R., Schlessinger, D., Whyte, M.P. and Thakker, R.V. 2005. An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism. Journal of Clinical Investigation. 115 (10), pp. 2822-2831. https://doi.org/10.1172/jci24156

Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice
Yalcin, B., Fullerton, J., Miller, S., Keays, D.A., Brady, S., Bhomra, A., Jefferson, A., Volpi, E., Copley, R.R., Flint, J. and Mott, R. 2004. Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0401189101

Mapping of three translocation breakpoints associated with orofacial clefting within 6p24 and identification of new transcripts within the region
Davies, S.J., Wise, C., Venkatesh, B., Mirza, G., Jefferson, A., Volpi, E.V. and Ragoussis, J. 2004. Mapping of three translocation breakpoints associated with orofacial clefting within 6p24 and identification of new transcripts within the region. Cytogenetic and Genome Research. 105, pp. 47-53. https://doi.org/10.1159/000078008

Would food irradiation as a means of technology transfer assist food productivity and security in Africa and sustain its development?
Tewfik, I., Amuna, P. and Zotor, F. 2004. Would food irradiation as a means of technology transfer assist food productivity and security in Africa and sustain its development? International Journal of Technology Policy and Management. 4 (1), pp. 44-52.

Human and economic development in developing countries: a public health dimension employing the food multimix concept
Amuna, P., Zotor, F. and Tewfik, I. 2004. Human and economic development in developing countries: a public health dimension employing the food multimix concept. World Review of Science, Technology and Sustainable Development. 1 (2), pp. 129-137.

Cohesion, but not too close
Volpi, E.V., Sheer, D. and Uhlmann, F. 2001. Cohesion, but not too close. Current Biology. 11 (10), p. R378. https://doi.org/10.1016/s0960-9822(01)00212-3

Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei.
Volpi, E.V., Chevret, E., Jones, T., Vatcheva, R., Williamson, J., Beck, S., Campbell, R.D., Goldsworthy, M., Powis, S.H., Ragoussis, J., Trowsdale, J. and Sheer, D. 2000. Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. Journal of Cell Science. 113 (Pt 9), pp. 1565-1576. https://doi.org/10.1242/jcs.113.9.1565

Mini review: form and function in the human interphase chromosome
Chevret, E., Volpi, E.V. and Sheer, D. 2000. Mini review: form and function in the human interphase chromosome. Cytogenetics and Cell Genetics. 90 (1-2), pp. 13-21. https://doi.org/10.1159/000015654

The effect of intermittent heating on some chemical parameters of refined oils used in Egypt. A public health nutrition concern
Tewfik, I., Ismail, H. and Sumar, S. 1998. The effect of intermittent heating on some chemical parameters of refined oils used in Egypt. A public health nutrition concern. International Journal of Food Sciences and Nutrition. 49 (5), pp. 339-342. https://doi.org/10.3109/09637489809089408

Nucleotide sequence and chromosomal mapping of the 5S rDNA repeat of the crustacean Proasellus coxalis.
Pelliccia, F., Barzotti, R., Volpi, E.V., Bucciarelli, E. and Rocchi, A. 1998. Nucleotide sequence and chromosomal mapping of the 5S rDNA repeat of the crustacean Proasellus coxalis. Genome. 41 (1), pp. 129-123. https://doi.org/10.1139/g97-110

Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples.
Muresu, R., Cossu, A., Scarpa, A.M., Volpi, E.V., Rocca, P.C., Pintus, A., Tibiletti, M.G., Tanda, F., Pirastu, M. and Massarelli, G. 1998. Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. Cancer Genetics and Cytogenetics. 107 (1), pp. 37-42. https://doi.org/10.1016/s0165-4608(98)00059-4

A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid supercritical fluid extraction method for the detection of 2-alkylcyclobutanones in gamma irradiated beef and chicken. Lebensmittel-Wissenschaft und-Technologie = Journal of Food Sciences and Technology. 31 (4), pp. 366-370. https://doi.org/10.1006/fstl.1998.0371

A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H. and Sumar, S. 1998. A rapid direct solvent extraction method (DSE-GC-MS) used to detect irradiated minced beef. Bulletin of High Institute of Public Health. 28 (3), pp. 85-92.

A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish
Tewfik, I. 1998. A rapid supercritical fluid extraction method for the qualitative detection of 2-alkylcyclobutanones in gamma-irradiated fresh and sea water fish. International Journal of Food Sciences and Nutrition. 50 (1), pp. 51-56. https://doi.org/10.1080/096374899101418

An integrated physical and genetic map spanning chromosome band 10q24.
Gray, I.C., Fallowfield, J., Ford, S., Nobile, C., Volpi, E.V. and Spurr, N.K. 1997. An integrated physical and genetic map spanning chromosome band 10q24. Genomics. 43 (1), pp. 85-88. https://doi.org/10.1006/geno.1997.4809

Detailed physical analysis of a 1.5-megabase YAC contig containing the MXI1 and ADRA2A genes.
Manca, A., Volpi, E.V., Laficara, F., Muresu, R., Gray, I.C., Spurr, N.K. and Nobile, C. 1997. Detailed physical analysis of a 1.5-megabase YAC contig containing the MXI1 and ADRA2A genes. Genomics. 45 (2), pp. 407-411. https://doi.org/10.1006/geno.1997.4924

Taxonomic and biogeographic analysis of the Proasellus coxalis-group (Crustacea, Isopoda, Asellidae) in Sicily, with description of Proasellus montalentii n.sp.
Stoch, F., Valentino, F. and Volpi, E. 1996. Taxonomic and biogeographic analysis of the Proasellus coxalis-group (Crustacea, Isopoda, Asellidae) in Sicily, with description of Proasellus montalentii n.sp. Hydrobiologia. 317, pp. 247-258. https://doi.org/10.1007/bf00036474

More detailed characterization of some of the HL60 karyotypic features by fluorescence in situ hybridization.
Volpi, E.V., Vatcheva, R., Labella, T. and Gan, S.U. 1996. More detailed characterization of some of the HL60 karyotypic features by fluorescence in situ hybridization. Cancer Genetics and Cytogenetics. 87 (2), pp. 103-106. https://doi.org/10.1016/0165-4608(95)00214-6

Molecular and genetic studies on the region of translocation and duplication in the neuroblastoma cell line NGP at the 1p36.13-p36.32 chromosomal site
Casciano, I., Marchi, J.V.M., Muresu, R., Volpi, E.V., Rozzo, C., Opdenakker, G. and Romani, M. 1996. Molecular and genetic studies on the region of translocation and duplication in the neuroblastoma cell line NGP at the 1p36.13-p36.32 chromosomal site. Oncogene. 12 (10), pp. 2101-2108.

A rapid method (SFE-GC-MS) used to detect irradiated minced beef
Tewfik, I., Ismail, H., Amine, E. and Rady, A. 1996. A rapid method (SFE-GC-MS) used to detect irradiated minced beef. Arab Journal of Nuclear Sciences and Applications. 29 (4), pp. 345-353.

Simple DNA repeats and sex chromosome differentiation in asellus aquaticus (Crustacea, isopoda)
Volpi, E.V., Pelliccia, F., Lanza, V., Barzotti, R. and Rocchi, A. 1995. Simple DNA repeats and sex chromosome differentiation in asellus aquaticus (Crustacea, isopoda). Heredity. 75, p. 267–272. https://doi.org/10.1038/hdy.1995.134

Cytogenetic and molecular studies on the neuroblastoma cell line NGP: identification of a reciprocal t(1;15) involving the "consensus region" 1p36.1.
Muresu, R., Casciano I., Volpi, E.V., Siniscalco, M. and Romani, M. 1995. Cytogenetic and molecular studies on the neuroblastoma cell line NGP: identification of a reciprocal t(1;15) involving the "consensus region" 1p36.1. Genes, Chromosomes & Cancer. 13 (1), pp. 66-71. https://doi.org/10.1002/gcc.2870130111

Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-->p34.3 and its position relative to the 1p marker D1S57.
Volpi, E.V., Romani, M. and Siniscalco, M. 1994. Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-->p34.3 and its position relative to the 1p marker D1S57. Cytogenetics and Cell Genetics. 67, pp. 187-189. https://doi.org/10.1159/000133819

Telomeric sequences of ase/lus aquaticus (Crust. isop.)
Pelliccia, F., Volpi, E.V., Lanza, V., Gaddini, L., Balding, A. and Rocchi, A. 1994. Telomeric sequences of ase/lus aquaticus (Crust. isop.). Heredity. 72, pp. 78-80. https://doi.org/10.1038/hdy.1994.9

Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRNA cluster (RNU1) within 400 kb of the chromosome region 1p36.1.
Romani, M., Baldini, A., Volpi, E., Casciano, I., Nobile, C., Muresu, R. and Siniscalco, M. 1994. Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRNA cluster (RNU1) within 400 kb of the chromosome region 1p36.1. Cytogenetics and Cell Genetics. 67, pp. 37-40. https://doi.org/10.1159/000133793

MULTIPRINS: a method for multicolour primed in situ labelling
Volpi, E. and Baldini, A. 1993. MULTIPRINS: a method for multicolour primed in situ labelling. Chromosome Research. 1, pp. 257-260. https://doi.org/10.1007/bf00710131

Morphological differentiation of a sex chromosome and ribosomal genes in asellus aquaticus (Crust. Isop.)
Volpi, E.V., Pelliccia, F., Lanza, V., Di Castro, M. and Rocchi, A. 1992. Morphological differentiation of a sex chromosome and ribosomal genes in asellus aquaticus (Crust. Isop.). Heredity. https://doi.org/10.1038/hdy.1992.153

GATA repeats in the genome of Asellus aquaticus (Crustacea, Isopoda).
Pelliccia, F., Di Castro, M., Lanza, V., Volpi, E.V. and Rocchi, A. 1991. GATA repeats in the genome of Asellus aquaticus (Crustacea, Isopoda). Chromosoma. 100, pp. 152-155. https://doi.org/10.1007/bf00337243

Light-dark cycle and mitotic index in Asellus aquaticus (L.) (Crustacea, Isopoda)
Valentino, F., Volpi, E.V., Antolini, R. and Migliore, L. 1990. Light-dark cycle and mitotic index in Asellus aquaticus (L.) (Crustacea, Isopoda). Genetica. 82, pp. 147-150. https://doi.org/10.1007/bf00124645

The genetic isolation between some populations of Proasellus coxalis
Volpi, E.V., Antolini, R. and Valentino, F. 1989. The genetic isolation between some populations of Proasellus coxalis. Journal of Zoological Systematics and Evolutionary Research. 27 (3), pp. 246-251. https://doi.org/10.1111/j.1439-0469.1989.tb00346.x

Characterization of the karyotype of proasellus meridianusby differential staining techniques
Di Castro, M., Lanza, V., Volpi, E.V. and Rocchi, A. 1989. Characterization of the karyotype of proasellus meridianusby differential staining techniques. Caryologia. 42 (3-4), pp. 235-242. https://doi.org/10.1080/00087114.1989.10796970

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