|Title||Genome Instability in Childhood Obesity – a potential role for bariatric surgery in cancer prevention?|
|Authors||Usman, M. and Volpi, E.|
Severe paediatric obesity is associated with a range of metabolic complications and is characterised by a chronic meta-inflammatory state. It is postulated that this inflammatory response may result in an excess of systemic reactive oxygen species (ROS) that are well known for inducing DNA damage and reducing the capability of DNA synthesis and repair enzymes. Consequently, chronic inflammation in obesity may promote an accumulation of deleterious DNA mutations, leading to genome instability and driving carcinogenesis.
|Keywords||Childhood obesity; DNA damage; Genome instability; chronic inflammation; bariatric surgery; cancer|
|Conference||Severe Paediatric Obesity: Current Medical and Surgical Management Paradigms - A Global Perspective|
|Publisher||International Consortium of Adolescent Bariatric Surgeons (ICABS)|
|Accepted author manuscript|
|Published||18 Jul 2017|