Expression patterns of CD180 in the lymph nodes of patients with chronic lymphocytic leukaemia

Edwards, K., Volpi, E., Lydyard, P., Zaitseva, K., Sayed, U., Krysov, S., Gribben, J., Nathwani, D.A. and Porakishvili, N. 2021. Expression patterns of CD180 in the lymph nodes of patients with chronic lymphocytic leukaemia. British Journal of Haematology. 195 (2), pp. e131-e134. https://doi.org/10.1111/bjh.17680

TitleExpression patterns of CD180 in the lymph nodes of patients with chronic lymphocytic leukaemia
TypeJournal article
AuthorsEdwards, K., Volpi, E., Lydyard, P., Zaitseva, K., Sayed, U., Krysov, S., Gribben, J., Nathwani, D.A. and Porakishvili, N.
Abstract

There is strong evidence implicating microenvironmental sensors, including toll-like receptors (TLRs), in the pathobiology of chronic lymphocytic leukaemia (CLL).1, 2 We have previously demonstrated that the orphan TLR CD180 is heterogeneously expressed on peripheral blood (PB) CLL cells in ~60% of cases.3 Ligation of CD180 with monoclonal antibody (mAb) resulted in the activation, cycling and proliferation of PB CLL cells.4 We further demonstrated that CD180 engagement utilised two, often alternative signalling pathways mediated by protein kinase B (AKT) or p38 mitogen-activated protein kinase (p38MAPK), which corresponded with CLL cell survival and apoptosis, respectively. Moreover, in our hands, ligation of CD180 rewired immunoglobulin M (IgM)-mediated signalling from AKT to p38MAPK pathway.5

Given the important role of proliferation centres in the pathobiology of CLL,6 we investigated for the first time the expression of CD180 in the lymph nodes (LNs) of 55 untreated and 55 treated patients with CLL and six normal controls, using immunohistochemistry and calculation of a semi-quantitative H-score.7 The paraffin sections of the LNs were collected between 1992 and 2013, and the patients were treated with various regimens applicable to the collection period.

KeywordsCLL, CD180, Lymph nodes
JournalBritish Journal of Haematology
Journal citation195 (2), pp. e131-e134
ISSN0007-1048
1365-2141
Year2021
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1111/bjh.17680
Web address (URL)https://onlinelibrary.wiley.com/doi/10.1111/bjh.17680
Publication dates
Published online05 Jul 2021

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Kulikova, N., Amaglobeli, N., Tsertsvadze, T., Tsagareishvili, P., Sereda, L., Tevzadze, M., Kardava, L., Ghirdaladze, M., Gachechiladze, N., Lukhumaidze, M. and Porakishvili, N. 2009. Association between seropositivity for cytomegalovirus (CMV) and CD4+ cytotoxic T cells expansions in patients with B-cell Chronic Lymphocyte Leukaemia (B-CLL) and healthy controls. Proceedings of the Georgian Academy of Sciences. 7 (3-4), pp. 41-46.

Engagement of different Fc-gamma receptors in phagocytosis of immune complexes containing antibodies to mutated human chorionic gonadotropin β chain (hCG-beta) and native hCG molecule
Chikadze, N., Janikashvili, N., Gachechiladze, N., Lomishvili, N., Kvirkvelia, N., Delves, P.J. and Porakishvili, N. 2009. Engagement of different Fc-gamma receptors in phagocytosis of immune complexes containing antibodies to mutated human chorionic gonadotropin β chain (hCG-beta) and native hCG molecule. Proceedings of the Georgian Academy of Sciences. 7 (1-2), pp. 39-46.

FISH glossary: an overview of the fluorescence in situ hybridization technique.
Volpi, E.V. and Bridger, J.M. 2008. FISH glossary: an overview of the fluorescence in situ hybridization technique. BioTechniques. 45 (4), pp. 385-409. https://doi.org/10.2144/000112811

Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice.
Bendall, J.K., Rinze, R., Adlam, D., Tatham, A.L., de Bono, J., Wilson, N., Volpi, E. and Channon, K.M. 2007. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circulation Research. 100, pp. 1016-1025. https://doi.org/10.1161/01.res.0000263381.83835.7b

Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2.
Wilson, N.D., Ross, L.J., Close, J., Mott, R., Crow, T.J. and Volpi, E.V. 2007. Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2. Chromosome Research. 15, pp. 485-498. https://doi.org/10.1007/s10577-007-1153-y

Search for neuroblastoma loci: characterization of tumor cell lines that could facilitate their positional cloning.
Romani, M., Muresu, R., Volpi, E.V., Rozzo, C., Marchi, J.M. and Casciano, I. 2007. Search for neuroblastoma loci: characterization of tumor cell lines that could facilitate their positional cloning. Journal of Neuro-oncology . 31, pp. 41-47. https://doi.org/10.1023/a:1005725112688

PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes.
Wilson, N.D., Ross, L.J., Crow, T.J. and Volpi, E.V. 2006. PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes. Cytogenetic and Genome Research. 114, pp. 137-139. https://doi.org/10.1159/000093329

The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci.
Laun, K., Coggill, P., Palmer, S., Sims, S., Ning, Z., Ragoussis, J., Volpi, E., Wilson, N., Beck, S., Ziegler, A. and Volz, A. 2006. The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci. PLoS Genetics. 2 (5) e73. https://doi.org/10.1371/journal.pgen.0020073

Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes
Porakishvili, N., Kulikova, N., Jewell, A.P., Youinou, P.Y., Yong, K.L., Nathwani, A., Heelan, B., Duke, V., Hamblin, T.J., Wallace, P., Ely, P., Clark, E.A. and Lydyard, P.M. 2005. Differential expression of CD180 and IgM by B-cell chronic lymphocytic leukaemia cells using mutated and unmutated immunoglobulin VH genes. British Journal of Haematology. 131 (3), pp. 313-319. https://doi.org/10.1111/j.1365-2141.2005.05775.x

B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients
Nedellec, S., Renaudineau, Y., Bordron, A., Berthou, C., Porakishvili, N., Lydyard, P.M., Pers, J.O. and Youinou, P.Y. 2005. B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients. Journal of Immunology. 174 (6), pp. 3749-3756.

An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism.
Bowl, M.R., Nesbit, M.A., Harding, B., Levy, E., Jefferson, A., Volpi, E.V., Rizzoti, K., Lovell-Badge, R., Schlessinger, D., Whyte, M.P. and Thakker, R.V. 2005. An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism. Journal of Clinical Investigation. 115 (10), pp. 2822-2831. https://doi.org/10.1172/jci24156

Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway
Porakishvili, N., Kardava, L., Jewell, A.P., Yong, K.L., Glennie, M.J., Akbar, A. and Lydyard, P.M. 2004. Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway. Haematologica. 89 (4), pp. 435-443.

Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice
Yalcin, B., Fullerton, J., Miller, S., Keays, D.A., Brady, S., Bhomra, A., Jefferson, A., Volpi, E., Copley, R.R., Flint, J. and Mott, R. 2004. Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0401189101

Mapping of three translocation breakpoints associated with orofacial clefting within 6p24 and identification of new transcripts within the region
Davies, S.J., Wise, C., Venkatesh, B., Mirza, G., Jefferson, A., Volpi, E.V. and Ragoussis, J. 2004. Mapping of three translocation breakpoints associated with orofacial clefting within 6p24 and identification of new transcripts within the region. Cytogenetic and Genome Research. 105, pp. 47-53. https://doi.org/10.1159/000078008

Patterns of the expression of CD32 and CD64 on monocytes of patients with B cell chronic lymphocytic leukaemia
Porakishvili, N. 2004. Patterns of the expression of CD32 and CD64 on monocytes of patients with B cell chronic lymphocytic leukaemia. Proceedings of the Georgian Academy of Sciences. 2 (3-4), pp. 86-91.

The role of complement in the clearance of human chorionic gonadotropin (HCG) containing immune complexes
Janikashvili, N., Chikadze, N., Gabunia, K. and Porakishvili, N. 2004. The role of complement in the clearance of human chorionic gonadotropin (HCG) containing immune complexes. Proceedings of the Georgian Academy of Sciences. 2 (3-4), pp. 92-96.

Impaired phagocytic function of monocytes in B cell chronic lymphocytic leukaemia
Akhobadze, T., Amaglobeli, N., Sereda, L., Shelegia, K., Lomishvili, N., Burjanadze, L., Ghirdaladze, D., Iosava, G. and Porakishvili, N. 2004. Impaired phagocytic function of monocytes in B cell chronic lymphocytic leukaemia. Bulletin of the Georgian Academy of Sciences. 169 (3), pp. 619-622.

The use of hepatitis B core antigen particles as a presentation scaffold for a peptide-based contraceptive vaccine
Kvirkvelia, N., Page, M., McBride, J.D., Porakishvili, N., Lund, T., Roitt, I.M. and Delves, P.J. 2003. The use of hepatitis B core antigen particles as a presentation scaffold for a peptide-based contraceptive vaccine. Journal of Reproductive Immunology. 58 (2), p. 138. https://doi.org/10.1016/S0165-0378(03)00056-1

Activation of B-CLL cells by CD180 monoclonal antibodies: responders and non-responders
Porakishvili, N., Slovick, N., Jewell, A.P., Youinou, P.Y., Nathwani, A., Yong, K.L., Stevenson, F.K., Clark, E.A. and Lydyard, P.M. 2003. Activation of B-CLL cells by CD180 monoclonal antibodies: responders and non-responders. Blood. 102, p. 432a.

Preferential expression of CD180 by B cell chronic lymphocytic leukaemia (B-CLL) cells using IgVh mutated than those using IgVh unmutated genes
Porakishvili, N., Kulikova, N., Jewell, A.P., Youinou, P.Y., Yong, K.L., Nathwani, C., Heelan, B., Duke, V., Stevenson, F.K., Hamblin, T.J., Wallace, P., Ely, P., Clark, E.A. and Lydyard, P.M. 2003. Preferential expression of CD180 by B cell chronic lymphocytic leukaemia (B-CLL) cells using IgVh mutated than those using IgVh unmutated genes. Leukemia and Lymphoma. 44 (Supp. 2), p. S17.

Aberrant expression of Ccy-receptor (CD64) by monoclytes and neutrophils from patients with B cell chronic lymphocytic leukaemia
Porakishvili, N., Akhobadze, T., Kapanadze, T. and Baloyan, D. 2003. Aberrant expression of Ccy-receptor (CD64) by monoclytes and neutrophils from patients with B cell chronic lymphocytic leukaemia. Proceedings of the Georgain Academy of Sciences. 1 (1-2), pp. 39-42.

Assessment of in vitro phagocytosis of immune complexes containing native molecules of human chorionic gonadotropin (hCG) and mutant sera
Chikadze, N., Janikashvili, N. and Porakishvili, N. 2003. Assessment of in vitro phagocytosis of immune complexes containing native molecules of human chorionic gonadotropin (hCG) and mutant sera. Bulletin of the Georgian Academy of Sciences. 168 (2), pp. 373-376.

Immunogenicity and cross-reactivity of a novel mutant recombinant hCGb-protein
Chikadze, N., Janikashvili, N., Delves, P.J. and Porakishvili, N. 2003. Immunogenicity and cross-reactivity of a novel mutant recombinant hCGb-protein. Bulletin of the Georgian Academy of Sciences. 167 (3), pp. 558-562.

Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin
Porakishvili, N., Dalla Chiesa, M., Chikadze, N., Martensen, P., Justesen, J., Lund, T., Delves, P.J. and Roitt, I.M. 2002. Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin. Vaccine. 20 (16), pp. 2053-2059. https://doi.org/10.1016/S0264-410X(02)00051-8

The role of IgE in the development of hypersensitivity in allergic and autoimmune conditions
Lomishvili, N., Mitskevichi, N., Amaglobeli, N. and Porakishvili, N. 2002. The role of IgE in the development of hypersensitivity in allergic and autoimmune conditions. Proceedings of the Georgian Academy of Sciences. 28, pp. 349-353.

Phagocytosis and the regulation of apoptosis in B-chronic lymphocytic leukaemia
Gabunia, K., Kardava, L., Kulikova, N., Jordania, T., Burjanadze, L., Sereda, L. and Porakishvili, N. 2002. Phagocytosis and the regulation of apoptosis in B-chronic lymphocytic leukaemia. Bulletin of the Georgian Academy of Sciences. 166 (1), pp. 153-157.

Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL)
Porakishvili, N., Roschupkina, T., Kalber, T., Jewell, A.P., Patterson, K., Yong, K.L. and Lydyard, P.M. 2001. Expansion of CD4+ T cells with a cytotoxic phenotype in patients with B-chronic lymphocytic leukaemia (B-CLL). Clinical and Experimental Immunology. 126 (1), pp. 29-36. https://doi.org/10.1046/j.1365-2249.2001.01639.x

Recent progress in the understanding of B-cell functions in autoimmunity
Porakishvili, N., Mageed, R.A., Jamin, C., Pers, J.O., Kulikova, N., Renaudineau, Y., Lydyard, P.M. and Youinou, P.Y. 2001. Recent progress in the understanding of B-cell functions in autoimmunity. Scandinavian Journal of Immunology. 54 (1-2), pp. 30-38. https://doi.org/10.1046/j.1365-3083.2001.00950.x

Refocusing of B-cell responses following a single amino acid substitution in an antigen
Dalla Chiesa, M., Martensen, P., Simmons, C., Porakishvili, N., Justesen, J., Dougan, G., Roitt, I.M., Delves, P.J. and Lund, T. 2001. Refocusing of B-cell responses following a single amino acid substitution in an antigen. Immunology. 103 (2), pp. 172-178. https://doi.org/10.1046/j.1365-2567.2001.01242.x

Cohesion, but not too close
Volpi, E.V., Sheer, D. and Uhlmann, F. 2001. Cohesion, but not too close. Current Biology. 11 (10), p. R378. https://doi.org/10.1016/s0960-9822(01)00212-3

The role of immune complexes in immunopathogenesis of extrinsic allergic alveolitis caused by the contact with organic dust
Mitskevichi, N., Machavarani, K., Khechinashvili, G. and Porakishvili, N. 2001. The role of immune complexes in immunopathogenesis of extrinsic allergic alveolitis caused by the contact with organic dust. Proceedings of the Georgian Academy of Sciences. 27, pp. 391-396.

Serum factors and T cell phenotype in patients with systemic lupus erythematosus (SLE), SLE-complicated with glomerulonephritis (SLE-GN) and in healthy controls
Lomishvili, N., Kalandadze, N. and Porakishvili, N. 2001. Serum factors and T cell phenotype in patients with systemic lupus erythematosus (SLE), SLE-complicated with glomerulonephritis (SLE-GN) and in healthy controls. Bulletin of the Georgian Academy of Sciences. 163 (3), pp. 233-236.

Autoantibodies to human chorionic gonadotropin in patients with systemic lupus erythematosus and patients with tumours of the reproductive systems
Lomishvili, N., Akhvlediani, L., Chikadze, N. and Porakishvili, N. 2001. Autoantibodies to human chorionic gonadotropin in patients with systemic lupus erythematosus and patients with tumours of the reproductive systems. Proceedings of the Georgian Academy of Sciences. 27, pp. 235-238.

Induction of apoptosis by anti-CD5 monoclonal antibodies in B-CLL cells correlates with the level of CD79b expression
Kulikova, N., Lydyard, P.M. and Porakishvili, N. 2001. Induction of apoptosis by anti-CD5 monoclonal antibodies in B-CLL cells correlates with the level of CD79b expression. Proceedings of the Georgian Academy of Sciences. 27, pp. 363-368.

Proliferation of B-chronic lymphocytic leukaemic cells in vitro in response to dihydroxycinnamate-derived polymers from symphytum asperum and symphytum caucasicum
Kardava, L., Tevzadze, M., Gabunia, K. and Porakishvili, N. 2001. Proliferation of B-chronic lymphocytic leukaemic cells in vitro in response to dihydroxycinnamate-derived polymers from symphytum asperum and symphytum caucasicum. Trans-Caucasian Journal of Immunology. 2, pp. 77-87.

The cell cycle progression of B-chronic lymphocytic leukaemia cells in vitro
Kardava, L., Kulikova, N., Tevzadze, M. and Porakishvili, N. 2001. The cell cycle progression of B-chronic lymphocytic leukaemia cells in vitro. Proceedings of the Georgian Academy of Sciences. 27, pp. 4-6.

CD5-induced apoptosis of B cells in some patients with chronic lymphocytic leukemia
Pers, J.O., Berthou, C., Porakishvili, N., Burdjanadze, N., Le Calvez, G., Abgrall, J.F., Lydyard, P.M., Youinou, P.Y. and Jamin, C. 2001. CD5-induced apoptosis of B cells in some patients with chronic lymphocytic leukemia. Leukemia. 16 (1), pp. 44-52. https://doi.org/10.1038/sj/leu/2402327

Impaired phagocytic function of polymorpho-nuclear neutrophils in B chronic lymphocytic leukemia.
Gabunia, K., Gachechiladze, N., Burjanadze, L., Roschupkina, T., Baloyan, D., Kardava, L., Ghirdaladze, D., Iosava, G., Jewell, A.P., Lydyard, P.M. and Porakishvili, N. 2000. Impaired phagocytic function of polymorpho-nuclear neutrophils in B chronic lymphocytic leukemia. Haematologica. 85 (Supple), pp. 28-29.

Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei.
Volpi, E.V., Chevret, E., Jones, T., Vatcheva, R., Williamson, J., Beck, S., Campbell, R.D., Goldsworthy, M., Powis, S.H., Ragoussis, J., Trowsdale, J. and Sheer, D. 2000. Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. Journal of Cell Science. 113 (Pt 9), pp. 1565-1576. https://doi.org/10.1242/jcs.113.9.1565

Mini review: form and function in the human interphase chromosome
Chevret, E., Volpi, E.V. and Sheer, D. 2000. Mini review: form and function in the human interphase chromosome. Cytogenetics and Cell Genetics. 90 (1-2), pp. 13-21. https://doi.org/10.1159/000015654

Nucleotide sequence and chromosomal mapping of the 5S rDNA repeat of the crustacean Proasellus coxalis.
Pelliccia, F., Barzotti, R., Volpi, E.V., Bucciarelli, E. and Rocchi, A. 1998. Nucleotide sequence and chromosomal mapping of the 5S rDNA repeat of the crustacean Proasellus coxalis. Genome. 41 (1), pp. 129-123. https://doi.org/10.1139/g97-110

Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples.
Muresu, R., Cossu, A., Scarpa, A.M., Volpi, E.V., Rocca, P.C., Pintus, A., Tibiletti, M.G., Tanda, F., Pirastu, M. and Massarelli, G. 1998. Numerical abnormalities of chromosomes 1 and 10 in endometrial adenocarcinoma: fluorescence in situ hybridization analysis of 23 archival paraffin-embedded samples. Cancer Genetics and Cytogenetics. 107 (1), pp. 37-42. https://doi.org/10.1016/s0165-4608(98)00059-4

An integrated physical and genetic map spanning chromosome band 10q24.
Gray, I.C., Fallowfield, J., Ford, S., Nobile, C., Volpi, E.V. and Spurr, N.K. 1997. An integrated physical and genetic map spanning chromosome band 10q24. Genomics. 43 (1), pp. 85-88. https://doi.org/10.1006/geno.1997.4809

Detailed physical analysis of a 1.5-megabase YAC contig containing the MXI1 and ADRA2A genes.
Manca, A., Volpi, E.V., Laficara, F., Muresu, R., Gray, I.C., Spurr, N.K. and Nobile, C. 1997. Detailed physical analysis of a 1.5-megabase YAC contig containing the MXI1 and ADRA2A genes. Genomics. 45 (2), pp. 407-411. https://doi.org/10.1006/geno.1997.4924

Taxonomic and biogeographic analysis of the Proasellus coxalis-group (Crustacea, Isopoda, Asellidae) in Sicily, with description of Proasellus montalentii n.sp.
Stoch, F., Valentino, F. and Volpi, E. 1996. Taxonomic and biogeographic analysis of the Proasellus coxalis-group (Crustacea, Isopoda, Asellidae) in Sicily, with description of Proasellus montalentii n.sp. Hydrobiologia. 317, pp. 247-258. https://doi.org/10.1007/bf00036474

More detailed characterization of some of the HL60 karyotypic features by fluorescence in situ hybridization.
Volpi, E.V., Vatcheva, R., Labella, T. and Gan, S.U. 1996. More detailed characterization of some of the HL60 karyotypic features by fluorescence in situ hybridization. Cancer Genetics and Cytogenetics. 87 (2), pp. 103-106. https://doi.org/10.1016/0165-4608(95)00214-6

Molecular and genetic studies on the region of translocation and duplication in the neuroblastoma cell line NGP at the 1p36.13-p36.32 chromosomal site
Casciano, I., Marchi, J.V.M., Muresu, R., Volpi, E.V., Rozzo, C., Opdenakker, G. and Romani, M. 1996. Molecular and genetic studies on the region of translocation and duplication in the neuroblastoma cell line NGP at the 1p36.13-p36.32 chromosomal site. Oncogene. 12 (10), pp. 2101-2108.

Simple DNA repeats and sex chromosome differentiation in asellus aquaticus (Crustacea, isopoda)
Volpi, E.V., Pelliccia, F., Lanza, V., Barzotti, R. and Rocchi, A. 1995. Simple DNA repeats and sex chromosome differentiation in asellus aquaticus (Crustacea, isopoda). Heredity. 75, p. 267–272. https://doi.org/10.1038/hdy.1995.134

Cytogenetic and molecular studies on the neuroblastoma cell line NGP: identification of a reciprocal t(1;15) involving the "consensus region" 1p36.1.
Muresu, R., Casciano I., Volpi, E.V., Siniscalco, M. and Romani, M. 1995. Cytogenetic and molecular studies on the neuroblastoma cell line NGP: identification of a reciprocal t(1;15) involving the "consensus region" 1p36.1. Genes, Chromosomes & Cancer. 13 (1), pp. 66-71. https://doi.org/10.1002/gcc.2870130111

Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-->p34.3 and its position relative to the 1p marker D1S57.
Volpi, E.V., Romani, M. and Siniscalco, M. 1994. Subregional mapping of the human lymphocyte-specific protein tyrosine kinase gene (LCK) to 1p35-->p34.3 and its position relative to the 1p marker D1S57. Cytogenetics and Cell Genetics. 67, pp. 187-189. https://doi.org/10.1159/000133819

Telomeric sequences of ase/lus aquaticus (Crust. isop.)
Pelliccia, F., Volpi, E.V., Lanza, V., Gaddini, L., Balding, A. and Rocchi, A. 1994. Telomeric sequences of ase/lus aquaticus (Crust. isop.). Heredity. 72, pp. 78-80. https://doi.org/10.1038/hdy.1994.9

Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRNA cluster (RNU1) within 400 kb of the chromosome region 1p36.1.
Romani, M., Baldini, A., Volpi, E., Casciano, I., Nobile, C., Muresu, R. and Siniscalco, M. 1994. Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRNA cluster (RNU1) within 400 kb of the chromosome region 1p36.1. Cytogenetics and Cell Genetics. 67, pp. 37-40. https://doi.org/10.1159/000133793

MULTIPRINS: a method for multicolour primed in situ labelling
Volpi, E. and Baldini, A. 1993. MULTIPRINS: a method for multicolour primed in situ labelling. Chromosome Research. 1, pp. 257-260. https://doi.org/10.1007/bf00710131

Morphological differentiation of a sex chromosome and ribosomal genes in asellus aquaticus (Crust. Isop.)
Volpi, E.V., Pelliccia, F., Lanza, V., Di Castro, M. and Rocchi, A. 1992. Morphological differentiation of a sex chromosome and ribosomal genes in asellus aquaticus (Crust. Isop.). Heredity. https://doi.org/10.1038/hdy.1992.153

GATA repeats in the genome of Asellus aquaticus (Crustacea, Isopoda).
Pelliccia, F., Di Castro, M., Lanza, V., Volpi, E.V. and Rocchi, A. 1991. GATA repeats in the genome of Asellus aquaticus (Crustacea, Isopoda). Chromosoma. 100, pp. 152-155. https://doi.org/10.1007/bf00337243

Light-dark cycle and mitotic index in Asellus aquaticus (L.) (Crustacea, Isopoda)
Valentino, F., Volpi, E.V., Antolini, R. and Migliore, L. 1990. Light-dark cycle and mitotic index in Asellus aquaticus (L.) (Crustacea, Isopoda). Genetica. 82, pp. 147-150. https://doi.org/10.1007/bf00124645

The genetic isolation between some populations of Proasellus coxalis
Volpi, E.V., Antolini, R. and Valentino, F. 1989. The genetic isolation between some populations of Proasellus coxalis. Journal of Zoological Systematics and Evolutionary Research. 27 (3), pp. 246-251. https://doi.org/10.1111/j.1439-0469.1989.tb00346.x

Characterization of the karyotype of proasellus meridianusby differential staining techniques
Di Castro, M., Lanza, V., Volpi, E.V. and Rocchi, A. 1989. Characterization of the karyotype of proasellus meridianusby differential staining techniques. Caryologia. 42 (3-4), pp. 235-242. https://doi.org/10.1080/00087114.1989.10796970

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