DNA damage in obesity: Initiator, promoter and predictor of cancer

Usman, M. and Volpi, E. 2018. DNA damage in obesity: Initiator, promoter and predictor of cancer. Mutation Research/Reviews in Mutation Research. 778, pp. 23-37. doi:10.1016/j.mrrev.2018.08.002

TitleDNA damage in obesity: Initiator, promoter and predictor of cancer
TypeJournal article
AuthorsUsman, M. and Volpi, E.
Abstract

Epidemiological evidence linking obesity with increased risk of cancer is steadily growing, although the causative aspects underpinning this association are only partially understood. Obesity leads to a physiological imbalance in the regulation of adipose tissue and its normal functioning, resulting in hyperglycaemia, dyslipidaemia and inflammation. These states promote the generation of oxidative stress, which is exacerbated in obesity by a decline in anti-oxidant defence systems. Oxidative stress can have a marked impact on DNA, producing mutagenic lesions that could prove carcinogenic. Here we review the current evidence for genomic instability, sustained DNA damage and accelerated genome ageing in obesity. We explore the notion of genotoxicity, ensuing from systemic oxidative stress, as a key oncogenic factor in obesity. Finally, we advocate for early, pre-malignant assessment of genome integrity and stability to inform surveillance strategies and interventions.

KeywordsDNA Damage Obesity Inflammation Oxidative Stress Cancer
JournalMutation Research/Reviews in Mutation Research
Journal citation778, pp. 23-37
ISSN1383-5742
Year2018
PublisherElsevier
Digital Object Identifier (DOI)doi:10.1016/j.mrrev.2018.08.002
Publication dates
Published online17 Aug 2018
Published in printOct 2018
LicenseCC BY-NC-ND 4.0

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