Title | Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease |
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Authors | Wardle, N.J., Hudson, H.R., Matthews, R.W., Nunn, C., Vella, C. and Bligh, S.W.A. |
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Abstract | Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development. |
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Journal | ChemMedChem |
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Journal citation | 8 (5), pp. 719-721 |
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ISSN | 1860-7179 |
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Year | May 2013 |
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Publisher | Wiley |
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Digital Object Identifier (DOI) | https://doi.org/10.1002/cmdc.201300051 |
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Publication dates |
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Published | May 2013 |
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