| Title | Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease |
|---|
| Authors | Wardle, N.J., Hudson, H.R., Matthews, R.W., Nunn, C., Vella, C. and Bligh, S.W.A. |
|---|
| Abstract | Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development. |
|---|
| Journal | ChemMedChem |
|---|
| Journal citation | 8 (5), pp. 719-721 |
|---|
| ISSN | 1860-7179 |
|---|
| Year | May 2013 |
|---|
| Publisher | Wiley |
|---|
| Digital Object Identifier (DOI) | https://doi.org/10.1002/cmdc.201300051 |
|---|
| Publication dates |
|---|
| Published | May 2013 |
|---|