Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging

Bligh, S.W.A., Harding, C.T., Sadler, P.J., Bulman, R.A., Bydder, G.M., Pennock, J.M., Kelly, J.D., Clatham, I.A. and Marriott, J.A. 1991. Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging. Magnetic Resonance in Medicine. 17 (2), pp. 516-532.

TitleUse of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging
AuthorsBligh, S.W.A., Harding, C.T., Sadler, P.J., Bulman, R.A., Bydder, G.M., Pennock, J.M., Kelly, J.D., Clatham, I.A. and Marriott, J.A.
Abstract

Soluble and insoluble polysaccharides were derivatized with diethylenetriaminepentaacetic acid (DTPA) and/or spin-labeled with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO). Polysaccharides derivatized with DTPA were prepared via cyanogen bromide activation, coupling to a diamine linker, and to DTPA anhydride. Spin-labeled polysaccharides were also prepared via cyanogen bromide activation. The extent of derivatization for dextran (18 kDa) was about 120 glucose units per DTPA, and for cellulose and starch about 15–30 units per DTPA. For spin-labeled polysaccharides, the average loading ranged from 1 nitroxide per 16 glucose units for starch to 181 for dextran (82 kDa). These derivatized paramagnetic polysaccharides were shown to be more effective relaxants than the small paramagnetic molecules alone. Both soluble and insoluble polysaccharide-linker-DTPA-Gd(III) complexes were effectively cleared from the body (rats) after oral administration. After intravenous administration, the biodistribution of dextran-linker-DTPA-Gd(III) complexes differed significantly from that of GdDTPA. Reduction of the nitroxide by ascorbic acid was retarded in the polysaccharide derivatives, particularly in starch enrivatized with both nitroxide and linker-DTPA-Cu(II). These agents showed contrast enhancement in the gastrointestinal tract of rabbits.

JournalMagnetic Resonance in Medicine
Journal citation17 (2), pp. 516-532
ISSN0740-3194
YearFeb 1991
PublisherWiley
Digital Object Identifier (DOI)doi:10.1002/mrm.1910170222
Publication dates
PublishedFeb 1991

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Zhang, F., Wang, C.-H., Xiong, A., Wang, W., Yang, L., Branford-White, C.J., Wang, Z. and Bligh, S.W.A. 2007. Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography. Analytica Chimica Acta. 605 (1), pp. 94-101.

Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography
Wang, Y., Kong, L., Hu, L., Lei, X., Yang, L., Chou, G.-X., Zou, H., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2007. Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. Journal of Chromatography B: Biomedical Sciences and Applications. 860 (2), pp. 185-194.

Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina
Wang, S.C., Bligh, S.W.A., Shi, S.S., Wang, Z., Hu, Z.B., Crowder, J., Branford-White, C.J. and Vella, C. 2007. Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina. International Journal of Biological Macromolecules. 41 (4), pp. 369-375.

Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone
Wang, C.-H., Cheng, X.M., He, Y.Q., White, K.N., Bligh, S.W.A., Branford-White, C.J. and Wang, Z. 2007. Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone. Archives of pharmacal research. 30 (9), pp. 1149-1154.

Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone
Wang, C.-H., Cheng, X.M., Bligh, S.W.A., White, K.N., Branford-White, C.J. and Wang, Z. 2007. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone. Journal of Pharmaceutical and Biomedical Analysis. 44 (5), pp. 1113-1117.

Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex
Wardle, N.J., Herlihy, A.H., So, P.W., Bell, J.D. and Bligh, S.W.A. 2007. Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex. Bioorganic & medicinal chemistry. 15 (14), pp. 4714-4721.

High-performance liquid chromatography-diode array detection/electrospray ionization mass spectrometry for the simultaneous analysis of cis-, trans- and dihydro-2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants
Yang, L., Nakamura, N., Hattori, M., Wang, Z., Bligh, S.W.A. and Xu, L. 2007. High-performance liquid chromatography-diode array detection/electrospray ionization mass spectrometry for the simultaneous analysis of cis-, trans- and dihydro-2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants. Rapid Communications in Mass Spectrometry. 21 (12), pp. 1833-1840.

ω-Phosphinyl-α-amino acids: synthesis, and development towards use as therapeutic agents
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2007. ω-Phosphinyl-α-amino acids: synthesis, and development towards use as therapeutic agents. Current Organic Chemistry. 11 (18), pp. 1635-1651.

Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes
Gudasi, K.B., Patil, S., Vadavi, R.S., Shenoy, R.V., Nethaji, M. and Bligh, S.W.A. 2006. Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes. Inorganica Chimica Acta. 359 (10), pp. 3229-3236.

A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities
Yang, L., Qin, L.H., Bligh, S.W.A., Bashall, A., Zhang, C.-F., Zhang, M., Wang, Z. and Xu, L. 2006. A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities. Bioorganic & medicinal chemistry. 14 (10), pp. 3496-3501.

Phytoestrogen levels in selected Jamaican food
Simon, G., McFarlane-Anderson, N., Fletcher, H., Golden, K., Wharfe, G., Ogegbo, O., Bligh, S.W.A. and Branford-White, C.J. 2006. Phytoestrogen levels in selected Jamaican food. West Indian Medical Journal. 55, p. 24.

Organophosphorus chemistry: therapeutic intervention in mechanisms of viral and cellular replication
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2005. Organophosphorus chemistry: therapeutic intervention in mechanisms of viral and cellular replication. Current Organic Chemistry. 9 (18), pp. 1803-1828.

Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii
Wu, T., Cheng, X.M., Bligh, S.W.A., Chou, G.-X., Wang, Z., Bashall, A. and Branford-White, C.J. 2005. Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii. Helvetica Chimica Acta. 88 (10), pp. 2617-2623.

Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum
Zhang, G.N., Zhong, L.Y., Bligh, S.W.A., Guo, Y.L., Zhang, C.-F., Zhang, M., Wang, Z. and Xu, L. 2005. Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum. Phytochemistry. 66 (10), pp. 1113-1120.

Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV
Wu, T., Bligh, S.W.A., Gu, L.-H., Wang, Z., Liu, H.P., Cheng, X.M., Branford-White, C.J. and Hu, Z.B. 2005. Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV. Fitoterapia. 76 (2), pp. 157-165.

Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice
Wang, C.-H., Wang, Z., Bligh, S.W.A., White, K.N. and Branford-White, C.J. 2004. Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. European Journal of Drug Metabolism and Pharmacokinetics. 29 (3), pp. 199-203.

Taraxer-14-en-3β-ol, an anti-inflammatory compound from Sterculia foetida L.
Naik, D.G., Mujumdar, A.M., Waghole, R.J., Misar, A.V., Bligh, S.W.A., Bashall, A. and Crowder, J. 2004. Taraxer-14-en-3β-ol, an anti-inflammatory compound from Sterculia foetida L. Planta Medica. 70 (1), pp. 68-69.

cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus
Cheng, Z.H., Wu, T., Bligh, S.W.A., Bashall, A. and Yu, B.Y. 2004. cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus. Journal of Natural Products. 67 (10), pp. 1761-1763.

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase
Collinson, A.D., Bligh, S.W.A., Graham, D.L., Mott, H.R., Chalk, P.A., Korniotis, N. and Lowe, P.N. 2004. Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase. Assay and Drug Development Technologies. 2 (6), pp. 659-673.

Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry
Bligh, S.W.A., Haley, T. and Lowe, P.N. 2003. Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry. Journal of Molecular Recognition. 16 (3), pp. 139-148.

Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(II) with nucleosides and its biological activity
Bligh, S.W.A., Bashall, A., Garrud, C., McPartlin, M., Wardle, N.J., White, K.N., Padhye, S., Barve, V. and Kundu, G. 2003. Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(II) with nucleosides and its biological activity. Dalton Transactions. 2003 (2), pp. 184-188.

How chemistry brought me to the life-sciences interface
Bligh, S.W.A. 2003. How chemistry brought me to the life-sciences interface. Science.

IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids
Fogg, P.G.T., Bligh, S.W.A., Derrick, M.E., Yampol’skii, Y.P., Clever, H.L., Skrzecz, A. and Young, C.L. 2001. IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids. Journal of Physical and Chemical Reference Data. 30 (6), pp. 1693-1875.

Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA
Bligh, S.W.A., Choi, N., Evagorou, E.G., McPartlin, M. and White, K.N. 2001. Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA. Journal of the Chemical Society, Dalton Transactions. 2001 (21), pp. 3169-3172.

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging
Prata, M.I.M., Santos, A.C., Bligh, S.W.A., Chowdhury, A.H.M.S., Geraldes, C.F.G.C. and de Lima, J.J.P. 2000. Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging. Nuclear Medicine and Biology. 27 (6), pp. 605-610.

Synthesis and structural properties of metal complexes of dialkyl α-hydroxyiminophosphonates
Bligh, S.W.A., Choi, N., McGrath, C.M., McPartlin, M. and Woodroffe, T.M. 2000. Synthesis and structural properties of metal complexes of dialkyl α-hydroxyiminophosphonates. Journal of the Chemical Society, Dalton Transactions. 2000 (15), pp. 2587-2594.

Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging
Bligh, S.W.A., Chowdhury, A.H.M.S., Kennedy, D., Luchinat, C. and Parigi, G. 1999. Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging. Magnetic Resonance in Medicine. 41 (4), pp. 767-773.

Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate
Bligh, S.W.A., McPartlin, M., Sanganee, M.J., Woodroffe, T.M. and Geraldes, C.F.G.C. 1998. Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate. Chemical Communications. 1998 (19), pp. 2073-2074.

A gadolinium cryptate with two coordinated water molecules
Bligh, S.W.A., Drew, M.G.B., Martin, N., Maubert, B. and Nelson, J. 1998. A gadolinium cryptate with two coordinated water molecules. Journal of the Chemical Society, Dalton Transactions. 1998 (22), pp. 3711-3714.

A novel hexaaza macrocycle with methylenephosphonate pendant arms: a potential useful chelate for biomedical applications
Bligh, S.W.A., Choi, N., Geraldes, C.F.G.C., Knoke, S., McPartlin, M., Sanganee, M.J. and Woodroffe, T.M. 1997. A novel hexaaza macrocycle with methylenephosphonate pendant arms: a potential useful chelate for biomedical applications. Journal of the Chemical Society, Dalton Transactions. 1997 (21), pp. 4119-4126.

Hexaaza and octaaza macrocycles with 2-hydroxy 3,5-dimethylbenzyl pendant arms
Bligh, S.W.A., Choi, N., Evagorou, E.G. and McPartlin, M. 1997. Hexaaza and octaaza macrocycles with 2-hydroxy 3,5-dimethylbenzyl pendant arms. Journal of the Chemical Society, Perkin Transactions. 1997 (21), pp. 3151-3156.

α-aminophosphonate monoesters in one step
Bligh, S.W.A., McGrath, C.M., Failla, S. and Finocchiaro, P. 1996. α-aminophosphonate monoesters in one step. Phosphorus, Sulfur, and Silicon and the Related Elements. 118 (1), pp. 189-194.

Lanthanide and transition metal complexes of dialkyl alpha-hydroxyiminophosphonates
Bligh, S.W.A., Choi, N., Green, D.S.C., Hudson, H.R., McGrath, C.M., McPartlin, M. and Pianka, M. 1996. Lanthanide and transition metal complexes of dialkyl alpha-hydroxyiminophosphonates. Phosphorus, Sulfur, and Silicon and the Related Elements. 111 (1-4), p. 49.

Body fluid spectroscopic studies
Bell, J.D. and Sadler, P.J. 1996. Body fluid spectroscopic studies. in: Grant, D.M. and Harris, R.K. (ed.) Encyclopedia of nuclear magnetic resonance Chichester Wiley.

Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging
Bligh, S.W.A., Chowdhury, A.H.M.S., McPartlin, M. and Scowen, I.J. 1995. Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging. Polyhedron. 14 (4), pp. 567-569.

Teaching techniques in inorganic chemistry
Bligh, S.W.A., Conole, G. and McPartlin, M. 1995. Teaching techniques in inorganic chemistry. in: Variety in Chemistry Proceedings UK Physical Sciences Centre.

Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents
Bligh, S.W.A., Harding, C.T., McEwen, A.B. and Sadler, P.J. 1994. Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents. Polyhedron. 13 (12), pp. 1937-1943.

Synthesis of the first lanthanide complexes of dialkyl α-hydroxyiminophosphonates; ambivalent ligand bonding in the PrIII and NdIII complexes of diisopropyl α-hydroxyiminopropylphosphonate (L1), [PrL13Cl3] and [NdL12(NO3)3(H2O)]
Bligh, S.W.A., Choi, N., Hudson, H.R., McGrath, C.M. and McPartlin, M. 1994. Synthesis of the first lanthanide complexes of dialkyl α-hydroxyiminophosphonates; ambivalent ligand bonding in the PrIII and NdIII complexes of diisopropyl α-hydroxyiminopropylphosphonate (L1), [PrL13Cl3] and [NdL12(NO3)3(H2O)]. Journal of the Chemical Society, Dalton Transactions. 1994 (15), pp. 2335-2337.

First structural characterisation of an amino phosphonate monoester metal complex
Bligh, S.W.A., Choi, N., Failla, S., Finocchiaro, P., Il'yasov, A., Libertini, M., McGrath, C.M., McPartlin, M. and Woodroffe, T.M. 1994. First structural characterisation of an amino phosphonate monoester metal complex. Journal of the Chemical Society, Dalton Transactions. 1994 (22), pp. 3333-3334.

Metal-ion controlled helicity of an 18-membered hexaaza tetraamine macrocycle
Bligh, S.W.A., Choi, N., Evagorou, E.G., Li, W.S. and McPartlin, M. 1994. Metal-ion controlled helicity of an 18-membered hexaaza tetraamine macrocycle. Journal of the Chemical Society, Chemical Communications. 1994 (20), pp. 2399-2400.

Yttrium(III) and lanthanide(III) metal complexes of an 18-membered hexaaza tetraimine macrocycle. Crystal structure of the gadolinium(III) complex
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D. and McPartlin, M. 1994. Yttrium(III) and lanthanide(III) metal complexes of an 18-membered hexaaza tetraimine macrocycle. Crystal structure of the gadolinium(III) complex. Journal of the Chemical Society, Dalton Transactions. 1994 (23), pp. 3369-3376.

Transition metal complexes of dialkyl α-hydroxyiminophosphonates, a novel class of metal complexes
Bligh, S.W.A., Choi, N., Green, D.S.C., Hudson, H.R., McGrath, C.M., McPartlin, M. and Pianka, M. 1993. Transition metal complexes of dialkyl α-hydroxyiminophosphonates, a novel class of metal complexes. Polyhedron. 12 (23), pp. 2887-2890.

Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D., McPartlin, M. and Parkes, H.G. 1993. Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging. Journal of Inorganic Biochemistry. 51 (1-2), p. 438.

Synthesis and crystal structure of a novel hexaaza macrocyclic ligand with 2-hydroxy-3,5-dimethylbenzyl pendant arms and its gadolinium(III) complex
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D. and McPartlin, M. 1993. Synthesis and crystal structure of a novel hexaaza macrocyclic ligand with 2-hydroxy-3,5-dimethylbenzyl pendant arms and its gadolinium(III) complex. Journal of the Chemical Society, Dalton Transactions. 1993 (24), pp. 3829-3831.

NMR: a clinical approach
Bell, J.D. and Sadler, P.J. 1993. NMR: a clinical approach. Chemistry in Britain. 29, pp. 597-600.

Detection of aluminium (III) binding to citrate in human blood plasma by proton nuclear magnetic resonance spectroscopy
Bell, J.D., Kubal, G., Radulovic, S., Sadler, P.J. and Tucker, A. 1993. Detection of aluminium (III) binding to citrate in human blood plasma by proton nuclear magnetic resonance spectroscopy. The Analyst. 118, pp. 241-244.

Distortional isomerism in oxomolybdenum systems: the evidence re-evaluated
Bashall, A., Bligh, S.W.A., Edwards, A.J., McPartlin, M., Gibson, V.C. and Robinson, O.B. 1992. Distortional isomerism in oxomolybdenum systems: the evidence re-evaluated. Angewandte Chemie: International Edition in English. 31 (12), pp. 1607-1609.

Synthesis and crystal structure of a gadolinium(III) complex of a tetraimine schiff-base macrocycle: a potential contrast agent for magnetic resonance imaging
Bligh, S.W.A., Choi, N., Evagorou, E.G., McPartlin, M., Cummins, W.J. and Kelly, J.D. 1992. Synthesis and crystal structure of a gadolinium(III) complex of a tetraimine schiff-base macrocycle: a potential contrast agent for magnetic resonance imaging. Polyhedron. 11 (19), pp. 2571-2573.

H-1-Nmr studies of reactions of copper complexes with human blood plasma and urine
Bligh, S.W.A., Boyle, H.A., McEwen, A.B., Sadler, P.J. and Woodham, R.H. 1992. H-1-Nmr studies of reactions of copper complexes with human blood plasma and urine. Biochemical Pharmacology. 43 (2), pp. 137-145.

Aluminium speciation: NMR studies of blood plasma, transferrin and citrate complexes
Bell, J.D., Evans, R.W., Kiang, W., Kubal, G., Radulovic, S., Sadler, P.J. and Williams, G. 1991. Aluminium speciation: NMR studies of blood plasma, transferrin and citrate complexes. Journal of Inorganic Biochemistry. 43 (2-3), p. 488.

Nuclear magnetic resonance studies of blood plasma and urine from subjects with chronic renal failure: identification of trimethylamine-N-oxide
Bell, J.D., Lee, J.D., Lee, H.A., Sadler, P.J., Wilkie, D.R. and Woodham, R.H. 1991. Nuclear magnetic resonance studies of blood plasma and urine from subjects with chronic renal failure: identification of trimethylamine-N-oxide. Biochimica et Biophysica Acta: general subjects. 1096 (2), pp. 101-107.

Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma
Bligh, S.W.A., Drake, A.F. and Sadler, P.J. 1990. Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma. Biochemical Society Transactions. 18, pp. 999-1000.

NMR studies of body fluids
Bell, J.D., Brown, J.C.C. and Sadler, P.J. 1989. NMR studies of body fluids. NMR in Biomedicine. 2 (5-6), pp. 246-256.

Ultraviolet and magnetic-circular-diochroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid
Bligh, S.W.A., Drake, A.F. and Sadler, P.J. 1989. Ultraviolet and magnetic-circular-diochroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid. European Journal of Biochemistry. 181 (1), pp. 223-224.

Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy
Grootveld, M., Bell, J.D., Halliwell, B., Aruoma, O.I., Bomford, A. and Sadler, P.J. 1989. Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. Journal of Biological Chemistry. 264 (8), pp. 4417-4422.

Characterization and invivo distribution of Tc-99m-labeled and In-111-labelled magnetite
Bligh, S.W.A., Sadler, P.J., Marriott, J.A., Latham, I.A. and Kelly, J.D. 1989. Characterization and invivo distribution of Tc-99m-labeled and In-111-labelled magnetite. Applied Radiation and Isotopes. 40, pp. 751-757.

Labels and contrast agents in biomedical magnetic resonance spectroscopy and imaging
Bligh, S.W.A. and Sadler, P.J. 1989. Labels and contrast agents in biomedical magnetic resonance spectroscopy and imaging. in: Dykes, J. and Delpy, D.T. (ed.) Clinical NMR spectroscopy York, England The Institute of Physical Sciences in Medicine. pp. 77-81

NMR-invisible lactate in blood plasma
Bell, J.D., Brown, J.C.C., Kubal, G. and Sadler, P.J. 1988. NMR-invisible lactate in blood plasma. FEBS Letters. 235 (1-2), pp. 81-86.

Factors affecting 1h NMR spectra of blood plasma: cancer, diet and freezing
Bell, J.D., Brown, J.C.C., Norman, R.E., Sadler, P.J. and Newell, D.R. 1988. Factors affecting 1h NMR spectra of blood plasma: cancer, diet and freezing. NMR in Biomedicine. 1 (2), pp. 90-94.

Metabolic profiling of body fluids by proton NMR: self-poisoning episodes with paracetamol (acetaminophen)
Bales, J.R., Bell, J.D., Nicholson, J.K., Sadler, P.J., Timbrell, J.A., Hughes, R.D., Bennett, P.N. and Williams, R. 1988. Metabolic profiling of body fluids by proton NMR: self-poisoning episodes with paracetamol (acetaminophen). Magnetic Resonance in Medicine. 6 (3), pp. 300-306.

NMR Spectroscopy of body fluids
Bell, J.D., Brown, J.C.C. and Sadler, P.J. 1988. NMR Spectroscopy of body fluids. Chemistry in Britain. 24, pp. 1021-1024.

Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media
Bell, J.D., Norman, R.E. and Sadler, P.J. 1987. Coordination chemistry in biological media: reactions of antitumor Pt(II) and Au(III) complexes with cell culture media. Journal of Inorganic Biochemistry. 31 (4), pp. 241-246.

1H NMR studies of human blood plasma assignment of resonances for lipoproteins
Bell, J.D., Sadler, P.J., MacLeod, A.F., Turner, P.R. and La Ville, A. 1987. 1H NMR studies of human blood plasma assignment of resonances for lipoproteins. FEBS Letters. 219 (1), pp. 239-243.

Assignment of resonances for ‘acute-phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma
Bell, J.D., Brown, J.C.C., Nicholson, J.K. and Sadler, P.J. 1987. Assignment of resonances for ‘acute-phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma. FEBS Letters. 215 (2), pp. 311-315.

High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid
Bell, J.D., Brown, J.C.C., Sadler, P.J., MacLeod, A.F., Sönksen, P.H., Hughes, R.D. and Williams, R. 1987. High resolution proton nuclear magnetic resonance studies of human cerebrospinal fluid. Clinical Science: an international journal of translational science and medicine. 72, pp. 563-570.

1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine
Bales, J.R., Bell, J.D., Nicholson, J.K. and Sadler, P.J. 1986. 1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine. Magnetic Resonance in Medicine. 3 (6), pp. 849-856.

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