Title | Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents |
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Authors | Bligh, S.W.A., Jin, M., Spillane, D.E.M., Geraldes, C.F.G.C. and Williams, G.R. |
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Abstract | The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd3+ diethylenetriaminepentaacetate and Gd3+ diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5–18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd3+ complexes in the intercalation compounds. The proton relaxivities of the Gd3+ complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents. |
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Journal | Dalton Transactions: The International Journal for Inorganic, Organometallic and Bioinorganic Chemistry |
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Journal citation | 44 (47), pp. 20728-20734 |
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ISSN | 1477-9226 |
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Year | 2015 |
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Publisher | Royal Society of Chemistry |
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Accepted author manuscript | |
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Digital Object Identifier (DOI) | https://doi.org/10.1039/C5DT03433G |
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Publication dates |
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Published | 04 Nov 2015 |
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Supplementary data or files | File |
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