Preparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles

Yu, D.G., Shen, X.X., Zhu, L.M., Branford-White, C.J., Bligh, S.W.A. and Yang, Y.C. 2009. Preparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles. in: ICBBE 2009: 3rd international conference on bioinformatics and biomedical engineering IEEE .

Chapter titlePreparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles
AuthorsYu, D.G., Shen, X.X., Zhu, L.M., Branford-White, C.J., Bligh, S.W.A. and Yang, Y.C.
Abstract

Fine and continuous composite medicated PAN/PVP fibers were prepared using wet spinning processes. The co-dissolving method was employed to prepare the spinning solution. The prepared fiberts had a diameter of 145 plusmn 17 mum. SEM images showed that the libers had a uniform and homogeneous structure with some nano drug particles aggregated on the fiber surface. X-ray diffraction analysis result suggested that ibuprofen existed in the fibers in an amorphous status. FTIR analysis result demonstrated the polymers and the drug had fine compatibility. The drug content in the fibers was found to be a little lower than that in the spinning liquid, 10.2% of the drug was lost during the spinning processes. In vitro dissolution tests indicated that composite medicated fibers had better release profiles than PAN medicated fibers, 84.2% of the incorporated ibuprofen was linearly released out during a time periods of 15 days.

Book titleICBBE 2009: 3rd international conference on bioinformatics and biomedical engineering
Year2009
PublisherIEEE
Publication dates
Published2009
ISBN9781424429011
Digital Object Identifier (DOI)https://doi.org/10.1109/ICBBE.2009.5163228

Related outputs

Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function
Sahuri Arisoylu, M., Mould, R., Shinjyo, N., Bligh, S.W.A., Nunn, A., Guy, G., Thomas, E.L. and Bell, J.D. 2021. Acetate induces growth arrest in colon cancer cells through modulation of mitochondrial function. Frontiers in Nutrition: Nutrition and Metabolism. 8 588466. https://doi.org/10.3389/fnut.2021.588466

High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells
Ghazali, R., Mehta, K., Bligh, S.W.A., Tewfik, I., Clemens, D.L. and Patel, V.B. 2020. High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. World Journal of Hepatology. 12 (3), pp. 84-98. https://doi.org/10.4254/wjh.v12.i3.84

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review
Shinjyo, N., Parkinson, J., Bell, J.D., Katsuno, T. and Bligh, S.W.A. 2020. Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Journal of Integrative Medicine. 18 (2), pp. 125-151. https://doi.org/10.1016/j.joim.2020.01.004

The effect of silymarin on chondrocytes
Can, V.C., Abouelnour, A., Locke, I.C., Bligh, S.W.A. and Getting, S.J. 2017. The effect of silymarin on chondrocytes. ICMAN/ IUPHAR Natural Products. Aberdeen, Scotland 27 - 29 Sep 2017 Elsevier. https://doi.org/10.1016/j.bcp.2017.06.036

Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’
Henley, A., Yang L., Chuang K-L., Sahuri Arisoylu, M., Wu, L-H., Bligh, S.W.A. and Bell, J.D. 2017. Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’. PLoS ONE. 12 (1) e0170917. https://doi.org/10.1371/journal.pone.0170917

Core-sheath nanofibers as drug delivery system for thermoresponsive controlled release
Lv, Y., Pan, Q., Bligh, S.W.A., Li, H., Wu, H, Sang, Qingqing and Zhu, Li-Min 2017. Core-sheath nanofibers as drug delivery system for thermoresponsive controlled release. Journal of Pharmaceutical Sciences. 106 (5), pp. 1258-1265. https://doi.org/10.1016/j.xphs.2016.12.031

Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique
Wang, D., Qi, M., Yang, Q., Tong, R, Wang, R, Bligh, S.W.A., Yang, L. and Wang, Z. 2016. Comprehensive metabolite profiling of Plantaginis Semen using ultra high performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry coupled with elevated energy technique. Journal of Separation Science. 39 (10), pp. 1842-1852. https://doi.org/10.1002/jssc.201501149

Theranostic Fibers for Simultaneous Imaging and Drug Delivery
Bligh, S.W.A., Williams, G.R., Yu, D.G., Jin, M. and Geraldes, C. 2016. Theranostic Fibers for Simultaneous Imaging and Drug Delivery. Molecular Pharmaceutics. 13 (7), pp. 2457-2465. https://doi.org/10.1021/acs.molpharmaceut.6b00197

Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process
Bligh, S.W.A., Yang, C., Yu, D.G., Pan, D., Liu, X.-K., Wang, X. and Williams, G.R. 2016. Electrospun pH-sensitive core–shell polymer nanocomposites fabricated using a tri-axial process. Acta Biomaterialia. 35, pp. 77-86. https://doi.org/10.1016/j.actbio.2016.02.029

Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI
Bligh, S.W.A., Jin, M., Yu, D.G., Wang, X., Geraldes, C.F.G.C. and Williams, G.R. 2016. Electrospun Contrast Agent-Loaded Fibers for Colon-Targeted MRI. Advanced Healthcare Materials. 5 (8), pp. 977-985. https://doi.org/10.1002/adhm.201500872

Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret
Bligh, S.W.A., Yu, D.G., Shen, C.Y., Jin, M., Williams, G.R., Zou, H. and Wang, X. 2016. Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret. Colloids and Surfaces B: Biointerfaces. 138, p. 110–116. https://doi.org/doi:10.1016/j.colsurfb.2015.11.055

Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents
Bligh, S.W.A., Jin, M., Spillane, D.E.M., Geraldes, C.F.G.C. and Williams, G.R. 2016. Hydroxy double salts intercalated with Mn(II) complexes as potential contrast agents. Solid State Sciences. 53, p. 9–16. https://doi.org/10.1016/j.solidstatesciences.2015.12.024.

Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide
Bligh, S.W.A., Lv, Y., Tao, L., Yang, H., Pan, Q. and Zhua, L. 2016. Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide. Materials Science and Engineering: C. 59, p. 652–660. https://doi.org/10.1016/j.msec.2015.10.065

Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents
Bligh, S.W.A., Jin, M., Spillane, D.E.M., Geraldes, C.F.G.C. and Williams, G.R. 2015. Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents. Dalton Transactions: The International Journal for Inorganic, Organometallic and Bioinorganic Chemistry. 44 (47), pp. 20728-20734. https://doi.org/10.1039/C5DT03433G

Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems
Yu, D.G., Wang, X., Li, X.-Y., Yang, J.-H., Bligh, S.W.A. and Williams, G.R. 2015. Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems. ACS Applied Materials & Interfaces. 7 (33), p. 18891–18897. https://doi.org/10.1021/acsami.5b06007

A thin-layer chromatography-bioautographic method for detecting dipeptidyl peptidase IV inhibitors in plants
Bligh, S.W.A., Gu, L.-H., Liao, L.P., Hu, H.J., Wang, C.-H., Chou, G.-X. and Wang, Z.T. 2015. A thin-layer chromatography-bioautographic method for detecting dipeptidyl peptidase IV inhibitors in plants. Journal of Chromatography A. 1411 (11), p. 116–122. https://doi.org/10.1016/j.chroma.2015.07.123

Structure-inhibition relationship of phenylethanoid glycosides on angiotensin-converting enzyme using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry
Bligh, S.W.A., Li, P., Qi, M., Hu, H., Liu, Q., Yang, Q., Wang, D., Guo, F., Wang, Z. and Yang, L. 2015. Structure-inhibition relationship of phenylethanoid glycosides on angiotensin-converting enzyme using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry. RSC Advances. 5 (64), pp. 51701-51707. https://doi.org/10.1039/C5RA05027H

Electrospun medicated shellac nanofibers for colon-targeted drug delivery
Wang, X., Yu, D.G., Li, X.-Y., Bligh, S.W.A. and Williams, G.R. 2015. Electrospun medicated shellac nanofibers for colon-targeted drug delivery. International Journal of Pharmaceutics. 490 (1-2), pp. 384-390. https://doi.org/doi:10.1016/j.ijpharm.2015.05.077

Molecularly imprinted polymer based on MWCNTs-QDs as fluorescent biomimetic sensor for specific recognition of target protein
Ding, X., Tao, L., Quan, J., Nie, H., Gong, X., Bligh, S.W.A. and Limin, Z. 2015. Molecularly imprinted polymer based on MWCNTs-QDs as fluorescent biomimetic sensor for specific recognition of target protein. Materials Science and Engineering C. 48, pp. 469-479. https://doi.org/10.1016/j.msec.2014.12.032

Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization
Sun, K., Bligh, S.W.A., Nie, H.L., Quan, J. and Zhu, L.M. 2014. Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization. RSC Advances. 4, pp. 34912-34921. https://doi.org/10.1039/C4RA04874A

A RG-II type polysaccharide purified from Aconitum coreanum and their anti-inflammatory activity
Li Xiaojun, Jiang Jiaye, Shi, S.S., Li Yuan, Jiang Yongbo, Huang Dan Ke Yan, Wang, S.C., Bligh, S.W.A. and Ke, Yan 2014. A RG-II type polysaccharide purified from Aconitum coreanum and their anti-inflammatory activity. PLoS ONE. 9 (6) e99697. https://doi.org/10.1371/journal.pone.0099697

Quinolone alkaloids from fructus euodiae show activity against methicillin-resistant staphylococcus aureus
Pan, X., Bligh, S.W.A. and Smith, E. 2014. Quinolone alkaloids from fructus euodiae show activity against methicillin-resistant staphylococcus aureus. Phytotherapy Research. 28 (2), pp. 305-307. https://doi.org/10.1002/ptr.4987

Metabolic profiles of 20(S)-protopanaxadiol in rats after oral administration using ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry
He, C., Li, J., Wang, R., Li, Z., Bligh, S.W.A., Yang, L. and Wang, Z. 2014. Metabolic profiles of 20(S)-protopanaxadiol in rats after oral administration using ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 28 (6), pp. 595-604. https://doi.org/10.1002/rcm.6813

Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives
Fan, H., Liu, F., Bligh, S.W.A., Shi, S.S. and Wang, S.C. 2014. Structure of a homofructosan from Saussurea costus and anti-complementary activity of its sulfated derivatives. Carbohydrate Polymers. 105, pp. 152-160. https://doi.org/10.1016/j.carbpol.2014.01.084

Characterization of two immunomodulating homogalacturonan pectins from green tea
Wang, H., Wei, G., Liu, F., Banerjee, G., Joshi, M., Bligh, S.W.A., Shi, S.S., Lian, H., Fan, H., Gu, X. and Wang, S.C. 2014. Characterization of two immunomodulating homogalacturonan pectins from green tea. International Journal of Molecular Sciences. 15 (6), pp. 9963-9978. https://doi.org/10.3390/ijms15069963

Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid
Cui, L., Liu, Z., Yu, D.G., Zhang, S.P., Bligh, S.W.A. and Zhao, N. 2014. Electrosprayed core-shell nanoparticles of PVP and shellac for furnishing biphasic controlled release of ferulic acid. Colloid and Polymer Science. 292 (9), pp. 2089-2096. https://doi.org/10.1007/s00396-014-3226-8

Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core
Machakanur, S.S., Patil, B.R., Naik, G.N., Bakale, R.P., Bligh, S.W.A. and Gudasi, K.B. 2014. Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core. Inorganica Chimica Acta. 421, pp. 459-464. https://doi.org/10.1016/j.ica.2014.06.040

Characterization of metabolites of sweroside in rat urine using ultra-high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and NMR spectroscopy
Han, H., Zeng, W., He, C., Bligh, S.W.A., Liu, Q., Yang, L. and Wang, Z. 2014. Characterization of metabolites of sweroside in rat urine using ultra-high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and NMR spectroscopy. Journal of Mass Spectrometry. 49 (11), pp. 1108-1116. https://doi.org/10.1002/jms.3429

Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease
Wardle, N.J., Hudson, H.R., Matthews, R.W., Nunn, C., Vella, C. and Bligh, S.W.A. 2013. Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease. ChemMedChem. 8 (5), pp. 719-721. https://doi.org/10.1002/cmdc.201300051

Dual drug release nanocomposites prepared using a combination of electrospraying and electrospinning
Yu, D.G., Williams, G.R., Wang, X., Liu, X.-K., Li, H.L. and Bligh, S.W.A. 2013. Dual drug release nanocomposites prepared using a combination of electrospraying and electrospinning. RSC Advances. 2013 (3), pp. 4652-4658. https://doi.org/10.1039/C3RA40334C

Coaxial electrospinning using a concentric Teflon spinneret to prepare biphasic-release nanofibers of helicid
Yu, D.G., Liu, F., Cui, L., Liu, Z., Wang, X. and Bligh, S.W.A. 2013. Coaxial electrospinning using a concentric Teflon spinneret to prepare biphasic-release nanofibers of helicid. RSC Advances. OnlineFirst. https://doi.org/10.1039/C3RA43222J

Sensitized terbium(III) macrocyclic-phthalimide complexes as luminescent pH switches
Chen, G., Wardle, N.J., Sarris, J.L., Chatterton, N.P. and Bligh, S.W.A. 2013. Sensitized terbium(III) macrocyclic-phthalimide complexes as luminescent pH switches. Dalton Transactions. OnlineFirst. https://doi.org/10.1039/C3DT51236C

Flavonoids by HPLC
Bligh, S.W.A., Ogegbo, O. and Wang, Z. 2013. Flavonoids by HPLC. in: Ramawat, K.G. and Merillon, J.M. (ed.) Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes Berlin Springer. pp. 2107-2144

Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy
Zhao, T., Zheng, S.S., Zhang, B.F., Li, Y.Y., Bligh, S.W.A., Wang, C.-H. and Wang, Z. 2012. Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy. Food Chemistry. 134 (2), pp. 1096-1105. https://doi.org/10.1016/j.foodchem.2012.03.024

Chemotaxonomically significant roburic acid from section cruciata of gentiana
Wu, L.H., Bligh, S.W.A., Leon, C., Li, X.S., Wang, Z., Branford-White, C.J. and Simmonds, M.S.J. 2012. Chemotaxonomically significant roburic acid from section cruciata of gentiana. Biochemical Systematics and Ecology. 43, pp. 152-155. https://doi.org/10.1016/j.bse.2012.03.008

Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles
Yeh, J.C., Garrard, I.J., Cho, C.W.C., Bligh, S.W.A., Lu, G.H., Fan, T.P. and Fisher, D. 2012. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. Journal of Chromatography A. 1236, pp. 132-138. https://doi.org/10.1016/j.chroma.2012.03.013

Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill
Yuan, J., Wang, Y., An, R., Wang, S., Li, S.J., Jia, J.Y., Bligh, S.W.A., Wang, X.H. and Ma, Y.M. 2012. Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography–tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill. Journal of Chromatography B: Biomedical Sciences and Applications. 895-896, pp. 154-161. https://doi.org/10.1016/j.jchromb.2012.03.036

Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells
Pan, X., Hartley, J.M., Hartley, J.A., White, K.N., Wang, Z. and Bligh, S.W.A. 2012. Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. Phytomedicine. 19 (7), pp. 618-624. https://doi.org/10.1016/j.phymed.2012.02.003

Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones
Machakanur, S.S., Patil, B.R., Badiger, D.S., Bakale, R.P., Gudasi, K.B. and Bligh, S.W.A. 2012. Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones. Journal of Molecular Structure. 1011, pp. 121-127. https://doi.org/10.1016/j.molstruc.2011.12.023

Coaxial electrospinning with sodium dodecylbenzene sulfonate solution for high quality polyacrylonitrile nanofibers
Yu, D.G., Williams, G.R., Gao, L.D., Bligh, S.W.A., Yang, J.-H. and Wang, X. 2012. Coaxial electrospinning with sodium dodecylbenzene sulfonate solution for high quality polyacrylonitrile nanofibers. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 396, pp. 161-168. https://doi.org/10.1016/j.colsurfa.2011.12.063

Metabolomics of four TCM herbal products: application of HPTLC analysis
Ogegbo, O., Eyob, S., Parmar, S., Wang, Z. and Bligh, S.W.A. 2012. Metabolomics of four TCM herbal products: application of HPTLC analysis. Analytical Methods. 4, pp. 2522-2527. https://doi.org/10.1039/C2AY25373A

Synthesis of novel tri-arm star shaped 1,3,5-triazine hydrazones from 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine core
Machakanur, S.S., Patil, B.R., Badiger, D.S., Pathan, A.H., Gudasi, K.B. and Bligh, S.W.A. 2012. Synthesis of novel tri-arm star shaped 1,3,5-triazine hydrazones from 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine core. Letters in Organic Chemistry. 9 (1), pp. 29-34. https://doi.org/10.2174/157017812799304051

N-Heterocyclic dronic acids: applications and synthesis
Hudson, H.R., Wardle, N.J., Bligh, S.W.A., Greiner, I., Grun, A. and Keglevich, G. 2012. N-Heterocyclic dronic acids: applications and synthesis. Minireviews in Medicinal Chemistry. 12, pp. 313-325.

Quantification of norisoboldine in Linderae Radix by ultra-performance liquid chromatography and high performance liquid chromatography with UV detection
Chen, J.Z., Chou, G.-X., Yang, L., Bligh, S.W.A. and Wang, Z. 2012. Quantification of norisoboldine in Linderae Radix by ultra-performance liquid chromatography and high performance liquid chromatography with UV detection. Journal of Liquid Chromatography and Related Technologies. 35 (6), pp. 788-797. https://doi.org/10.1080/10826076.2011.608236

A chemically unlocked binary molecular switch
Chen, G., Sarris, J.L., Wardle, N.J., Bligh, S.W.A. and Chatterton, N.P. 2012. A chemically unlocked binary molecular switch. Chemical Communications. 48 (72), pp. 9026-9028. https://doi.org/10.1039/C2CC34425D

Urinary 1H-NMR metabonomics study on intervention effects of soya milk in Africans
Ogegbo, O., Dissanyake, W., Crowder, J., Asekun, O., Familoni, O., Branford-White, C.J. and Bligh, S.W.A. 2012. Urinary 1H-NMR metabonomics study on intervention effects of soya milk in Africans. Phytotherapy Research. 26 (1), pp. 127-135. https://doi.org/10.1002/ptr.3547

Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes
Cooke, B.R., Bligh, S.W.A., Cybulski, Z.R., Ioannides, C. and Hall, M. 2012. Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes. Drug Metabolism and Disposition. 40 (1), pp. 70-75. https://doi.org/10.1124/dmd.111.041566

Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
Han, H., Yang, L., Xu, Y., Ding, Y., Bligh, S.W.A., Zhang, T. and Wang, Z. 2011. Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 25 (21), pp. 3339-3350. https://doi.org/10.1002/rcm.5216

1H NMR study of monocrotaline and its metabolites in human blood
Yang, Y.C., Crowder, J., Wardle, N.J., Yang, L., White, K.N., Wang, Z. and Bligh, S.W.A. 2011. 1H NMR study of monocrotaline and its metabolites in human blood. Food and Chemical Toxicology. 49 (11), pp. 2793-2799. https://doi.org/10.1016/j.fct.2011.07.063

Hexa-arm star shaped hydrazone derivatives from hexakis(4-formylphenoxy)-cyclotriphosphazene core
Patil, B.R., Machakanur, S.S., Badiger, D.S., Hunoor, R.S., Gudasi, K.B., Nethaji, M. and Bligh, S.W.A. 2011. Hexa-arm star shaped hydrazone derivatives from hexakis(4-formylphenoxy)-cyclotriphosphazene core. Journal of Molecular Structure. 1003 (1-3), pp. 52-61. https://doi.org/10.1016/j.molstruc.2011.07.020

Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features
Wardle, N.J., Kalber, T., Bell, J.D. and Bligh, S.W.A. 2011. Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features. Bioorganic and Medicinal Chemistry Letters. 21 (11), pp. 3346-3348. https://doi.org/10.1016/j.bmcl.2011.04.014

Improving polymer nanofiber quality using a modified co-axial electrospinning process
Yu, D.G., Branford-White, C.J., Bligh, S.W.A., White, K.N., Chatterton, N.P. and Zhu, L.M. 2011. Improving polymer nanofiber quality using a modified co-axial electrospinning process. Macromolecular Rapid Communications. 32 (9-10), pp. 744-750. https://doi.org/10.1002/marc.201100049

Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticles
Yu, D.G., Zhu, L.M., Bligh, S.W.A., Branford-White, C.J. and White, K.N. 2011. Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticles. Chemical Communications. 47 (4), pp. 1216-1218. https://doi.org/10.1039/C0CC03521A

Self-assembled liposomes from amphiphilic electrospun nanofibers
Yu, D.G., Branford-White, C.J., Williams, G.R., Bligh, S.W.A., White, K.N., Zhu, L.M. and Chatterton, N.P. 2011. Self-assembled liposomes from amphiphilic electrospun nanofibers. Soft matter. 7, pp. 8239-8247. https://doi.org/10.1039/C1SM05961K

Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives
Patil, B.R., Machakanur, S.S., Hunoor, R.S., Badiger, D.S., Gudasi, K.B. and Bligh, S.W.A. 2011. Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives. Der Pharma Chemica. 3 (4), pp. 377-388.

Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy
Chen, J.Z., Chou, G.-X., Wang, C.-H., Yang, L., Bligh, S.W.A. and Wang, Z. 2010. Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography/mass spectrometry and NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 52 (5), pp. 687-693. https://doi.org/10.1016/j.jpba.2010.02.008

Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography–circular dichroism analysis
Zhu, J.-J., Zhang, C.-F., Zhang, M., Bligh, S.W.A., Yang, L., Wang, Z.-M. and Wang, Z. 2010. Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography–circular dichroism analysis. Journal of Chromatography A. 1217 (33), pp. 5384-5388. https://doi.org/10.1016/j.chroma.2010.05.039

O-phosphotyrosine analogues: aynthesis and therapeutic role in modulation of signal transduction
Wardle, N.J., Hudson, H.R. and Bligh, S.W.A. 2010. O-phosphotyrosine analogues: aynthesis and therapeutic role in modulation of signal transduction. Current Organic Chemistry. 14 (5), pp. 426-446. https://doi.org/10.2174/138527210790601189

Treatment with qing'e, a kidney-invigorating chinese herbal formula, antagonizes the estrogen decline in ovariectomized mice
Xu, Y., Zhang, Z.J., Geng, F., Su, S.B., White, K.N., Bligh, S.W.A., Branford-White, C.J. and Wang, Z. 2010. Treatment with qing'e, a kidney-invigorating chinese herbal formula, antagonizes the estrogen decline in ovariectomized mice. Rejuvenation Research. 13 (4), pp. 479-488. https://doi.org/10.1089/rej.2009.1000

Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry
Xiong, A., Yang, L., He, Y.Q., Zhang, F., Wang, J., Han, H., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2009. Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry. 23 (24), pp. 3907-3916. https://doi.org/10.1002/rcm.4329

Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction
Wang, Y., Kong, L., Lei, X., Hu, L., Zou, H., Welbeck, E., Bligh, S.W.A. and Wang, Z. 2009. Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction. Journal of Chromatography A. 1216 (11), pp. 2185-2191. https://doi.org/10.1016/j.chroma.2008.05.074

Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers
Yu, D.G., Shen, X.X., Branford-White, C.J., White, K.N., Zhu, L.M. and Bligh, S.W.A. 2009. Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers. Nanotechnology. 20 (5), p. 055104. https://doi.org/10.1088/0957-4484/20/5/055104

Presentation of the beta-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PR
Wardle, N.J., Hudson, H.R., Matthews, R.W., Nunn, C., Vella, C. and Bligh, S.W.A. 2009. Presentation of the beta-carboxamidophosphonate arrangement in substrate structures targeting HIV-1 PR. Letters in Drug Design and Discovery. 6, pp. 139-145.

Cytotoxic sesquiterpenes from Ligularia platyglossa
Liu, J.Q., Zhang, M., Zhang, C.-F., Qi, H.Y., Bashall, A., Bligh, S.W.A. and Wang, Z. 2008. Cytotoxic sesquiterpenes from Ligularia platyglossa. Phytochemistry. 69 (11), pp. 2231-2236. https://doi.org/10.1016/j.phytochem.2008.05.018

Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection
Wang, Y., Yang, L., He, Y.Q., Wang, C.-H., Welbeck, E., Bligh, S.W.A. and Wang, Z. 2008. Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection. Rapid Communications in Mass Spectrometry. 22 (12), pp. 1767-1778. https://doi.org/10.1002/rcm.3536

High performance liquid chromatography-ion trap mass spectrometric analysis for metabolites of isoline in rat urine and bile
Zhang, F., Zhong, D.F., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2008. High performance liquid chromatography-ion trap mass spectrometric analysis for metabolites of isoline in rat urine and bile. Drug Metabolism Reviews. 40, p. 216.

Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens
Zhang, F., Wang, C.-H., Wang, W., Chen, L.X., Ma, H.Y., Zhang, C.-F., Zhang, M., Bligh, S.W.A. and Wang, Z. 2008. Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens. Phytochemical Analysis. 19 (1), pp. 25-31. https://doi.org/10.1002/pca.1009

Organophosphorus compounds: intervention in mechanisms of signal transduction relevant to proliferative, immunological and circulatory disorders
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2008. Organophosphorus compounds: intervention in mechanisms of signal transduction relevant to proliferative, immunological and circulatory disorders. Current Medicinal Chemistry. 15, pp. 2230-2257.

Sulfated beta-glucan derived from oat bran with potent anti-HIV activity
Wang, S.C., Bligh, S.W.A., Zhu, C.L., Shi, S.S., Wang, Z., Hu, Z.B., Crowder, J., Branford-White, C.J. and Vella, C. 2008. Sulfated beta-glucan derived from oat bran with potent anti-HIV activity. Journal of Agricultural and Food Chemistry. 56 (8), pp. 2624-2629. https://doi.org/10.1021/jf072888h

Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography
Zhang, F., Wang, C.-H., Xiong, A., Wang, W., Yang, L., Branford-White, C.J., Wang, Z. and Bligh, S.W.A. 2007. Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography. Analytica Chimica Acta. 605 (1), pp. 94-101. https://doi.org/10.1016/j.aca.2007.10.021

Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography
Wang, Y., Kong, L., Hu, L., Lei, X., Yang, L., Chou, G.-X., Zou, H., Wang, C.-H., Bligh, S.W.A. and Wang, Z. 2007. Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. Journal of Chromatography B: Biomedical Sciences and Applications. 860 (2), pp. 185-194. https://doi.org/10.1016/j.jchromb.2007.10.027

Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina
Wang, S.C., Bligh, S.W.A., Shi, S.S., Wang, Z., Hu, Z.B., Crowder, J., Branford-White, C.J. and Vella, C. 2007. Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia filicina. International Journal of Biological Macromolecules. 41 (4), pp. 369-375. https://doi.org/10.1016/j.ijbiomac.2007.05.008

Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone
Wang, C.-H., Cheng, X.M., He, Y.Q., White, K.N., Bligh, S.W.A., Branford-White, C.J. and Wang, Z. 2007. Pharmacokinetic behavior of gentiopicroside from decoction of radix gentianae, gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone. Archives of pharmacal research. 30 (9), pp. 1149-1154. https://doi.org/10.1007/BF02980251

Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone
Wang, C.-H., Cheng, X.M., Bligh, S.W.A., White, K.N., Branford-White, C.J. and Wang, Z. 2007. Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats: comparison with gentiopicroside alone. Journal of Pharmaceutical and Biomedical Analysis. 44 (5), pp. 1113-1117. https://doi.org/10.1016/j.jpba.2007.04.036

Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex
Wardle, N.J., Herlihy, A.H., So, P.W., Bell, J.D. and Bligh, S.W.A. 2007. Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[β,d-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex. Bioorganic & medicinal chemistry. 15 (14), pp. 4714-4721. https://doi.org/10.1016/j.bmc.2007.05.004

High-performance liquid chromatography-diode array detection/electrospray ionization mass spectrometry for the simultaneous analysis of cis-, trans- and dihydro-2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants
Yang, L., Nakamura, N., Hattori, M., Wang, Z., Bligh, S.W.A. and Xu, L. 2007. High-performance liquid chromatography-diode array detection/electrospray ionization mass spectrometry for the simultaneous analysis of cis-, trans- and dihydro-2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants. Rapid Communications in Mass Spectrometry. 21 (12), pp. 1833-1840. https://doi.org/10.1002/rcm.3025

ω-Phosphinyl-α-amino acids: synthesis, and development towards use as therapeutic agents
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2007. ω-Phosphinyl-α-amino acids: synthesis, and development towards use as therapeutic agents. Current Organic Chemistry. 11 (18), pp. 1635-1651. https://doi.org/10.2174/138527207783221200

Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes
Gudasi, K.B., Patil, S., Vadavi, R.S., Shenoy, R.V., Nethaji, M. and Bligh, S.W.A. 2006. Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes. Inorganica Chimica Acta. 359 (10), pp. 3229-3236. https://doi.org/10.1016/j.ica.2006.03.009

A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities
Yang, L., Qin, L.H., Bligh, S.W.A., Bashall, A., Zhang, C.-F., Zhang, M., Wang, Z. and Xu, L. 2006. A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities. Bioorganic & medicinal chemistry. 14 (10), pp. 3496-3501. https://doi.org/10.1016/j.bmc.2006.01.004

Phytoestrogen levels in selected Jamaican food
Simon, G., McFarlane-Anderson, N., Fletcher, H., Golden, K., Wharfe, G., Ogegbo, O., Bligh, S.W.A. and Branford-White, C.J. 2006. Phytoestrogen levels in selected Jamaican food. West Indian Medical Journal. 55, p. 24.

Organophosphorus chemistry: therapeutic intervention in mechanisms of viral and cellular replication
Wardle, N.J., Bligh, S.W.A. and Hudson, H.R. 2005. Organophosphorus chemistry: therapeutic intervention in mechanisms of viral and cellular replication. Current Organic Chemistry. 9 (18), pp. 1803-1828. https://doi.org/10.2174/138527205774913123

Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii
Wu, T., Cheng, X.M., Bligh, S.W.A., Chou, G.-X., Wang, Z., Bashall, A. and Branford-White, C.J. 2005. Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii. Helvetica Chimica Acta. 88 (10), pp. 2617-2623. https://doi.org/10.1002/hlca.200590202

Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum
Zhang, G.N., Zhong, L.Y., Bligh, S.W.A., Guo, Y.L., Zhang, C.-F., Zhang, M., Wang, Z. and Xu, L. 2005. Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum. Phytochemistry. 66 (10), pp. 1113-1120. https://doi.org/10.1016/j.phytochem.2005.04.001

Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV
Wu, T., Bligh, S.W.A., Gu, L.-H., Wang, Z., Liu, H.P., Cheng, X.M., Branford-White, C.J. and Hu, Z.B. 2005. Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV. Fitoterapia. 76 (2), pp. 157-165. https://doi.org/10.1016/j.fitote.2004.11.006

Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice
Wang, C.-H., Wang, Z., Bligh, S.W.A., White, K.N. and Branford-White, C.J. 2004. Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. European Journal of Drug Metabolism and Pharmacokinetics. 29 (3), pp. 199-203. https://doi.org/10.1007/BF03190598

Taraxer-14-en-3β-ol, an anti-inflammatory compound from Sterculia foetida L.
Naik, D.G., Mujumdar, A.M., Waghole, R.J., Misar, A.V., Bligh, S.W.A., Bashall, A. and Crowder, J. 2004. Taraxer-14-en-3β-ol, an anti-inflammatory compound from Sterculia foetida L. Planta Medica. 70 (1), pp. 68-69. https://doi.org/10.1055/s-2004-815459

cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus
Cheng, Z.H., Wu, T., Bligh, S.W.A., Bashall, A. and Yu, B.Y. 2004. cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus. Journal of Natural Products. 67 (10), pp. 1761-1763. https://doi.org/10.1021/np049864e

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase
Collinson, A.D., Bligh, S.W.A., Graham, D.L., Mott, H.R., Chalk, P.A., Korniotis, N. and Lowe, P.N. 2004. Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase. Assay and Drug Development Technologies. 2 (6), pp. 659-673. https://doi.org/10.1089/adt.2004.2.659

Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry
Bligh, S.W.A., Haley, T. and Lowe, P.N. 2003. Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry. Journal of Molecular Recognition. 16 (3), pp. 139-148. https://doi.org/10.1002/jmr.622

Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(II) with nucleosides and its biological activity
Bligh, S.W.A., Bashall, A., Garrud, C., McPartlin, M., Wardle, N.J., White, K.N., Padhye, S., Barve, V. and Kundu, G. 2003. Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(II) with nucleosides and its biological activity. Dalton Transactions. 2003 (2), pp. 184-188. https://doi.org/10.1039/B208790A

How chemistry brought me to the life-sciences interface
Bligh, S.W.A. 2003. How chemistry brought me to the life-sciences interface. Science.

IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids
Fogg, P.G.T., Bligh, S.W.A., Derrick, M.E., Yampol’skii, Y.P., Clever, H.L., Skrzecz, A. and Young, C.L. 2001. IUPAC-NIST solubility data series. 76. Solubility of ethyne in liquids. Journal of Physical and Chemical Reference Data. 30 (6), pp. 1693-1875. https://doi.org/10.1063/1.1397768

Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA
Bligh, S.W.A., Choi, N., Evagorou, E.G., McPartlin, M. and White, K.N. 2001. Dimeric yttrium(III) and neodymium(III) macrocyclic complexes: potential catalysts for hydrolysis of double-stranded DNA. Journal of the Chemical Society, Dalton Transactions. 2001 (21), pp. 3169-3172. https://doi.org/10.1039/B102533N

Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging
Prata, M.I.M., Santos, A.C., Bligh, S.W.A., Chowdhury, A.H.M.S., Geraldes, C.F.G.C. and de Lima, J.J.P. 2000. Characterization of 111In3+ complexes of DTPA amide derivatives: biodistribution and clearance studied by gamma imaging. Nuclear Medicine and Biology. 27 (6), pp. 605-610. https://doi.org/10.1016/S0969-8051(00)00127-X

Synthesis and structural properties of metal complexes of dialkyl α-hydroxyiminophosphonates
Bligh, S.W.A., Choi, N., McGrath, C.M., McPartlin, M. and Woodroffe, T.M. 2000. Synthesis and structural properties of metal complexes of dialkyl α-hydroxyiminophosphonates. Journal of the Chemical Society, Dalton Transactions. 2000 (15), pp. 2587-2594. https://doi.org/10.1039/B003241G

Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging
Bligh, S.W.A., Chowdhury, A.H.M.S., Kennedy, D., Luchinat, C. and Parigi, G. 1999. Non-ionic bulky Gd(III) DTPA-bisamide complexes as potential contrast agents for magnetic resonance imaging. Magnetic Resonance in Medicine. 41 (4), pp. 767-773. https://doi.org/10.1002/(SICI)1522-2594(199904)41:4<767::AID-MRM16>3.0.CO;2-G

Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate
Bligh, S.W.A., McPartlin, M., Sanganee, M.J., Woodroffe, T.M. and Geraldes, C.F.G.C. 1998. Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate. Chemical Communications. 1998 (19), pp. 2073-2074. https://doi.org/10.1039/A805189E

A gadolinium cryptate with two coordinated water molecules
Bligh, S.W.A., Drew, M.G.B., Martin, N., Maubert, B. and Nelson, J. 1998. A gadolinium cryptate with two coordinated water molecules. Journal of the Chemical Society, Dalton Transactions. 1998 (22), pp. 3711-3714. https://doi.org/10.1039/A805859H

A novel hexaaza macrocycle with methylenephosphonate pendant arms: a potential useful chelate for biomedical applications
Bligh, S.W.A., Choi, N., Geraldes, C.F.G.C., Knoke, S., McPartlin, M., Sanganee, M.J. and Woodroffe, T.M. 1997. A novel hexaaza macrocycle with methylenephosphonate pendant arms: a potential useful chelate for biomedical applications. Journal of the Chemical Society, Dalton Transactions. 1997 (21), pp. 4119-4126. https://doi.org/10.1039/A703678G

Hexaaza and octaaza macrocycles with 2-hydroxy 3,5-dimethylbenzyl pendant arms
Bligh, S.W.A., Choi, N., Evagorou, E.G. and McPartlin, M. 1997. Hexaaza and octaaza macrocycles with 2-hydroxy 3,5-dimethylbenzyl pendant arms. Journal of the Chemical Society, Perkin Transactions. 1997 (21), pp. 3151-3156. https://doi.org/10.1039/A704835A

α-aminophosphonate monoesters in one step
Bligh, S.W.A., McGrath, C.M., Failla, S. and Finocchiaro, P. 1996. α-aminophosphonate monoesters in one step. Phosphorus, Sulfur, and Silicon and the Related Elements. 118 (1), pp. 189-194. https://doi.org/10.1080/10426509608038811

Lanthanide and transition metal complexes of dialkyl alpha-hydroxyiminophosphonates
Bligh, S.W.A., Choi, N., Green, D.S.C., Hudson, H.R., McGrath, C.M., McPartlin, M. and Pianka, M. 1996. Lanthanide and transition metal complexes of dialkyl alpha-hydroxyiminophosphonates. Phosphorus, Sulfur, and Silicon and the Related Elements. 111 (1-4), p. 49. https://doi.org/10.1080/10426509608054678

Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging
Bligh, S.W.A., Chowdhury, A.H.M.S., McPartlin, M. and Scowen, I.J. 1995. Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging. Polyhedron. 14 (4), pp. 567-569. https://doi.org/10.1016/0277-5387(94)00318-9

Teaching techniques in inorganic chemistry
Bligh, S.W.A., Conole, G. and McPartlin, M. 1995. Teaching techniques in inorganic chemistry. in: Variety in Chemistry Proceedings UK Physical Sciences Centre.

Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents
Bligh, S.W.A., Harding, C.T., McEwen, A.B. and Sadler, P.J. 1994. Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents. Polyhedron. 13 (12), pp. 1937-1943. https://doi.org/10.1016/0277-5387(94)80018-9

Synthesis of the first lanthanide complexes of dialkyl α-hydroxyiminophosphonates; ambivalent ligand bonding in the PrIII and NdIII complexes of diisopropyl α-hydroxyiminopropylphosphonate (L1), [PrL13Cl3] and [NdL12(NO3)3(H2O)]
Bligh, S.W.A., Choi, N., Hudson, H.R., McGrath, C.M. and McPartlin, M. 1994. Synthesis of the first lanthanide complexes of dialkyl α-hydroxyiminophosphonates; ambivalent ligand bonding in the PrIII and NdIII complexes of diisopropyl α-hydroxyiminopropylphosphonate (L1), [PrL13Cl3] and [NdL12(NO3)3(H2O)]. Journal of the Chemical Society, Dalton Transactions. 1994 (15), pp. 2335-2337. https://doi.org/10.1039/DT9940002335

First structural characterisation of an amino phosphonate monoester metal complex
Bligh, S.W.A., Choi, N., Failla, S., Finocchiaro, P., Il'yasov, A., Libertini, M., McGrath, C.M., McPartlin, M. and Woodroffe, T.M. 1994. First structural characterisation of an amino phosphonate monoester metal complex. Journal of the Chemical Society, Dalton Transactions. 1994 (22), pp. 3333-3334. https://doi.org/10.1039/DT9940003333

Metal-ion controlled helicity of an 18-membered hexaaza tetraamine macrocycle
Bligh, S.W.A., Choi, N., Evagorou, E.G., Li, W.S. and McPartlin, M. 1994. Metal-ion controlled helicity of an 18-membered hexaaza tetraamine macrocycle. Journal of the Chemical Society, Chemical Communications. 1994 (20), pp. 2399-2400. https://doi.org/10.1039/C39940002399

Yttrium(III) and lanthanide(III) metal complexes of an 18-membered hexaaza tetraimine macrocycle. Crystal structure of the gadolinium(III) complex
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D. and McPartlin, M. 1994. Yttrium(III) and lanthanide(III) metal complexes of an 18-membered hexaaza tetraimine macrocycle. Crystal structure of the gadolinium(III) complex. Journal of the Chemical Society, Dalton Transactions. 1994 (23), pp. 3369-3376. https://doi.org/10.1039/DT9940003369

Transition metal complexes of dialkyl α-hydroxyiminophosphonates, a novel class of metal complexes
Bligh, S.W.A., Choi, N., Green, D.S.C., Hudson, H.R., McGrath, C.M., McPartlin, M. and Pianka, M. 1993. Transition metal complexes of dialkyl α-hydroxyiminophosphonates, a novel class of metal complexes. Polyhedron. 12 (23), pp. 2887-2890. https://doi.org/10.1016/S0277-5387(00)80073-X

Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D., McPartlin, M. and Parkes, H.G. 1993. Macrocyclic lanthanide complexes as potential contrast agents for NMR imaging. Journal of Inorganic Biochemistry. 51 (1-2), p. 438. https://doi.org/10.1016/0162-0134(93)85467-M

Synthesis and crystal structure of a novel hexaaza macrocyclic ligand with 2-hydroxy-3,5-dimethylbenzyl pendant arms and its gadolinium(III) complex
Bligh, S.W.A., Choi, N., Cummins, W.J., Evagorou, E.G., Kelly, J.D. and McPartlin, M. 1993. Synthesis and crystal structure of a novel hexaaza macrocyclic ligand with 2-hydroxy-3,5-dimethylbenzyl pendant arms and its gadolinium(III) complex. Journal of the Chemical Society, Dalton Transactions. 1993 (24), pp. 3829-3831. https://doi.org/10.1039/DT9930003829

Distortional isomerism in oxomolybdenum systems: the evidence re-evaluated
Bashall, A., Bligh, S.W.A., Edwards, A.J., McPartlin, M., Gibson, V.C. and Robinson, O.B. 1992. Distortional isomerism in oxomolybdenum systems: the evidence re-evaluated. Angewandte Chemie: International Edition in English. 31 (12), pp. 1607-1609. https://doi.org/10.1002/anie.199216071

Synthesis and crystal structure of a gadolinium(III) complex of a tetraimine schiff-base macrocycle: a potential contrast agent for magnetic resonance imaging
Bligh, S.W.A., Choi, N., Evagorou, E.G., McPartlin, M., Cummins, W.J. and Kelly, J.D. 1992. Synthesis and crystal structure of a gadolinium(III) complex of a tetraimine schiff-base macrocycle: a potential contrast agent for magnetic resonance imaging. Polyhedron. 11 (19), pp. 2571-2573. https://doi.org/10.1016/S0277-5387(00)83580-9

H-1-Nmr studies of reactions of copper complexes with human blood plasma and urine
Bligh, S.W.A., Boyle, H.A., McEwen, A.B., Sadler, P.J. and Woodham, R.H. 1992. H-1-Nmr studies of reactions of copper complexes with human blood plasma and urine. Biochemical Pharmacology. 43 (2), pp. 137-145. https://doi.org/10.1016/0006-2952(92)90270-S

Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging
Bligh, S.W.A., Harding, C.T., Sadler, P.J., Bulman, R.A., Bydder, G.M., Pennock, J.M., Kelly, J.D., Clatham, I.A. and Marriott, J.A. 1991. Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging. Magnetic Resonance in Medicine. 17 (2), pp. 516-532. https://doi.org/10.1002/mrm.1910170222

Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma
Bligh, S.W.A., Drake, A.F. and Sadler, P.J. 1990. Nuclear magnetic resonance and circular dichroism spectroscopic studies of copper complexation in blood plasma. Biochemical Society Transactions. 18, pp. 999-1000. https://doi.org/10.1042/bst0180999

Ultraviolet and magnetic-circular-diochroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid
Bligh, S.W.A., Drake, A.F. and Sadler, P.J. 1989. Ultraviolet and magnetic-circular-diochroic spectroscopic studies of Gd(III) complexed with diethylenetriaminepentaacetic acid. European Journal of Biochemistry. 181 (1), pp. 223-224. https://doi.org/10.1111/j.1432-1033.1989.tb14714.x

Characterization and invivo distribution of Tc-99m-labeled and In-111-labelled magnetite
Bligh, S.W.A., Sadler, P.J., Marriott, J.A., Latham, I.A. and Kelly, J.D. 1989. Characterization and invivo distribution of Tc-99m-labeled and In-111-labelled magnetite. Applied Radiation and Isotopes. 40, pp. 751-757.

Labels and contrast agents in biomedical magnetic resonance spectroscopy and imaging
Bligh, S.W.A. and Sadler, P.J. 1989. Labels and contrast agents in biomedical magnetic resonance spectroscopy and imaging. in: Dykes, J. and Delpy, D.T. (ed.) Clinical NMR spectroscopy York, England The Institute of Physical Sciences in Medicine. pp. 77-81

Permalink - https://westminsterresearch.westminster.ac.uk/item/91095/preparation-and-characterization-of-medicated-pan-pvp-composite-fibers-for-better-drug-release-profiles


Share this

Usage statistics

140 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.