Saliva: physiology and diagnostic potential in health and disease

Farnaud, S., Kosti, O., Getting, S.J. and Renshaw, D. 2010. Saliva: physiology and diagnostic potential in health and disease. ScientificWorldJournal. 10, pp. 434-456.

TitleSaliva: physiology and diagnostic potential in health and disease
AuthorsFarnaud, S., Kosti, O., Getting, S.J. and Renshaw, D.
Abstract

This article discusses the origin and the role of saliva in the mouth, and how by measuring substances in saliva, we can diagnose a range of human diseases. Saliva is simple to sample and requires no specialised training, unlike blood. A range of human diseases and infections can be diagnosed from saliva, and this review discusses the most recent literature describing the specific biomarkers used to diagnose each disease.

JournalScientificWorldJournal
Journal citation10, pp. 434-456
ISSN1537-744X
YearMar 2010
PublisherScientificWorld Ltd.
Digital Object Identifier (DOI)doi:10.1100/tsw.2010.38
Publication dates
PublishedMar 2010

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Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley. pp. PO136

The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119. Physiology 2010. University of Manchester 30 June - 2 July 2010

Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3)
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3). Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010

Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis
Patel, H.B., Bombardieri, M., Sampaio, A.L.F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S.J., Pitzalis, C. and Perretti, M. 2010. Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis. FASEB Journal. 24 (12), pp. 4835-4843.

Melanocortin peptide therapy for the treatment of arthritic pathologies
Getting, S.J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, G., Patel, H.B., Kerrigan, M.J.P. and Locke, I.C. 2009. Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal. 9, pp. 1394-1414.

The Dr Hadwen Trust for humane research: 39 years of replacement science
Farnaud, S. 2009. The Dr Hadwen Trust for humane research: 39 years of replacement science. Alternatives to Laboratory Animals. 37 (S2), pp. 39-43.

Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation. British Orthopaedic Research Society (BORS) Annual Meeting. Newcastle 22nd - 23rd June 2009

The evolution of the three Rs
Farnaud, S. 2009. The evolution of the three Rs. Alternatives to Laboratory Animals. 37 (3), pp. 249-254.

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study
Tripatara, P., Patel, N.S.A., Brancaleone, V., Renshaw, D., Rocha, J., Sepodes, B., Mota-Filipe, H., Perretti, M. and Thiemermann, C. 2009. Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. European Journal of Pharmacology. 606 (1-3), pp. 205-209.

The effects of REV5901 on chondrocyte viability following mechanical trauma
Parker, E., Getting, S.J., Hucklebridge, F., Vleck, V.E. and Kerrigan, M.J.P. 2009. The effects of REV5901 on chondrocyte viability following mechanical trauma. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4), p. P0149.

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society.

Molecular characterization of the melanocortin 3 receptor in the testes of mice
Horanin, M.M., Akindele, K., Getting, S.J., Smith, C.L. and Murray, J.F. 2009. Molecular characterization of the melanocortin 3 receptor in the testes of mice. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4).

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Murray, J.F., Grieco, P., Getting, S.J. and Perretti, M. 2008. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. FASEB Journal. 22 (12), pp. 4228-4238.

A role for MC3R in modulating lung inflammation
Getting, S.J., Riffo-Vasquez, Y., Pitchford, S., Kaneva, M., Grieco, P., Page, C.P., Perretti, M. and Spina, D. 2008. A role for MC3R in modulating lung inflammation. Pulmonary Pharmacology and Therapeutics. 21 (6), pp. 866-873.

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles
Dalli, J., Norling, L.V., Renshaw, D., Cooper, D., Leung Kit-Y and Perretti, M. 2008. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood. 112 (6), pp. 2512-2519.

Identification of an iron-hepcidin complex
Farnaud, S., Rapisarda, C., Bui, T.T.T., Drake, A.F., Cammack, R. and Evans, R.W. 2008. Identification of an iron-hepcidin complex. Biochemical Journal. 413 (3), pp. 553-557.

Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies
Conesa, C., Sánchez, L., Rota, C., Pérez, M.D., Calvo, M., Farnaud, S. and Evans, R.W. 2008. Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies. Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology. 150 (1), pp. 131-139.

The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes
Junkes, C., Wessolowski, A., Farnaud, S., Evans, R.W., Good, L., Bienert, M. and Dathe, M. 2008. The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes. Journal of Peptide Science. 14 (4), pp. 535-543.

Melanocortin 3 receptor in the testes of mice
Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. Society for Reproduction and Fertility. Edinburgh 29 Jun - 01 Jul 2008 pp. Abstract P80

Melanocortin 3 receptor in the testes of mice
Wotherspoon, G., Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. P008.

Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro
Stenbeck, G., Joseph, J., Getting, S.J. and Smith, C.L. 2008. Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C041.

The role of the actin cytoskeleton in chondrocyte protection following single impact
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2008. The role of the actin cytoskeleton in chondrocyte protection following single impact. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4).

Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor. Journal of Vascular Research. 45 (Suppl2).

Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation. William Harvey Day. St. Barts Hospital, London 14th October 2008

A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells
Getting, S.J., Kaneva, M. and Kerrigan, M.J.P. 2008. A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C020.

Melanocortins
Getting, S.J. 2008. Melanocortins. in: Offermanns, S. and Rosenthal, W. (ed.) Encyclopedia of molecular pharmacology. 2nd edition Berlin Springer. pp. 752-757

Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins
Farnaud, S., Amini, M., Rapisarda, C., Cammack, R., Buic, T., Drake, A.F., Evans, R.W., Rahmanto, Y.S. and Richardson, D.R. 2008. Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins. International Journal of Biochemistry & Cell Biology. 40 (12), pp. 2739-2745.

The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling
Ali, N., Getting, S.J. and Kerrigan, M.J.P. 2008. The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4).

Therapeutic exploitation of endogenous anti-inflammatory mechanisms: old and new leads
Renshaw, D., Urquhart, P. and Perretti, M. 2007. Therapeutic exploitation of endogenous anti-inflammatory mechanisms: old and new leads. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5 (4), pp. 289-305.

Endogenous MC3R and inhibition of inflammatory arthritis. PC112
Patel, H.B., Sampaio, A.L.F., Getting, S.J., Gray, M. and Perretti, M. 2007. Endogenous MC3R and inhibition of inflammatory arthritis. PC112. Life Sciences. Glasgow 8th - 12th July 2007

Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106
Leoni, G., Getting, S.J., Gavins, F.N.E. and Perretti, M. 2007. Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106. Life Sciences. Glasgow 8th - 12th July 2007

Glucocorticoid and melanocortins: special issue
Getting, S.J. 2007. Glucocorticoid and melanocortins: special issue. ScientificWorldJournal. 7, pp. 1463-1464.

[D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse)
Getting, S.J., Lam, C.W., Leoni, G., Gavins, F.N.E., Grieco, P. and Perretti, M. 2006. [D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse). Molecular Pharmacology. 70 (6), pp. 1850-1855.

Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae
Sargent, P.J., Farnaud, S., Cammack, R., Zoller, H.M.P. and Evans, R.W. 2006. Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae. BioMetals. 19 (5), pp. 513-519.

Modelling of a metal-containing hepcidin
Farnaud, S., Patel, A. and Evans, R.W. 2006. Modelling of a metal-containing hepcidin. BioMetals. 19 (5), pp. 527-533.

Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart
Gavins, F.N.E., Leoni, G. and Getting, S.J. 2006. Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart. ScientificWorldJournal. 6, pp. 1008-1023.

Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells
Schwarz, N., Renshaw, D., Kapas, S. and Hinson, J.P. 2006. Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells. Journal of Endocrinology. 190 (2), pp. 505-514.

Targeting melanocortin receptors as potential novel therapeutics
Getting, S.J. 2006. Targeting melanocortin receptors as potential novel therapeutics. Pharmacology & Therapeutics. 111 (1), pp. 1-15.

Intra-adrenal mechanisms in the response to chronic stress: investigation in a rat model of emotionality
Kosti, O., Raven, P.W., Renshaw, D. and Hinson, J.P. 2006. Intra-adrenal mechanisms in the response to chronic stress: investigation in a rat model of emotionality. Journal of Endocrinology. 189 (2), pp. 211-218.

Melanocortin receptor signaling in RAW264.7 macrophage cell line
Lam, C.W., Perretti, M. and Getting, S.J. 2006. Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides. 27 (2), pp. 404-412.

The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage
Getting, S.J., Di Filippo, C., D'Amico, M. and Perretti, M. 2006. The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. European Journal of Pharmacology. 532 (1-2), pp. 138-144.

An overview of molecular aspects of iron metabolism
Syed, B.A., Sargent, P.J., Farnaud, S. and Evans, R.W. 2006. An overview of molecular aspects of iron metabolism. Hemoglobin. 30 (1), pp. 69-80.

Mode of glucocorticoid actions in airway disease
Ito, K., Getting, S.J. and Charron, C.E. 2006. Mode of glucocorticoid actions in airway disease. ScientificWorldJournal. 28 (6), pp. 1750-1769.

Melanocortin 3 receptors control crystal-induced inflammation
Getting, S.J., Lam, C.W., Chen, A.S., Grieco, P. and Perretti, M. 2006. Melanocortin 3 receptors control crystal-induced inflammation. FASEB Journal. 20 (13), pp. 2234-2241.

Towards a tree-induction approach to antimicrobial activity analysis of cationic peptides
Farnaud, S., Wang, Z., Dybowski, R., Odell, E.W. and Evans, R.W. 2006. Towards a tree-induction approach to antimicrobial activity analysis of cationic peptides. Biochemistry and Cell Biology. 84 (3), p. 394.

Structure/function overview of proteins involved in iron storage and transport
Sargent, P.J., Farnaud, S. and Evans, R.W. 2005. Structure/function overview of proteins involved in iron storage and transport. Current Medicinal Chemistry. 12 (23), pp. 2683-2693.

In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation
Lam, C.W., Getting, S.J. and Perretti, M. 2005. In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. Journal of Immunology. 174 (4), pp. 2297-2304.

Lactoferrin: the conductor of the immunological system?
Farnaud, S. and Evans, R.W. 2005. Lactoferrin: the conductor of the immunological system? in: Veskler, B.A. (ed.) New research on immunology New York Nova Science Publishers.

MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct
Getting, S.J., Di Filippo, C., Christian, H.C., Lam, C.W., Rossi, F., D'Amico, M. and Perretti, M. 2004. MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. Journal of Leukocyte Biology. 76 (4), pp. 845-853.

Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo
Cao, T.V., La, M., Getting, S.J. and Day, A.J. 2004. Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation. 11 (7), pp. 615-624.

Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling
Farnaud, S., Patel, A., Odell, E.W. and Evans, R.W. 2004. Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling. FEMS Microbiology Letters. 238 (1), pp. 221-226.

Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis
Getting, S.J., Di Filippo, C., Lam, C.W., Rossi, F. and D'Amico, M. 2004. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. Journal of Pharmacology and Experimental Therapeutics. 310 (1), pp. 90-97.

The plug domain of a neisserial TonB-dependent transporter retains structural integrity in the absence of its transmembrane β-barrel
Oke, M., Sarra, R., Ghirlando, R., Farnaud, S., Gorringe, A.R., Evans, R.W. and Buchanan, S.K. 2004. The plug domain of a neisserial TonB-dependent transporter retains structural integrity in the absence of its transmembrane β-barrel. FEBS Letters. 564 (3), pp. 294-300.

Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity
Farnaud, S., Spiller, C., Moriarty, L.C., Patel, A., Gant, V., Odell, E.W. and Evans, R.W. 2004. Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity. FEMS Microbiology Letters. 233 (2/29), pp. 193-199.

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis
Yang, Y.H., Morand, E.F., Getting, S.J. and Paul-Clark, M. 2004. Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis & Rheumatism. 50 (3), pp. 976-984.

The annexin 1-/- mouse: phenotypic studies
Wells, D., Wells, K., Liu, K., Hannon, R., Croxtall, J.D., Damazo, A.S., Oliani, S.M., Getting, S.J., Parente, L., Paul-Clark, M., Yona, S., Gavins, F.N.E., Martin, J., Christian, H.C., Cover, P.O., John, C.D., Solito, E., Morris, J.F., Perretti, M., Buckingham, J.C. and Flower, R.J. 2004. The annexin 1-/- mouse: phenotypic studies. Annexins. 1 (2), pp. 109-120.

Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages
Lam, C.W., Getting, S.J. and Perretti, M. 2004. Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages. pA2 Online. Winter 2004 Meeting: Proceedings of the British Pharmacological Society.

Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy
Lam, C.W. and Getting, S.J. 2004. Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy. Current Drug Targets. Inflammation & Allergy. 3 (3), pp. 311-315.

Lactoferrin: a multifunctional protein with antimicrobial properties
Farnaud, S. and Evans, R.W. 2003. Lactoferrin: a multifunctional protein with antimicrobial properties. Molecular Immunology. 40 (7), pp. 395-405.

Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
Getting, S.J., Schiöth, H.B. and Perretti, M. 2003. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics. 306 (2), pp. 631-637.

Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor
Getting, S.J., Christian, H.C., Lam, C.W., Gavins, F.N.E., Flower, R.J., Schiöth, H.B. and Perretti, M. 2003. Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. Journal of Immunology. 170 (6), pp. 3323-3330.

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
Hannon, R., Croxtall, J.D., Getting, S.J., Roviezzo, F., Yona, S., Paul-Clark, M., Gavins, F.N.E., Perretti, M., Morris, J.F., Buckingham, J.C. and Flower, R.J. 2003. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB Journal. 17 (2), pp. 253-255.

Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo. Methods in Molecular Biology. 225, pp. 139-146.

Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo. in: Winyard, P.G. and Willoughby, D.A. (ed.) Inflammation Protocols Totowa, NJ Humana Press. pp. 139-146

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner
Getting, S.J., Mahoney, D.J., Cao, T.V., Rugg, M.S., Fries, E., Milner, C.M., Perretti, M. and Day, A.J. 2002. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. Journal of Biological Chemistry. 277 (52), pp. 51068-51076.

Bacterial lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells
Vakharia, K., Renshaw, D. and Hinson, J.P. 2002. Bacterial lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells. Endocrine Research. 28 (4), pp. 357-361.

Bacterial Lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells
Vakharia, K., Renshaw, D. and Hinson, J.P. 2002. Bacterial Lipopolysaccharide directly stimulates cortisol secretion in human adrenal cells. Endocrine Research. 28 (4), pp. 357-361.

The annexin-1 knockout mouse: what it tells us about the inflammatory response
Roviezzo, F., Getting, S.J., Paul-Clark, M., Yona, S., Gavins, F.N.E., Perretti, M., Hannon, R., Croxtall, J.D., Buckingham, J.C. and Flower, R.J. 2002. The annexin-1 knockout mouse: what it tells us about the inflammatory response. Journal of Physiology and Pharmacology. 53 (4, part 1), pp. 541 -553.

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Perretti, M., Chiang, N., La, M., Fierro, I.M., Marullo, S., Getting, S.J., Solito, E. and Serhan, C.N. 2002. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nature Medicine. 8 (11), pp. 1296-1302.

Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis
Getting, S.J., Christian, H.C., Flower, R.J. and Perretti, M. 2002. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis & Rheumatism. 46 (10), pp. 2765-2775.

Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy
Getting, S.J. 2002. Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends in Pharmacological Sciences. 23 (10), pp. 447-449.

Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity
Novo, C., Farnaud, S., Tata, R., Clemente, A. and Brown, P.R. 2002. Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity. Biochemical Journal. 365 (3), pp. 731-738.

A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones
Malcangio, M., Getting, S.J., Grist, J., Cunningham, J.R., Bradbury, E.J., Issa, P.C., Lever, I.J., Pezet, S. and Perretti, M. 2002. A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB Journal. 16 (7), pp. 730-732.

Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma
Carollo, M., Getting, S.J., Delaney, S., Christie, M.I. and Perretti, M. 2002. Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma. Inflammation Research. 51 (2), pp. 110-111.

Regulation of rat adrenal vasoactive intestinal peptide content: effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake
Hinson, J.P., Renshaw, D., Carroll, M. and Kapas, S. 2001. Regulation of rat adrenal vasoactive intestinal peptide content: effects of adrenocorticotropic hormone treatment and changes in dietary sodium intake. Journal of Neuroendocrinology. 13 (9), pp. 769-773.

Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics
Perretti, M., Getting, S.J., Solito, E., Murphy, P.M. and Gao, J.L. 2001. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. American Journal of Pathology. 158 (6), pp. 1969-1973.

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Mabley, J.G., Jagtap, P., Perretti, M., Getting, S.J., Salzman, A.L., Virag, L., Szabo, E., Soriano, F.G., Liaudet, L., Hasko, G., Marton, A., Southan, G.J., Abdelkarim, G.E. and Szabo, C. 2001. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflammation Research. 50 (11), pp. 561-569.

Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics
Getting, S.J. and Perretti, M. 2001. Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current opinion in investigational drugs. 2 (8), pp. 1064-1069.

Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties
Getting, S.J., Allcock, G.H., Flower, R.J. and Perretti, M. 2001. Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. Journal of Leukocyte Biology. 69 (1), pp. 98-104.

MC3-R as a novel target for anti-inflammatory therapy
Getting, S.J. and Perretti, M. 2000. MC3-R as a novel target for anti-inflammatory therapy. Drug News & Perspectives. 13 (1), pp. 19-27.

Evidence that cysteine-166 is the active-site nucleophile of Pseudomonas aeruginosa amidase: crystallization and preliminary X-ray diffraction analysis of the enzyme
Farnaud, S., Tata, R., Sohi, M.K., Wan, T., Brown, P.R. and Sutton, B.J. 1999. Evidence that cysteine-166 is the active-site nucleophile of Pseudomonas aeruginosa amidase: crystallization and preliminary X-ray diffraction analysis of the enzyme. Biochemical Journal. 340 (3), pp. 711-714.

POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation
Getting, S.J., Gibbs, L., Clark, A.J.L., Flower, R.J. and Perretti, M. 1999. POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology. 162 (12), pp. 7446-7453.

Compounds for use in the treatment of inflammation
Flower, R.J., Getting, S.J. and Perretti, M. 1998. Compounds for use in the treatment of inflammation.

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects
Szabo, C., Lim, L.H.K., Cuzzocrea, S., Getting, S.J., Zingarelli, B., Flower, R.J., Salzman, A.L. and Perretti, M. 1997. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. Journal of experimental medicine. 186 (7), pp. 1041-1049.

Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins
Getting, S.J., Flower, R.J., Parente, L., de Medicis, R., Lussier, A., Woliztky, B.A., Martins, M.A. and Perretti, M. 1997. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics. 283 (1), pp. 123-130.

Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1
Getting, S.J., Flower, R.J. and Perretti, M. 1997. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. British Journal of Pharmacology. 120 (6), pp. 1075-1082.

Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes
Tailor, A., Das, A.M., Getting, S.J., Flower, R.J. and Perretti, M. 1997. Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. Biochemical and Biophysical Research Communications. 231 (3), pp. 675-678.

Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S. and Whitton, P.S. 1996. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Research. 717 (1-2), pp. 196-199.

Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats
Segieth, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats. Neuroscience Letters. 200 (2), pp. 101-104.

Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo
Segieth-Beever, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo. Wiley.

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