Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity

Edward S. Wickstead, Bradley T. Elliott, Sarah Pokorny, Christopher Biggs, Stephen J. Getting and Simon McArthur 2023. Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity. International Journal of Molecular Sciences. 24 (21). https://doi.org/10.3390/ijms242115996

TitleStimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
TypeJournal article
AuthorsEdward S. Wickstead, Bradley T. Elliott, Sarah Pokorny, Christopher Biggs, Stephen J. Getting and Simon McArthur
Abstract

Neuroinflammation driven primarily by microglia directly contributes to neuronal death in many neurodegenerative diseases. Classical anti-inflammatory approaches aim to suppress pro-inflammatory mediator production, but exploitation of inflammatory resolution may also be of benefit. A key driver of peripheral inflammatory resolution, formyl peptide receptor 2 (Fpr2), is expressed by microglia, but its therapeutic potential in neurodegeneration remains unclear. Here, we studied whether targeting of Fpr2 could reverse inflammatory microglial activation induced by the potent bacterial inflammogen lipopolysaccharide (LPS). Exposure of murine primary or immortalised BV2 microglia to LPS triggered pro-inflammatory phenotypic change and activation of ROS production, effects significantly attenuated by subsequent treatment with the Fpr2 agonist C43. Mechanistic studies showed C43 to act through p38 MAPK phosphorylation and reduction of LPS-induced NFκB nuclear translocation via prevention of IκBα degradation. Here, we provide proof-of-concept data highlighting Fpr2 as a potential target for control of microglial pro-inflammatory activity, suggesting that it may be a promising therapeutic target for the treatment of neuroinflammatory disease.

JournalInternational Journal of Molecular Sciences
Journal citation24 (21)
ISSN1422-0067
Year2023
PublisherMDPI
Publisher's version
License
CC BY 4.0
File Access Level
Open (open metadata and files)
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms242115996
PubMed ID37958978
Web address (URL)https://doi.org/10.3390/ijms242115996
Publication dates
Published06 Nov 2023

Related outputs

Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females
Isabella D. Cooper, Yvoni Kyriakidou, Lucy Petagine, Kurtis Edwards, Adrian Soto-Mota, Kenneth Brookler and Bradley T. Elliott 2024. Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females. Biomedicines. 12 (7) 1553. https://doi.org/10.3390/biomedicines12071553

Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model
Cooper, Isabella D., Sanchez-Pizarro, Claudio, Norwitz, Nicholas G., Feldman, David, Kyriakidou, Yvoni, Edwards, Kurtis, Petagine, Lucy, Elliot, Bradley T. and Soto-Mota, Adrian 2023. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model. Frontiers in Endocrinology. 14, p. 1326768. https://doi.org/10.3389/fendo.2023.1326768

Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females
Cooper, I., Kyriakidou, Y., Edwards, K., Petagine, L., Seyfried, T., Duraj, T., Soto-Mota, A., Scarborough, A., Jacome, S, Brookler, K., Borgogni, V., Novaes, V., Al-Faour, R. and Elliott, B. 2023. Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females. International Journal of Molecular Sciences. 24 15621. https://doi.org/10.3390/ijms242115621

Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan
Isabella D. Cooper, Yvoni Kyriakidou, Lucy Petagine, Kurtis Edwards and Bradley T. Elliott 2023. Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan. Antioxidants. 12 (9). https://doi.org/10.3390/antiox12091749

Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model
Allen, Sophie L., Elliott, Bradley T., Carson, Brian P. and Breen, Leigh 2023. Improving Physiological Relevance of Cell Culture: The Possibilities, Considerations and Future Directions of the Ex Vivo Co-Culture Model. American Journal of Physiology: Cell Physiology. 324 (2), pp. C420-C427. https://doi.org/10.1152/ajpcell.00473.2022

The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females
Bagheri, Reza, Ashtary-Larky, Damoon, Elliott, B., Willoughby, Darryn S., Kargarfard, Mehdi, Alipour, Meysam, Lamuchi-Deli, Nasrin, Kooti, Wesam, Asbaghi, Omid and Wong, Alexei 2023. The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females. Archives of Physiology and Biochemistry. 129 (3), pp. 821-828. https://doi.org/10.1080/13813455.2021.1874020

Development of chitosan, pullulan, and alginate based drug-loaded nano-emulsions as a potential malignant melanoma delivery platform
Hatami Fard, G., Moinipoor, Z., Anastasova-Ivanova, S., Iqbal, H.M.N., Dwek, M., Getting, S.J. and Keshavarz, T. 2022. Development of chitosan, pullulan, and alginate based drug-loaded nano-emulsions as a potential malignant melanoma delivery platform . Carbohydrate Polymer Technologies and Applications. 4 100250. https://doi.org/10.1016/j.carpta.2022.100250

Editorial: Exercise as a Countermeasure to Human Aging, Volume II
Hayes, L., Burtscher, M. and Elliott, B. 2022. Editorial: Exercise as a Countermeasure to Human Aging, Volume II. Frontiers in Physiology. 13 (878983). https://doi.org/10.3389/fphys.2022.878983

Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment.
Wickstead, E. S., Irving, M. A., Getting, S. J. and McArthur, S. 2022. Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. The FEBS Journal. 289 (7), pp. 1801-1822. https://doi.org/10.1111/febs.15861

Regulation of TNF-Induced Osteoclast Differentiation.
Yao, Zhenqiang, Getting, Stephen J and Locke, Ian C 2021. Regulation of TNF-Induced Osteoclast Differentiation. Cells. 11 (1) e132. https://doi.org/cells11010132

Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men
Kyriakidou, Y., Cooper, I., Kraev, I., Lange, S. and Elliott, B. 2021. Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men. Frontiers in Physiology. 12 723931. https://doi.org/10.3389/fphys.2021.723931

High Intensity Interval Training (HIIT) as a Potential Countermeasure for Phenotypic Characteristics of Sarcopenia: A Scoping Review
Hayes, L., Elliott, B., Yasar, Z., Bampouras, T., Sculthorpe, N., Sanal-Hayes, N. and Hurst, C. 2021. High Intensity Interval Training (HIIT) as a Potential Countermeasure for Phenotypic Characteristics of Sarcopenia: A Scoping Review. Frontiers in Physiology. 12 715044. https://doi.org/10.3389/fphys.2021.715044

Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm.
Cooper, I., Brookler, Kenneth H, Kyriakidou, Yvoni, Elliott, B. and Crofts, C. 2021. Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm. Biomedicines. 9 (7) 800. https://doi.org/10.3390/biomedicines9070800

Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males
Bagheri, R., Hooshmand Moghadam, B., Candow, D., Elliott, B., Wong, A., Ashtary-Larky, D., Forbes, S. and Rashidlamir, A. 2021. Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males. British Journal of Nutrition. 127 (9), pp. 1334-1342. https://doi.org/10.1017/S0007114521002166

Strategic Ingestion of High-Protein Dairy Milk during a Resistance Training Program Increases Lean Mass, Strength, and Power in Trained Young Males
Pourabbas, M., Bagheri, Reza, Hooshmand Moghadam, B., S. Willoughby, Darryn, G. Candow, Darren, Elliott, B., C. Forbes, S., Ashtary-Larky, Damoon, Eskandari, Mozhgan, Wong, Alexei and Dutheil, Frédéric 2021. Strategic Ingestion of High-Protein Dairy Milk during a Resistance Training Program Increases Lean Mass, Strength, and Power in Trained Young Males. Nutrients. 13 (3), p. e948. https://doi.org/10.3390/nu13030948

Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men
Yasar, Z., Elliott, B., Kyriakidou, Y., Nwokoma, C., Postlethwaite, R., Gaffney, C., Dewhurst, S. and Hayes, L. 2021. Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men. European Journal of Applied Physiology. 121, pp. 1909-1919. https://doi.org/10.1007/s00421-021-04635-2

The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage
Kyriakidou, Y., Wood, C., Ferrier, C., Dolci, A. and Elliott, B. 2021. The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage. Journal of the International Society of Sports Nutrition. 18 (1) 9. https://doi.org/10.1186/s12970-020-00405-1

Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management
Cooper, I., Crofts, C., DiNicolantonio, J., Malhotra, A., Elliott, B., Kyriakidou, Y. and Brookler, K. 2020. Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management . Open Heart. 7 e001356. https://doi.org/10.1136/openhrt-2020-001356

"I've Seen You": A conversation about the Transformative Potential of Working in Partnership
Fraser, J., Usman, M., Thomas, K.C., Ahmed, M., Dolidze, A., Zuruwath Zareer, F., Begum, G., Elliott, B. and Macleod, E. 2020. "I've Seen You": A conversation about the Transformative Potential of Working in Partnership. in: Mercer-Mapstone, L. and Abbot, S. (ed.) The Power of Partnership: Students, Staff and Faculty Revolutionizing Higher Education Elon, North Carolina Elon University. pp. 205-219

Editorial: Exercise as a Countermeasure to Human Aging
Elliott, B., Hayes, L., Hughes, D. and Burtscher, M. 2020. Editorial: Exercise as a Countermeasure to Human Aging. Frontiers in Physiology. 11 883. https://doi.org/10.3389/fphys.2020.00883

Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women.
Arazi, H., Salek, L., Nikfal, E., Izadi, M., Tufano, J.J., Elliott, B. and Brughelli, M. 2020. Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women. Journal of translational medicine. 18 (239) 239. https://doi.org/10.1186/s12967-020-02411-y

Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3
Getting, S.J., McArthur, S., Wickstead, E. and Biggs, C.S. 2020. Reversal of beta-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3. Oxidative Medicine and Cellular Longevity. 2020 2139192. https://doi.org/10.1155/2020/2139192

Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes
Can, V., Locke, I.C., Kaneva, M., Kerrigan, M.J.P., Merlino, F., De Pascale, C., Grieco, P. and Getting, S.J. 2020. Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes. European Journal of Pharmacology. 872 172971. https://doi.org/10.1016/j.ejphar.2020.172971

Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners
Edwards, K., Elliott, B. and Silva, C. 2020. Carbohydrate intake and ketosis in self-sufficient multi-stage ultramarathon runners. Journal of Sports Sciences. 38 (4), pp. 366-374. https://doi.org/10.1080/02640414.2019.1702269

Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration?
De Pascale, C., Marcello, E., Getting, S.J., Roy, I. and Locke, I.C. Forthcoming. Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration? OARSI World Congress on Osteoarthritis . Toronto, Canada 02 Mar - 05 May 2019

The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease
Wickstead, E. 2019. The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease. PhD thesis University of Westminster School of Life Sciences https://doi.org/10.34737/qy292

Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men.
Bagheri, R., Rashidlamir, A., Motevalli, M., Elliott, B., Mehrabani, J. and Wong, A. 2019. Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men. European Journal of Applied Physiology. 119 (9), p. 1921–1931. https://doi.org/10.1007/s00421-019-04180-z

Short-Term Exercise Training Inconsistently Influences Basel Testosterone in Older Men: A Systematic Review and Meta-Analysis
Hayes, L. and Elliott, B. 2019. Short-Term Exercise Training Inconsistently Influences Basel Testosterone in Older Men: A Systematic Review and Meta-Analysis. Frontiers in Physiology. 9 1878. https://doi.org/10.3389/fphys.2018.01878

The Effect of Omega-3 Supplementation on Exercise-Induced Muscle Damage
Kyriakidou, Y., Wood, C., Elliott, B. and Dolci, A. 2018. The Effect of Omega-3 Supplementation on Exercise-Induced Muscle Damage. Europhysiology 2018. London 14 - 16 Sep 2018 The Physiological Society.

Activin subfamily peptides predict chronological age in humans
Barrios-Silva, L., Parnell, M., Shinwari, Z., Chaudhary, G., Xenofontos, T, van Bekhoven, A., McArthur, S. and Elliott, B. 2018. Activin subfamily peptides predict chronological age in humans. Physiological Report. 6 (17), p. e13823. https://doi.org/10.14814/phy2.13823

Extracellular vesicles and their nucleic acids for biomarker discovery
Momen Heravi, F., Getting, S.J. and Moschos, S.A. 2018. Extracellular vesicles and their nucleic acids for biomarker discovery. Pharmacology and Therapeutics. 192, pp. 170-187. https://doi.org/10.1016/j.pharmthera.2018.08.002

Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2018. Quin-C1: a selective Fpr2 agonist that shifts microglial phenotype following LPS and Aβ1-42 exposure. Alzheimer's Research UK Conference. London 20 - 21 Mar 2018

Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in Vitro
Kalampouka, I., van Bekhoven, A. and Elliott, B. 2018. Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in Vitro. Frontiers in Physiology. 9 152. https://doi.org/10.3389/fphys.2018.00152

High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals
Naufahu, J., Elliott, B., Markiv, A., Dunning-Foreman, P., McGrady, M., Howard, D., Watt, P.W. and Mackenzie, R.W.A. 2018. High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity in glucose intolerant individuals. Journal of Clinical Endocrinology and Metabolism. 103 (4), pp. 1479-1490. https://doi.org/10.1210/jc.2017-02019

An automated panel for assessing pro-oxidant and antioxidant status in human serum
Ferrier, C., Reed, S.C. and Elliott, B. 2017. An automated panel for assessing pro-oxidant and antioxidant status in human serum.

The effect of the selective human MC3 receptor agonist PG992 on high density human chondrocyte micromass cultures activated by IL-1beta.
Can, V.C., Locke, I.C., Grieco, P. and Getting, S.J. 2017. The effect of the selective human MC3 receptor agonist PG992 on high density human chondrocyte micromass cultures activated by IL-1beta. Pharmacology 2017. London, U.K. 11 - 13 Dec 2017 British Pharmacological Society.

The effect of silymarin on chondrocytes
Can, V.C., Abouelnour, A., Locke, I.C., Bligh, S.W.A. and Getting, S.J. 2017. The effect of silymarin on chondrocytes. ICMAN/ IUPHAR Natural Products. Aberdeen, Scotland 27 - 29 Sep 2017 Elsevier. https://doi.org/10.1016/j.bcp.2017.06.036

Reversal of β-amyloid induced microglial activation by an agonist of Fpr2
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Reversal of β-amyloid induced microglial activation by an agonist of Fpr2. British Pharmacological Society: Pharmacology 2017. London 11 - 13 Dec 2017

Fpr2: a novel drug target to tackle oxidative stress and inflammation in Alzheimer’s disease
Wickstead, E. 2017. Fpr2: a novel drug target to tackle oxidative stress and inflammation in Alzheimer’s disease. Alzheimer's Research UK Conference. Aberdeen 14 - 15 Mar 2017

PhytoCloud: A gamified Mobile Web Application to modulate diet and physical activity of women with breast cancer
Economou, D., Dwek, M., Elliott, B., Ramezanian Kalahroudi, M. and Azimi, T. 2017. PhytoCloud: A gamified Mobile Web Application to modulate diet and physical activity of women with breast cancer. IEEE 30th International Symposium on Computer-Based Medical Systems. Thessaloniki, Greece 22 Jun - 24 Sep 2017 IEEE . https://doi.org/10.1109/CBMS.2017.164

Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation. BNA Festival of Neuroscience. Birmingham 10 - 13 Apr 2017 Sage. https://doi.org/10.1177/2398212817705279

The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha
Getting, S.J., Can, V.C., Locke, I.C. and Grieco, P 2017. The effect of the selective MC3 agonist PG990 on high density human chondrocytes micromass cultures activated by TNF-alpha. World Congress on Inflammation. London 08 - 12 Jul 2017

Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects
Wickstead, E., Getting, S.J., Biggs, C.S. and McArthur, S. 2017. Fpr2 and neuroinflammation: selective agonists with synergistic anti-oxidative and pro-resolving effects. World Congress on Inflammation. London 08 - 12 Jul 2017

Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation
Elliott, B., Herbert, P., Sculthorpe, N., Grace, F., Stratton, D. and Hayes, L. 2017. Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. Physiological Report. 5 (13), p. e13343 e13343. https://doi.org/10.14814/phy2.13343

The formyl peptide receptor 2 (Fpr2) agonist, Compound 43 (Cpd43), attenuates and promotes the release of pro-inflammatory, and anti-inflammatory cytokines, respectively
Wickstead, E., Getting, S.J. and McArthur, S. 2016. The formyl peptide receptor 2 (Fpr2) agonist, Compound 43 (Cpd43), attenuates and promotes the release of pro-inflammatory, and anti-inflammatory cytokines, respectively. British Pharmacological Society: Pharmacology 2016. London 13 - 15 Dec 2016

Circulating myostatin is reduced with aging in humans but not altered by short-term, high intensity training
Elliott, B., Shinwari, Z.B., Altayar, Z., Barrios, L., Chaudhary, G.A., Hanifa, E., Parnell, M., Xenofontos, T., Sculthorpe, N., Herbert, P., Grace, F. and Hayes, L. 2016. Circulating myostatin is reduced with aging in humans but not altered by short-term, high intensity training. Physiology 2016. Dublin, Ireland 29 2016 - 31 Jul 2017 The Physiological Society.

The restorative role of annexin A1 at the blood–brain barrier
McArthur, S., Azevedo Loila, R, Maggioli, E, Errede, M, Virgintino, D and Solito, E 2016. The restorative role of annexin A1 at the blood–brain barrier. Fluids & Barriers of the CNS. 13, pp. 17-33. https://doi.org/10.1186/s12987-016-0043-0

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory
Virdee, K., Kentrop, J., Jupp, B., Venus, B., Hensman, D., McArthur, S., Wilkinson, J., Robbins, T.W., Gillies, G.E. and Dalley, J.W. 2016. Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory. Psychopharmacology. 233 (21), pp. 3751-3761. https://doi.org/10.1007/s00213-016-4405-8

Complete and Voluntary Starvation of 50 days
Elliott, B., Mina, A. and Ferrier, C. 2016. Complete and Voluntary Starvation of 50 days. Clinical Medical Insights: Case Reports. 2016:9, pp. 67-70. https://doi.org/10.4137/CCRep.S39776

Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy
Rossi, S., Maisto, R., Gesualdo, C., Trotta, M.C., Ferraraccio, F., Kaneva, M.K., Getting, S.J., Surace, E., Testa, F., Simonelli, F., Grieco, P., Merlino, F., Perretti, M., D'Amico, M. and Di Filippo, C. 2016. Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy. Mediators of inflammation. 2016 7368389. https://doi.org/10.1155/2016/7368389

The role of acute ambient hypoxia in the regulation of myostatin
Elliott, B. 2015. The role of acute ambient hypoxia in the regulation of myostatin. PhD thesis University of Westminster Biomedical Sciences https://doi.org/10.34737/9ww8v

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation
Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015 . Cardiff, UK. 08 Jul 2015

Wearable technology in academia: the use of Google Glass in the life sciences
Elliott, B. and Sukan, A. 2015. Wearable technology in academia: the use of Google Glass in the life sciences. Compass: Journal of Learning & Teaching . 6 (10).

The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation
Can, V.C., Locke, I.C. and Getting, S.J. 2015. The effect of melanocortin peptides on Interleukin 1-beta induced chondrocyte cell death and inflammation. Physiology 2015. Cardiff Jun 2015

Acute hypoxia reduces plasma myostatin independent of hypoxic dose
Elliott, B., Simonson, T.S., Getting, S.J., Renshaw, D., Wagner Peter, D. and MacKenzie, R. 2015. Acute hypoxia reduces plasma myostatin independent of hypoxic dose. 8th International Conference on Cachexia, Sarcopenia and Muscle Wasting. Paris 04 - 06 Dec 2015 The Society on Sarcopenia, Cachexia and Wasting Disorders.

Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking
Maggioli, E., McArthur, S., Mauro, C., Kieswich, J., Kusters, D.H.M., Reutelingsperger, C.P.M., Yaqoob, M.M. and Solito, E. 2015. Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Brain Behavior & Immunity. 51, p. 212–222. https://doi.org/10.1016/j.bbi.2015.08.020

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.
Holloway, P.M., Durrenberger, P.F., Trutschl, M., Cvek, U., Cooper, D., Orr, A.W., Perretti, M., Getting, S.J. and Gavins, F.N. 2015. Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. Arteriosclerosis, Thrombosis and Vascular biology . 35 (9), pp. 1936-44. https://doi.org/10.1161/ATVBAHA.115.305348

Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation.
McArthur, S., Gobbetti, T., Kusters, D.H.M., Reutelingsperger, C.P.M., Flower, R.J. and Perretti, M. 2015. Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. Journal of Immunology. 195 (3), pp. 1139-1151. https://doi.org/10.4049/jimmunol.1500733

Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment
McArthur, S., Pienaar, I.S., Siddiqi, S.M., Gillies, G.E. and Mazhar-Siddiqi, S. 2015. Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment. Brain Stucture & Function. https://doi.org/10.1007/s00429-015-1049-0

Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone
Shende Vishvesh, McArthur, S. and Opacka-Juffry Jolanta 2015. Astroglial Plasticity Is Implicated in Hippocampal Remodelling in Adult Rats Exposed to Antenatal Dexamethasone. Neural Plasticity. 2015, p. Article ID 694347 694347. https://doi.org/10.1155/2015/694347

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
MacKenzie, R. and Elliott, B. 2014. Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 7, pp. 55-67. https://doi.org/10.2147/DMSO.S48260

What range of methods is available to evaluate the implementation and impact of complex environmental policies on complex systems?
Fagan-Watson, B., Watson, T., Elliott, B., Vanner, R., Shaw, Ben and Morris, S. 2014. What range of methods is available to evaluate the implementation and impact of complex environmental policies on complex systems? A report to the Department for Environment, Food and Rural Affairs. Policy Studies Institute. Defra, London.

The melanocortin receptor antagonist SHU9119 inhibits the anti-inflammatory/pro-resolving properties of a-MSH and D[TRP8]-y-MSH in lipopolysaccharide stimulated chondrocytes
Can, V.C., Locke, I.C. and Getting, S.J. 2014. The melanocortin receptor antagonist SHU9119 inhibits the anti-inflammatory/pro-resolving properties of a-MSH and D[TRP8]-y-MSH in lipopolysaccharide stimulated chondrocytes. Pharmacology 2014. Queen Elizabeth Centre II, London, UK 16 Dec 2014 British Pharmacological Society.

Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo
Elliott, B., Renshaw, D., Getting, S.J., Watt, P.W. and MacKenzie, R. 2014. Acute hypoxia alters myotube size in vitro and myostatin signalling in vivo. FASEB. San Diego Jul 2015 Federation of American Societies for Experimental Biology.

The role of acute hypoxia in skeletal muscle atrophy
Elliott, B., Renshaw, D., Getting, S.J., Watt, P., Howard, D. and MacKenzie, R. 2014. The role of acute hypoxia in skeletal muscle atrophy. Physiology. London 30 Jun 2014 The Physiological Society.

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury
Kaneva, M., Kerrigan, M.J.P., Grieco, P., Curley, G.P., Locke, I.C. and Getting, S.J. 2014. Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Biochemical Pharmacology. 92 (2), pp. 336-347. https://doi.org/10.1016/j.bcp.2014.08.019

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis
Gobbetti, T., Coldewey, S.M., Chen, J., McArthur, S., le Faouder, P., Cenac, N., Flower, R.J., Thiemermann, C. and Perretti, M. 2014. Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of the National Academy of Sciences. 111 (52), pp. 18685-90. https://doi.org/10.1073/pnas.1410938111

Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis
Thompson, D., McArthur, S., Hislop, J.N., Flower, R.J., Perretti, M. and James N. Hislop 2014. Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis. Journal of Biological Chemistry. 289 (52), pp. 36166-78. https://doi.org/10.1074/jbc.M114.612630

Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience
Virdee, K., McArthur, S., Brischoux, F., Caprioli, D., Ungless, M.A., Robbins, T.W., Dalley, J.W. and Gillies, G.E. 2014. Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39 (2), pp. 339-350. https://doi.org/10.1038/npp.2013.196

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
Locatelli, I., Sutti, S., Jindal, A., Vacchiano, M., Bozzola, C., Reutelingsperger, C.P.M., Kusters, D.H.M., Bena, S., Parola, M., Paternostro, C., Bugianesi, E., McArthur, S., Albano, E. and Perretti, M. 2014. Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. Hepatology. 60 (2), pp. 531-544. https://doi.org/10.1002/hep.27141

The melanocortin system in the male reproductive axis
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. The melanocortin system in the male reproductive axis. Endocrine Abstracts. 34, p. P338. https://doi.org/10.1530/endoabs.34.P338

Melanocortin receptor expression in the hypothalamo-pituitary-gonadal system of WT and MC3 null mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. Melanocortin receptor expression in the hypothalamo-pituitary-gonadal system of WT and MC3 null mice. International Congress of Neuroendocrinology 2014. Sydney 17-20 August 2014

Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2014. Melanocortin 3 receptors (MC3) exert anti-inflammatory effects in mouse testicular inflammation by reducing nitric oxide (NO) release from Leydig cells. Society for Reproduction and Fertility Conference. EICC2, Edinburgh 1-2 September 2014

Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: a molecular, cellular and behavioral analysis
Gillies, G.E., Virdee, K., McArthur, S. and Dalley, J.W. 2014. Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: a molecular, cellular and behavioral analysis. Neuroscience. 282C, pp. 69-85. https://doi.org/10.1016/j.neuroscience.2014.05.033

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses
Cooray, S.N., Gobbetti, T., Montero-Melendez, T., McArthur, S., Thompson, D., Clark, A.J.L., Flower, R.J. and Perretti, M. 2013. Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proceedings of the National Academy of Sciences of the United States of America. 110 (45), pp. 18232-18237. https://doi.org/10.1073/pnas.1308253110

Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
Katsouri, L., Vizcaychipi, M.P., McArthur, S., Harrison, I., Suárez-Calvet, M., Lleo, A., Lloyd, D.G., Ma, D. and Sastre, M. 2013. Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. Neurobiology of Aging. 34 (4), pp. 1105-15. https://doi.org/10.1016/j.neurobiolaging.2012.09.010

Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity
Nadkarni, S. and McArthur, S. 2013. Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity. Current Opinion in Pharmacology. 13 (4), pp. 576-581. https://doi.org/10.1016/j.coph.2013.05.007

Melanocortin 3 receptor (MC3) activation effects on testicular testosterone and nitrite production in vitro
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2013. Melanocortin 3 receptor (MC3) activation effects on testicular testosterone and nitrite production in vitro. Society for Reproduction and Fertility (SRF) Annual Conference. Cambridge 11th July 2013

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications
Cristante, E., McArthur, S., Mauro, C., Maggioli, E., Romero, I.A., Wylezinska-Arridge, M., Couraud, P.O., Lopez-Tremoleda, J., Christian, H.C., Weksler, B.B., Malaspina, A. and Solito, E. 2013. Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proceedings of the National Academy of Sciences of the United States of America. 110 (3), pp. 832-841. https://doi.org/10.1073/pnas.1209362110

Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23
Cash, J.L., Bena, S., Headland, S.E., McArthur, S., Brancaleone, V. and Perretti, M. 2013. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. EMBO reports. 14 (11), pp. 999-1007. https://doi.org/10.1038/embor.2013.138

Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion
Ashioti, M., Getting, S.J., Locke, I.C. and Milton, N.G.N. 2013. Neuroprotective efficacy of the endogenous neuropeptide Urocortin in a oxygen-glucose deprivation model of transient cerebral ischaemia with reperfusion. British Neuroscience Association 22nd Biennial Meeting. London 7th-10th April 2013

Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis?
Intekhab Alam, N.Y., White, O.B., Getting, S.J., Petsa, A., Knight, R.A., Townsend, P.A., Lawrence, K.M. and Locke, I.C. 2013. Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis? Cell Death and Disease. 4, p. e717. https://doi.org/10.1038/cddis.2013.231

The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential
Qusous, A., Kaneva, M., Can, V.C., Getting, S.J. and Kerrigan, M.J.P. 2012. The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential. Cells Tissues Organs. 196 (3), pp. 251-261. https://doi.org/10.1159/000332144

Novel methods for the quantification of changes in actin organization in chondrocytes using fluorescent imaging and linear profiling
Qusous, A., Parker, E., Geewan, C., Kapasi, A., Getting, S.J., Hucklebridge, F., Keshavarz, T. and Kerrigan, M.J.P. 2012. Novel methods for the quantification of changes in actin organization in chondrocytes using fluorescent imaging and linear profiling. Microscopy Research and Technique. 75 (7), pp. 991-999. https://doi.org/10.1002/jemt.22055

Expression of melanocortin 3 receptors (MC3) in the reproductive axes of both male and female mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Le Tissier, P. and Murray, J.F. 2012. Expression of melanocortin 3 receptors (MC3) in the reproductive axes of both male and female mice. Society for Reproduction and Fertility. Edinburgh 9th - 11th July 2012

The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes
MacKenzie, R., Elliott, B., Maxwell, N.S., Brickley, G. and Watt, P.W. 2012. The effect of hypoxia and work intensity on insulin resistance in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (1), pp. 155-62. https://doi.org/10.1210/jc.2011-1843

Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes
MacKenzie, R., Maxwell, N.S., Castle, P.C., Elliott, B., Brickley, G. and Watt, P.W. 2012. Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism. 97 (4), pp. 46-55. https://doi.org/10.1210/jc.2011-2829

The central role of myostatin in skeletal muscle and whole body homeostasis
Elliott, B., Renshaw, D., Getting, S.J. and MacKenzie, R. 2012. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica. 205 (3), pp. 324-40. https://doi.org/10.1111/j.1748-1716.2012.02423.x

Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system
Gavins, F.N.E., Hughes, E.L., Buss, N.A.P.S., Holloway, P.M., Getting, S.J. and Buckingham, J.C. 2012. Leukocyte recruitment in the brain in sepsis: involvement of the annexin 1-FPR2/ALX anti-inflammatory system. FASEB Journal. 26 (12), pp. 4977-4989. https://doi.org/10.1096/fj.12-205971

The central role of myostatin in skeletal muscle and whole body homeostasis
Elliott, B.T., Renshaw, D., Getting, S.J. and Mackenzie, R.W.A. 2012. The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica. 205 (3), pp. 324-340. https://doi.org/10.1111/j.1748-1716.2012.02423.x

Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils
Dalli, J., Montero-Melendez, T., McArthur, S. and Perretti, M. 2012. Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Frontiers in Pharmacology. 3 28. https://doi.org/10.3389/fphar.2012.00028

The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes
Can, V.C., Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2012. The anti-inflammatory effects of melanocortin peptides in lipopolysaccharide activated chondrocytes. British Phamacological Society Winter Meeting 2012. London, UK 18th-20th December

Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes
Kaneva, M., Kerrigan, M.J.P., Grieco, P., Curley, G.P., Locke, I.C. and Getting, S.J. 2012. Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes. British Journal of Pharmacology. 167 (1), pp. 67-79. https://doi.org/10.1111/j.1476-5381.2012.01968.x

The Melanocortin receptor system as an anti-inflammatory therapeutic target for stroke
Holloway, P.M., Getting, S.J. and Gavins, F.N.E. 2011. The Melanocortin receptor system as an anti-inflammatory therapeutic target for stroke. pA2 online, E-journal of the British Pharmacological Society.

Investigating the role of melanocortin receptor subtypes in mediating anti-inflammatory protection following cerebral ischemia reperfusion injury
Holloway, P.M., Getting, S.J. and Gavins, F.N.E. 2011. Investigating the role of melanocortin receptor subtypes in mediating anti-inflammatory protection following cerebral ischemia reperfusion injury. pA2 online, E-journal of the British Pharmacological Society.

Targeting the melanocortin receptor system for anti-stroke therapy
Holloway, P.M., Smith, H.K., Renshaw, D., Flower, R.J., Getting, S.J. and Gavins, F.N.E. 2011. Targeting the melanocortin receptor system for anti-stroke therapy. Trends in Pharmacological Sciences. 32 (2), pp. 90-98. https://doi.org/10.1016/j.tips.2010.11.010

REV5901 induces calcium dependant chondroprotective effects post in vitro mechanical loading
Parker, E., Qusous, A., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2011. REV5901 induces calcium dependant chondroprotective effects post in vitro mechanical loading. ORS Annual Meeting vol. 36. Long Beach, California

Novel ontogenetic patterns of sexual differentiation in arcuate nucleus GHRH neurons revealed in GHRH-enhanced green fluorescent protein transgenic mice
McArthur, S., Robinson, I.C. and Gillies, G.E. 2011. Novel ontogenetic patterns of sexual differentiation in arcuate nucleus GHRH neurons revealed in GHRH-enhanced green fluorescent protein transgenic mice. Endocrinology. 152 (2), pp. 607-617. https://doi.org/10.1210/en.2010-0798

Peripheral vs. central sex steroid hormones in experimental Parkinson's disease
McArthur, S. and Gillies, G.E. 2011. Peripheral vs. central sex steroid hormones in experimental Parkinson's disease. Frontiers in Endocrinology. 2 82. https://doi.org/10.3389/fendo.2011.00082

α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2011. α-MSH and [DTRP]8-γ-MSH inhibit pro-inflammatory cytokine release from stimulated primary bovine chondrocytes. 10th World Congress on Inflammation. Paris, France 25–29 June 2011

MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2011. MC1 and MC3 activation inhibits caspase-3 production and activity, promotes cell-viability, and induces IL-10 and HO-1 release from human C20/A4 chondrocytes. Physiological Society Meeting 23. University of Oxford

Total pituitary hormone content in wild type and MC3 null male and female mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Perretti, M., Le Tissier, P. and Murray, J.F. 2011. Total pituitary hormone content in wild type and MC3 null male and female mice. British Society for Neuroendocrinology. Cambridge 3rd - 5th July 2011

Comparison between the total pituitary hormone content in wild type and melanocortin 3 receptor (MC3) null male and female mice
Dowejko, M.M., Smith, C.L., Getting, S.J., Perretti, M., Le Tissier, P. and Murray, J.F. 2011. Comparison between the total pituitary hormone content in wild type and melanocortin 3 receptor (MC3) null male and female mice. Society for Reproduction and Fertility. Brighton 11th - 13th July 2011

Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via Annexin-A1 mobilization
Yazid, S., Leoni, G., Getting, S.J., Cooper, D., Solito, E., Perretti, M. and Flower, R.J. 2010. Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via Annexin-A1 mobilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (9), pp. 1718-1724. https://doi.org/10.1161/ATVBAHA.110.209536

Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines
Gillies, G.E. and McArthur, S. 2010. Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacological reviews. 62 (2), pp. 155-198. https://doi.org/10.1124/pr.109.002071

The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature
Leoni, G., Voisin, M.B., Carlson, K., Getting, S.J., Nourshargh, S. and Perretti, M. 2010. The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. British Journal of Pharmacology. 160 (1), pp. 171-180. https://doi.org/10.1111/j.1476-5381.2010.00688.x

Saliva: physiology and diagnostic potential in health and disease
Farnaud, S., Kosti, O., Getting, S.J. and Renshaw, D. 2010. Saliva: physiology and diagnostic potential in health and disease. ScientificWorldJournal. 10, pp. 434-456. https://doi.org/10.1100/tsw.2010.38

Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production. Society for Endocrinology BES 2010. Manchester 15th - 18th March 2010

Anti-allergic drugs and the Annexin-A1 system
Yazid, S., Ayoub, S.S., Solito, E., McArthur, S., Vo, P., Dufton, N. and Flower, R.J. 2010. Anti-allergic drugs and the Annexin-A1 system. Pharmacological reports. 62 (3), pp. 511-517. https://doi.org/10.1016/S1734-1140(10)70307-8

A13/BACII, a novel bovine chondrocytic cell line with differentiation potential
Qusous, A., Kaneva, M., Getting, S.J. and Kerrigan, M.J.P. 2010. A13/BACII, a novel bovine chondrocytic cell line with differentiation potential. Combined Meeting of Orthopaedic Research Societies. Kyoto, Japan

Cartilage and macrophages: evidence for a paracrine loop. Poster no. 278
Parker, E., Qusous, A., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Cartilage and macrophages: evidence for a paracrine loop. Poster no. 278. Combined Meeting of Orthopaedic Research Societies. Kyoto, Japan

Tamoxifen: chondroprotective effects post-mechanical trauma
Parker, E., Peetroons, C., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Tamoxifen: chondroprotective effects post-mechanical trauma. Physiological Society Meeting 21. University of Durham

REV5901: chondroprotective effects post mechanical trauma
Parker, E., Noureen, S., Getting, S.J., Vleck, V.E., Hucklebridge, F. and Kerrigan, M.J.P. 2010. REV5901: chondroprotective effects post mechanical trauma. Physiological Society Meeting 19. University of Manchester

The effects of REV5901 on chondrocyte viability following mechanical trauma
Parker, E., Getting, S.J., Hucklebridge, F., Vleck, V.E. and Kerrigan, M.J.P. 2010. The effects of REV5901 on chondrocyte viability following mechanical trauma. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley.

Diurnal inflammatory cytokine changes post-exercise. Poster no. 319
Parker, E., Getting, S.J., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Diurnal inflammatory cytokine changes post-exercise. Poster no. 319. Combined Meeting of Orthopaedic Research Societies. Kyoto, Japan

Knee forces and inflammation: the effects of foot strike patterns and footwear
Parker, E., Domah, S., Getting, S.J., Vleck, V.E., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Knee forces and inflammation: the effects of foot strike patterns and footwear. Physiological Society Meeting 19. University of Manchester

Chondroitin and glucosamine supplementation results in increased chondrocyte viability post mechanical trauma in vitro
Parker, E., Begum, N., Wunderlich, C., Ravichandran, N., Getting, S.J., Vleck, V.E., Hucklebridge, F. and Kerrigan, M.J.P. 2010. Chondroitin and glucosamine supplementation results in increased chondrocyte viability post mechanical trauma in vitro. Physiological Society Meeting 19. University of Manchester

REV5901: the protective effect on bovine articular chondrocytes following single impact trauma
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2010. REV5901: the protective effect on bovine articular chondrocytes following single impact trauma. Physiological Society Meeting 19. University of Manchester

REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2010. REV5901: an investigation on the chondroprotective effect in bovine chondrocytes following single impact trauma. Physiological Society Meeting 21. University of Durham

Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia
McArthur, S., Cristante, E., Paterno, M., Christian, H.C., Roncaroli, F., Gillies, G.E. and Solito, E. 2010. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. Journal of Immunology. 185 (10), pp. 6317-6328. https://doi.org/10.4049/jimmunol.1001095

α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes
Kaneva, M., Locke, I.C., Kerrigan, M.J.P. and Getting, S.J. 2010. α-MSH and dTRP8-γ-MSH inhibit TNF-α induced MMP 1 and 13 expression in human C20/A4 chondrocytes. British Pharmacological Society Winter Meeting 2010. London, UK 14th-16th December 2010

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. British Orthopaedic Research Society Annual Meeting. Newcastle upon Tyne 22 - 23 Jun 2009 Wiley. pp. PO136

The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2010. The MC3 agonist dTRP8-γ-MSH inhibits IL-6 and IL-8 release from TNF-α stimulated C-20/A4 chondrocytes, an effect blocked by the MC3R antagonist SHU9119. Physiology 2010. University of Manchester 30 June - 2 July 2010

Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3)
Akindele, K., Horanin, M.M., Getting, S.J., Smith, C.L. and Murray, J.F. 2010. Testicular LH-stimulated testosterone production is inhibited by activation of melanocortin 3 receptors (MC3). Society for Reproduction and Fertility. Sutton Bonnington 11th - 13th July 2010

Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: a contribution to sex-specific neuroprotection by estrogens
Gillies, G.E. and McArthur, S. 2010. Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: a contribution to sex-specific neuroprotection by estrogens. Hormones and behavior. 57 (1), pp. 23-34. https://doi.org/10.1016/j.yhbeh.2009.06.002

Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis
Patel, H.B., Bombardieri, M., Sampaio, A.L.F., D'Acquisto, F., Gray, M., Grieco, P., Getting, S.J., Pitzalis, C. and Perretti, M. 2010. Anti-inflammatory and antiosteoclastogenesis propertiesof endogenous melanocortin receptor type 3 inexperimental arthritis. FASEB Journal. 24 (12), pp. 4835-4843. https://doi.org/10.1096/fj.10-167759

Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1
Yazid, S., Solito, E., Christian, H.C., McArthur, S., Goulding, N. and Flower, R.J. 2009. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochemical Pharmacology. 77 (12), pp. 1814-1826. https://doi.org/10.1016/j.bcp.2009.03.010

Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Pro-inflammatory mediator release from TNF-α stimulated C-20/A4 cells results in Col II degradation. British Orthopaedic Research Society (BORS) Annual Meeting. Newcastle 22nd - 23rd June 2009

The effects of REV5901 on chondrocyte viability following mechanical trauma
Parker, E., Getting, S.J., Hucklebridge, F., Vleck, V.E. and Kerrigan, M.J.P. 2009. The effects of REV5901 on chondrocyte viability following mechanical trauma. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4), p. P0149. https://doi.org/http://www.pa2online.org/abstracts/Vol7Issue4abst127P.pdf

Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization
McArthur, S., Yazid, S., Christian, H.C., Sirha, R., Flower, R.J., Buckingham, J.C. and Solito, E. 2009. Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23 (11), pp. 4000-4010. https://doi.org/10.1096/fj.09-131391

Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells
Kaneva, M., Kerrigan, M.J.P., Locke, I.C. and Getting, S.J. 2009. Melanocortin peptides modulate pro-inflammatory mediator release from TNF-a stimulated C-20/A4 cells. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society.

Molecular characterization of the melanocortin 3 receptor in the testes of mice
Horanin, M.M., Akindele, K., Getting, S.J., Smith, C.L. and Murray, J.F. 2009. Molecular characterization of the melanocortin 3 receptor in the testes of mice. pA2 Online. From the Queen Elizabeth II Conference Centre London, Winter 2009 Meeting: Proceedings of the British Pharmacological Society. 7 (4). https://doi.org/http://www.pa2online.org/abstracts/Vol7Issue4abst089P.pdf

Melanocortin peptide therapy for the treatment of arthritic pathologies
Getting, S.J., Kaneva, M., Bhadresa, Y., Renshaw, D., Leoni, G., Patel, H.B., Kerrigan, M.J.P. and Locke, I.C. 2009. Melanocortin peptide therapy for the treatment of arthritic pathologies. The Scientific World Journal. 9, pp. 1394-1414. https://doi.org/10.1100/tsw.2009.163

Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Murray, J.F., Grieco, P., Getting, S.J. and Perretti, M. 2008. Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion. FASEB Journal. 22 (12), pp. 4228-4238. https://doi.org/10.1096/fj.08-113886

A role for MC3R in modulating lung inflammation
Getting, S.J., Riffo-Vasquez, Y., Pitchford, S., Kaneva, M., Grieco, P., Page, C.P., Perretti, M. and Spina, D. 2008. A role for MC3R in modulating lung inflammation. Pulmonary Pharmacology and Therapeutics. 21 (6), pp. 866-873. https://doi.org/10.1016/j.pupt.2008.09.004

Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats
Legerlotz, K., Elliott, B., Guillemin, B. and Smith, H. 2008. Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats. Experimental Physiology. 93 (6), pp. 754-62. https://doi.org/10.1113/expphysiol.2007.041244

Melanocortin 3 receptor in the testes of mice
Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. Society for Reproduction and Fertility. Edinburgh 29 Jun - 01 Jul 2008 pp. Abstract P80

Melanocortin 3 receptor in the testes of mice
Wotherspoon, G., Yogarajah, S., Lynch, S., Smith, C.L., Getting, S.J., Perretti, M. and Murray, J.F. 2008. Melanocortin 3 receptor in the testes of mice. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. P008.

Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro
Stenbeck, G., Joseph, J., Getting, S.J. and Smith, C.L. 2008. Asymmetric dimethylarginine negatively influences osteoblast differentiation in vitro. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C041.

Annexin A1 in the brain: undiscovered roles?
Solito, E., McArthur, S., Christian, H.C., Gavins, F.N.E., Buckingham, J.C. and Gillies, G.E. 2008. Annexin A1 in the brain: undiscovered roles? Trends in Pharmacological Sciences. 29 (3), pp. 135-42. https://doi.org/10.1016/j.tips.2007.12.003

The role of the actin cytoskeleton in chondrocyte protection following single impact
Nedelcheva, Y., Getting, S.J. and Kerrigan, M.J.P. 2008. The role of the actin cytoskeleton in chondrocyte protection following single impact. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4). https://doi.org/http://www.pa2online.org/abstracts/Vol6Issue4abst148P.pdf

Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Tonic inhibitory control of the mesenteric microcirculation by the melanocortin type 3 receptor. Journal of Vascular Research. 45 (Suppl2).

Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation
Leoni, G., Patel, H.B., Sampaio, A.L.F., Gavins, F.N.E., Getting, S.J. and Perretti, M. 2008. Inhibitory role of endogenous melanocortin type 3 receptor in the inflamed microcirculation. William Harvey Day. St. Barts Hospital, London 14th October 2008

A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells
Getting, S.J., Kaneva, M. and Kerrigan, M.J.P. 2008. A role for melanocortin peptides in modulating oxidative stress induced inflammation in A549 cells. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4), p. C020.

Melanocortins
Getting, S.J. 2008. Melanocortins. in: Offermanns, S. and Rosenthal, W. (ed.) Encyclopedia of molecular pharmacology. 2nd edition Berlin Springer. pp. 752-757

The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling
Ali, N., Getting, S.J. and Kerrigan, M.J.P. 2008. The effect of prolonged hypotonicity on chondrocyte volume regulation and intracellular calcium signalling. pA2 Online. From the University of Brighton, Winter 2008 Meeting: Proceedings of the British Pharmacological Society. 6 (4). https://doi.org/http://www.pa2online.org/abstracts/Vol6Issue4abst092P.pdf

Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease
Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S. and Whitton, P.S. 2008. Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease. Journal of Neuroinflammation. 5 19. https://doi.org/10.1186/1742-2094-5-19

Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition
McArthur, S., Murray, H.E., Dhankot, A., Dexter, D.T. and Gillies, G.E. 2007. Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition. Journal of Neurochemistry. 100 (3), pp. 678-692. https://doi.org/10.1111/j.1471-4159.2006.04226.x

Endogenous MC3R and inhibition of inflammatory arthritis. PC112
Patel, H.B., Sampaio, A.L.F., Getting, S.J., Gray, M. and Perretti, M. 2007. Endogenous MC3R and inhibition of inflammatory arthritis. PC112. Life Sciences. Glasgow 8th - 12th July 2007

The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner
McArthur, S., McHale, E. and Gillies, G.E. 2007. The size and distribution of midbrain dopaminergic populations are permanently altered by perinatal glucocorticoid exposure in a sex- region- and time-specific manner. Neuropsychopharmacology. 32 (7), pp. 1462-1476. https://doi.org/10.1038/sj.npp.1301277

Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106
Leoni, G., Getting, S.J., Gavins, F.N.E. and Perretti, M. 2007. Crucial role for endogenous melanocortin type 3 receptor in mesenteric post-reperfusion injury. PC106. Life Sciences. Glasgow 8th - 12th July 2007

Glucocorticoid and melanocortins: special issue
Getting, S.J. 2007. Glucocorticoid and melanocortins: special issue. ScientificWorldJournal. 7, pp. 1463-1464. https://doi.org/10.1100/tsw.2007.93

The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease
Abuirmeileh, A., Lever, R., Kingsbury, A.E., Lees, A.J., Locke, I.C., Knight, R.A., Chowdrey, H.S., Biggs, C.S. and Whitton, P.S. 2007. The corticotrophin-releasing factor-like peptide urocortin reverses key deficits in two rodent models of Parkinson's disease. European Journal of Neuroscience. 26 (2), pp. 417-423. https://doi.org/10.1111/j.1460-9568.2007.05653.x

Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
Abuirmeileh, A., Harkavyi, A., Lever, R., Biggs, C.S. and Whitton, P.S. 2007. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. Journal of Neuroinflammation. 4 19. https://doi.org/10.1186/1742-2094-4-19

[D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse)
Getting, S.J., Lam, C.W., Leoni, G., Gavins, F.N.E., Grieco, P. and Perretti, M. 2006. [D -Trp8]-γ -melanocyte -stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1 R(Recessive Yellow e/e Mouse). Molecular Pharmacology. 70 (6), pp. 1850-1855. https://doi.org/10.1124/mol.106.028878

Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart
Gavins, F.N.E., Leoni, G. and Getting, S.J. 2006. Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart. ScientificWorldJournal. 6, pp. 1008-1023. https://doi.org/10.1100/tsw.2006.196

Targeting melanocortin receptors as potential novel therapeutics
Getting, S.J. 2006. Targeting melanocortin receptors as potential novel therapeutics. Pharmacology & Therapeutics. 111 (1), pp. 1-15. https://doi.org/10.1016/j.pharmthera.2005.06.022

Melanocortin receptor signaling in RAW264.7 macrophage cell line
Lam, C.W., Perretti, M. and Getting, S.J. 2006. Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides. 27 (2), pp. 404-412. https://doi.org/10.1016/j.peptides.2005.01.031

The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage
Getting, S.J., Di Filippo, C., D'Amico, M. and Perretti, M. 2006. The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. European Journal of Pharmacology. 532 (1-2), pp. 138-144. https://doi.org/10.1016/j.ejphar.2005.12.023

Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats
McArthur, S., Siddique, Z.L., Christian, H.C., Capone, G., Theogaraj, E., John, C.D., Smith, S.F., Morris, J.F., Buckingham, J.C. and Gillies, G.E. 2006. Perinatal glucocorticoid treatment disrupts the hypothalamo-lactotroph axis in adult female, but not male, rats. Endocrinology. 147 (4), pp. 1904-1915. https://doi.org/10.1210/en.2005-1496

Mode of glucocorticoid actions in airway disease
Ito, K., Getting, S.J. and Charron, C.E. 2006. Mode of glucocorticoid actions in airway disease. ScientificWorldJournal. 28 (6), pp. 1750-1769. https://doi.org/10.1100/tsw.2006.274

Melanocortin 3 receptors control crystal-induced inflammation
Getting, S.J., Lam, C.W., Chen, A.S., Grieco, P. and Perretti, M. 2006. Melanocortin 3 receptors control crystal-induced inflammation. FASEB Journal. 20 (13), pp. 2234-2241.

Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure
McArthur, S., McHale, E., Dalley, J.W., Buckingham, J.C. and Gillies, G.E. 2005. Altered mesencephalic dopaminergic populations in adulthood as a consequence of brief perinatal glucocorticoid exposure. Journal of Neuroendocrinology. 17 (8), pp. 475-482. https://doi.org/10.1111/j.1365-2826.2005.01331.x

In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation
Lam, C.W., Getting, S.J. and Perretti, M. 2005. In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation. Journal of Immunology. 174 (4), pp. 2297-2304.

Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat
Biggs, C.S., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Evidence for a neuroprotective role of the CRH-like peptide, urocortin, in the 6-hydroxydopamine treated rat. 18th National Meeting of the British Neuroscience Association. Brighton, UK 03-06 Apr 2005

Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model
Biggs, C.S., Abuirmeileh, A., Locke, I.C., Knight, R.A., Chowdrey, H.S. and Whitton, P.S. 2005. Urocortin attenuates key indicators of nigrostriatal pathway destruction in a rat hemiparkinsonian model. Proceedings of the British Pharmacological Society. 3 (4).

MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct
Getting, S.J., Di Filippo, C., Christian, H.C., Lam, C.W., Rossi, F., D'Amico, M. and Perretti, M. 2004. MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. Journal of Leukocyte Biology. 76 (4), pp. 845-853. https://doi.org/10.1189/jlb.0306175

Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo
Cao, T.V., La, M., Getting, S.J. and Day, A.J. 2004. Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation. 11 (7), pp. 615-624. https://doi.org/10.1080/10739680490503438

Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease
Gillies, G.E., Murray, H.E., Dexter, D.T. and McArthur, S. 2004. Sex dimorphisms in the neuroprotective effects of estrogen in an animal model of Parkinson's disease. Pharmacology, biochemistry, and behavior. 78 (3), pp. 513-522. https://doi.org/10.1016/j.pbb.2004.04.022

Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis
Getting, S.J., Di Filippo, C., Lam, C.W., Rossi, F. and D'Amico, M. 2004. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. Journal of Pharmacology and Experimental Therapeutics. 310 (1), pp. 90-97. https://doi.org/10.1124/jpet.104.065573

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis
Yang, Y.H., Morand, E.F., Getting, S.J. and Paul-Clark, M. 2004. Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis & Rheumatism. 50 (3), pp. 976-984. https://doi.org/10.1002/art.20201

The annexin 1-/- mouse: phenotypic studies
Wells, D., Wells, K., Liu, K., Hannon, R., Croxtall, J.D., Damazo, A.S., Oliani, S.M., Getting, S.J., Parente, L., Paul-Clark, M., Yona, S., Gavins, F.N.E., Martin, J., Christian, H.C., Cover, P.O., John, C.D., Solito, E., Morris, J.F., Perretti, M., Buckingham, J.C. and Flower, R.J. 2004. The annexin 1-/- mouse: phenotypic studies. Annexins. 1 (2), pp. 109-120.

Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages
Lam, C.W., Getting, S.J. and Perretti, M. 2004. Activation of melanocortin receptors induces cAMP-dependent hemeoxygenase-1 expression in murine macrophages. pA2 Online. Winter 2004 Meeting: Proceedings of the British Pharmacological Society.

Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy
Lam, C.W. and Getting, S.J. 2004. Melanocortin receptor type 3 as a potential target for anti-inflammatory therapy. Current Drug Targets. Inflammation & Allergy. 3 (3), pp. 311-315.

Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides
Getting, S.J., Schiöth, H.B. and Perretti, M. 2003. Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. Journal of Pharmacology and Experimental Therapeutics. 306 (2), pp. 631-637. https://doi.org/10.1124/jpet.103.051623

Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor
Getting, S.J., Christian, H.C., Lam, C.W., Gavins, F.N.E., Flower, R.J., Schiöth, H.B. and Perretti, M. 2003. Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. Journal of Immunology. 170 (6), pp. 3323-3330.

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
Hannon, R., Croxtall, J.D., Getting, S.J., Roviezzo, F., Yona, S., Paul-Clark, M., Gavins, F.N.E., Perretti, M., Morris, J.F., Buckingham, J.C. and Flower, R.J. 2003. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB Journal. 17 (2), pp. 253-255. https://doi.org/10.1096/fj.02-0239fje

Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females
Murray, H.E., Pillai, A.V., McArthur, S., Razvi, N., Datla, K.P., Dexter, D.T. and Gillies, G.E. 2003. Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females. Neuroscience. 116 (1), pp. 213-222. https://doi.org/10.1016/S0306-4522(02)00578-X

Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo. Methods in Molecular Biology. 225, pp. 139-146. https://doi.org/10.1385/1-59259-374-7:139

Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo
Perretti, M. and Getting, S.J. 2003. Migration of specific leukocyte sub-sets in response to cytokine or chemokine application in vivo. in: Winyard, P.G. and Willoughby, D.A. (ed.) Inflammation Protocols Totowa, NJ Humana Press. pp. 139-146

The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner
Getting, S.J., Mahoney, D.J., Cao, T.V., Rugg, M.S., Fries, E., Milner, C.M., Perretti, M. and Day, A.J. 2002. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. Journal of Biological Chemistry. 277 (52), pp. 51068-51076. https://doi.org/10.1074/jbc.M205121200

The annexin-1 knockout mouse: what it tells us about the inflammatory response
Roviezzo, F., Getting, S.J., Paul-Clark, M., Yona, S., Gavins, F.N.E., Perretti, M., Hannon, R., Croxtall, J.D., Buckingham, J.C. and Flower, R.J. 2002. The annexin-1 knockout mouse: what it tells us about the inflammatory response. Journal of Physiology and Pharmacology. 53 (4, part 1), pp. 541 -553.

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Perretti, M., Chiang, N., La, M., Fierro, I.M., Marullo, S., Getting, S.J., Solito, E. and Serhan, C.N. 2002. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nature Medicine. 8 (11), pp. 1296-1302. https://doi.org/10.1038/nm786

Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis
Getting, S.J., Christian, H.C., Flower, R.J. and Perretti, M. 2002. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis & Rheumatism. 46 (10), pp. 2765-2775. https://doi.org/10.1002/art.10526

Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy
Getting, S.J. 2002. Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends in Pharmacological Sciences. 23 (10), pp. 447-449. https://doi.org/10.1016/S0165-6147(02)02103-X

A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones
Malcangio, M., Getting, S.J., Grist, J., Cunningham, J.R., Bradbury, E.J., Issa, P.C., Lever, I.J., Pezet, S. and Perretti, M. 2002. A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. FASEB Journal. 16 (7), pp. 730-732. https://doi.org/10.1096/fj.01-0971fje.

Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma
Carollo, M., Getting, S.J., Delaney, S., Christie, M.I. and Perretti, M. 2002. Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma. Inflammation Research. 51 (2), pp. 110-111. https://doi.org/10.1007/BF02684013

Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics
Perretti, M., Getting, S.J., Solito, E., Murphy, P.M. and Gao, J.L. 2001. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. American Journal of Pathology. 158 (6), pp. 1969-1973.

Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
Mabley, J.G., Jagtap, P., Perretti, M., Getting, S.J., Salzman, A.L., Virag, L., Szabo, E., Soriano, F.G., Liaudet, L., Hasko, G., Marton, A., Southan, G.J., Abdelkarim, G.E. and Szabo, C. 2001. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflammation Research. 50 (11), pp. 561-569. https://doi.org/10.1007/PL00000234

Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics
Getting, S.J. and Perretti, M. 2001. Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current Opinion in Investigational Drugs. 2 (8), pp. 1064-1069.

Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties
Getting, S.J., Allcock, G.H., Flower, R.J. and Perretti, M. 2001. Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. Journal of Leukocyte Biology. 69 (1), pp. 98-104.

MC3-R as a novel target for anti-inflammatory therapy
Getting, S.J. and Perretti, M. 2000. MC3-R as a novel target for anti-inflammatory therapy. Drug News & Perspectives. 13 (1), pp. 19-27.

POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation
Getting, S.J., Gibbs, L., Clark, A.J.L., Flower, R.J. and Perretti, M. 1999. POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology. 162 (12), pp. 7446-7453.

Compounds for use in the treatment of inflammation
Flower, R.J., Getting, S.J. and Perretti, M. 1998. Compounds for use in the treatment of inflammation.

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects
Szabo, C., Lim, L.H.K., Cuzzocrea, S., Getting, S.J., Zingarelli, B., Flower, R.J., Salzman, A.L. and Perretti, M. 1997. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts anti-inflammatory effects. Journal of experimental medicine. 186 (7), pp. 1041-1049. https://doi.org/10.1084/jem.186.7.1041

Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins
Getting, S.J., Flower, R.J., Parente, L., de Medicis, R., Lussier, A., Woliztky, B.A., Martins, M.A. and Perretti, M. 1997. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Journal of Pharmacology and Experimental Therapeutics. 283 (1), pp. 123-130.

Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1
Getting, S.J., Flower, R.J. and Perretti, M. 1997. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. British Journal of Pharmacology. 120 (6), pp. 1075-1082. https://doi.org/10.1038/sj.bjp.0701029

Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes
Tailor, A., Das, A.M., Getting, S.J., Flower, R.J. and Perretti, M. 1997. Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. Biochemical and Biophysical Research Communications. 231 (3), pp. 675-678. https://doi.org/10.1006/bbrc.1997.6168

Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo
Getting, S.J., Segieth, J., Ahmad, S., Biggs, C.S. and Whitton, P.S. 1996. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Research. 717 (1-2), pp. 196-199. https://doi.org/10.1016/0006-8993(96)00127-8

Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats
Segieth, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats. Neuroscience Letters. 200 (2), pp. 101-104. https://doi.org/10.1016/0304-3940(95)12088-L

Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo
Segieth-Beever, J., Getting, S.J., Biggs, C.S. and Whitton, P.S. 1995. Effect of nitric oxide on basal and NMDA-evoked release of glutamate and aspartate release in vivo. Wiley. https://doi.org/10.1111/j.1476-5381.1995.tb17200.x

Permalink - https://westminsterresearch.westminster.ac.uk/item/w6w29/stimulation-of-the-pro-resolving-receptor-fpr2-reverses-inflammatory-microglial-activity-by-suppressing-nf-b-activity


Share this

Usage statistics

53 total views
22 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.