The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females

Bagheri, Reza, Ashtary-Larky, Damoon, Elliott, B., Willoughby, Darryn S., Kargarfard, Mehdi, Alipour, Meysam, Lamuchi-Deli, Nasrin, Kooti, Wesam, Asbaghi, Omid and Wong, Alexei 2023. The effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females. Archives of Physiology and Biochemistry. 129 (3), pp. 821-828. https://doi.org/10.1080/13813455.2021.1874020

TitleThe effects of gradual vs. rapid weight loss on serum concentrations of myokines and body composition in overweight and obese females
TypeJournal article
AuthorsBagheri, Reza, Ashtary-Larky, Damoon, Elliott, B., Willoughby, Darryn S., Kargarfard, Mehdi, Alipour, Meysam, Lamuchi-Deli, Nasrin, Kooti, Wesam, Asbaghi, Omid and Wong, Alexei
Abstract Research has shown the modulations of Follistatin (FST) and Myostatin (MST) following weight loss. We evaluated the effects of gradual weight loss (GWL) and rapid weight loss (RWL) on serum MST, FST, and body composition in overweight and obese females. Thirty-six overweight and obese females successfully completed the study interventions: GWL (  = 18) or RWL (  = 18). Serum MST and FST concentrations, as well as anthropometric measurements, were collected at baseline and at the conclusion of each weight loss intervention. MST concentration significantly (  < .05) decreased in the GWL; while FST concentration, body fat percentage and skeletal muscle mass significantly declined in both conditions. The loss in skeletal muscle mass was significantly greater in RWL relative to GWL. GWL was more effective than RWL in preserving skeletal muscle mass in overweight and obese females. Moreover, GWL leads to declines in MST concentrations.
KeywordsPhysiology (medical)
Physiology
General Medicine
JournalArchives of Physiology and Biochemistry
Journal citation129 (3), pp. 821-828
ISSN1381-3455
1744-4160
Year2023
PublisherTaylor & Francis
Accepted author manuscript
Digital Object Identifier (DOI)https://doi.org/10.1080/13813455.2021.1874020
PubMed ID33502906
Web address (URL)https://www.tandfonline.com/doi/full/10.1080/13813455.2021.1874020
Publication dates
Published online27 Jan 2021
Published in print2023
Page range1-8

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